Phenotypic Characterization and Antibiograms of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Isolated at the Human-Animal-Environment Interface Using a One Health Approach Among Households in Wakiso District, Uganda

References

• Ferri M, Ranucci E, Romagnoli P, Giaccone V. Antimicrobial resistance: a global emerging threat to public health systems. Crit Rev Food Sci Nutr. 2017;57:2857–2876. doi:10.1080/10408398.2015.1077192
   PubMed Web of Science ®Google Scholar
• Bassetti M, Poulakou G, Ruppe E, et al. Antimicrobial resistance in the next 30 years, humankind, bugs and drugs: a visionary approach. Intensive Care Med. 2017;43:1464–1475. doi:10.1007/s00134-017-4878-x
   PubMed Web of Science ®Google Scholar
• Patel A. Tackling antimicrobial resistance in the shadow of covid-19. MBio. 2021;12. doi:10.1128/mBio.00473-21
   Web of Science ®Google Scholar
• Cassini A, Högberg LD, Plachouras D, et al. Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis. Lancet Infect Dis. 2019;19:56–66. doi:10.1016/S1473-3099(18)30605-4
   PubMed Web of Science ®Google Scholar
• World Health Organization. WHO Report on Surveillance of Antibiotic Consumption: 2016–2018 Early Implementation. Geneva: World Health Organization; 2018.
   Google Scholar
• Adekanmbi AO, Akinpelu MO, Olaposi AV, Oyelade AA. Extended spectrum beta-lactamase encoding gene-fingerprints in multidrug resistant Escherichia coli isolated from wastewater and sludge of a hospital treatment plant in Nigeria. Int J Environmental Stud. 2020;140–150. doi:10.1080/00207233.2020.1778271
   Google Scholar
• Gekenidis MT, Qi W, Hummerjohann J, et al. Antibiotic-resistant indicator bacteria in irrigation water: high prevalence of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli. PLoS One. 2018;13:e0207857. doi:10.1371/journal.pone.0207857
   PubMed Web of Science ®Google Scholar
• Mbyemeire H, Ssekatawa K, Kato CD, Wampande EM. Molecular characterization and distribution of cephalosporin resistance determinants in Escherichia coli and Klebsiella pneumoniae isolated from patients attending Kampala International University Teaching Hospital in Bushenyi, Western Uganda. Alexandria J Med. 2021;57:205–214. doi:10.1080/20905068.2021.1952821
   Web of Science ®Google Scholar
• Odongo I, Ssemambo R, Kungu JM. Prevalence of Escherichia coli and its antimicrobial susceptibility profiles among patients with UTI at Mulago Hospital, Kampala, Uganda. Interdiscip Perspect Infect Dis. 2020;2020. doi:10.1155/2020/8042540
   PubMedGoogle Scholar
• Dunn SJ, Connor C, McNally A. The evolution and transmission of multi-drug resistant Escherichia coli and Klebsiella pneumoniae: the complexity of clones and plasmids. Curr Opin Microbiol. 2019;51:51–56. doi:10.1016/j.mib.2019.06.004
   PubMed Web of Science ®Google Scholar
• Thanner S, Drissner D, Walsh F. Antimicrobial resistance in agriculture. MBio. 2016;7. doi:10.1128/mBio.02227-15
   PubMed Web of Science ®Google Scholar
• Gwenzi W, Musiyiwa K, Mangori L. Sources, behaviour and health risks of antimicrobial resistance genes in wastewaters: a hotspot reservoir. J Environ Chem Eng. 2020;8:102220. doi:10.1016/j.jece.2018.02.028
   Web of Science ®Google Scholar
• Musoke D, Kitutu FE, Mugisha L, et al. A one health approach to strengthening antimicrobial stewardship in Wakiso District, Uganda. Antibiot. 2020;9:764. doi:10.3390/antibiotics9110764
   Google Scholar
• Patel MP, Hu L, Brown CA, et al. Synergistic effects of functionally distinct substitutions in Î2-lactamase variants shed light on the evolution of bacterial drug resistance. J Biol Chem. 2018. doi:10.1074/jbc.RA118.003792
   Web of Science ®Google Scholar
• Bush K, Bradford PA. Interplay between β-lactamases and new β-lactamase inhibitors. Nat Rev Microbiol. 2019;17:295–306. doi:10.1038/s41579-019-0159-8
   PubMed Web of Science ®Google Scholar
• Sonda T, Kumburu H, van Zwetselaar M, et al. Meta-analysis of proportion estimates of extended-spectrum-beta-lactamase-producing Enterobacteriaceae in East Africa hospitals. Antimicrob Resist Infect Control. 2016;5:18. doi:10.1186/s13756-016-0117-4
   PubMed Web of Science ®Google Scholar
• Bader MS, Loeb M, Brooks AA. An update on the management of urinary tract infections in the era of antimicrobial resistance. Postgrad Med. 2016;129:242–258. doi:10.1080/00325481.2017.1246055
   PubMed Web of Science ®Google Scholar
• Mazzariol A, Bazaj A, Cornaglia G. Multi-drug-resistant Gram-negative bacteria causing urinary tract infections: a review. J Chemother. 2017;29:2–9. doi:10.1080/1120009X.2017.1380395
   PubMed Web of Science ®Google Scholar
• Shnaiderman-Torban A, Navon-Venezia S, Baron H, et al. Prevalence and molecular characterization of extended-spectrum β-lactamase producing enterobacterales in healthy community dogs in Israel. Antibiotics. 2022;11:1069. doi:10.3390/antibiotics11081069
   Google Scholar
• Kakooza S, Munyiirwa D, Ssajjakambwe P, et al. Epidemiological dynamics of extended-spectrum β -lactamase- or AmpC β -lactamase-producing Escherichia coli screened in apparently healthy chickens in Uganda. Scientifica. 2021;2021:1–6. doi:10.1155/2021/3258059
   Web of Science ®Google Scholar
• Seni J, Najjuka CF, Kateete DP, et al. Antimicrobial resistance in hospitalized surgical patients: a silently emerging public health concern in Uganda. BMC Res Notes. 2013;6:1–7. doi:10.1186/1756-0500-6-298
   PubMedGoogle Scholar
• Kateregga JN, Kantume R, Atuhaire C, Lubowa MN, Ndukui JG. Phenotypic expression and prevalence of ESBL-producing Enterobacteriaceae in samples collected from patients in various wards of Mulago Hospital, Uganda. BMC Pharmacol Toxicol. 2015;16:1–6. doi:10.1186/s40360-015-0013-1
   PubMed Web of Science ®Google Scholar
• Ball T, Monte D, Aidara-Kane A, et al. International lineages of Salmonella enterica serovars isolated from chicken farms, Wakiso District, Uganda. PLoS One. 2020;15:e0220484. doi:10.1371/journal.pone.0220484
   PubMed Web of Science ®Google Scholar
• Kivumbi MT, Standley CJ. Efforts to identify and combat antimicrobial resistance in Uganda: a systematic review. Trop Med Infect Dis. 2021;6:86. doi:10.3390/tropicalmed6020086
   PubMedGoogle Scholar
• World Health Organization. Global Antimicrobial Resistance and Use Surveillance System (GLASS): Early Implementation 2020. Available from: https://www.who.int/publications/i/item/9789240005587. Accessed 12 April 2023.
   Google Scholar
• Babalola TO. Utilization of microbial consortia as biofertilizers and biopesticides for the production of feasible agricultural product. Int J Life Sci. 2021;57:57–66.
   Google Scholar
• Dégi J, Moțco O-A, Dégi DM, et al. Antibiotic susceptibility profile of Pseudomonas aeruginosa canine isolates from a multicentric study in Romania. Antibiotics (Basel, Switzerland). 2021;10:846. doi:10.3390/antibiotics10070846
   PubMed Web of Science ®Google Scholar
• Gaire U, Thapa Shrestha U, Adhikari S, et al. Antibiotic susceptibility, biofilm production, and detection of mecA gene among Staphylococcus aureus isolates from different clinical specimens. Diseases. 2021;9:80. doi:10.3390/diseases9040080
   PubMedGoogle Scholar
• Aksel H, Küçükkaya Eren S, Çakar A, et al. Effect of instrumentation techniques and preparation taper on apical extrusion of bacteria. J Endod. 2017;43:1008–1010. doi:10.1016/j.joen.2017.01.014
   PubMed Web of Science ®Google Scholar
• Gekenidis M-T, Kläui A, Smalla K, Drissner D. Transferable extended-spectrum β-lactamase (ESBL) plasmids in Enterobacteriaceae from irrigation water. Microorganisms. 2020;8:978. doi:10.3390/microorganisms8070978
   PubMed Web of Science ®Google Scholar
• Elbehiry A, Marzouk E, Moussa IM, et al. Acinetobacter baumannii as a community foodborne pathogen: peptide mass fingerprinting analysis, genotypic of biofilm formation and phenotypic pattern of antimicrobial resistance. Saudi J Biol Sci. 2021;28:1158–1166. doi:10.1016/j.sjbs.2020.11.052
   PubMed Web of Science ®Google Scholar
• Shakya P, Shrestha D, Maharjan E, Sharma VK, Paudyal R. ESBL Production among E. coli and Klebsiella spp. causing urinary tract infection: a hospital based study. Open Microbiol J. 2017;11:23. doi:10.2174/1874285801711010023
   PubMedGoogle Scholar
• Subramanya SH, Bairy I, Metok Y, Baral BP, Gautam D, Nayak N. Detection and characterization of ESBL-producing Enterobacteriaceae from the gut of subsistence farmers, their livestock, and the surrounding environment in rural Nepal. Sci Rep. 2021;11:1–13.
   PubMed Web of Science ®Google Scholar
• D’Angelo RG, Johnson JK, Bork JT, Heil EL. Treatment options for extended-spectrum beta-lactamase (ESBL) and AmpC-producing bacteria. Expert Opin Pharmacother. 2016;17:953–967. doi:10.1517/14656566.2016.1154538
   PubMed Web of Science ®Google Scholar
• Abalkhail A, AlYami AS, Alrashedi SF, et al. The prevalence of multidrug-resistant Escherichia coli producing ESBL among male and female patients with urinary tract infections in Riyadh Region, Saudi Arabia. Healthc. 2022;10:1778. doi:10.3390/healthcare10091778
   Google Scholar
• Armah EO, Tuntufye HN. Antibiogram and diversity of extended-spectrum beta-lactamase genes in scavenging local chicken in Morogoro Municipality, Tanzania. Int J Curr Microbiol Appl Sci. 2020;9:2699–2709. doi:10.20546/ijcmas.2020.903.308
   Google Scholar
• El-Gamal MI, Brahim I, Hisham N, et al. Recent updates of carbapenem antibiotics. Eur J Med Chem. 2017;131:185–195. doi:10.1016/j.ejmech.2017.03.022
   PubMed Web of Science ®Google Scholar
• Vannakovida C, Lampang KN, Chuammitri P, et al. Comparative occurrence and antibiogram of extended-spectrum β-lactamase-producing Escherichia coli among post-weaned calves and lactating cows from smallholder dairy farms in a parallel animal husbandry area. Vet World. 2021;14:1311. doi:10.14202/vetworld.2021.1311-1318
   PubMed Web of Science ®Google Scholar
• Ojdana D, Sieńko A, Sacha P, et al. Genetic basis of enzymatic resistance of E. coli to aminoglycosides. Adv Med Sci. 2018;63:9–13. doi:10.1016/j.advms.2017.05.004
   PubMed Web of Science ®Google Scholar
• Alyamani EJ, Khiyami AM, Booq RY, et al. The occurrence of ESBL-producing Escherichia coli carrying aminoglycoside resistance genes in urinary tract infections in Saudi Arabia. Ann Clin Microbiol Antimicrob. 2017;16:1–13. doi:10.1186/s12941-016-0177-6
   PubMed Web of Science ®Google Scholar
• Kettani Halabi M, Lahlou FA, Diawara I, et al. Antibiotic resistance pattern of extended spectrum beta lactamase producing Escherichia coli isolated from patients with urinary tract infection in Morocco. Front Cell Infect Microbiol. 2021;11:720701. doi:10.3389/fcimb.2021.720701
   PubMed Web of Science ®Google Scholar
• Somily AM, Habib HA, Absar MM, et al. ESBL-producing Escherichia coli and Klebsiella pneumoniae at a tertiary care hospital in Saudi Arabia. J Infect Dev Ctries. 2014;8:1129–1136. doi:10.3855/jidc.4292
   PubMed Web of Science ®Google Scholar
• Preena PG, Swaminathan TR, Kumar VJR, Singh ISB. Antimicrobial resistance in aquaculture: a crisis for concern. Biologia. 2020;75:1497–1517. doi:10.2478/s11756-020-00456-4
   Web of Science ®Google Scholar
• Mutuku C, Gazdag Z, Melegh S. Occurrence of antibiotics and bacterial resistance genes in wastewater: resistance mechanisms and antimicrobial resistance control approaches. World J Microbiol Biotechnol. 2022;38:152. doi:10.1007/s11274-022-03334-0
   PubMed Web of Science ®Google Scholar
• Sivakumar M, Abass G, Vivekanandhan R, et al. Extended-spectrum beta-lactamase (ESBL) producing and multidrug-resistant Escherichia coli in street foods: a public health concern. J Food Sci Technol. 2020;58:1247–1261. doi:10.1007/s13197-020-04634-9
   PubMed Web of Science ®Google Scholar
• Naziri Z, Derakhshandeh A, Borchaloee AS, Poormaleknia M, Azimzadeh N. Treatment failure in urinary tract infections: a warning witness for virulent multi-drug resistant ESBL-producing Escherichia coli. Infect Drug Resist. 2020;13:1839. doi:10.2147/IDR.S256131
   PubMed Web of Science ®Google Scholar
• Chai MH, Sukiman MZ, Jasmy N, et al. Molecular detection and antibiogram of ESBL-producing and carbapenem-resistant Escherichia coli from rabbit, swine, and poultry in Malaysia. Trop Anim Sci J. 2022;45:16–23. doi:10.5398/tasj.2022.45.1.16
   Web of Science ®Google Scholar
• Dheda K, Gumbo T, Maartens G, et al. The Lancet Respiratory Medicine Commission: 2019 update: epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant and incurable tuberculosis. Lancet Respir Med. 2019;7:820–826. doi:10.1016/S2213-2600(19)30263-2
   PubMed Web of Science ®Google Scholar
• Wall BA, Mateus AL, Marshall L, et al. Drivers, Dynamics and Epidemiology of Antimicrobial Resistance in Animal Production. Food and Agriculture Organization of the United Nations; 2016.
   Google Scholar
• Birgand G, Zahar J-R, Lucet J-C. Insight into the complex epidemiology of multidrug-resistant Enterobacteriaceae. Clin Infect Dis. 2018;66:494–496. doi:10.1093/cid/cix826
   PubMed Web of Science ®Google Scholar
• Aarestrup FM, Wegener HC, Collignon P. Resistance in bacteria of the food chain: epidemiology and control strategies. Expert Rev Anti Infect Ther. 2008;6:733–750. doi:10.1586/14787210.6.5.733
   PubMed Web of Science ®Google Scholar
• Haque KJ. Knowledge, attitude, and practices on antimicrobial use in broiler and layer farms at Cumilla District, Bangladesh. 2021.
   Google Scholar
• Lim C, Takahashi E, Hongsuwan M, et al. Epidemiology and burden of multidrug-resistant bacterial infection in a developing country. Elife. 2016;5:e18082. doi:10.7554/eLife.18082
   PubMed Web of Science ®Google Scholar
• Boehmer T, Vogler AJ, Thomas A, et al. Phenotypic characterization and whole genome analysis of extended-spectrum beta-lactamase-producing bacteria isolated from dogs in Germany. PLoS One. 2018;13:e0206252. doi:10.1371/journal.pone.0206252
   PubMed Web of Science ®Google Scholar
• Landfried K, Barnidge E, Pithua P, et al. Antibiotic use on goat farms: an investigation of knowledge, attitudes, and behaviors of missouri goat farmers. Animals. 2018;8:198. doi:10.3390/ani8110198
   Web of Science ®Google Scholar
• Clement M, Olabisi M, David E, Issa M. Veterinary pharmaceuticals and antimicrobial resistance in developing countries. In: Veterinary Medicine and Pharmaceuticals. IntechOpen; 2019.
   Google Scholar
• Manyi-Loh C, Mamphweli S, Meyer E, Okoh A. Antibiotic Use in Agriculture and Its Consequential Resistance in Environmental Sources: potential Public Health Implications. Mol AJ Synth Chem Nat Prod Chem. 2018;23:54.
   Google Scholar