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CASE REPORT

Metagenomic Next-Generation Sequencing Assists in the Diagnosis of Mediastinal Aspergillus fumigatus Abscess in an Immunocompetent Patient: A Case Report and Literature Review

ORCID Icon, , , ORCID Icon, , , , , ORCID Icon, , ORCID Icon, , , , , & show all
Pages 1865-1874 | Received 30 Nov 2022, Accepted 06 Mar 2023, Published online: 30 Mar 2023

References

  • Lian XH, Scott-Thomas A, Lewis JG, et al. Monoclonal antibodies and invasive Aspergillosis: diagnostic and therapeutic perspectives. Int J Mol Sci. 2022;23(10):5563. doi:10.3390/ijms23105563
  • Borges A, Ferreira L, Pacheco R, Fonseca I. Invasive aspergillosis of the skull base in an immunocompetent patient: a diagnostic challenge. BMJ Case Rep. 2021;14(11):e245517. doi:10.1136/bcr-2021-245517
  • Danion F, Rouzaud C, Duréault A, et al. Why are so many cases of invasive aspergillosis missed? Med Mycol. 2019;57(Supplement_2):S94–S103. doi:10.1093/mmy/myy081
  • Son HJ, Song JS, Choi S, et al. A comparison of histomorphologic diagnosis with culture- and immunohistochemistry-based diagnosis of invasive aspergillosis and mucormycosis. Infect Dis. 2020;52(4):279–283. doi:10.1080/23744235.2020.1716063
  • Chen Z, Cheng H, Cai Z, et al. Identification of microbiome etiology associated with drug resistance in pleural empyema. Front Cell Infect Microbiol. 2021;11:637018. doi:10.3389/fcimb.2021.637018
  • Yang L, Song J, Wang Y, Feng J. Metagenomic next-generation sequencing for pulmonary fungal infection diagnosis: lung biopsy versus bronchoalveolar lavage fluid. Infect Drug Resist. 2021;14:4333–4359. doi:10.2147/IDR.S333818
  • Nguyen PT, Wacker T, Brown AJP, Dantas AD, Shekhova E. Understanding the role of nitronate monooxygenases in virulence of the human fungal pathogen Aspergillus fumigatus. J Fungi. 2022;8(7):736. doi:10.3390/jof8070736
  • Wang C, You Z, Fu J, et al. Application of metagenomic next-generation sequencing in the diagnosis of pulmonary invasive fungal disease. Front Cell Infect Microbiol. 2022;12:949505. doi:10.3389/fcimb.2022.949505
  • Guo YL, Chen YQ, Wang K, Qin SM, Wu C, Kong JL. Accuracy of BAL galactomannan in diagnosing invasive aspergillosis: a bivariate metaanalysis and systematic review. Chest. 2010;138(4):817–824. doi:10.1378/chest.10-0488
  • Miceli MH, Kauffman CA. Aspergillus galactomannan for diagnosing invasive Aspergillosis. J Am Med Assoc. 2017;318(12):1175–1176. doi:10.1001/jama.2017.10661
  • Morton CO, White PL, Barnes RA, et al. Determining the analytical specificity of PCR-based assays for the diagnosis of IA: what is Aspergillus? Med Mycol. 2017;55(4):402–413. doi:10.1093/mmy/myw093
  • Bretagne S. Primary diagnostic approaches of invasive aspergillosis--molecular testing. Med Mycol. 2011;49(Suppl S1):S48–S53. doi:10.3109/13693786.2010.508186
  • Egger M, Jenks JD, Hoenigl M, Prattes J. Blood Aspergillus PCR: the good, the bad, and the ugly. J Fungi. 2020;6(1):1. doi:10.3390/jof6010018
  • Springer J, Lackner M, Nachbaur D, et al. Prospective multicentre PCR-based Aspergillus DNA screening in high-risk patients with and without primary antifungal mould prophylaxis. Clin Microbiol Infect. 2016;22(1):80–86. doi:10.1016/j.cmi.2015.09.009
  • Li Y, Song Z, Wang E, et al. Potential antifungal targets based on histones post-translational modifications against invasive aspergillosis. Front Microbiol. 2022;13:980615. doi:10.3389/fmicb.2022.980615
  • Miao Q, Ma Y, Wang Q, et al. Microbiological diagnostic performance of metagenomic next-generation sequencing when applied to clinical practice. Clin Infect Dis. 2018;67(suppl_2):S231–S240. doi:10.1093/cid/ciy693
  • Li N, Cai Q, Miao Q, Song Z, Fang Y, Hu B. High-throughput metagenomics for identification of pathogens in the clinical settings. Small Methods. 2021;5(1):2000792. doi:10.1002/smtd.202000792
  • Liu N, Kan J, Cao W, et al. Metagenomic next-generation sequencing diagnosis of peripheral pulmonary infectious lesions through virtual navigation, radial EBUS, ultrathin bronchoscopy, and ROSE. J Int Med Res. 2019;47(10):4878–4885. doi:10.1177/0300060519866953
  • Latgé JP, Chamilos G. Aspergillus fumigatus and Aspergillosis in 2019. Clin Microbiol Rev. 2019;33(1). doi:10.1128/CMR.00140-18
  • van de Veerdonk FL, Gresnigt MS, Romani L, Netea MG, Latgé JP. Aspergillus fumigatus morphology and dynamic host interactions. Nat Rev Microbiol. 2017;15(11):661–674. doi:10.1038/nrmicro.2017.90
  • Donnelly JP, Chen SC, Kauffman CA, et al. Revision and update of the consensus definitions of invasive fungal disease from the European Organization For Research And Treatment Of Cancer and the Mycoses Study Group education and research consortium. Clin Infect Dis. 2020;71(6):1367–1376. doi:10.1093/cid/ciz1008
  • Chalumeau M, Adamsbaum C, Raymond J, Iniguez JL, Gendrel D. Mediastinal aspergilloma ten years after thoracic surgery. Pediatr Infect Dis J. 2000;19(7):662–664. doi:10.1097/00006454-200007000-00020
  • Levin T, Suh B, Beltramo D, Samuel R. Aspergillus mediastinitis following orthotopic heart transplantation: case report and review of the literature. Transpl Infect Dis. 2004;6(3):129–131. doi:10.1111/j.1399-3062.2004.00064.x
  • Forestier E, Remy V, Lesens O, et al. A case of Aspergillus mediastinitis after heart transplantation successfully treated with liposomal amphotericin B, caspofungin and voriconazole. Eur J Clin Microbiol Infect Dis. 2005;24(5):347–349. doi:10.1007/s10096-005-1327-5
  • Shlobin OA, Dropulic LK, Orens JB, et al. Mediastinal mass due to Aspergillus fumigatus after lung transplantation: a case report. J Heart Lung Transplant. 2005;24(11):1991–1994. doi:10.1016/j.healun.2005.02.020
  • Sendino O, Pellisé M, Ghita G, Solé M, Rimola J, Ginès A. Aspergillus mediastinitis diagnosed by EUS-guided FNA. Gastrointest Endosc. 2008;67(1):153;commentary 154. doi:10.1016/j.gie.2007.07.029
  • Shakoor MT, Ayub S, Ayub Z, Mahmood F. Fulminant invasive aspergillosis of the mediastinum in an immunocompetent host: a case report. J Med Case Rep. 2012;6(1):311. doi:10.1186/1752-1947-6-311
  • Argento AC, Wolfe CR, Wahidi MM, Shofer SL, Mahmood K. Bronchomediastinal fistula caused by endobronchial aspergilloma. Ann Am Thorac Soc. 2015;12(1):91–95. doi:10.1513/AnnalsATS.201406-247BC
  • El-Sayed Ahmed MM, Almanfi A, Aftab M, Singh SK, Mallidi HR, Frazier OH. Aspergillus mediastinitis after orthotopic heart transplantation: a case report. Tex Heart Inst J. 2015;42(5):468–470. doi:10.14503/THIJ-14-4732
  • Agarwal S, Das A, Gochhait D, Trehan A, Srinivasan R, Singh M. Aspergillus mediastinitis presenting as superior mediastinal syndrome in an immunocompetent child. Pediatr Infect Dis J. 2015;34(2):221–222. doi:10.1097/INF.0000000000000518
  • Caballero MJ, Mongardon N, Haouache H, et al. Aspergillus mediastinitis after cardiac surgery. Int J Infect Dis. 2016;44:16–19. doi:10.1016/j.ijid.2016.01.014
  • Farid S, AbuSaleh O, Aburjania N, Sohail MR. Postsurgical mediastinal aspergilloma masquerading as malignancy. BMJ Case Rep. 2017;2017:bcr–2017.
  • Mustafa SF, Khan HA, Fatimi SH. Extensive mediastinal aspergillosis presenting with dyspnoea and cardiac tamponade symptoms. Hong Kong Med J. 2017;23(2):202–203. doi:10.12809/hkmj154790
  • Kartik M, Kanala A, Sunilnadikuda RSM, Prakasham PS. Invasive mediastinal Aspergillosis in immunocompetent male with invasion of left atrium and hilar structures. Indian J Crit Care Med. 2017;21(6):408–411. doi:10.4103/ijccm.IJCCM_18_17
  • Rahim Y, Memon A, Khan JA. Invasive mediastinal aspergillosis presenting as superior vena cava syndrome in an immunocompetent patient. BMJ Case Rep. 2018;2018. doi:10.1136/bcr-2018-225614
  • Caron J, Conti M, Pietro R, et al. Atypical presentation of Aspergillus mediastinitis infection in a heart transplant patient: the importance of combined medical and surgical treatment. Exp Clin Transplant. 2019;17(5):695–698. doi:10.6002/ect.2018.0185
  • Monteiro OMC, Higa Júnior MG, Palhares MA, et al. Case of Aspergillus mediastinitis after coronary artery bypass surgery: a case report and literature review. Am J Case Rep. 2021;22:e933193. doi:10.12659/AJCR.933193
  • Giammarino AT, Sarmiento IC, Scheinerman S, et al. Robotic-assisted closed-chest management of a fungal-infected prosthetic aortic graft: a case report. J Med Case Rep. 2022;16(1):186. doi:10.1186/s13256-022-03380-0