200
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Molecular Characteristics of Macrolide Resistance in Treponema pallidum from Patients with Latent Syphilis in Xinjiang, China

ORCID Icon, &
Pages 1231-1236 | Received 13 Dec 2022, Accepted 21 Feb 2023, Published online: 01 Mar 2023

References

  • Liu AY, Zang WJ, Yuan LL, et al. Latent syphilis among inpatients in an Urban Area of China. Glob J Health Sci. 2014;7(3):249–253. doi:10.5539/gjhs.v7n3p249
  • Zhang X, Hou F, Li X, et al. Study of surveillance data for class B notifiable disease in China from 2005 to 2014. Int J Infect Dis. 2016;48:7–13. doi:10.1016/j.ijid.2016.04.010
  • Chen YX, Jie L, Yi Z. Tredds in the epidemiology of sexually transmitted disease, Acquired Immune Deficiency Syndrome(AIDS), gonorrhea, and syphilis, in the 31 provinces of Mainland China. Med Sci Monit. 2019;25:5657–5665. doi:10.12659/MSM.915732
  • Bourgeois G, Grange P, Terrier CSP, et al. Azithromycin resistance in Treponema pallidum in Reunion Island: a cross-sectional study. Ann Dermatol Venereol. 2021;148(3):249–253. doi:10.1016/j.annder.2020.12.003
  • Venter JME, Müller EE, Mahlangu MP, et al. Treponema pallidum macrolide resistance and molecular epidemiology in Southern Africa, 2008 to 2018. J Clin Microbiol. 2021;59(10):e0238520. doi:10.1128/JCM.02385-20
  • Molini BJ, Tantalo LC, Sahi SK, et al. Macrolide resistance in Treponema palidum correlates with 23S rDNA mutations in recently isolated clincal strains. Sex Transm Dis. 2016;43(9):579–583. doi:10.1097/OLQ.0000000000000486
  • Posana Y, Yasmon A, Indriatmi W, et al. Detection of A2058G and A2059G on the 23S rRNA gene by multiplex nested PCR to identify Treponema palidum resistance to azithromycin in Indonesia. Jpn J Infect Dis. 2022;75:355–360. doi:10.7883/yoken.JJID.2021.738
  • Lu H, Li K, Gong W, et al. High frequency of the 23S rRNA A2058G mutation of Treponema pallidum in Shanghai is associated with a current strategy for the treatment of syphilis. Emerg Microbes Infect. 2015;4(2):e10. doi:10.1038/emi.2015.10
  • Xiao Y, Liu S, Liu Z, et al. Molecular subtyping and surveillance of resistance genes in Treponema pallidum DNA from patients with secondary and latent Syphilis in Hunan, China. Sex Transm Dis. 2016;43(5):310–316. doi:10.1097/OLQ.0000000000000445
  • Li Z, Hou J, Zheng R, et al. Two mutations associated with macrolide resistance in Treponema pallidum in Shangdong, China. J Clin Microbiol. 2013;51(12):4270–4271. doi:10.1128/JCM.01261-13
  • Liu D, He SM, Zhu XZ, et al. Molecular characterization based on MLST and ECDC typing schemes and antibiotic resistance analyses of Treponema pallidum subsp. Pallidum in Xiamen, China. Front Cell Infect Microbiol. 2021;10:618747. doi:10.3389/fcimb.2020.618747
  • Zondag HCA, Cornelissen AR, Dam AP, et al. Molecular diversity of Treponema pallidum subspecies pallidum isolates in Amsterdam, the Netherlands. Sex Transm Infect. 2020;96(3):223–226. doi:10.1136/sextrans-2019-054044
  • Khairullin R, Vorobyev D, Obukhov A, et al. Syphillis epidemiology in 1994–2013, molecular epidemiological strain typing and determination of macrolide resistance in Treponema pallidum in 2013–2014 in Tuva Republic, Russia. APMIS. 2016;124(7):595–602. doi:10.1111/apm.12541
  • Nishiki S, Arima Y, Kanai M, et al. Epidemiology, molecular strain types, and macrolide resistance of Treponema pallidum in Japan, 2017–2018. J Infect Chemother. 2020;26(10):1042–1047. doi:10.1016/j.jiac.2020.05.022
  • Fernández-Naval C, Arando M, Espasa M, et al. Enhanced molecular typing and macrolide and tetracycline-resistance mutations of Treponema pallidum in Barcelona. Future Microbiol. 2019;14(13):1099–1108. doi:10.2217/fmb-2019-0123
  • Workowski KA, Bolan. GA. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep. 2015;64(RR–03):1–137.
  • Martin IE, Tsang RSW, Sutherland K, et al. Molecular characterization of syphilis in patients in Canada: azithromycin resistance and detection of Treponema pallidum DNA in whole-blood samples versus ulcerative swabs. J Clin Microbiol. 2009;47(6):1668–1673. doi:10.1128/JCM.02392-08
  • Sheila A, Godornes C, Barbara J, et al. Macrolide resistance in Treponema pallidum in the United States and Ireland. N Engl J Med. 2004;351(2):154–158. doi:10.1056/NEJMoa040216
  • Matějková P, Flasarová M, Zákoucká H, et al. Macrolide treatment failure in a case of secondary syphilis: a novel A2059G mutation in the 23S rRNA gene of Treponema pallidum subsp. pallidum. J Med Microbiol. 2009;58(Pt6):832–836. doi:10.1099/jmm.0.007542-0
  • Wang C, Cheng Y, Liu B, et al. Sensitive detection of Treponema pallidum DNA from the whole blood of patients with syphilis by the nested PCR assay. Emerg Microbes Infect. 2018;7(1):83. doi:10.1038/s41426-018-0085-2
  • Kenyon C. Prevalence of macrolide resistance in Treponema pallidum is associated with macrolide consumption. J Med Microbiol. 2019;68(2):119–123. doi:10.1099/jmm.0.000885
  • Marra CM, Colina AP, Godornes C, et al. Antibiotic selection may contribute to increases in macrolide-resistant Treponema pallidum. J Infect Dis. 2006;194:1771–1773. doi:10.1086/509512