Epidemiological and Molecular Characteristics of bla_NDM-1 and bla_KPC-2 Co-Occurrence Carbapenem-Resistant Klebsiella pneumoniae

References

• Navon-Venezia S, Kondratyeva K, Carattoli A. Klebsiella pneumoniae: a major worldwide source and shuttle for antibiotic resistance. FEMS Microbiol Rev. 2017;41(3):252–275. doi:10.1093/femsre/fux013
   PubMed Web of Science ®Google Scholar
• Yigit H, Queenan AM, Anderson GJ, et al. Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae. Antimicrob Agents Chemother. 2001;45:1151–1161. doi:10.1128/AAC.45.4.1151-1161.2001
   PubMed Web of Science ®Google Scholar
• Nishida S, Matsunaga N, Kamimura Y, et al. Emergence of Enterobacter cloacae complex co-producing IMP-10 and CTX-M, and Klebsiella pneumoniae producing VIM-1 in clinical isolates in Japan. Microorganisms. 2020;8(11):1816. doi:10.3390/microorganisms8111816
   PubMedGoogle Scholar
• Pérez-Vázquez M, Sola Campoy PJ, Ortega A, et al; Spanish NDM Study Group. Emergence of NDM-producing Klebsiella pneumoniae and Escherichia coli in Spain: phylogeny, resistome, virulence and plasmids encoding blaNDM-like genes as determined by WGS. J Antimicrob Chemother. 2019;74(12):3489–3496. doi:10.1093/jac/dkz366
   PubMedGoogle Scholar
• Fukigai S, Alba J, Kimura S, et al. Nosocomial outbreak of genetically related IMP-1 beta-lactamase-producing Klebsiella pneumoniae in a general hospital in Japan. Int J Antimicrob Agents. 2007;29(3):306–310. doi:10.1016/j.ijantimicag.2006.10.011
   PubMedGoogle Scholar
• Lu MC, Chen YT, Tang HL, et al. Transmission and evolution of OXA-48-producing Klebsiella pneumoniae ST11 in a single hospital in Taiwan. J Antimicrob Chemother. 2020;75:318–326. doi:10.1093/jac/dkz431
   PubMedGoogle Scholar
• Chen L, Mathema B, Chavda KD, et al. Carbapenemase-producing Klebsiella pneumoniae: molecular and genetic decoding. Trends Microbiol. 2014;22(12):686–696. doi:10.1016/j.tim.2014.09.003
   PubMed Web of Science ®Google Scholar
• Zhang P, Shi Q, Hu H, et al. Emergence of ceftazidime/avibactam resistance in carbapenem-resistant Klebsiella pneumoniae in China. Clin Microbiol Infect. 2020;26(1):124.e1–124.e4. doi:10.1016/j.cmi.2019.08.020
   PubMed Web of Science ®Google Scholar
• Gu D, Dong N, Zheng Z, et al. A fatal outbreak of ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae in a Chinese hospital: a molecular epidemiological study. Lancet Infect Dis. 2018;18(1):37–46. doi:10.1016/S1473-3099(17)30489-9
   PubMed Web of Science ®Google Scholar
• Shon AS, Bajwa RP, Russo TA. Hypervirulent (hypermucoviscous) Klebsiella pneumoniae. Virulence. 2013;4(2):107–118. doi:10.4161/viru.22718
   PubMed Web of Science ®Google Scholar
• Russo TA, Marr CM. Hypervirulent Klebsiella pneumoniae. Clin Microbiol Rev. 2019;32(3):e00001–e00019. doi:10.1128/CMR.00001-19
   PubMed Web of Science ®Google Scholar
• Wyres KL, Lam MMC, Holt KE. Population genomics of Klebsiella pneumoniae. Nat Rev Microbiol. 2020;18:344–359. doi:10.1038/s41579-019-0315-1
   PubMed Web of Science ®Google Scholar
• Yang X, Dong N, Chan EW, et al. Carbapenem resistance-encoding and virulence-encoding conjugative plasmids in Klebsiella pneumoniae. Trends Microbiol. 2021;29(1):65–83. doi:10.1016/j.tim.2020.04.012
   PubMed Web of Science ®Google Scholar
• Chen L, Kreiswirth BN. Convergence of carbapenem-resistance and hypervirulence in Klebsiella pneumoniae. Lancet Infect Dis. 2018;18(1):2–3. doi:10.1016/S1473-3099(17)30517-0
   PubMed Web of Science ®Google Scholar
• Wong MHY, Shum HP, Chen JHK, et al. Emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae. Lancet Infect Dis. 2018;18(1):24. doi:10.1016/S1473-3099(17)30629-1
   PubMedGoogle Scholar
• Xie M, Dong N, Chen K, et al. A hybrid plasmid formed by recombination of a virulence plasmid and a resistance plasmid in Klebsiella pneumoniae. J Glob Antimicrob Resist. 2020;23:466–470. doi:10.1016/j.jgar.2020.10.018
   PubMedGoogle Scholar
• Yao H, Qin S, Chen S, et al. Emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae. Lancet Infect Dis. 2018;18:25.
   PubMed Web of Science ®Google Scholar
• Xu M, Fu Y, Fang Y, et al. High prevalence of KPC-2-producing hypervirulent Klebsiella pneumoniae causing meningitis in Eastern China. Infect Drug Resist. 2019;12:641–653. doi:10.2147/IDR.S191892
   PubMed Web of Science ®Google Scholar
• Poirel L, Walsh TR, Cuvillier V, et al. Multiplex PCR for detection of acquired carbapenemase genes. Diagn Microbiol Infect Dis. 2011;70(1):119–123. doi:10.1016/j.diagmicrobio.2010.12.002
   PubMed Web of Science ®Google Scholar
• Chen R, Liu Z, Xu P, et al. Deciphering the epidemiological characteristics and molecular features of blaKPC-2- or blaNDM-1-positive Klebsiella pneumoniae isolates in a newly established hospital. Front Microbiol. 2021;12:741093. doi:10.3389/fmicb.2021.741093
   PubMed Web of Science ®Google Scholar
• Baraniak A, Grabowska A, Izdebski R, et al.; KPC-PL Study Group. Molecular characteristics of KPC-producing Enterobacteriaceae at the early stage of their dissemination in Poland, 2008–2009. Antimicrob Agents Chemother. 2011;55(12):5493–5499. doi:10.1128/AAC.05118-11
   PubMedGoogle Scholar
• Hu Y, Liu C, Shen Z, et al. Prevalence, risk factors and molecular epidemiology of carbapenem-resistant Klebsiella pneumoniae in patients from Zhejiang, China, 2008–2018. Emerg Microbes Infect. 2020;9(1):1771–1779. doi:10.1080/22221751.2020.1799721
   PubMed Web of Science ®Google Scholar
• Wang R, Yang Q, Zhang S, et al. Trends and correlation of antibiotic susceptibility and antibiotic consumption at a large teaching hospital in China (2007–2016): a surveillance study. Ther Clin Risk Manag. 2019;15:1019–1027. doi:10.2147/TCRM.S210872
   PubMed Web of Science ®Google Scholar
• Singh A, Goering RV, Simjee S, et al. Application of molecular techniques to the study of hospital infection. Clin Microbiol Rev. 2006;19(3):512–530. doi:10.1128/CMR.00025-05
   PubMed Web of Science ®Google Scholar
• Gopalakrishnan S, Kamalanathan A, Rajan S, et al. Emergence of armA and rmtB genes among VIM, NDM, and IMP metallo-β-lactamase-producing multidrug-resistant gram-negative pathogens. Acta Microbiol Immunol Hung. 2018;65(1):107–118. doi:10.1556/030.64.2017.027
   PubMedGoogle Scholar
• Zhu WM, Yuan Z, Zhou HY. Risk factors for carbapenem-resistant Klebsiella pneumoniae infection relative to two types of control patients: a systematic review and meta-analysis. Antimicrob Resist Infect Control. 2020;9:23. doi:10.1186/s13756-020-0686-0
   PubMed Web of Science ®Google Scholar
• Qin X, Wu S, Hao M, et al. The colonization of carbapenem-resistant Klebsiella pneumoniae: epidemiology, resistance mechanisms, and risk factors in patients admitted to intensive care units in China. J Infect Dis. 2020;221(Suppl 2):S206–S214. doi:10.1093/infdis/jiz622
   PubMed Web of Science ®Google Scholar
• Yu F, Hu L, Zhong Q, et al. Dissemination of Klebsiella pneumoniae ST11 isolates with carbapenem resistance in integrated and emergency intensive care units in a Chinese tertiary hospital. J Med Microbiol. 2019;68(6):882–889. doi:10.1099/jmm.0.000981
   PubMedGoogle Scholar
• Yang Q, Jia X, Zhou M, et al. Emergence of ST11-K47 and ST11-K64 hypervirulent carbapenem-resistant Klebsiella pneumoniae in bacterial liver abscesses from China: a molecular, biological, and epidemiological study. Emerg Microbes Infect. 2020;9(1):320–331. doi:10.1080/22221751.2020.1721334
   PubMed Web of Science ®Google Scholar
• Munoz-Price LS, Poirel L, Bonomo RA, et al. Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases. Lancet Infect Dis. 2013;13(9):785–796. doi:10.1016/S1473-3099(13)70190-7
   PubMed Web of Science ®Google Scholar
• Ko KS. Antibiotic-resistant clones in gram-negative pathogens: presence of global clones in Korea. J Microbiol. 2019;57(3):195–202. doi:10.1007/s12275-019-8491-2
   PubMedGoogle Scholar
• Zhan L, Wang S, Guo Y, et al. Outbreak by hypermucoviscous Klebsiella pneumoniae ST11 isolates with carbapenem resistance in a tertiary hospital in China. Front Cell Infect Microbiol. 2017;7:182. doi:10.3389/fcimb.2017.00182
   PubMed Web of Science ®Google Scholar
• Yang Y, Yang Y, Chen G, et al. Molecular characterization of carbapenem-resistant and virulent plasmids in Klebsiella pneumoniae from patients with bloodstream infections in China. Emerg Microbes Infect. 2021;10(1):700–709. doi:10.1080/22221751.2021.1906163
   PubMed Web of Science ®Google Scholar
• Zhou K, Xiao T, David S, et al. Novel subclone of carbapenem-resistant Klebsiella pneumoniae sequence type 11 with enhanced virulence and transmissibility, China. Emerg Infect Dis. 2020;26(2):289–297. doi:10.3201/eid2602.190594
   PubMed Web of Science ®Google Scholar
• Jin X, Chen Q, Shen F, et al. Resistance evolution of hypervirulent carbapenem-resistant Klebsiella pneumoniae ST11 during treatment with tigecycline and polymyxin. Emerg Microbes Infect. 2021;10(1):1129–1136. doi:10.1080/22221751.2021.1937327
   PubMed Web of Science ®Google Scholar
• Jiang Y, Wei Z, Wang Y, et al. Tracking a hospital outbreak of KPC-producing ST11 Klebsiella pneumoniae with whole genome sequencing. Clin Microbiol Infect. 2015;21(11):882–889. doi:10.1016/j.cmi.2015.07.001
   Google Scholar
• Spencer MD, Winglee K, Passaretti C, et al. Whole genome sequencing detects inter-facility transmission of carbapenem-resistant Klebsiella pneumoniae. J Infect. 2019;78(3):187–199. doi:10.1016/j.jinf.2018.11.003
   PubMedGoogle Scholar
• Choby JE, Howard-Anderson J, Weiss DS. Hypervirulent Klebsiella pneumoniae - clinical and molecular perspectives. J Intern Med. 2020;287:283–300. doi:10.1111/joim.13007
   PubMed Web of Science ®Google Scholar
• Takeuchi D, Akeda Y, Yoshida H, et al. Genomic reorganization by IS26 in a blaNDM-5-bearing FII plasmid of Klebsiella pneumoniae isolated from a patient in Japan. J Med Microbiol. 2018;67:1221–1224. doi:10.1099/jmm.0.000817
   PubMedGoogle Scholar
• Sun L, Xu J, He F. Draft genome sequence of an NDM-5, CTX-M-15 and OXA-1 co-producing Escherichia coli ST167 clinical strain isolated from a urine sample. J Glob Antimicrob Resist. 2018;14:284–286. doi:10.1016/j.jgar.2018.08.005
   PubMed Web of Science ®Google Scholar