High Prevalence of Group III-Like Mutations Among BLPACR and First Report of Haemophilus influenzae ST95 Isolated from Blood in China

References

• Zhang J, Zhu Z, Zuo X, Pan H, Gu Y, Yuan Y. The role of NTHi colonization and infection in the pathogenesis of neutrophilic asthma. Respir Res. 2020;21(1):170. doi:10.1186/s12931-020-01438-5
   PubMed Web of Science ®Google Scholar
• Soeters HM, Oliver SE, Plumb ID, et al. Epidemiology of invasive Haemophilus influenzae serotype a disease—United States, 2008–2017. Clin Infect Dis. 2021;73(2):e371–e379. doi:10.1093/cid/ciaa875
   PubMed Web of Science ®Google Scholar
• Eton V, Schroeter A, Kelly L, Kirlew M, Tsang RSW, Ulanova M. Epidemiology of invasive pneumococcal and Haemophilus influenzae diseases in Northwestern Ontario, Canada, 2010–2015. Int J Infect Dis. 2017;65:27–33. doi:10.1016/j.ijid.2017.09.016
   PubMed Web of Science ®Google Scholar
• Yang Y, Leng D, Lu D. Pediatric Haemophilus influenzae type b meninngitis in Hefei city: an epidemiologic study. Zhonghua Yi Xue Za Zhi. 1998;78(4):251–253.
   PubMedGoogle Scholar
• Dong B-Q, Tang -Z-Z, Li M, et al. Epidemiologic surveillance for bacterial meningitis in 140 000 children under 5 years of age in Nanning district, Guangxi province. Zhonghua Liu Xing Bing Xue Za Zhi. 2004;25(5):391–395.
   PubMedGoogle Scholar
• Van Eldere J, Slack MPE, Ladhani S, Cripps,AW. Non-typeable Haemophilus influenzae, an under-recognised pathogen. Lancet Infect Dis. 2014;14(12):1281–1292. doi:10.1016/S1473-3099(14)70734-0
   PubMed Web of Science ®Google Scholar
• Slack Mary PE. The evidence for non-typeable Haemophilus influenzae as a causative agent of childhood pneumonia. Pneumonia. 2017;9(1):9. doi:10.1186/s41479-017-0033-2
   Google Scholar
• Karlsson E, Melhus Å. Nontypeable Haemophilus influenzae strains with the capsule-associated insertion element IS1016 may mimic encapsulated strains. APMIS. 2006;114(9):633–640. doi:10.1111/j.1600-0463.2006.apm_333.x
   PubMed Web of Science ®Google Scholar
• Mell JC, Lee JY, Firme M, Sinha S, Redfield,RJ. Extensive cotransformation of natural variation into chromosomes of naturally competent Haemophilus influenzae. G3. 2014;4(4):717–731. doi:10.1534/g3.113.009597
   Web of Science ®Google Scholar
• Langereis JD, Weiser JN. Shielding of a lipooligosaccharide IgM epitope allows evasion of neutrophil-mediated killing of an invasive strain of nontypeable Haemophilus influenzae. mBio. 2014;5(4):e01478–01414. doi:10.1128/mBio.01478-14
   PubMed Web of Science ®Google Scholar
• Takla A, Schönfeld V, Claus H. Invasive Haemophilus influenzae infections in Germany after the introduction of routine childhood immunization, 2001––2016. Open Forum Infect Dis. 2020;7(10):ofaa444. doi:10.1093/ofid/ofaa444
   PubMed Web of Science ®Google Scholar
• Hotomi M, Fujihara K, Billal DS, Suzuki K, Nishimura T. Genetic characteristics and clonal dissemination of β-lactamase-negative ampicillin-resistant Haemophilus influenzae strains isolated from the upper respiratory tract of patients in Japan. Antimicrob Agents Chemother. 2007;51(11):3969–3976. doi:10.1128/AAC.00422-07
   PubMed Web of Science ®Google Scholar
• Ubukata K, Shibasaki Y, Yamamoto K, Chiba N, Hasegawa K. Association of amino acid substitutions in penicillin-binding protein 3 with β-lactam resistance in β-lactamase-negative ampicillin-resistant Haemophilus influenzae. Antimicrob Agents Chemother. 2001;45(6):1693–1699. doi:10.1128/AAC.45.6.1693-1699.2001
   PubMed Web of Science ®Google Scholar
• Zhou M, Fu P, Fang C, et al. Antimicrobial resistance of Haemophilus influenzae isolates from pediatric hospitals in Mainland China: report from the ISPED program, 2017–2019. Indian J Med Microbiol. 2021;39(4):434–438. doi:10.1016/j.ijmmb.2021.09.001
   PubMed Web of Science ®Google Scholar
• Dabernat H, Delmas C, Seguy M, Pelissier R, Faucon G, Bennamani S. Diversity of β-lactam resistance-conferring amino acid substitutions in penicillin-binding protein 3 of Haemophilus influenzae. Antimicrob Agents Chemother. 2002;46(7):2208–2218. doi:10.1128/AAC.46.7.2208-2218.2002
   PubMed Web of Science ®Google Scholar
• Wang H-J, Wang C-Q, Hua C-Z, et al. Antibiotic resistance profiles of Haemophilus influenzae isolates from children in 2016: a multicenter study in China. Can J Infect Dis Med Microbiol. 2019;2019:6456321. doi:10.1155/2019/6456321
   PubMed Web of Science ®Google Scholar
• León ME, Kawabata A, Nagai M, et al. Estudio epidemiológico de Haemophilus influenzae causante de enfermedad invasiva y no invasiva en Paraguay (1999–2017) [Epidemiological study of Haemophilus influenzae causing invasive and non-invasive disease in Paraguay]. Enferm Infecc Microbiol Clin. 2021;39(2):59–64. doi:10.1016/j.eimc.2020.02.020
   Web of Science ®Google Scholar
• Zhu X, Ye T, Zhong H, et al. Distribution and drug resistance of bacterial pathogens associated with lower respiratory tract infection in children and the effect of COVID-19 on the distribution of pathogens. Can J Infect Dis Med Microbiol. 2022;2022:1181283. doi:10.1155/2022/1181283
   PubMed Web of Science ®Google Scholar
• Shen XZ, Lu Q, Deng L, et al. Resistance of Haemophilus influenzae isolates in children under 5 years old with acute respiratory infections in china between 2000 and 2002. J Int Med Res. 2007;35(4):554–563. doi:10.1177/147323000703500416
   PubMed Web of Science ®Google Scholar
• Wang GL, Hua CZ, Yang LH, et al. Clinical characteristics of 84 children with invasive Haemophilus influenzae infection from 2014 to 2018. Zhonghua Er Ke Za Zhi. 2019;57(8):592–596. doi:10.3760/cma.j.issn.0578-1310.2019.08.004
   PubMedGoogle Scholar
• Kaczmarek FS, Gootz TD, Dib-Hajj F, Shang W, Hallowell S, Cronan M. Genetic and molecular characterization of β-lactamase-negative ampicillin-resistant Haemophilus influenzae with unusually high resistance to ampicillin. Antimicrob Agents Chemother. 2004;48(5):1630–1639. doi:10.1128/AAC.48.5.1630-1639.2004
   PubMed Web of Science ®Google Scholar
• García-Cobos S, Campos J, Lázaro E, et al. Ampicillin-resistant non-β-lactamase-producing Haemophilus influenzae in Spain: recent emergence of clonal isolates with increased resistance to cefotaxime and cefixime. Antimicrob Agents Chemother. 2007;51(7):2564–2573. doi:10.1128/AAC.00354-07
   PubMed Web of Science ®Google Scholar
• Kostyanev TS, Sechanova LP. Virulence factors and mechanisms of antibiotic resistance of Haemophilus influenzae. Folia Med. 2012;54(1):19–23. doi:10.2478/v10153-011-0073-y
   Google Scholar
• Yuan M, Shu JT, Li J, Zhang JY, Kong N. Capsular typing and drug resistance patterns of Haemophilus influenzae strains isolated from children in Yunnan. Chin J Nosocomiology. 2021;31(18):2826–2830.
   Google Scholar
• Shuel M, Hoang L, Law DKS, Tsang R. Invasive Haemophilus influenzae in British Columbia: non-hib and non-typeable strains causing disease in children and adults. Int J Infect Dis. 2011;15(3):e167e173. doi:10.1016/j.ijid.2010.10.005
   Web of Science ®Google Scholar
• Han MS, Jung HJ, Lee HJ, Choi,EH. Increasing prevalence of group III penicillin-binding protein 3 mutations conferring high-level resistance to beta-lactams among nontypeable Haemophilus influenzae isolates from children in Korea. Microb Drug Resist. 2019;25(4):567–576. doi:10.1089/mdr.2018.0342
   PubMed Web of Science ®Google Scholar
• Honda H, Sato T, Shinagawa M, et al. Multiclonal expansion and high prevalence of β-lactamase-negative Haemophilus influenzae with high-level ampicillin resistance in Japan and susceptibility to quinolones. Antimicrob Agents Chemother. 2018;62(9):e00851–00818. doi:10.1128/AAC.00851-18
   PubMed Web of Science ®Google Scholar
• Li -X-X, Xiao S-Z, Gu -F-F, He W-P, Ni Y-X, Han,L-Z. Molecular epidemiology and antimicrobial resistance of Haemophilus influenzae in adult patients in Shanghai, China. Front Public Health. 2020;8:95. doi:10.3389/fpubh.2020.00095
   PubMed Web of Science ®Google Scholar
• Wang XL, Xie J, Guo YB, et al. Lower respiratory tract isolates of non-typeable Haemophilus influenzae in Western Sichuan, China: antimicrobial susceptibility, mechanisms of β-lactam resistance and decade changes. J Glob Antimicrob Resist. 2020;21:324–330. doi:10.1016/j.jgar.2019.10.026
   PubMed Web of Science ®Google Scholar
• Leavis HL, Willems RJL, van Wamel WJB, Schuren FH, Caspers MP, Martien PM. Insertion Sequence–driven diversification creates a globally dispersed emerging multiresistant subspecies of E. faecium. PLoS Pathog. 2007;3(1):e7. doi:10.1371/journal.ppat.0030007
   PubMed Web of Science ®Google Scholar
• Tanaka E, Wajima T, Nakaminami H, Noguchi N. Whole-genome sequence of Haemophilus influenzae ST422 outbreak clone strain 2018-Y40 with low quinolone susceptibility isolated from a paediatric patient. J Glob Antimicrob Resist. 2020;22:759–761. doi:10.1016/j.jgar.2020.06.024
   PubMed Web of Science ®Google Scholar
• Otsuka T, Fujii K, Okazaki M, Komiyama K, Yoshida K, Ishikawa Y. Genotyping of Haemophilus influenzae type b in pre-vaccination era. J Infect Chemother. 2012;18(2):213–218. doi:10.1007/s10156-011-0323-1
   PubMed Web of Science ®Google Scholar
• Tsang RSW, Li A, Mullen A, et al. Laboratory characterization of invasive Haemophilus influenzae isolates from Nunavut, Canada, 2000–2012. Int J Circumpolar Health. 2016;75(1):29798. doi:10.3402/ijch.v75.29798
   PubMedGoogle Scholar
• Mironov KO, Tagachenkova TA, Platonov AE, Iakovenko ML, Koroleva IS, Shipulin,GA. Genetic characteristics of Haemophilus influenzae type b isolated from children with bacterial meningitis in Moscow in 2007–2009. Zh Mikrobiol Epidemiol Immunobiol. 2010;4:3–8.
   Google Scholar
• Wang FS, Yang TT, Yao PP, Xu BX, Ye JL. Comparison of typing among 4 Haemophilus influenzae isolates with capsule. Chin J Health Lab Technol. 2012;22(12):2892–2894.
   Google Scholar
• Moxon ER, Kroll JS. Type b capsular polysaccharide as a virulence factor of Haemophilus influenzae. Vaccine. 1988;6(2):113–115. doi:10.1016/S0264-410X(88)80011-2
   PubMed Web of Science ®Google Scholar
• Cardoso B, Fontana H, Esposito F, et al. Genomic insights of international clones of Haemophilus influenzae causing invasive infections in vaccinated and unvaccinated infants. Microb Pathog. 2021;150:104644. doi:10.1016/j.micpath.2020.104644
   PubMed Web of Science ®Google Scholar
• Ali TR, Kroll JS, Langford,PR. Haemophilus influenzae microarrays: virulence and vaccines. Comp Funct Genomics. 2002;3(4):358–361. doi:10.1002/cfg.194
   PubMedGoogle Scholar
• Burroughs M, Cabellos C, Prasad S, Tuomanen E. Bacterial components and the pathophysiology of injury to the blood-brain barrier: does cell wall add to the effects of endotoxin in gram-negative meningitis? J Infect Dis. 1992;Suppl 165(Supplement 1):S82–S85. doi:10.1093/infdis/165-Supplement_1-S82
   Google Scholar
• Griffin R, Bayliss CD, Herbert MA, et al. Digalactoside expression in the lipopolysaccharide of Haemophilus influenzae and its role in intravascular survival. Infect Immun. 2005;73(10):7022–7026. doi:10.1128/IAI.73.10.7022-7026.2005
   PubMed Web of Science ®Google Scholar