Prevalence, Antibiotic Susceptibility Profile and Associated Factors of Group A Streptococcal pharyngitis Among Pediatric Patients with Acute Pharyngitis in Gondar, Northwest Ethiopia

References

• Sidrah K, Pradeep V. Streptococcus Pyogenes - StatPearls - NCBI Bookshelf. Stat Pearls; 2022.
   Google Scholar
• Lancefield RC. A micro precipitin-technic for classifying hemolytic streptococci, and improved methods for producing antisera. Proc Soc Exp Biol Med. 1938;38:4.
   Google Scholar
• Arnold JC, Nizet V. Pharyngitis. In: Long SS, Proper CG, Fischer M, editors. Principles and Practice of Pediatric Infectious Diseases. Elsevier; 2018.
   Google Scholar
• Jasim SA, Hatem ZA, Mohammed ZA. Virulence factors and clinical features of Streptococcus pyogenes: overview. Ann Rom Soc Cell Biol. 2021;25:1.
   Google Scholar
• Terao Y. The virulence factors and pathogenic mechanisms of Streptococcus pyogenes. J Oral Biosci. 2012;54(2):96–100.
   Google Scholar
• Darenberg J, Henriques-Normark B, Lepp T, Tegmark-Wisell K, Tegnell A, Widgren K. Increased incidence of invasive group A streptococcal infections in Sweden, January 2012–February 2013. Eurosurveillance. 2013;18:14.
   Google Scholar
• Ibrahim J, Eisen JA, Jospin G, Coil DA, Khazen G, Tokajian S. Genome analysis of Streptococcus pyogenes associated with pharyngitis and skin infections. PLoS One. 2016;11(12):e0168177.
   PubMedGoogle Scholar
• Bennett JE, Dolin R, Blaser MJ, editors, Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. Philadelphia, PA: Elsevier; 2020:5407.
   Google Scholar
• Wessels MR. Streptococcal Pharyngitis. N Engl J Med. 2011;364(7):648–655.
   PubMed Web of Science ®Google Scholar
• Cunningham MW. Pathogenesis of group A streptococcal infections. Clin Microbiol Rev. 2000;13(3):470–511.
   PubMed Web of Science ®Google Scholar
• Ashurst JV, Edgerley-Gibb L. Streptococcal Pharyngitis. N Eng J Med. 2011;364(7):648–655.
   PubMedGoogle Scholar
• Renner B, Mueller CA, Shephard A. Environmental and non-infectious factors in the aetiology of pharyngitis (sore throat). Inflamm Res. 2012;61(10):1041–1052.
   PubMed Web of Science ®Google Scholar
• Olafsdottir LB, Erlendsdóttir H, Melo-Cristino J, et al. Invasive infections due to Streptococcus pyogenes: seasonal variation of severity and clinical characteristics, Iceland, 1975 to 2012. Eurosurveillance. 2014;19:17.
   Google Scholar
• Shulman ST, Bisno AL, Clegg HW, et al. Clinical practice guideline for the diagnosis and management of group a streptococcal pharyngitis: 2012 update by the infectious diseases society of America. Clin Infect Dis. 2012;55(10):e86–102.
   PubMed Web of Science ®Google Scholar
• Gunnarsson RK, Holm SE, Söderström M. The prevalence of beta-haemolytic streptococci in throat specimens from healthy children and adults: implications for the clinical value of throat cultures. Scand J Prim Health Care. 1997;15(3):149–155.
   PubMed Web of Science ®Google Scholar
• Al-Hasnawi EAF, Abbas OK, Al-Taie W. Detection and evaluation of Streptococcus pyogenes (group A) as a superior infectious agent of acute pharyngitis among school age children. Ann Trop Med Public Heal. 2020;23(7):562–569.
   Google Scholar
• Ferretti JJ, Stevens DL, Fischetti VA, editors. Streptococcus Pyogenes: Basic Biology to Clinical Manifestations. University of Oklahoma Health Sciences Center; 2016:467–476.
   Google Scholar
• Wolford RW, Goyal A, Belgam Syed SY, Schaefer TJ. Pharyngitis. StatPearls; 2022.
   Google Scholar
• Carapetis JR, Steer AC, Mulholland EK, Weber M. The global burden of group A streptococcal diseases. Lancet Infect Dis. 2005;5(11):685–694.
   PubMed Web of Science ®Google Scholar
• Miller KM, Carapetis JR, Van Beneden CA, et al. The global burden of sore throat and group A Streptococcus pharyngitis: a systematic review and meta-analysis. eClinicalMedicine. 2022;48:101458.
   PubMedGoogle Scholar
• Ryan ET, Hill DR, Solomon T, Aronson NE, Endy TP. Hunter’s Tropical Medicine and Emerging Infectious Disease. 9th ed. Ryan ET; 2020:429–438 p.
   Google Scholar
• Bennett J, Moreland NJ, Zhang J, et al. Risk factors for group A streptococcal pharyngitis and skin infections: a case control study. Lancet Reg Heal. 2022;26:100507.
   Google Scholar
• Avire NJ, Whiley H, Ross K. A review of Streptococcus pyogenes: public health risk factors, prevention and control. Pathogens. 2021;10(2):248.
   PubMedGoogle Scholar
• Good MF. Streptococcus: an organism causing diseases beyond neglect. PLoS Negl Trop Dis. 2020;14(5):e0008095.
   PubMedGoogle Scholar
• Gemechu T, Mahmoud H, Parry EH, Phillips DI, Yacoub MH. Community-based prevalence study of rheumatic heart disease in rural Ethiopia. Eur J Prev Cardiol. 2017;24(7):717–723.
   PubMedGoogle Scholar
• Martin JM. Pharyngitis and streptococcal throat infections. Pediatr Ann. 2010;39:1.
   Google Scholar
• Gunnarsson MS, Sundvall PD, Gunnarsson R. In primary health care, never prescribe antibiotics to patients suspected of having an uncomplicated sore throat caused by group A beta-haemolytic streptococci without first confirming the presence of this bacterium. Scand J Infect Dis. 2012;44(12):915–921.
   PubMed Web of Science ®Google Scholar
• McCaig LF, Besser RE, Hughes JM. Trends in antimicrobial prescribing rates for children and adolescents. JAMA. 2002;287(23):3096.
   PubMed Web of Science ®Google Scholar
• Pfaller MA, Carvalhaes CG, Smith CJ, Diekema DJ, Castanheira M. Bacterial and fungal pathogens isolated from patients with bloodstream infection: frequency of occurrence and antimicrobial susceptibility patterns from the SENTRY antimicrobial surveillance program (2012–2017). Diagn Microbiol Infect Dis. 2020;97(2):115016.
   PubMedGoogle Scholar
• Barsenga S, Mitiku H, Tesfa T, Shume T. Throat carriage rate, associated factors, and antimicrobial susceptibility pattern of group A Streptococcus among healthy school children in Jigjiga City, Eastern Ethiopia. BMC Pediatr. 2022;22(1):227.
   PubMedGoogle Scholar
• Kebede D, Admas A, Mekonnen D. Prevalence and antibiotics susceptibility profiles of Streptococcus pyogenes among pediatric patients with acute pharyngitis at Felege Hiwot Comprehensive Specialized Hospital, Northwest Ethiopia. BMC Microbiol. 2021;21(1):135.
   PubMedGoogle Scholar
• Magiorakos A-P, Srinivasan A, Carey RB, et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect. 2012;18(3):268–281.
   PubMed Web of Science ®Google Scholar
• Flores AR, Caserta MT. Pharyngitis. In: Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. Elsevier; 2015:753–759.e2.
   Google Scholar
• McDonald M, Towers R, Fagan P, et al. Recovering streptococci from the throat, a practical alternative to direct plating in remote tropical communities. J Clin Microbiol. 2006;44(2):547–552.
   PubMedGoogle Scholar
• World Health Organization. Guidelines for the Collection of Clinical Specimens During Field Investigation of Outbreaks. World Health Organization; 2000.
   Google Scholar
• Cheesbrough M. District Laboratory Practice in Tropical Countries: Part 2. 2nd ed. New York: Cambridge University Press; 2006:76–79.
   Google Scholar
• CLSI. Performance Standards for Antimicrobial Susceptibility Testing: CLSI Supplement M100. 31st ed. Clinical and Laboratory Standards Institute; 2021.
   Google Scholar
• Basu S, Pal A, Desai P. Quality control of culture media in a microbiology laboratory. Indian J Med Microbiol. 2005;23(3):159.
   PubMedGoogle Scholar
• Ahmed M, Hassan M, Eida M, Metwally L. Evaluation of appropriateness of antibiotic use and validation of the McIsaac-modified Centor score for group a beta hemolytic streptococcal acute pharyngitis in Suez Canal area. Suez Canal Univ Med J. 2015;18(2):117–124.
   Google Scholar
• Mustafa Z, Ghaffari M. Diagnostic methods, clinical guidelines, and antibiotic treatment for group a Streptococcal pharyngitis: a narrative review. Front Cell Infect Microbiol. 2020;15:10.
   Google Scholar
• Tesfaw G, Kibru G, Mekonnen D, Abdissa A. Prevalence of group A β-haemolytic Streptococcus among children with pharyngitis in Jimma town, Southwest Ethiopia. Egypt J Ear Nose Throat Allied Sci. 2015;16(1):35–40.
   Google Scholar
• Altun M, Mericli Yapıcı B. Detection of group a beta hemolytic streptococci species, emm, and exotoxin genes isolated from patients with tonsillopharyngitis. Curr Microbiol. 2020;77(9):2064–2070.
   PubMedGoogle Scholar
• Malino IY, Utama DL, Soenarto Y. McIsaac criteria for diagnosis of acute group-A β-hemolytic streptococcal pharyngitis. Paediatr Indones. 2016;53(5):258.
   Google Scholar
• Benouda A, Sibile S, Ziane Y, Elouennass M, Dahani K, Hassani A. Place de Streptococcus pyogenes dans les angines au Maroc et état actuel de sa sensibilité aux antibiotiques. Pathol Biol. 2009;57(1):76–80.
   PubMedGoogle Scholar
• Sherkatolabbasieh H, Firouzi M, Shafizadeh S, Amiri I. Antibiotic susceptibility evaluation of bacterial agents causing infection in children with acute tonsillopharyngitis. Infect Disord. 2021;21:6.
   Google Scholar
• Himri S, Oumokhtar B, Atmani S, et al. Prevalence of group a streptococci in Moroccan children with pharyngitis and emm type distribution. Arch Pediatr Infect Dis. 2021;9:4.
   Google Scholar
• Khandekar A, Dangre-Mudey G. Tackling rheumatic heart disease: prevalence and antibiogram of Streptococcus pyogenes in cases of paediatric pharyngitis. J Clin Diagn Res. 2019;2019:1.
   Google Scholar
• Bobia AA, Blaj OA, Oancea D, et al. The prevalence of beta hemolytic Streptococcus in a children’s tertiary care hospital in Timisoara. Cent Eur J Clin Res. 2019;2(1):73–78.
   Google Scholar
• Kumar R, Vohra H, Chakraborty A, et al. Epidemiology of group a streptococcal pharyngitis & impetigo: a cross-sectional & follow up study in a rural community of northern India. Indian J Med Res. 2009;130:6.
   Google Scholar
• Khosravi AD, Ebrahimifard N, Shamsizadeh A, Shoja S. Isolation of Streptococcus pyogenes from children with pharyngitis and emm type analysis. J Chin Med Assoc. 2016;79(5):276–280.
   PubMedGoogle Scholar
• Rathi SK, Ahmed R. Pakistan prevalence survey in acute pharyngitis. J Pak Med Assoc. 2014;64:8.
   Google Scholar
• Bhalla K, Bhardwaj P, Gupta A, Mehra S, Nehra D, Nanda S. Role of epidemiological risk factors in improving the clinical diagnosis of streptococcal sore throat in pediatric clinical practice. J Fam Med Prim Care. 2019;8(10):3130.
   PubMedGoogle Scholar
• Sayyahfar S, Fahimzad A, Naddaf A, Tavassoli S. Antibiotic susceptibility evaluation of group a Streptococcus isolated from children with pharyngitis: a study from Iran. Infect Chemother. 2015;47(4):225.
   PubMedGoogle Scholar
• Ba-Saddik IA, Munibari AA, Alhilali AM, et al. Prevalence of Group A beta-haemolytic Streptococcus isolated from children with acute pharyngotonsillitis in Aden, Yemen. Trop Med Int Heal. 2014;19(4):431–439.
   PubMedGoogle Scholar
• Coffey PM, Ralph AP, Krause VL. The role of social determinants of health in the risk and prevention of group A streptococcal infection, acute rheumatic fever and rheumatic heart disease: a systematic review. PLoS Negl Trop Dis. 2018;12(6):e0006577.
   PubMedGoogle Scholar
• Shaikh N, Leonard E, Martin JM. Prevalence of streptococcal pharyngitis and streptococcal carriage in children: a meta-analysis. Pediatrics. 2010;126(3):e557–64.
   PubMed Web of Science ®Google Scholar
• Falagas ME, Mourtzoukou EG, Vardakas KZ. Sex differences in the incidence and severity of respiratory tract infections. Respir Med. 2007;101(9):1845–1863.
   PubMed Web of Science ®Google Scholar
• Jo SA, Ma SH, Kim S. Diagnostic impact of clinical manifestations of group A Streptococcal pharyngitis. Infect Chemother. 2021;53(3):553.
   PubMedGoogle Scholar
• Palla AH, Khan RA, Gilani AH, Marra F. Over prescription of antibiotics for adult pharyngitis is prevalent in developing countries but can be reduced using McIsaac modification of Centor scores: a cross-sectional study. BMC Pulm Med. 2012;12(1):70.
   PubMedGoogle Scholar
• Smeesters PR, Campos D, Van Melderen L, de Aguiar E, Vanderpas J, Vergison A. Pharyngitis in low-resources settings: a pragmatic clinical approach to reduce unnecessary antibiotic use. Pediatrics. 2006;118(6):e1607–11.
   PubMed Web of Science ®Google Scholar
• Teng CL, Tong SF, Khoo EM, et al. Antibiotics for URTI and UTI – prescribing in Malaysian primary care settings. Aust Fam Physician. 2011;40(5):325–329.
   PubMedGoogle Scholar
• Regoli M, Chiappini E, Bonsignori F, Galli L, de Martino M. Update on the management of acute pharyngitis in children. Ital J Pediatr. 2011;37(1):10.
   PubMedGoogle Scholar
• Pichichero ME, Casey JR. Safe use of selected cephalosporins in penicillin‐allergic patients: a meta‐analysis. Otolaryngol Neck Surg. 2007;136(3):340–347.
   PubMed Web of Science ®Google Scholar
• Romano A, Valluzzi RL, Caruso C, Maggioletti M, Quaratino D, Gaeta F. Cross-reactivity and tolerability of cephalosporins in patients with IgE-mediated hypersensitivity to penicillins. J Allergy Clin Immunol Pract. 2018;6(5):1662–1672.
   PubMed Web of Science ®Google Scholar
• Chuang P-K, Wang S-M, Lin H-C, et al. The trend of macrolide resistance and emm types of group A streptococci from children at a medical center in southern Taiwan. J Microbiol Immunol Infect. 2015;48(2):160–167.
   PubMedGoogle Scholar
• Tsai W-C, Shen C-F, Lin Y-L, et al. Emergence of macrolide-resistant Streptococcus pyogenes emm12 in southern Taiwan from 2000 to 2019. J Microbiol Immunol Infect. 2021;54(6):1086–1093.
   PubMedGoogle Scholar
• Silva-Costa C, Friães A, Ramirez M, Melo-Cristino J. Macrolide-resistant Streptococcus pyogenes: prevalence and treatment strategies. Expert Rev Anti Infect Ther. 2015;13(5):615–628.
   PubMed Web of Science ®Google Scholar
• DeMuri GP, Sterkel AK, Kubica PA, Duster MN, Reed KD, Wald ER. Macrolide and clindamycin resistance in group A streptococci isolated from children with pharyngitis. Pediatr Infect Dis J. 2017;36(3):342–344.
   PubMed Web of Science ®Google Scholar
• Leclercq R, Courvalin P. Bacterial resistance to macrolide, lincosamide, and streptogramin antibiotics by target modification. Antimicrob Agents Chemother. 1991;35:1.
   PubMedGoogle Scholar
• Creti R, Imperi M, Baldassarri L, et al. Types, virulence factors, and antibiotic resistance of invasive Streptococcus pyogenes isolates from Italy: what has changed in 11 years? J Clin Microbiol. 2007;45(7):2249–2256.
   PubMed Web of Science ®Google Scholar
• Anja A, Beyene G, Mariam Z, Daka D. Asymptomatic pharyngeal carriage rate of Streptococcus pyogenes, its associated factors and antibiotic susceptibility pattern among school children in Hawassa town, southern Ethiopia. BMC Res Notes. 2019;12(1):564.
   PubMedGoogle Scholar
• Kehrenberg C, Schwarz S, Jacobsen L, Hansen LH, Vester B. A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503. Mol Microbiol. 2005;57(4):1064–1073.
   PubMed Web of Science ®Google Scholar
• Schwarz S, Kehrenberg C, Doublet B, Cloeckaert A. Molecular basis of bacterial resistance to chloramphenicol and florfenicol. FEMS Microbiol Rev. 2004;28(5):519–542.
   PubMed Web of Science ®Google Scholar
• Oong GC, Tadi P. Chloramphenicol. In: StatPearls. StatPearls Publishing; 2022.
   Google Scholar
• Chopra I, Roberts M. Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. Microbiol Mol Biol Rev. 2001;65(2):232–260.
   PubMed Web of Science ®Google Scholar
• Belachew SA, Hall L, Selvey LA. Non-prescription dispensing of antibiotic agents among community drug retail outlets in Sub-Saharan African countries: a systematic review and meta-analysis. Antimicrob Resist Infect Control. 2021;10(1):13.
   PubMed Web of Science ®Google Scholar
• World Medical Association. Declaration of Helsinki. JAMA. 2013;310(20):2191.
   PubMed Web of Science ®Google Scholar