Prevalence of Quorum Sensing and Virulence Factor Genes Among Pseudomonas aeruginosa Isolated from Patients Suffering from Different Infections and Their Association with Antimicrobial Resistance

References

• Awan AB, Schiebel J, Böhm A, et al. Association of biofilm formation and cytotoxic potential with multidrug resistance in clinical isolates of Pseudomonas aeruginosa. Excli J. 2019;18:79.
   PubMed Web of Science ®Google Scholar
• Strateva T, Yordanov D. Pseudomonas aeruginosa – a phenomenon of bacterial resistance. J Med Microbiol. 2009;58(9):1133–1148. doi:10.1099/jmm.0.009142-0
   PubMed Web of Science ®Google Scholar
• Driscoll JA, Brody SL, Kollef MH. The epidemiology, pathogenesis and treatment of Pseudomonas aeruginosa infections. Drugs. 2007;67(3):351–368. doi:10.2165/00003495-200767030-00003
   PubMed Web of Science ®Google Scholar
• Schaechter M. Encyclopedia of Microbiology. Academic Press; 2009.
   Google Scholar
• Van Delden C, Iglewski BH. Cell-to-cell signaling and Pseudomonas aeruginosa infections. Emerg Infect Dis. 1998;4(4):551. doi:10.3201/eid0404.980405
   PubMed Web of Science ®Google Scholar
• Cevahir N, Demir M, Kaleli I, Gurbuz M, Tikvesli S. Evaluation of biofilm production, gelatinase activity, and mannose-resistant hemagglutination in Acinetobacter baumannii strains. J Microbiol Immunol Infect. 2008;41(6):513–518.
   PubMedGoogle Scholar
• Ciofu O, Lee B, Johannesson M, Hermansen NO, Meyer P, Høiby N. Investigation of the algT operon sequence in mucoid and non-mucoid Pseudomonas aeruginosa isolates from 115 Scandinavian patients with cystic fibrosis and in 88 in vitro non-mucoid revertants. Microbiology. 2008;154(1):103–113. doi:10.1099/mic.0.2007/010421-0
   PubMedGoogle Scholar
• Raafat MM, Ali-Tammam M, Ali AE. Phenotypic and genotypic characterization of Pseudomonas aeruginosa isolates from Egyptian hospitals. Afr J Microbiol Res. 2016;10(39):1645–1653. doi:10.5897/AJMR2016.8254
   Google Scholar
• Mahmoud AB, Zahran WA, Hindawi GR, Labib AZ, Galal R. Prevalence of multidrug-resistant Pseudomonas aeruginosa in patients with nosocomial infections at a university hospital in Egypt, with special reference to typing methods. J Virol Microbiol. 2013;13:165.
   Google Scholar
• Lim K-T, Yasin RM, Yeo -C-C, et al. Genetic fingerprinting and antimicrobial susceptibility profiles of Pseudomonas aeruginosa hospital isolates in Malaysia. J Microbiol Immunol Infect. 2009;42(3):197–209.
   PubMedGoogle Scholar
• Talebi-Taher M, Gholami A, Rasouli-Kouhi S, Adabi M, Adabi M. Role of efflux pump inhibitor in decreasing antibiotic cross-resistance of Pseudomonas aeruginosa in a burn hospital in Iran. J Infect Dev Count. 2016;10(06):600–604. doi:10.3855/jidc.7619
   Google Scholar
• Gales AC, Castanheira M, Jones RN, Sader HS. Antimicrobial resistance among gram-negative bacilli isolated from Latin America: results from SENTRY Antimicrobial surveillance program (Latin America, 2008–2010). Diagn Microbiol Infect Dis. 2012;73(4):354–360. doi:10.1016/j.diagmicrobio.2012.04.007
   PubMed Web of Science ®Google Scholar
• İnat G, Sırıken B, Başkan C, Erol İ, Yıldırım T, Çiftci A. Quorum sensing systems and related virulence factors in Pseudomonas aeruginosa isolated from chicken meat and ground beef. Sci Rep. 2021;11(1):15639. doi:10.1038/s41598-021-94906-x
   PubMed Web of Science ®Google Scholar
• Krall R, Schmidt G, Aktories K, Barbieri JT. Pseudomonas aeruginosa ExoT is a Rho GTPase-activating protein. Infect Immun. 2000;68(10):6066–6068. doi:10.1128/IAI.68.10.6066-6068.2000
   PubMed Web of Science ®Google Scholar
• Fazeli N, Momtaz H. Virulence gene profiles of multidrug-resistant Pseudomonas aeruginosa isolated from Iranian hospital infections. Iran Red Crescent Med J. 2014;16(10). doi:10.5812/ircmj.15722
   PubMed Web of Science ®Google Scholar
• Christensen GD, Simpson WA, Younger J, et al. Adherence of coagulase-negative staphylococci to plastic tissue culture plates: a quantitative model for the adherence of staphylococci to medical devices. J Clin Microbiol. 1985;22(6):996–1006. doi:10.1128/jcm.22.6.996-1006.1985
   PubMed Web of Science ®Google Scholar
• Wayne P. Clinical and Laboratory Standards Institute: performance standards for antimicrobial susceptibility testing: 20th informational supplement. CLSI Doc M100-S20. 2010;85(4):355–359.
   Google Scholar
• Agnello M, Wong-Beringer A. Differentiation in Quinolone Resistance by Virulence Genotype in Pseudomonas Aeruginosa. Public Library of Science San Francisco; 2012.
   Google Scholar
• Badamchi A, Masoumi H, Javadinia S, Asgarian R, Tabatabaee A. Molecular detection of six virulence genes in Pseudomonas aeruginosa isolates detected in children with urinary tract infection. Microb Pathog. 2017;107:44–47. doi:10.1016/j.micpath.2017.03.009
   PubMed Web of Science ®Google Scholar
• Asghari-Moghadam N, Rasoolzadeh R, Hoseini-Moghadam S-M-M, Seifi M, Pour-Shafie MR, Talebi M. Isolation, antibiotic resistance determination and genotypic analysis of pseudomonas aeruginosa strains causing urinary tract infection in catheterized patients of shohada and Labafi Nejad Hospitals, Tehran, Iran. J Isfahan Med Sch. 2014;32(272):1–8.
   Google Scholar
• Cowell BA, Twining SS, Hobden JA, Kwong MS, Fleiszig SM. Mutation of lasA and lasB reduces Pseudomonas aeruginosa invasion of epithelial cells. Microbiology. 2003;149(8):2291–2299. doi:10.1099/mic.0.26280-0
   PubMedGoogle Scholar
• Khan MA, Faiz A. Antimicrobial resistance patterns of Pseudomonas aeruginosa in tertiary care hospitals of Makkah and Jeddah. Ann Saudi Med. 2016;36(1):23–28. doi:10.5144/0256-4947.2016.23
   PubMed Web of Science ®Google Scholar
• Shahcheraghi F, Nikbin V-S, Feizabadi MM. Prevalence of ESBLs genes among multidrug-resistant isolates of Pseudomonas aeruginosa isolated from patients in Tehran. Microb Drug Resist. 2009;15(1):37–39. doi:10.1089/mdr.2009.0880
   PubMed Web of Science ®Google Scholar
• Nakhaei MM, Hosseini HM, Mobaiyen H. Evaluation of antibiotic resistance and detection of CTX-M type extended spectrum beta-lactamase in clinical isolates of pseudomonas aeruginosa in mashhad. J Ilam Univ Med Sci. 2014;22(5):70–77.
   Google Scholar
• Zahra T, Rezvan M, Ahmad K. Detection and characterization of multidrug resistance and extended-spectrum-beta-lactamase-producing (ESBLS) Pseudomonas aeruginosa isolates in teaching hospital. Afr J Microbiol Res. 2011;5(20):3223–3228. doi:10.5897/AJMR11.260
   Google Scholar
• Tambekar D, Dhanorkar D, Gulhane S, Khandelwal V, Dudhane M. Antibacterial susceptibility of some urinary tract pathogens to commonly used antibiotics. Afr J Biotechnol. 2006;5:17.
   Google Scholar
• Ehinmidu JO. Antibiotics susceptibility patterns of urine bacterial isolates in Zaria, Nigeria. Trop J Pharm Res. 2003;2(2):223–228.
   Google Scholar
• Nwanze P, Nwaru L, Oranusi S, et al. Urinary tract infection in Okada village: prevalence and antimicrobial susceptibility pattern. Sci Res Essays. 2007;2(4):112–116.
   Google Scholar
• Saeidi S, Alavi-Naini R, Shayan S. Antimicrobial susceptibility and distribution of tem and ctx-m genes among esbl-producing Klebsiella pneumoniae and Pseudomonas aeruginosa causing urinary tract infections. Zahedan J Res Med Sci. 2014;16(4):1–5.
   Google Scholar
• Akingbade O, Balogun S, Ojo D, et al. Plasmid profile analysis of multidrug resistant Pseudomonas aeruginosa isolated from wound infections in South West, Nigeria. World Appl Sci J. 2012;20(6):766–775.
   Google Scholar
• Ilham HH, Banyan A. Isolation of Pseudomonas aeruginosa from clinical cases and environmental samples, and analysis of its antibiotic resistant spectrum at Hilla Teaching Hospital; 2011.
   Google Scholar
• Bagge N, Schuster M, Hentzer M, et al. Pseudomonas aeruginosa biofilms exposed to imipenem exhibit changes in global gene expression and beta-lactamase and alginate production. Antimicrob Agents Chemother. 2004;48(4):1175–1187. doi:10.1128/AAC.48.4.1175-1187.2004
   PubMed Web of Science ®Google Scholar
• Koeppen K, Barnaby R, Jackson AA, Gerber SA, Hogan DA, Stanton BA. Tobramycin reduces key virulence determinants in the proteome of Pseudomonas aeruginosa outer membrane vesicles. PLoS One. 2019;14(1):e0211290. doi:10.1371/journal.pone.0211290
   PubMed Web of Science ®Google Scholar
• Kadhim D, Ali Mi R. Prevalence study of quorum sensing groups among clinical isolates of Pseudomonas aeruginosa. Int J Curr Microbiol App Sci. 2014;3(11):204–215.
   Google Scholar
• Aghamollaei H, Azizi BK, Moosazadeh MM. Rapid detection of Pseudomonas aeruginosa by PCR method using specific primers of quorum sensing LasI gene. Armaghane Danesh. 2014;18(9):723–735.
   Google Scholar
• Senturk S, Ulusoy S, Bosgelmez-Tinaz G, Yagci A. Quorum sensing and virulence of Pseudomonas aeruginosa during urinary tract infections. J Infect Dev Count. 2012;6(06):501–507. doi:10.3855/jidc.2543
   Google Scholar
• Bjarnsholt T, Jensen PØ, Fiandaca MJ, et al. Pseudomonas aeruginosa biofilms in the respiratory tract of cystic fibrosis patients. Pediatr Pulmonol. 2009;44(6):547–558. doi:10.1002/ppul.21011
   PubMed Web of Science ®Google Scholar
• Rutherford S, Bassler B. Bacterial quorum sensing: its role in virulence and possibilities for its control. Cold Spring Harb Perspect Med. 2012;2:a012427–a012427. doi:10.1101/cshperspect.a012427
   PubMed Web of Science ®Google Scholar
• Chadha J, Harjai K, Chhibber S. Revisiting the virulence hallmarks of Pseudomonas aeruginosa: a chronicle through the perspective of quorum sensing. Environ Microbiol. 2022;24(6):2630–2656. doi:10.1111/1462-2920.15784
   PubMed Web of Science ®Google Scholar
• Papenfort K, Bassler BL. Quorum sensing signal–response systems in Gram-negative bacteria. Nat Rev Microbiol. 2016;14(9):576–588. doi:10.1038/nrmicro.2016.89
   PubMed Web of Science ®Google Scholar
• Karthic A, Gopinath P. Detection of biofilm among clinical isolates of Pseudomonas aeruginosa by tissue culture plate (TCP) method. J Chem Pharm Sci. 2016;9(4):3236–3238.
   Google Scholar
• Heydari S, Eftekhar F. Biofilm formation and β-lactamase production in burn isolates of Pseudomonas aeruginosa. Jundishapur J Microbiol. 2015;8(3). doi:10.5812/jjm.15514
   PubMed Web of Science ®Google Scholar
• Rewatkar A, Wadher B. Staphylococcus aureus and Pseudomonas aeruginosa-Biofilm formation Methods. J Pharm Biol Sci. 2013;8(5):36–40.
   Google Scholar
• Azam MW, Khan AU. Updates on the pathogenicity status of Pseudomonas aeruginosa. Drug Discov Today. 2019;24(1):350–359. doi:10.1016/j.drudis.2018.07.003
   PubMed Web of Science ®Google Scholar
• Wretlind B, Olǵerts RP. Pseudomonas aeruginosa elastase and its role in pseudomonas infections. Rev Infect Dis. 1983;5:S998–S1004. doi:10.1093/clinids/5.Supplement_5.S998
   PubMedGoogle Scholar
• Mittal R, Aggarwal S, Sharma S, Chhibber S, Harjai K. Urinary tract infections caused by Pseudomonas aeruginosa: a minireview. J Infect Public Health. 2009;2(3):101–111. doi:10.1016/j.jiph.2009.08.003
   PubMedGoogle Scholar
• Berry A, DeVault JD, Chakrabarty A. High osmolarity is a signal for enhanced algD transcription in mucoid and nonmucoid Pseudomonas aeruginosa strains. J Bacteriol. 1989;171(5):2312–2317. doi:10.1128/jb.171.5.2312-2317.1989
   PubMed Web of Science ®Google Scholar
• Kamath S, Kapatral V, Chakrabarty A. Cellular function of elastase in Pseudomonas aeruginosa: role in the cleavage of nucleoside diphosphate kinase and in alginate synthesis. Mol Microbiol. 1998;30(5):933–941. doi:10.1046/j.1365-2958.1998.01121.x
   PubMed Web of Science ®Google Scholar
• Donlan RM. Biofilms: microbial life on surfaces. Emerg Infect Dis. 2002;8(9):881. doi:10.3201/eid0809.020063
   PubMed Web of Science ®Google Scholar
• Morin CD, Déziel E, Gauthier J, Levesque RC, Lau GW. An organ system-based synopsis of pseudomonas aeruginosa virulence. Virulence. 2021;12(1):1469–1507. doi:10.1080/21505594.2021.1926408
   PubMed Web of Science ®Google Scholar
• Terada LS, Johansen KA, Nowbar S, Vasil AI, Vasil ML. Pseudomonas aeruginosa hemolytic phospholipase C suppresses neutrophil respiratory burst activity. Infect Immun. 1999;67(5):2371–2376. doi:10.1128/IAI.67.5.2371-2376.1999
   PubMed Web of Science ®Google Scholar
• Wargo MJ, Gross MJ, Rajamani S, et al. Hemolytic phospholipase C inhibition protects lung function during Pseudomonas aeruginosa infection. Am J Respir Crit Care Med. 2011;184(3):345–354. doi:10.1164/rccm.201103-0374OC
   PubMed Web of Science ®Google Scholar
• Galdino ACM, Viganor L, de Castro AA, et al. Disarming Pseudomonas aeruginosa Virulence by the Inhibitory Action of 1, 10-Phenanthroline-5,6-Dione-Based Compounds: elastase B (LasB) as a chemotherapeutic target. Front Microbiol. 2019;10:1701. doi:10.3389/fmicb.2019.01701
   PubMedGoogle Scholar
• Moradali MF, Ghods S, Rehm BH. Pseudomonas aeruginosa Lifestyle: a Paradigm for Adaptation, Survival, and Persistence. Front Cell Infect Microbiol. 2017;7:39. doi:10.3389/fcimb.2017.00039
   PubMed Web of Science ®Google Scholar
• Anju VT, Busi S, Imchen M, et al. Polymicrobial infections and biofilms: clinical significance and eradication strategies. Antibiotics. 2022;11(12):1731. doi:10.3390/antibiotics11121731
   Google Scholar
• Qin S, Xiao W, Zhou C, et al. Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics. Signal Transduct Target Ther. 2022;7(1):199. doi:10.1038/s41392-022-01056-1
   PubMed Web of Science ®Google Scholar
• Chadha J, Harjai K, Chhibber S. Repurposing phytochemicals as anti-virulent agents to attenuate quorum sensing-regulated virulence factors and biofilm formation in Pseudomonas aeruginosa. Microb Biotechnol. 2022;15(6):1695–1718. doi:10.1111/1751-7915.13981
   PubMed Web of Science ®Google Scholar
• Olaniyi TD, Adetutu A. In silico anti-quorum sensing activities of phytocompounds of Psidium guajava in Salmonella enterica serovar Typhi. J Umm Al-Qura Univ Appl Sci. 2023. doi:10.1007/s43994-023-00029-6
   Google Scholar
• Martins VV, Pitondo‐Silva A, de Melo Manço L, et al. Pathogenic potential and genetic diversity of environmental and clinical isolates of P seudomonas aeruginosa. Apmis. 2014;122(2):92–100. doi:10.1111/apm.12112
   PubMed Web of Science ®Google Scholar
• Woods DE, Cryz SJ, Friedman R, Iglewski B. Contribution of toxin A and elastase to virulence of Pseudomonas aeruginosa in chronic lung infections of rats. Infect Immun. 1982;36(3):1223–1228. doi:10.1128/iai.36.3.1223-1228.1982
   PubMed Web of Science ®Google Scholar
• Lima JL, Alves LR, Jacomé PR, Bezerra Neto JP, Maciel MAV, Morais MM. Biofilm production by clinical isolates of Pseudomonas aeruginosa and structural changes in LasR protein of isolates non biofilm-producing. Braz J Infect Dis. 2018;22:129–136. doi:10.1016/j.bjid.2018.03.003
   PubMed Web of Science ®Google Scholar