Severe Community-Acquired Pneumonia Caused by Methicillin-Sensitive Staphylococcus aureus: Successfully Treated with Contezolid – A Case Report and Literature Review

References

• Sader HS, Castanheira M, Arends SJR, et al. Geographical and temporal variation in the frequency and antimicrobial susceptibility of bacteria isolated from patients hospitalized with bacterial pneumonia: results from 20 years of the SENTRY Antimicrobial Surveillance Program (1997–2016). J Antimicrob Chemother. 2019;74(6):1595–1606. doi:10.1093/jac/dkz074
   PubMed Web of Science ®Google Scholar
• Patil SM, Beck PP, Patel TP, et al. Electronic vaping-induced methicillin-sensitive Staphylococcus aureus pneumonia and empyema. Case Rep Infect Dis. 2021;2021:6651430. doi:10.1155/2021/6651430
   PubMed Web of Science ®Google Scholar
• Self WH, Wunderink RG, Williams DJ, et al. Staphylococcus aureus community-acquired pneumonia: prevalence, clinical characteristics, and outcomes. Clin Infect Dis. 2016;63(3):300–309. doi:10.1093/cid/ciw300
   PubMed Web of Science ®Google Scholar
• Woodhead M, Welch CA, Harrison DA, et al. Community-acquired pneumonia on the intensive care unit: secondary analysis of 17,869 cases in the ICNARC Case Mix Programme Database. Crit Care. 2006;10(Suppl2):S1.
   PubMedGoogle Scholar
• Martin-Loeches I, Torres A. New guidelines for severe community-acquired pneumonia. Curr Opin Pulm Med. 2021;27(3):210–215. doi:10.1097/MCP.0000000000000760
   PubMed Web of Science ®Google Scholar
• Martin-Loeches I, Lisboa T, Rodriguez A, et al. Combination antibiotic therapy with macrolides improves survival in intubated patients with community-acquired pneumonia. Intensive Care Med. 2010;36(4):612–620. doi:10.1007/s00134-009-1730-y
   PubMed Web of Science ®Google Scholar
• Carvalhaes CG, Duncan LR, Wang W, et al. In vitro activity and potency of the novel oxazolidinone contezolid (MRX-I) tested against gram-positive clinical isolates from the United States and Europe. Antimicrob Agents Chemother. 2020;64(11). doi:10.1128/AAC.01195-20
   Web of Science ®Google Scholar
• Diekema DJ, Jones RN. Oxazolidinone antibiotics. Lancet. 2001;358(9297):1975–1982. doi:10.1016/S0140-6736(01)06964-1
   PubMed Web of Science ®Google Scholar
• Gordeev MF, Yuan ZY. New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. J Med Chem. 2014;57(11):4487–4497. doi:10.1021/jm401931e
   PubMed Web of Science ®Google Scholar
• Zhao X, Huang H, Yuan H, et al. A Phase III multicentre, randomized, double-blind trial to evaluate the efficacy and safety of oral contezolid versus linezolid in adults with complicated skin and soft tissue infections. J Antimicrob Chemother. 2022;77(6):1762–1769. doi:10.1093/jac/dkac073
   PubMed Web of Science ®Google Scholar
• Huang Y, Xu Y, Liu S, et al. Selection and characterisation of Staphylococcus aureus mutants with reduced susceptibility to the investigational oxazolidinone MRX-I. Int J Antimicrob Agents. 2014;43(5):418–422. doi:10.1016/j.ijantimicag.2014.02.008
   PubMed Web of Science ®Google Scholar
• Martin-Loeches I, Garduno A, Povoa P, et al. Choosing antibiotic therapy for severe community-acquired pneumonia. Curr Opin Infect Dis. 2022;35(2):133–139. doi:10.1097/QCO.0000000000000819
   PubMed Web of Science ®Google Scholar
• Long B, Koyfman A. Best clinical practice: blood culture utility in the emergency department. J Emerg Med. 2016;51(5):529–539. doi:10.1016/j.jemermed.2016.07.003
   PubMed Web of Science ®Google Scholar
• Hogea SP, Tudorache E, Pescaru C, et al. Bronchoalveolar lavage: role in the evaluation of pulmonary interstitial disease. Expert Rev Respir Med. 2020;14(11):1117–1130. doi:10.1080/17476348.2020.1806063
   PubMed Web of Science ®Google Scholar
• Izumo T, Matsumoto Y, Sasada S, et al. Utility of rapid on-site cytologic evaluation during endobronchial ultrasound with a guide sheath for peripheral pulmonary lesions. Jpn J Clin Oncol. 2017;47(3):221–225. doi:10.1093/jjco/hyw180
   PubMed Web of Science ®Google Scholar
• Wei Y, Zhang H, Fu M, Ma R, Li R, Kong L. Plasma and intrapulmonary pharmacokinetics, and dosage regimen optimization of linezolid for treatment of gram-positive cocci infections in patients with pulmonary infection after cerebral hemorrhage. Infect Drug Resist. 2022;15:1733–1742. doi:10.2147/IDR.S357300
   PubMed Web of Science ®Google Scholar
• De Pascale G, Fortuna S, Tumbarello M, et al. Linezolid plasma and intrapulmonary concentrations in critically ill obese patients with ventilator-associated pneumonia: intermittent vs continuous administration. Intensive Care Med. 2015;41(1):103–110. doi:10.1007/s00134-014-3550-y
   PubMed Web of Science ®Google Scholar
• Vinh DC, Rubinstein E. Linezolid: a review of safety and tolerability. J Infect. 2009;59(Suppl 1):S59–S74. doi:10.1016/S0163-4453(09)60009-8
   PubMed Web of Science ®Google Scholar
• Kang Y, Ge C, Zhang H, et al. Compassionate use of contezolid for the treatment of tuberculous pleurisy in a patient with a leadless pacemaker. Infect Drug Resist. 2022;15:4467–4470. doi:10.2147/IDR.S373082
   PubMed Web of Science ®Google Scholar
• Macht M, Wimbish T, Clark BJ, et al. Diagnosis and treatment of post-extubation dysphagia: results from a national survey. J Crit Care. 2012;27(6):578–586. doi:10.1016/j.jcrc.2012.07.016
   PubMed Web of Science ®Google Scholar
• Skoretz SA, Flowers HL, Martino R. The incidence of dysphagia following endotracheal intubation: a systematic review. Chest. 2010;137(3):665–673. doi:10.1378/chest.09-1823
   PubMed Web of Science ®Google Scholar
• Schefold JC, Berger D, Zürcher P, et al. Dysphagia in mechanically ventilated ICU patients (DYnAMICS): a prospective observational trial. Crit Care Med. 2017;45(12):2061–2069. doi:10.1097/CCM.0000000000002765
   PubMed Web of Science ®Google Scholar
• Macht M, King CJ, Wimbish T, et al. Post-extubation dysphagia is associated with longer hospitalization in survivors of critical illness with neurologic impairment. Crit Care. 2013;17(3):R119. doi:10.1186/cc12791
   PubMed Web of Science ®Google Scholar
• Regala M, Marvin S, Ehlenbach WJ. Association between postextubation dysphagia and long-term mortality among critically ill older adults. J Am Geriatr Soc. 2019;67(9):1895–1901. doi:10.1111/jgs.16039
   PubMed Web of Science ®Google Scholar
• El Gharib AZG, Berretin-Felix G, Rossoni DF, Seiji Yamada S. Effectiveness of therapy on post-extubation dysphagia: clinical and electromyographic findings. Clin Med Insights. 2019;12:1179550619873364. doi:10.1177/1179550619873364
   Google Scholar