248
Views
1
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Identification of Two Novel Carbapenemase-Encoding Hybrid Plasmids Harboring blaNDM-5 and blaKPC-2 in a Clinical ST11-KL47 Klebsiella pneumoniae

, ORCID Icon, , , , , ORCID Icon, , & show all
Pages 4073-4081 | Received 16 Feb 2023, Accepted 16 Jun 2023, Published online: 24 Jun 2023

References

  • Shrivastava SR, Shrivastava PS, Ramasam JJ. World health organization releases global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics. J Med Soc. 2018;32(1):76. doi:10.4103/jms.jms_25_17
  • Yang Y, Yang Y, Chen G, et al. Molecular characterization of carbapenem-resistant and virulent plasmids in Klebsiella pneumoniae from patients with bloodstream infections in China. Emerg Microbes Infect. 2021;10(1):1–42. doi:10.1080/22221751.2020.1868951
  • Leon-Sampedro R, DelaFuente J, Diaz-Agero C, et al. Pervasive transmission of a carbapenem resistance plasmid in the gut microbiota of hospitalized patients. Nat Microbiol. 2021;6(5):606–616. doi:10.1038/s41564-021-00879-y
  • Bush K, Bradford PA. Epidemiology of beta-lactamase-producing pathogens. Clin Microbiol Rev. 2020;33(2). doi:10.1128/CMR.00047-19
  • Gao H, Liu Y, Wang R, Wang Q, Jin L, Wang H. The transferability and evolution of NDM-1 and KPC-2 co-producing Klebsiella pneumoniae from clinical settings. EBioMedicine. 2020;51:102599. doi:10.1016/j.ebiom.2019.102599
  • Hao J, Zhang B, Deng J, Wei Y, Xiao X, Liu J. Emergence of a hypervirulent tigecycline-resistant Klebsiella pneumoniae Strain Co-producing bla NDM-1 and bla KPC-2 With an Uncommon Sequence Type ST464 in Southwestern China. Front Microbiol. 2022;13:868705. doi:10.3389/fmicb.2022.868705
  • Zou H, Jia X, Liu H, Li S, Wu X, Huang S. Emergence of NDM-5-producing Escherichia coli in a Teaching Hospital in Chongqing, China: incF-Type plasmids may contribute to the prevalence of bla NDM- 5. Front Microbiol. 2020;11:334. doi:10.3389/fmicb.2020.00334
  • Zheng B, Xu H, Yu X, et al. Identification and genomic characterization of a KPC-2-, NDM-1- and NDM-5-producing Klebsiella michiganensis isolate. J Antimicrob Chemother. 2018;73(2):536–538. doi:10.1093/jac/dkx415
  • Clinical and Laboratory Standards Institute. CLSI Performance Standards for Antimicrobial Susceptibility Testing; Twenty-Second Informational Supplement. CLSI Document M100–Ed31. Wayne, PA: Clinical and Laboratory Standards Institute; 2021.
  • Liao Q, Yuan Y, Li Q, et al. Comparing three different phenotypic methods for accurate detection of carbapenemase-producing Enterobacterales. J Infect Chemother. 2021;27(6):794–799. doi:10.1016/j.jiac.2021.01.003
  • Dong H, Li Y, Cheng J, et al. Genomic epidemiology insights on NDM-producing pathogens revealed the pivotal role of plasmids on blaNDM transmission. Microbiol Spectr. 2022;10(2):e0215621. doi:10.1128/spectrum.02156-21
  • Lam MMC, Wick RR, Watts SC, Cerdeira LT, Wyres KL, Holt KE. A genomic surveillance framework and genotyping tool for Klebsiella pneumoniae and its related species complex. Nat Commun. 2021;12(1):4188. doi:10.1038/s41467-021-24448-3
  • Sullivan MJ, Petty NK, Beatson SA. Easyfig: a genome comparison visualizer. Bioinformatics. 2011;27(7):1009–1010. doi:10.1093/bioinformatics/btr039
  • Alikhan N-F, Petty NK, Ben Zakour NL, Beatson SA. BLAST Ring Image Generator (BRIG): simple prokaryote genome comparisons. BMC Genomics. 2011;12(1):1–10. doi:10.1186/1471-2164-12-402
  • Yang X, Dong N, Chan EW, Zhang R, Chen S. Carbapenem resistance-encoding and virulence-encoding conjugative plasmids in Klebsiella pneumoniae. Trends Microbiol. 2021;29(1):65–83. doi:10.1016/j.tim.2020.04.012
  • Chen L, Mathema B, Chavda KD, DeLeo FR, Bonomo RA, Kreiswirth BN. Carbapenemase-producing Klebsiella pneumoniae: molecular and genetic decoding. Trends Microbiol. 2014;22(12):686–696. doi:10.1016/j.tim.2014.09.003
  • Huang Q-S, Liao W, Xiong Z, et al. Prevalence of the NTEKPC-I on IncF plasmids among Hypervirulent Klebsiella pneumoniae isolates in Jiangxi Province, South China. Front Microbiol. 2021;12:1338.
  • He S, Hickman AB, Varani AM, et al. Insertion Sequence IS26 reorganizes plasmids in clinically isolated multidrug-resistant bacteria by replicative transposition. mBio. 2015;6(3):e00762. doi:10.1128/mBio.00762-15
  • Pfeifer E, Bonnin RA, Rocha EPC, Goldman GH. Phage-plasmids spread antibiotic resistance genes through infection and lysogenic conversion. mBio. 2022;13(5):e0185122. doi:10.1128/mbio.01851-22
  • Wang M, Jiang L, Wei J, et al. Similarities of P1-like phage plasmids and their role in the dissemination of bla(CTX-M-55). Microbiol Spectr. 2022;10(5):e0141022. doi:10.1128/spectrum.01410-22
  • Wei DD, Wan LG, Liu Y. Draft genome sequence of an NDM-1- and KPC-2-coproducing hypervirulent carbapenem-resistant Klebsiella pneumoniae strain isolated from burn wound infections. Genome Announc. 2018;6(13). doi:10.1128/genomeA.00192-18
  • Hu R, Li Q, Zhang F, Ding M, Liu J, Zhou Y. Characterisation of blaNDM-5 and blaKPC-2 co-occurrence in K64-ST11 carbapenem-resistant Klebsiella pneumoniae. J Glob Antimicrob Resist. 2021;27:63–66. doi:10.1016/j.jgar.2021.08.009