Clinical and Molecular Profile of Carbapenem Resistant Klebsiella pneumoniae Infections in a Tertiary Care Hospital –Mangalore

References

• Lin D, Chen J, Yang Y, Cheng J, Sun C. Epidemiological study of carbapenem-resistant Klebsiella pneumoniae. Open Med. 2018;13(1):460–466. doi:10.1515/med-2018-0070
   Web of Science ®Google Scholar
• Ferreira CM, Ferreira WA, Silva LM, Barbosa TC, Souza VC, Naveca FG. Molecular epidemiology of KPC-2 producing Klebsiella pneumoniae. SOJ Microbiol Infect Dis. 2018;5:1–3.
   Google Scholar
• Amann S, Neef K, Kohl S. Antimicrobial resistance (AMR). Eur J Hosp Pharm. 2019;26(3):175–177. doi:10.1136/ejhpharm-2018-001820
   PubMedGoogle Scholar
• Rello J, Kalwaje Eshwara V, Lagunes L, et al. A global priority list of the TOp TEn resistant Microorganisms (TOTEM) study at intensive care: a prioritization exercise based on multi-criteria decision analysis. Eur J Clin Microbiol Infect Dis. 2019;38(2):319–323. PMID: 30426331. doi:10.1007/s10096-018-3428-y
   PubMed Web of Science ®Google Scholar
• Eatemadi A, Al Risi E, Kasliwal AK, Al Zaabi A, Moradzadegan H, Aslani Z. A proposed evidence-based local guideline for definition of multidrug-resistant (MDR), extensively drug-resistant (XDR) and pan drug-resistant (PDR) bacteria by the Microbiology Laboratory. Int J Curr Sci Res Rev. 2021;4(3):146–153. doi:10.47191/ijcsrr/V4-i3-01
   Google Scholar
• Kobayashi SD, Porter AR, Freedman B, et al. Antibody-mediated killing of carbapenem-resistant ST258 Klebsiella pneumoniae by human neutrophils. mBio. 2018;9(2):e00297–18. doi:10.1128/mBio.00297-18
   PubMed Web of Science ®Google Scholar
• Ragheb SM, Tawfick MM, El-Kholy AA, Abdulall AK. Phenotypic and genotypic features of Klebsiella pneumoniae harboring carbapenemases in Egypt: OXA-48-like carbapenemases as an investigated model. Antibiotics. 2020;9(12):852. doi:10.3390/antibiotics9120852
   Web of Science ®Google Scholar
• Hammoudi Halat D, Ayoub Moubareck C. The current burden of carbapenemases: review of significant properties and dissemination among gram-negative bacteria. Antibiotics. 2020;9(4):186. doi:10.3390/antibiotics9040186
   Web of Science ®Google Scholar
• Eichenberger EM, Thaden JT. Epidemiology and mechanisms of resistance of extensively drug resistant gram-negative bacteria. Antibiotics. 2019;8(2):37. doi:10.3390/antibiotics8020037
   Web of Science ®Google Scholar
• Hu Y, Liu C, Shen Z, et al. Prevalence, risk factors and molecular epidemiology of carbapenem-resistant Klebsiella pneumoniae in patients from Zhejiang, China, 2008–2018. Emerg Microbes Infect. 2020;9(1):1771–1779. doi:10.1080/22221751.2020.1799721
   PubMed Web of Science ®Google Scholar
• Dai G, Xu Y, Kong H, Xie W, Wang H. Risk factors for carbapenem-resistant Klebsiella pneumoniae infection and associated clinical outcomes. Am J Transl Res. 2021;13(6):7276–7281. PMID: 34306493; PMCID: PMC8290679.
   PubMed Web of Science ®Google Scholar
• Tacconelli E, Carrara E, Savoldi A, et al.; WHO Pathogens Priority List Working Group. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis. Lancet Infect Dis. 2018;18(3):318–327. PMID: 29276051. doi:10.1016/S1473-3099(17)30753-3
   PubMed Web of Science ®Google Scholar
• Cassini A, Högberg LD, Plachouras D, et al. Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis. Lancet Infect Dis. 2019;19(1):56–66. doi:10.1016/S1473-3099(18)30605-4
   PubMed Web of Science ®Google Scholar
• Han JH, Goldstein EJC, Wise J, Bilker WB, Tolomeo P, Lautenbach E. Epidemiology of carbapenem-resistant Klebsiella pneumoniae in a network of long-term acute care hospitals. Clin Infect Dis. 2017;64(7):839–844. PMID: 28013258; PMCID: PMC5399931. doi:10.1093/cid/ciw856
   PubMed Web of Science ®Google Scholar
• Zhou M, Wang Y, Liu C, et al. Comparison of five commonly used automated susceptibility testing methods for accuracy in the China Antimicrobial Resistance Surveillance System (CARSS) hospitals. Infect Drug Resist. 2018;11:1347–1358. doi:10.2147/IDR.S166790
   PubMed Web of Science ®Google Scholar
• Wang N, Zhan M, Liu J, et al. Prevalence of carbapenem-resistant Klebsiella pneumoniae infection in a Northern Province in China: clinical characteristics, drug resistance, and geographic distribution. Infect Drug Resist. 2022;15:569–579. doi:10.2147/IDR.S347343
   PubMed Web of Science ®Google Scholar
• Lee CR, Lee JH, Park KS, Kim YB, Jeong BC, Lee SH. Global dissemination of carbapenemase-producing Klebsiella pneumoniae: epidemiology, genetic context, treatment options, and detection methods. Front Microbiol. 2016;7. doi:10.3389/fmicb.2016.00895
   Web of Science ®Google Scholar
• Connie R, Donald C. Textbook of Diagnostic Microbiology. 6th ed. Mosby, Churchill: Elsevied -Saunders; 2018.
   Google Scholar
• Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Susceptibility Testing: 29th Informational Supplement (M100-S26). Wayne, PA: CLSI; 2019.
   Google Scholar
• Magiorakos AP, Srinivasan A, Carey RB, et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect. 2012;18(3):268–281. PMID: 21793988. doi:10.1111/j.1469-0691.2011.03570.x
   PubMed Web of Science ®Google Scholar
• Ravikant Kumari P, Kumar M, Roy P, Jeya M, Jeya M. Detection of carbapenem-resistant Enterobacteriaceae by real-time PCR and assessment of hospitalization related risk factors associated with their fecal carriage: a case-control study. J Pure Appl Microbiol. 2022;16(2):1111–1121. doi:10.22207/JPAM.16.2.37
   Web of Science ®Google Scholar
• Yoshioka N, Hagiya H, Deguchi M, et al. Multiplex real-time PCR assay for six major carbapenemase genes. Pathogens. 2021;10(3):276. doi:10.3390/pathogens10030276
   PubMed Web of Science ®Google Scholar
• Vamsi SK, Moorthy RS, Hemiliamma MN, Chandra Reddy RB, Chanderakant DJ, Sirikonda S. Phenotypic and genotypic detection of carbapenemase production among gram negative bacteria isolated from hospital acquired infections. Saudi Med J. 2022;43(3):236–243. doi:10.15537/smj.2022.43.3.20210809
   PubMed Web of Science ®Google Scholar
• Taneja N, Sharma M. Antimicrobial resistance in the environment: the Indian scenario. Indian J Med Res. 2019;149(2):119. doi:10.4103/ijmr.IJMR_331_18
   PubMed Web of Science ®Google Scholar
• Kumari N, Kumar M, Katiyar A, et al. Genome-wide identification of carbapenem-resistant Gram-negative bacterial (CR-GNB) isolates retrieved from hospitalized patients in Bihar, India. Sci Rep. 2022;12(1):8477. PMID: 35590022; PMCID: PMC9120164. doi:10.1038/s41598-022-12471-3
   PubMed Web of Science ®Google Scholar
• Remya P, Shanthi M, Sekar U. Occurrence and characterization of hyperviscous K1 and K2 serotype in Klebsiella pneumoniae. J Lab Physicians. 2018;10(03):283–288. doi:10.4103/JLP.JLP_48_18
   PubMedGoogle Scholar
• Indrajith S, Mukhopadhyay AK, Chowdhury G, et al. Molecular insights of Carbapenem resistance Klebsiella pneumoniae isolates with focus on multidrug resistance from clinical samples. J Infect Public Health. 2021;14(1):131–138. doi:10.1016/j.jiph.2020.09.018
   PubMed Web of Science ®Google Scholar
• Al-Zahrani IA, Alasiri BA. The emergence of carbapenem-resistant Klebsiella pneumoniae isolates producing OXA-48 and NDM in the Southern (Asir) province, Saudi Arabia. Saudi Med J. 2018;39(1):23–30. doi:10.15537/smj.2018.1.21094
   PubMed Web of Science ®Google Scholar
• Alhazmi W, Al-Jabri A, Al-Zahrani I. The molecular characterization of nosocomial carbapenem-resistant Klebsiella pneumoniae Co-Harboring blaNDM and blaOXA-48 in Jeddah. Microbiol Res. 2022;13(4):753–764. doi:10.3390/microbiolres13040054
   Web of Science ®Google Scholar
• Gupta P, Bollam N, Mehta Y, Sengupta S, Gandra S. Risk factors associated with carbapenem-resistant Klebsiella pneumoniae bloodstream infections in a tertiary-care hospital in India. Infect Control Hosp Epidemiol. 2021;42(11):1418–1420. doi:10.1017/ice.2020.1280
   PubMed Web of Science ®Google Scholar
• Pawar S, Mohite S, Shinde R, Patil S, Karande G. Carbapenem resistant Enterobacteriaceae: prevalence and bacteriological profile in tertiary teaching hospital from rural western India. Indian J Microbiol Res. 2018;5(3):342–347.
   Google Scholar
• Katchanov J, Asar L, Klupp EM, et al. Carbapenem-resistant Gram-negative pathogens in a German university medical center: prevalence, clinical implications and the role of novel β-lactam/β lactamase inhibitor combinations. PLoS One. 2018;13(4):e0195757. doi:10.1371/journal.pone.0195757
   PubMed Web of Science ®Google Scholar
• Zhao D, Zuo Y, Wang Z, Li J. Characterize carbapenem-resistant Klebsiella pneumoniae isolates for nosocomial pneumonia and their Gram-negative bacteria neighbors in the respiratory tract. Mol Biol Rep. 2019;46(1):609–616. doi:10.1007/s11033-018-4515-y
   PubMed Web of Science ®Google Scholar
• Zhang S, Yang Z, Sun L, et al. Clinical observation and prognostic analysis of patients with Klebsiella pneumoniae bloodstream infection. Front Cell Infect Microbiol. 2020;10:577244. PMID: 33240822; PMCID: PMC7680902. doi:10.3389/fcimb.2020.577244
   PubMed Web of Science ®Google Scholar
• Moghnieh R, Abdallah D, Jadayel M, et al. Epidemiology, risk factors, and prediction score of carbapenem resistance among inpatients colonized or infected with 3rd generation cephalosporin resistant Enterobacterales. Sci Rep. 2021;11(1):14757. PMID: 34285312; PMCID: PMC8292374. doi:10.1038/s41598-021-94295-1
   PubMed Web of Science ®Google Scholar
• Xu T, Feng W, Sun F, Qian Y. Clinical and resistance characterization of carbapenem-resistant Klebsiella pneumoniae isolated from intensive care units in China. Ann Transl Med. 2022;10(20):1109. doi:10.21037/atm-22-4323
   PubMed Web of Science ®Google Scholar
• Walia K, Madhumathi J, Veeraraghavan B, et al. Establishing antimicrobial resistance surveillance & Research network in India: journey so far. Indian J Med Res. 2019;149(2):164. doi:10.4103/ijmr.IJMR_226_18
   PubMed Web of Science ®Google Scholar
• Sharma A, Thakur A, Thakur N, et al. Changing trend in the antibiotic resistance pattern of Klebsiella pneumonia isolated from endotracheal aspirate samples of ICU patients of a tertiary care hospital in North India. Cureus. 2023;15(3). doi:10.7759/cureus.36317
   Web of Science ®Google Scholar
• Garg A, Garg J, Upadhyay GC, Agarwal A, Bhattacharjee A. Evaluation of the Rapidec Carba NP test kit for detection of carbapenemase-producing gram-negative bacteria. Antimicrob Agents Chemother. 2015;59(12):7870–7872. doi:10.1128/AAC.01783-15
   PubMed Web of Science ®Google Scholar
• Jaggi N, Chatterjee N, Singh V, et al. Carbapenem resistance in Escherichia coli and Klebsiella pneumoniae among Indian and international patients in North India. Acta Microbiol Immunol Hung. 2019;66(3):367–376. doi:10.1556/030.66.2019.02
   PubMed Web of Science ®Google Scholar
• Nordmann P, Poirel L. Epidemiology and diagnostics of carbapenem resistance in gram-negative bacteria. Clin Infect Dis. 2019;69(Supplement_7):S521–S528. doi:10.1093/cid/ciz824
   PubMed Web of Science ®Google Scholar
• Karampatakis T, Tsergouli K, Politi L, et al. Molecular epidemiology of endemic carbapenem-resistant gram-negative bacteria in an intensive care unit. Microb Drug Resist. 2019;25(5):712–716. PMID: 30589601. doi:10.1089/mdr.2018.0266
   PubMed Web of Science ®Google Scholar