Novel Biomarker Panel of Let-7d-5p and MiR-140-5p Can Distinguish Latent Tuberculosis Infection from Active Tuberculosis Patients

References

• World Health Organization. Global tuberculosis report 2021; 2021. Availble from: https://www.who.int/publications/digital/global-tuberculosis-report-2021. Accessed October 15, 2021.
   Google Scholar
• Dorhoi A, Kaufmann SH. Pathology and immune reactivity: understanding multidimensionality in pulmonary tuberculosis. Semin Immunopathol. 2016;38:153–166. doi:10.1007/s00281-015-0531-3
   PubMed Web of Science ®Google Scholar
• Smith I. Mycobacterium tuberculosis pathogenesis and molecular determinants of virulence. Clin Microbiol Rev. 2003;16:463–496. doi:10.1128/CMR.16.3.463-496.2003
   PubMed Web of Science ®Google Scholar
• Herrera V, Perry S, Parsonnet J, Banaei N. Clinical application and limitations of interferon-gamma release assays for the diagnosis of latent tuberculosis infection. Clin Infect Dis. 2011;52:1031–1037. doi:10.1093/cid/cir068
   PubMed Web of Science ®Google Scholar
• Wang S, Diao N, Lu C, et al. Evaluation of the diagnostic potential of IP-10 and IL-2 as biomarkers for the diagnosis of active and latent tuberculosis in a BCG-vaccinated population. PLoS One. 2012;7:e51338. doi:10.1371/journal.pone.0051338
   PubMed Web of Science ®Google Scholar
• Schmidt CM, Lovero KL, Carvalho FR, et al. Serum anti-Mce1A immunoglobulin detection as a tool for differential diagnosis of tuberculosis and latent tuberculosis infection in children and adolescents. Tuberculosis. 2020;120:101893. doi:10.1016/j.tube.2019.101893
   PubMed Web of Science ®Google Scholar
• Sudbury EL, Clifford V, Messina NL, Song R, Curtis N. Mycobacterium tuberculosis-specific cytokine biomarkers to differentiate active TB and LTBI: a systematic review. J Infect. 2020;81:873–881. doi:10.1016/j.jinf.2020.09.032
   PubMed Web of Science ®Google Scholar
• Warsinske H, Vashisht R, Khatri P. Host-response-based gene signatures for tuberculosis diagnosis: a systematic comparison of 16 signatures. PLoS Med. 2019;16:e1002786. doi:10.1371/journal.pmed.1002786
   PubMed Web of Science ®Google Scholar
• Zhao YL, Zhang JX, Yang JJ, et al. MiR-205-5p promotes lung cancer progression and is valuable for the diagnosis of lung cancer. Thorac Cancer. 2022;13:832–843. doi:10.1111/1759-7714.14331
   PubMed Web of Science ®Google Scholar
• Min H, Fan S, Song S, et al. Plasma microRNAs are associated with acute exacerbation in idiopathic pulmonary fibrosis. Diagn Pathol. 2016;11:135. doi:10.1186/s13000-016-0583-2
   PubMed Web of Science ®Google Scholar
• Benfey PN. Molecular biology: microRNA is here to stay. Nature. 2003;425:244–245. doi:10.1038/425244a
   PubMed Web of Science ®Google Scholar
• Yang T, Ge B. miRNAs in immune responses to Mycobacterium tuberculosis infection. Cancer Lett. 2018;431:22–30. doi:10.1016/j.canlet.2018.05.028
   PubMed Web of Science ®Google Scholar
• Yang F, Yang Y, Chen Y, et al. MiR-21 is remotely governed by the commensal bacteria and impairs anti-TB immunity by down-regulating IFN-gamma. Front Microbiol. 2020;11:512581. doi:10.3389/fmicb.2020.512581
   PubMed Web of Science ®Google Scholar
• Zhu T, Liu H, Su L, et al. MicroRNA-18b-5p downregulation favors mycobacterium tuberculosis clearance in macrophages via HIF-1alpha by promoting an inflammatory response. ACS Infect Dis. 2021;7:800–810. doi:10.1021/acsinfecdis.0c00650
   PubMed Web of Science ®Google Scholar
• Chen YC, Lee CP, Hsiao CC, et al. MicroRNA-23a-3p down-regulation in active pulmonary tuberculosis patients with high bacterial burden inhibits mononuclear cell function and phagocytosis through TLR4/TNF-alpha/TGF-beta1/IL-10 signaling via targeting IRF1/SP1. Int J Mol Sci. 2020;21:8587. doi:10.3390/ijms21228587
   PubMed Web of Science ®Google Scholar
• Sinigaglia A, Peta E, Riccetti S, Venkateswaran S, Manganelli R, Barzon L. Tuberculosis-associated MicroRNAs: from pathogenesis to disease biomarkers. Cells. 2020;10:9. doi:10.3390/cells9102160
   PubMedGoogle Scholar
• Zhu Y, Xiao Y, Kong D, et al. Down-Regulation of miR-378d Increased Rab10 expression to help clearance of mycobacterium tuberculosis in macrophages. Front Cell Infect Microbiol. 2020;10:108. doi:10.3389/fcimb.2020.00108
   PubMed Web of Science ®Google Scholar
• Yuan Q, Chen H, Yang Y, Fu Y, Yi Z. miR-18a promotes Mycobacterial survival in macrophages via inhibiting autophagy by down-regulation of ATM. J Cell Mol Med. 2020;24:2004–2012. doi:10.1111/jcmm.14899
   PubMed Web of Science ®Google Scholar
• Lytle JR, Yario TA, Steitz JA. Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5’ UTR as in the 3’ UTR. Proc Natl Acad Sci U S A. 2007;104:9667–9672. doi:10.1073/pnas.0703820104
   PubMed Web of Science ®Google Scholar
• Wu M, Aung H, Hirsch CS, Toossi Z. Inhibition of Mycobacterium tuberculosis-induced signalling by transforming growth factor-beta in human mononuclear phagocytes. Scand J Immunol. 2012;75:301–304. doi:10.1111/j.1365-3083.2011.02668.x
   PubMed Web of Science ®Google Scholar
• Nalbandian A, Yan BS, Pichugin A, Bronson RT, Kramnik I. Lung carcinogenesis induced by chronic tuberculosis infection: the experimental model and genetic control. Oncogene. 2009;28:1928–1938. doi:10.1038/onc.2009.32
   PubMed Web of Science ®Google Scholar
• Alatas F, Alatas O, Metintas M, Ozarslan A, Erginel S, Yildirim H. Vascular endothelial growth factor levels in active pulmonary tuberculosis. Chest. 2004;125:2156–2159. doi:10.1378/chest.125.6.2156
   PubMed Web of Science ®Google Scholar
• Warsinske HC, Pienaar E, Linderman JJ, Mattila JT, Kirschner DE. Deletion of TGF-beta1 increases bacterial clearance by cytotoxic T cells in a tuberculosis granuloma model. Front Immunol. 2017;8:1843. doi:10.3389/fimmu.2017.01843
   PubMed Web of Science ®Google Scholar
• Wang H, Wu C, Kong D. miR-140-5p overexpression protects against lipopolysaccharide-induced necrotizing pneumonia via targeting toll-like receptor 4. Cell Mol Bioeng. 2021;14:339–348. doi:10.1007/s12195-021-00673-0
   PubMed Web of Science ®Google Scholar
• Yang Y, Liu D, Xi Y, Li J, Liu B, Li J. Upregulation of miRNA-140-5p inhibits inflammatory cytokines in acute lung injury through the MyD88/NF-kappaB signaling pathway by targeting TLR4. Exp Ther Med. 2018;16:3913–3920. doi:10.3892/etm.2018.6692
   PubMed Web of Science ®Google Scholar
• Zhuo E, Cai C, Liu W, Li K, Zhao W. Downregulated microRNA-140-5p expression regulates apoptosis, migration and invasion of lung cancer cells by targeting zinc finger protein 800. Oncol Lett. 2020;20:390. doi:10.3892/ol.2020.12253
   PubMed Web of Science ®Google Scholar
• Dong MN, Xiao Y, Li YF, et al. Amelioration of paraquat-induced pulmonary fibrosis in mice by regulating miR-140-5p expression with the fibrogenic inhibitor Xuebijing. Int J Immunopathol Pharmacol. 2020;34:2058738420923911. doi:10.1177/2058738420923911
   Web of Science ®Google Scholar
• Li X, Chen Y, Wang J, Jiang C, Huang Y. Lung cancer cell-derived exosomal let-7d-5p down-regulates OPRM1 to promote cancer-induced bone pain. Front Cell Dev Biol. 2021;9:666857. doi:10.3389/fcell.2021.666857
   PubMed Web of Science ®Google Scholar
• Min H, Ma D, Zou W, et al. FLCN-regulated miRNAs suppressed reparative response in cells and pulmonary lesions of Birt-Hogg-Dube syndrome. Thorax. 2020;75:476–485. doi:10.1136/thoraxjnl-2019-213225
   PubMed Web of Science ®Google Scholar
• Sun L, Sun M, Ma K, Liu J. Let-7d-5p suppresses inflammatory response in neonatal rats with necrotizing enterocolitis via LGALS3-mediated TLR4/NF-kappaB signaling pathway. Am J Physiol Cell Physiol. 2020;319:C967–C79. doi:10.1152/ajpcell.00571.2019
   PubMed Web of Science ®Google Scholar
• Ling HZ, Xu SZ, Leng RX, et al. Discovery of new serum biomarker panels for systemic lupus erythematosus diagnosis. Rheumatology. 2020;59:1416–1425. doi:10.1093/rheumatology/kez634
   PubMed Web of Science ®Google Scholar