427
Views
1
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Identification of Bacterial Uropathogen and Antimicrobial Resistance Patterns Among Patients with Diabetic and Hypertension Attending Dilla University General Hospital, Dilla, Ethiopia

ORCID Icon, &
Pages 4621-4633 | Received 09 May 2023, Accepted 11 Jul 2023, Published online: 17 Jul 2023

References

  • Vasudevan R. Urinary tract infection: an overview of the infection and the associated risk factors. J Microbiol Exp. 2014;1(2):00008.
  • Flores-Mireles AL, Walker JN, Caparon M, Hultgren SJ. Urinary tract infections: epidemiology, mechanisms of infection and treatment options. Nat Rev Microbiol. 2015;13(5):269–284. doi:10.1038/nrmicro3432
  • Worku GY, Abegaz WE. Prevalence of bacterial urinary tract infection and antimicrobial susceptibility patterns among diabetes mellitus patients attending Zewditu Memorial Hospital, Addis Ababa, Ethiopia. Infect Drug Resist.2020;14:1441–1454.
  • Sussman P, Gally M, Phd DL. The biology of cystitis: host and bacterial factors. Annu Rev Med. 1999;50(1):149–158. doi:10.1146/annurev.med.50.1.149
  • Islam MA, Khan M, Basak P, Khanam M, Bhattacharyya P. Evaluation of liver function tests in type2 diabetic patients. J Teach Ass. 2016;29(1):21–23.
  • Hickling DR, Sun TT, Wu XR. Anatomy and physiology of the urinary tract: relation to host defense and microbial infection. In: Urinary Tract Infections: Molecular Pathogenesis and Clinical Management. Wiley Online Library; 2017:1–25.
  • Jatileni NJV, Maposa I, Mavenyengwa RT. A retrospective study of the variability in etiological agents of urinary tract infections among patients in Windhoek-Namibia. Open J Med Microbiol. 2015;5(04):184. doi:10.4236/ojmm.2015.54023
  • Pargavi B, Mekala T, Selvi AT, Moorthy K. Prevalence of urinary tract infection (UTI) among diabetics patients in Vandavasi, Tamil Nadu, India. Int J Biotechnol. 2011;2(2):42–45.
  • Beyene G, Tsegaye W. Bacterial uropathogens in urinary tract infection and antibiotic susceptibility pattern in Jimma university specialized hospital, southwest Ethiopia. Ethiop J Health Sci. 2011;21(2):141–146. doi:10.4314/ejhs.v21i2.69055
  • Yismaw G, Asrat D, Woldeamanuel Y, Unakal CG. Urinary tract infection: bacterial etiologies, drug resistance profile and associated risk factors in diabetic patients attending Gondar University Hospital, Gondar, Ethiopia. Eur J Experiment Biol. 2012;2(4):889–898.
  • Gizaw M, Harries A, Ade S, et al. Diabetes mellitus in Addis Ababa, Ethiopia: admissions, complications and outcomes in a large referral hospital. Public Health Action. 2015;5(1):74–78. doi:10.5588/pha.14.0107
  • Bloom DE, Cafiero E, Jané-Llopis E, et al. The global economic burden of noncommunicable diseases. Program on the Global Demography of Aging; 2012.
  • El-Nagar MM, Abd El-Salam AE, Gabr HM, Abd El EE. Prevalence of urinary tract infection in Damietta diabetic patients. Menoufia Med J. 2015;28(2):559. doi:10.4103/1110-2098.163918
  • Worku S, Derbie A, Sinishaw MA, Adem Y, Biadglegne F. Prevalence of bacteriuria and antimicrobial susceptibility patterns among diabetic and nondiabetic patients attending at Debre Tabor Hospital, Northwest Ethiopia. Int J Microbiol. 2017;2017:1–8. doi:10.1155/2017/5809494
  • Sasirekha R. A Study on Comparison of Different Phenotypic Methods for Detection of Extended Spectrum Beta Lactamase Production Among Enterobacteriaceae in Urinary Tract Infection in a Tertiary Care Centre. Madurai: Madurai Medical College; 2017.
  • Abubakar E-M-M. Antimicrobial susceptibility pattern of pathogenic bacteria causing urinary tract infections at the Specialist Hospital, Yola, Adamawa state, Nigeria. J Clinic Med Res. 2009;1(1):1–8.
  • Yu S, Fu AZ, Qiu Y, et al. Disease burden of urinary tract infections among type 2 diabetes mellitus patients in the US. J Diabetes Complications. 2014;28(5):621–626. doi:10.1016/j.jdiacomp.2014.03.012
  • Boyko EJ, Fihn SD, Scholes D, Chen C-L, Normand EH, Yarbro P. Diabetes and the risk of acute urinary tract infection among postmenopausal women. Diabetes Care. 2002;25(10):1778–1783. doi:10.2337/diacare.25.10.1778
  • Kumar Jha P, Baral R, Khanal B. Prevalence of uropathogens in diabetic patients and their susceptibility pattern at a tertiary care center in Nepal-a retrospective study. Int J Bio Lab Sci. 2014;3:29–34.
  • Abdul-Sahib KY. Study of ciprofloxacin resistant Escherichia coli (CREC) in type 2 diabetic patients with symptomatic urinary tract infections. IRAQI J Community Med. 2008;21(1):58–63.
  • Baqai R, Aziz M, Rasool G. Urinary tract infections in diabetic patients and biofilm formation of uropathogens. Infect Dis J Pak. 2008;17(1):21–24.
  • Longdoh NA, Assob JCN, Nsagha S, et al. Uropathogens from diabetic patients with asymptomatic bacteriuria and urinary tract infections. West Lond Med J. 2013;5(1):7–14.
  • Casqueiro J, Casqueiro J, Alves C. Infections in patients with diabetes mellitus: a review of pathogenesis. Indian J Endocrinol Metab. 2012;16(Suppl1):S27. doi:10.4103/2230-8210.94253
  • Nitzan O, Elias M, Chazan B, Saliba W. Urinary tract infections in patients with type 2 diabetes mellitus: review of prevalence, diagnosis, and management. Diabetes Metab Syndr Obes. 2015;8:129. doi:10.2147/DMSO.S51792
  • Gupta K, Hooton TM, Naber KG, et al. International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: a 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clinic Infect Dis. 2011;52(5):e103–e20. doi:10.1093/cid/ciq257
  • Woldemariam HK, Geleta DA, Tulu KD, et al. Common uropathogens and their antibiotic susceptibility pattern among diabetic patients. BMC Infect Dis. 2019;19(1):1–10. doi:10.1186/s12879-018-3669-5
  • Mohammed A, Beyene G, Teshager L. Urinary pathogenic bacterial profile, antibiogram of isolates and associated risk factors among diabetic patients in Hawassa town, southern Ethiopia: a cross-sectional study. Urol Nephrol Open Access J. 2020;8(4):84–91. doi:10.15406/unoaj.2020.08.00282
  • Wkler MA, Cockerill FR, Bush K, et al. Clinical and Laboratory Standard Institute: Performance Standards for Antimicrobial Disc susceptibility Tests; Approved Standard. Clinical and Laboratory Standard Institute; 2010.
  • Jorgensen JH, Turnidge JD. Susceptibility test methods: dilution and disk diffusion methods. In: Manual of Clinical Microbiology. 11th ed. American Society of Microbiology; 2015:1253–1273.
  • Abate D, Kabew G, Urgessa F, Meaza D. Bacterial etiologies, antimicrobial susceptibility patterns and associated risk factors of urinary tract infection among diabetic patients attending diabetic clinics in Harar, Eastern Ethiopia. East Afr J Health Biomed Sci. 2017;1(2):11–20.
  • Gutema T, Weldegebreal F, Marami D, Teklemariam Z. Prevalence, antimicrobial susceptibility pattern, and associated factors of urinary tract infections among adult diabetic patients at Metu Karl Heinz Referral Hospital, Southwest Ethiopia. Int J Microbiol. 2018;2018:1–7. doi:10.1155/2018/7591259
  • Kebamo S, Dabso R, Deressa A, Gebrie M. Urinary tract infection: bacterial etiologies, drug resistance profile and associated risk factors among diabetic patients attending Nekemte Referral Hospital, Ethiopia. Am J Curr Microbiol. 2017;5(1):19–31.
  • Evans J, McOwan A, Hillman R, Forster G. Incidence of symptomatic urinary tract infections in HIV seropositive patients and the use of cotrimoxazole as prophylaxis against Pneumocystis carinii pneumoniae. Sex Transm Infect. 1995;71(2):120–122. doi:10.1136/sti.71.2.120
  • Nashtar SB, Hashim I, Hamdan SJ. Assessment of antimicrobial susceptibility patterns in urine culture of patients with urinary tract infection attending Al-Kindy teaching hospital. Iraqi Med J. 2018;64(1):37–41.
  • Nigussie D, Amsalu A. Prevalence of uropathogen and their antibiotic resistance pattern among diabetic patients. Turk J Urol. 2017;43(1):85. doi:10.5152/tud.2016.86155
  • Chiţă T, Timar B, Muntean D, et al. Urinary tract infections in Romanian patients with diabetes: prevalence, etiology, and risk factors. Ther Clin Risk Manag. 2016;13:1–7. doi:10.2147/TCRM.S123226
  • Sewify M, Nair S, Warsame S, et al. Prevalence of urinary tract infection and antimicrobial susceptibility among diabetic patients with controlled and uncontrolled glycemia in Kuwait. J Diabetes Res. 2016;2016:1–7. doi:10.1155/2016/6573215
  • Sharma V, Gupta V, Mittal M. Prevalence of uropathogens in diabetic patients and their antimicrobial susceptibility pattern. Natl J Lab Med. 2012;1(1):26–28.
  • Nabaigwa BI, Mwambi B, Okiria J, Oyet C. Common uropathogens among diabetic patients with urinary tract infection at Jinja Regional Referral Hospital, Uganda. Afr J Lab Med. 2018;7(1):1. doi:10.4102/ajlm.v7i1.621
  • Mama M, Manilal A, Gezmu T, Kidanewold A, Gosa F, Gebresilasie A. Prevalence and associated factors of urinary tract infections among diabetic patients in Arba Minch Hospital, Arba Minch province, South Ethiopia. Turk J Urol. 2019;45(1):56. doi:10.5152/tud.2018.32855
  • Hamdan HZ, Kubbara E, Adam AM, Hassan OS, Suliman SO, Adam I. Urinary tract infections and antimicrobial sensitivity among diabetic patients at Khartoum, Sudan. Ann Clin Microbiol Antimicrob. 2015;14(1):1–6. doi:10.1186/s12941-015-0082-4
  • Pragash DS, Girija S, Sekar U, Rayapu V, Sheriff D. Uropathogens and diabetes mellitus-a perspective. IOSR J Dent Med Sci. 2017;16(5):29–32. doi:10.9790/0853-1605052932
  • Kumar D, Singh AK, Ali MR, Chander Y. Antimicrobial susceptibility profile of extended spectrum β-lactamase (ESBL) producing Escherichia coli from various clinical samples. Infect Dis. 2014;7:IDRT. S13820.
  • Mulvey MA. Adhesion and entry of uropathogenic Escherichia coli. Cell Microbiol. 2002;4(5):257–271. doi:10.1046/j.1462-5822.2002.00193.x
  • Anejo-Okopi JA, Okojokwu OJ, Ramyil SM-C, et al. Bacterial and antibiotic susceptibility pattern of urinary tract infection isolated from asymptomatic and symptomatic diabetic patients attending tertiary hospital in Jos, Nigeria. Trends Med. 2017;17(1):1–5.
  • Bishu KG, Jenkins C, Yebyo HG, Atsbha M, Wubayehu T, Gebregziabher M. Diabetes in Ethiopia: a systematic review of prevalence, risk factors, complications, and cost. Obes Med. 2019;15:100132. doi:10.1016/j.obmed.2019.100132
  • Majeed HT, Aljanaby AAJ. Antibiotic susceptibility patterns and prevalence of some extended spectrum beta-lactamases genes in gram-negative bacteria isolated from patients infected with urinary tract infections in Al-Najaf City, Iraq. Avicenna J Med Biotechnol. 2019;11(2):192.
  • Yeshitela B, Gebre-Selassie S, Feleke Y. Asymptomatic bacteriuria and symptomatic urinary tract infections (UTI) in patients with diabetes mellitus in Tikur Anbessa Specialized University Hospital, Addis Ababa, Ethiopia. Ethiop Med J. 2012;50(3):239–249.
  • Alemu M, Belete MA, Gebreselassie S, Belay A, Gebretsadik D. Bacterial profiles and their associated factors of urinary tract infection and detection of extended spectrum beta-lactamase producing gram-negative uropathogens among patients with diabetes mellitus at Dessie referral hospital, northeastern Ethiopia. Diabetes Metab Syndr Obes. 2020;13:2935. doi:10.2147/DMSO.S262760
  • Alebiosu C, Osinupebi O, Olajubu F. Significant asymptomatic bacteriuria among Nigerian type 2 diabetics. J Natl Med Assoc. 2003;95(5):344.
  • Hall JE, Kuo JJ, da Silva AA, de Paula RB, Liu J, Tallam L. Obesity-associated hypertension and kidney disease. Curr Opin Nephrol Hypertens. 2003;12(2):195–200. doi:10.1097/00041552-200303000-00011
  • Haile Hantalo A, Haile Taassaw K, Solomon Bisetegen F, Woldeamanuel Mulate Y. Isolation and antibiotic susceptibility pattern of bacterial uropathogens and associated factors among adult people living with HIV/AIDS attending the HIV Center at Wolaita Sodo University Teaching Referral Hospital, South Ethiopia. HIV/AIDS Res Palliat Care. 2020;12:799–808. doi:10.2147/HIV.S244619
  • Alo M, Saidu A, Ugah U, Alhassan M. Prevalence and antibiogram of bacterial isolates causing urinary tract infections at Federal Teaching Hospital Abakaliki I (FETHA I). Br Microbiol Res J. 2015;8(2):403–417. doi:10.9734/BMRJ/2015/16696
  • Nayaju T, Upreti MK, Ghimire A, et al. Higher prevalence of ESBL producing uropathogenic Escherichia coli among Diabetic patients from a Tertiary Care Hospital of Kathmandu; 2020.