Efficacy and Safety of Add-On Plant-Based Drugs for COVID-19 Patients: A Review of the Randomized Control Trials

References

• World Health Organization. Weekly epidemiological update on COVID-19 - 13 April 2023. Available from: https://www.who.int/publications/m/item/weekly-epidemiological-update-on-covid-19---13-april-2023. Accessed April 18, 2023.
   Google Scholar
• Looi M-K. How are covid-19 symptoms changing? BMJ. 2023;380:3. doi:10.1136/bmj.p3
   PubMedGoogle Scholar
• Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):1054–1062. doi:10.1016/S0140-6736(20)30566-3
   PubMed Web of Science ®Google Scholar
• Yang J, Zheng Y, Gou X, et al. Prevalence of comorbidities in the novel Wuhan coronavirus (COVID-19) infection: a systematic review and meta-analysis. Int J Infect Dis. 2020. doi:10.1016/j.ijid.2020.03.017
   Web of Science ®Google Scholar
• Wang T, Du Z, Zhu F, et al. Comorbidities and multi-organ injuries in the treatment of COVID-19. Lancet. 2020;395(10228):e52. doi:10.1016/S0140-6736(20)30558-4
   PubMed Web of Science ®Google Scholar
• Hoffmann M, Hofmann-Winkler H, Pöhlmann S. Priming Time: how Cellular Proteases Arm Coronavirus Spike Proteins. Act Viruses by Host Proteases. 2018;71–98. doi:10.1007/978-3-319-75474-1_4
   Google Scholar
• Megantara S, Levita J, Ibrahim S, Nguyen BP. Andrographolide, a diterpenoid lactone compound of andrographis paniculata, binds to lys353 and asp38 in the peptidase domain of human angiotensin-converting enzyme 2. Rasayan J Chem. 2021;14(1):241–247. doi:10.31788/RJC.2021.1416070
   Google Scholar
• Lestari K, Sitorus T, Instiaty I, Megantara S, Levita J. Molecular Docking of Quinine, Chloroquine and Hydroxychloroquine to Angiotensin Converting Enzyme 2 (ACE2) Receptor for Discovering New Potential COVID-19 Antidote. J Adv Pharm Educ Res. 2020;10(2):1–4.
   Google Scholar
• Hillen HS, Kokic G, Farnung L, Dienemann C, Tegunov D, Cramer P. Structure of replicating SARS-CoV-2 polymerase. Nature. 2020;584(7819):154–156. doi:10.1038/s41586-020-2368-8
   PubMed Web of Science ®Google Scholar
• Aftab SO, Ghouri MZ, Masood MU, et al. Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeutic drug target using a computational approach. J Transl Med. 2020;18(1):275. doi:10.1186/s12967-020-02439-0
   PubMed Web of Science ®Google Scholar
• Hofmeyr SA. An interpretative introduction to the immune system. Des Princ Immune Syst Other Distrib Auton Syst. 2000;3:3–26.
   Google Scholar
• Jantan I, Ahmad W, Bukhari SNA. Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trials. Front Plant Sci. 2015;6:655. doi:10.3389/fpls.2015.00655
   PubMed Web of Science ®Google Scholar
• Yuandani JI, Rohani AS, Sumantri IB. Immunomodulatory Effects and Mechanisms of Curcuma Species and Their Bioactive Compounds: a Review. Front Pharmacol. 2021;12(April):1–26. doi:10.3389/fphar.2021.643119
   Google Scholar
• Shanker K, Rangnekar H, Wele A, et al. A randomized controlled pilot study of add-on therapy of CIM-MEG19 (standardized Andrographis paniculata formulation) in mild to moderate COVID-19. Phytomedicine Plus Int J Phyther Phytopharm. 2023;3(1):100398. doi:10.1016/j.phyplu.2022.100398
   PubMedGoogle Scholar
• Adel Mehraban MS, Shirzad M, Taghizadeh Kashani L M, et al. Efficacy and safety of add-on Viola odorata L. in the treatment of COVID-19: a randomized double-blind controlled trial. J Ethnopharmacol. 2023;304:116058. doi:10.1016/j.jep.2022.116058
   PubMed Web of Science ®Google Scholar
• Taghavi MR, Tavanaei Tamanaei T, Oghazian MB, et al. Effectiveness of Fortified Garlic Extract Oral Capsules as Adjuvant Therapy in Hospitalized Patients with Coronavirus Disease 2019: a Triple-Blind Randomized Controlled Clinical Trial. Curr Ther Res Clin Exp. 2023;98:100699. doi:10.1016/j.curtheres.2023.100699
   PubMed Web of Science ®Google Scholar
• Chitre D, Nadkarni S, Jagtap N, et al. Phase III randomized clinical trial of BV-4051, an Ayurvedic polyherbal formulation in moderate SARS-CoV-2 infections and its impact on inflammatory biomarkers. Phytother Res. 2023;37(4):1232–1241. doi:10.1002/ptr.7683
   PubMed Web of Science ®Google Scholar
• Hasanpour M, Safari H, Mohammadpour AH, et al. Efficacy of Covexir® (Ferula foetida oleo-gum) treatment in symptomatic improvement of patients with mild to moderate COVID-19: a randomized, double-blind, placebo-controlled trial. Phytother Res. 2022;36(12):4504–4515. doi:10.1002/ptr.7567
   PubMed Web of Science ®Google Scholar
• Damle L, Damle H, Br B. Plant formulation ATRICOV 452 in improving the level of COVID-19 specific inflammatory markers in patients. Contemp Clin Trials Commun. 2022;28:100961. doi:10.1016/j.conctc.2022.100961
   PubMed Web of Science ®Google Scholar
• Shakeeb N, Varkey P, Hynse A, Mandlecha A. Anti-inflammatory response of cardamom extract and prediction of therapeutic window in COVID-19 patients by assessing inflammatory markers using RT-PCR. Inflammopharmacology. 2022;30(3):883–894. doi:10.1007/s10787-022-00951-x
   PubMed Web of Science ®Google Scholar
• Singh H, Srivastava S, Yadav B, et al. AYUSH-64 as an adjunct to standard care in mild to moderate COVID-19: an open-label randomized controlled trial in Chandigarh, India. Complement Ther Med. 2022;66:102814. doi:10.1016/j.ctim.2022.102814
   PubMed Web of Science ®Google Scholar
• Ebrahimi M, Farhadian N, Amiri AR, Hataminia F, Soflaei SS, Karimi M. Evaluating the efficacy of extracted squalene from seed oil in the form of microemulsion for the treatment of COVID-19: a clinical study. J Med Virol. 2022;94(1):119–130. doi:10.1002/jmv.27273
   PubMed Web of Science ®Google Scholar
• Devpura G, Tomar BS, Nathiya D, et al. Randomized placebo-controlled pilot clinical trial on the efficacy of ayurvedic treatment regime on COVID-19 positive patients. Phytomedicine. 2021;84:153494. doi:10.1016/j.phymed.2021.153494
   PubMed Web of Science ®Google Scholar
• Shohan M, Nashibi R, Mahmoudian-Sani M-R, et al. The therapeutic efficacy of quercetin in combination with antiviral drugs in hospitalized COVID-19 patients: a randomized controlled trial. Eur J Pharmacol. 2022;914:174615. doi:10.1016/j.ejphar.2021.174615
   PubMed Web of Science ®Google Scholar
• Hawkins J, Hires C, Keenan L, Dunne E. Aromatherapy blend of thyme, Orange, clove bud, and frankincense boosts energy levels in post-COVID-19 female patients: a randomized, double-blinded, placebo controlled clinical trial. Complement Ther Med. 2022;67:102823. doi:10.1016/j.ctim.2022.102823
   PubMed Web of Science ®Google Scholar
• Mahmoud N, Radwan N, Alkattan A, et al. Post-COVID-19 syndrome: nature of symptoms and associated factors. J Public Health (Bangkok). 2023. doi:10.1007/s10389-022-01802-3
   Google Scholar
• Liu T, Zhang J, Yang Y, et al. The role of interleukin-6 in monitoring severe case of coronavirus disease 2019. EMBO Mol Med. 2020;12(7):e12421. doi:10.15252/emmm.202012421
   PubMed Web of Science ®Google Scholar
• Tanaka T, Narazaki M, Kishimoto T. IL-6 in inflammation, immunity, and disease. Cold Spring Harb Perspect Biol. 2014;6(10):a016295. doi:10.1101/cshperspect.a016295
   PubMed Web of Science ®Google Scholar
• Nehring SM, Goyal A, Patel BC. C Reactive Protein. Treasure Island (FL); 2023.
   Google Scholar
• Young B, Gleeson M, Cripps AW. C-reactive protein: a critical review. Pathology. 1991;23(2):118–124. doi:10.3109/00313029109060809
   PubMed Web of Science ®Google Scholar
• Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395(10223):507–513. doi:10.1016/S0140-6736(20)30211-7
   PubMed Web of Science ®Google Scholar
• Gao Y, Li T, Han M, et al. Diagnostic utility of clinical laboratory data determinations for patients with the severe COVID-19. J Med Virol. 2020;92(7):791–796. doi:10.1002/jmv.25770
   PubMed Web of Science ®Google Scholar
• Soleymani S, Naghizadeh A, Karimi M, et al. COVID-19: general Strategies for Herbal Therapies. J Evidence-Based Integr Med. 2022;27:2515690X211053641. doi:10.1177/2515690X211053641
   PubMed Web of Science ®Google Scholar
• Alhazmi HA, Najmi A, Javed SA, et al. Medicinal Plants and Isolated Molecules Demonstrating Immunomodulation Activity as Potential Alternative Therapies for Viral Diseases Including COVID-19. Front Immunol. 2021;12:1–24. doi:10.3389/fimmu.2021.637553
   Web of Science ®Google Scholar
• Rajanna M, Bharathi B, Shivakumar BR, et al. Immunomodulatory effects of Andrographis paniculata extract in healthy adults - An open-label study. J Ayurveda Integr Med. 2021;12(3):529–534. doi:10.1016/j.jaim.2021.06.004
   PubMed Web of Science ®Google Scholar
• Zhang X-Y, Lv L, Zhou Y-L, et al. Efficacy and safety of Xiyanping injection in the treatment of COVID-19: a multicenter, prospective, open-label and randomized controlled trial. Phytother Res. 2021;35(8):4401–4410. doi:10.1002/ptr.7141
   PubMed Web of Science ®Google Scholar
• Discovery C-D. A Comprehensive Review of Andrographis paniculata (Burm. f.) Nees and Its Constituents as Potential Lead Compounds for COVID-19 Drug Discovery. Molecules. 2022;27:4479.
   PubMed Web of Science ®Google Scholar
• Jayakumar T, Hsieh CY, Lee JJ, Sheu JR. Experimental and clinical pharmacology of andrographis paniculata and its major bioactive phytoconstituent andrographolide. Evidence-Based Complement Altern Med. 2013;2013. doi:10.1155/2013/846740
   Web of Science ®Google Scholar
• Enmozhi SK, Raja K, Sebastine I, Joseph J. Andrographolide as a potential inhibitor of SARS-CoV-2 main protease: an in silico approach. J Biomol Struct Dyn. 2021;39(9):3092–3098. doi:10.1080/07391102.2020.1760136
   PubMed Web of Science ®Google Scholar
• Chandramohan V, Kaphle A, Chekuri M, Gangarudraiah S, Bychapur Siddaiah G. Evaluating Andrographolide as a Potent Inhibitor of NS3-4A Protease and Its Drug-Resistant Mutants Using In Silico Approaches. Adv Virol. 2015;2015:972067. doi:10.1155/2015/972067
   PubMed Web of Science ®Google Scholar
• Li Y, He S, Tang J, et al. Andrographolide Inhibits Inflammatory Cytokines Secretion in LPS-Stimulated RAW264.7 Cells through Suppression of NF-κB/MAPK Signaling Pathway. Evid Based Complement Alternat Med. 2017;2017:8248142. doi:10.1155/2017/8248142
   PubMed Web of Science ®Google Scholar
• Tharakan A, Shukla H, Benny IR, Tharakan M, George L, Koshy S. Immunomodulatory Effect of Withania somnifera (Ashwagandha) Extract-A Randomized, Double-Blind, Placebo Controlled Trial with an Open Label Extension on Healthy Participants. J Clin Med. 2021;10(16). doi:10.3390/jcm10163644
   PubMed Web of Science ®Google Scholar
• Albassam AA, Alanazi A, Alhaqbani N, et al. The potential of drug-herbal interaction among patients with chronic diseases in Saudi Arabia. Complement Ther Clin Pract. 2021;43:101324. doi:10.1016/j.ctcp.2021.101324
   PubMed Web of Science ®Google Scholar
• Chen X-W, Serag ES, Sneed KB, et al. Clinical herbal interactions with conventional drugs: from molecules to maladies. Curr Med Chem. 2011;18(31):4836–4850. doi:10.2174/092986711797535317
   PubMed Web of Science ®Google Scholar
• Kasarla SS, Borse SP, Kumar Y, Sharma N, Dikshit M. In vitro effect of Withania somnifera, AYUSH-64, and remdesivir on the activity of CYP-450 enzymes: implications for possible herb-drug interactions in the management of COVID-19. Front Pharmacol. 2022;13:973768. doi:10.3389/fphar.2022.973768
   PubMed Web of Science ®Google Scholar
• Ye L, Cheng L, Deng Y, et al. Herb-Drug Interaction Between Xiyanping Injection and Lopinavir/Ritonavir, Two Agents Used in COVID-19 Pharmacotherapy. Front Pharmacol. 2021;12:773126. doi:10.3389/fphar.2021.773126
   PubMed Web of Science ®Google Scholar