Molecular Profile and the Effectiveness of Antimicrobials Drugs Against Staphylococcus aureus and Pseudomonas aeruginosa in the Diagnostic Approaches of Otitis Infection

References

• Danishyar A, Ashurst JV. Acute Otitis Media. Treasure Island (FL): StatPearls Publishing; 2022.
   Google Scholar
• Sander RW. Otitis externa: a practical guide to treatment and prevention. AFP. 2001;63:927.
   Google Scholar
• Monasta L, Ronfani L, Marchetti F, et al. Burden of disease caused by otitis media: systematic review and global estimates. PLoS One. 2012;7:e36226. doi:10.1371/journal.pone.0036226
   PubMed Web of Science ®Google Scholar
• Deen J, Von Seidlein L, Clemens JD. Issues and challenges of public-health research in developing countries. Manson’s Tropical Infect Dis. 2014;40–48.e1. doi:10.1016/B978-0-7020-5101-2.00006-6
   Google Scholar
• Shaikh N, Hoberman A, Kaleida PH, Ploof DL, Paradise JL. Diagnosing otitis media — otoscopy and cerumen removal. N Engl J Med. 2010;362:e62. doi:10.1056/NEJMvcm0904397
   PubMed Web of Science ®Google Scholar
• Ilechukwu GC, Ilechukwu CGA, Ubesie AC, et al. Otitis Media in Children: review Article. OJPed. 2014;4:47–53. doi:10.4236/ojped.2014.41006
   Google Scholar
• Klein JO. Otitis Externa, Otitis Media, and Mastoiditis. Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. Int J Med. 2015:767–773.e1. doi:10.1016/B978-1-4557-4801-3.00062-X
   PubMedGoogle Scholar
• Rosenfeld RM, Schwartz SR, Cannon CR, et al. Clinical Practice Guideline: acute Otitis Externa. Otolaryngol Head Neck Surg. 2014;150:S1–S24. doi:10.1177/0194599813517083
   PubMed Web of Science ®Google Scholar
• Lieberthal AS, Carroll AE, Chonmaitree T, et al. The Diagnosis and Management of Acute Otitis Media. Pediatrics. 2013;131:e964–e999. doi:10.1542/peds.2012-3488
   PubMed Web of Science ®Google Scholar
• Byrne AHV, DiMauro E, Frackowiak S, et al. Chapter 97 - The Neurological Vasculitides. In: Neurology and Clinical Neuroscience. Schapira: Philadelphia; 2007:1313–1322.
   Google Scholar
• Chronic otitis media (middle ear infection) and hearing loss. Available from: http://www.drrobertoliver.com/what-we-do/sinus-and-ent/chronic-otitis-media-middle-ear-infection-and-hearing-loss. Accessed on April 5, 2022.
   Google Scholar
• Trojanowska A, Drop A, Trojanowski P, Rosińska-Bogusiewicz K, Klatka J, Bobek-Billewicz B. External and middle ear diseases: radiological diagnosis based on clinical signs and symptoms. Insights Imaging. 2011;3:33–48. doi:10.1007/s13244-011-0126-z
   PubMedGoogle Scholar
• Hailu D, Mekonnen D, Derbie A, et al. Pathogenic Bacteria Profile and Antimicrobial Susceptibility Patterns of Ear Infection at Bahir Dar Regional Health Research Laboratory Center, Ethiopia. Springerplus. 2016;5:466. doi:10.1186/s40064-016-2123-7
   PubMedGoogle Scholar
• Earwood JS, Rogers TS, Rathjen NA. Ear Pain: diagnosing Common and Uncommon Causes. AFP. 2018;97:20–27.
   Google Scholar
• Lin M-F, Lan C-Y. Antimicrobial resistance in Acinetobacter baumannii: from bench to bedside. World J Clin Cases. 2014;2:787–814. doi:10.12998/wjcc.v2.i12.787
   PubMed Web of Science ®Google Scholar
• Qurban R, Ain QU, Khan JK, et al. Bacterial profile of middle ear infections, coexistence of pseudomonas, proteus species in middle ear infections and their antibiotic sensitivity pattern. Pakistan Postgraduate Med J. 2017;28(4):117.
   Google Scholar
• Getaneh A, Ayalew G, Belete D, Jemal M, Biset S. Bacterial Etiologies of Ear Infection and Their Antimicrobial Susceptibility Pattern at the University of Gondar Comprehensive Specialized Hospital, Gondar, Northwest Ethiopia: a Six-Year Retrospective Study. Infect Drug Resist. 2021;14:4313–4322. doi:10.2147/IDR.S332348
   PubMed Web of Science ®Google Scholar
• Kono M, Umar NK, Takeda S, et al. Novel antimicrobial treatment strategy based on drug delivery systems for acute otitis media. Front Pharmacol. 2021;12:640514.
   PubMed Web of Science ®Google Scholar
• Pichichero ME. Acute otitis media: part ii. treatment in an era of increasing antibiotic resistance. Am Fam Physician. 2000;61:2410–2416.
   PubMed Web of Science ®Google Scholar
• Baraibar R. Incidence and risk factors of acute otitis media in children. Clin Microbiol Infection. 1997;3:3S13–3S22. doi:10.1016/S1198-743X(14)64947-8
   Google Scholar
• Kaplan SL, Mason EO. Management of infections due to antibiotic-resistant streptococcus pneumoniae. Clin Microbiol Rev. 1998;11:628–644. doi:10.1128/CMR.11.4.628
   PubMed Web of Science ®Google Scholar
• Bennett PM. Plasmid encoded antibiotic resistance: acquisition and transfer of antibiotic resistance genes in bacteria. Br J Pharmacol. 2008;153:S347–S357. doi:10.1038/sj.bjp.0707607
   PubMed Web of Science ®Google Scholar
• Sun D, Jeannot K, Xiao Y, Knapp CW. Editorial: horizontal gene transfer mediated bacterial antibiotic resistance. Front Microbiol. 2019;10:10. doi:10.3389/fmicb.2019.00010
   PubMedGoogle Scholar
• Nikaido H. Multidrug resistance in bacteria. Annu Rev Biochem. 2009;78:119–146. doi:10.1146/annurev.biochem.78.082907.145923
   PubMed Web of Science ®Google Scholar
• Amaral L, Martins A, Spengler G, Molnar J. Efflux pumps of gram-negative bacteria: what they do, how they do it, with what and how to deal with them. Front Pharmacol. 2014;5:4. doi:10.3389/fphar.2014.00004
   PubMedGoogle Scholar
• Fernández L, Hancock REW. Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance. Clin Microbiol Rev. 2012;25:661–681. doi:10.1128/CMR.00043-12
   PubMed Web of Science ®Google Scholar
• Li X-Z, Plésiat P, Nikaido H. The challenge of efflux-mediated antibiotic resistance in gram-negative bacteria. Clin Microbiol Rev. 2015;28:337–418. doi:10.1128/CMR.00117-14
   PubMed Web of Science ®Google Scholar
• Peterson E, Kaur P. Antibiotic resistance mechanisms in bacteria: relationships between resistance determinants of antibiotic producers, environmental bacteria, and clinical pathogens. Front Microbiol. 2018;9:9. doi:10.3389/fmicb.2018.00009
   PubMed Web of Science ®Google Scholar
• Skov R, Larsen AR, Frimodt-Møller N, Espersen F. Evaluation of different disk diffusion/media combinations for detection of methicillin resistance in Staphylococcus aureus and coagulase-negative staphylococci. APMIS. 2003;111:905–914. doi:10.1034/j.1600-0463.2003.1110909.x
   PubMed Web of Science ®Google Scholar
• Overton N. Oxoid Manual Prelims. 9th ed. England: OXOID Limited; 2006.
   Google Scholar
• Liu D. Handbook of Nucleic Acid Purification. CRC Press; 2009.
   Google Scholar
• Vos T, Allen C, Arora M. Global, Regional, and National Incidence, Prevalence, and Years Lived with Disability for 310 Diseases and Injuries, 1990–2015: a Systematic Analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388:1545–1602. doi:10.1016/S0140-6736(16)31678-6
   PubMed Web of Science ®Google Scholar
• Korver AMH, Smith RJH, Van Camp G, et al. Congenital Hearing Loss. Nat Rev Dis Primers. 2017;3:16094. doi:10.1038/nrdp.2016.94
   PubMed Web of Science ®Google Scholar
• Burton MJ, Ramke J, Marques AP, et al. The lancet global health commission on global eye health: vision beyond 2020. Lancet Global Health. 2021;9:e489–e551. doi:10.1016/S2214-109X(20)30488-5
   PubMed Web of Science ®Google Scholar
• Albrecht BA. CHAPTER 61 - Mastitis. In: Samper JC, Pycock JF, McKinnon AO, editors. Current Therapy in Equine Reproduction. W.B. Saunders: Saint Louis; 2007:441–445.
   Google Scholar
• Leekha S, Terrell CL, Edson RS. General principles of antimicrobial therapy. Mayo Clinic Proceedings. 2011;86:156. doi:10.4065/mcp.2010.0639
   PubMed Web of Science ®Google Scholar
• Wasihun AG, Zemene Y. Bacterial Profile and Antimicrobial Susceptibility Patterns of Otitis Media in Ayder Teaching and Referral Hospital, Mekelle University, Northern Ethiopia. Springerplus. 2015;4:701. doi:10.1186/s40064-015-1471-z
   PubMedGoogle Scholar
• Agrawal A, Kumar D, Goyal A, et al. Microbiological Profile and Their Antimicrobial Sensitivity Pattern in Patients of Otitis Media with Ear Discharge. Indian J Otol. 2013;19:5. doi:10.4103/0971-7749.108149
   Google Scholar
• Raad I, Hanna H, Jiang Y, et al. Comparative activities of daptomycin, linezolid, and tigecycline against catheter-related methicillin-resistant staphylococcus bacteremic isolates embedded in biofilm. Antimicrob Agents Chemother. 2007;51:1656–1660. doi:10.1128/AAC.00350-06
   PubMed Web of Science ®Google Scholar
• Pachori P, Gothalwal R, Gandhi P. Emergence of Antibiotic Resistance Pseudomonas Aeruginosa in Intensive Care Unit; a Critical Review. Genes Dis. 2019;6:109–119. doi:10.1016/j.gendis.2019.04.001
   PubMed Web of Science ®Google Scholar
• Tadesse S, Alemayehu H, Tenna A, et al. Antimicrobial re sistance profile of Staphylococcus aureus isolated from patients with infection at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. BMC Pharm Toxicol. 2018;19(1):1–8. doi:10.1186/s40360-018-0210-9
   PubMedGoogle Scholar
• Mama M, Abdissa A, Sewunet T. Antimicrobial susceptibility pattern of bacterial isolates from wound infection and their sensitivity to alternative topical agents at Jimma University Specialized Hospital, South-West Ethiopia. Ann Clin Microbiol Antimicrob. 2014;13:14. doi:10.1186/1476-0711-13-14
   PubMed Web of Science ®Google Scholar
• Okwu MU, Mitsan OO, Okeke OP. Prevalence and antimicrobial susceptibility profiles of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) isolates among healthy individuals in Okada, South-South, Nigeria. Pharm Biol Chem Sci J. 2014;1(1):1–9.
   Google Scholar
• Soltani R, Khalili H, Rasoolinejad M. Antimicrobial Susceptibility Pattern of Staphylococcus aureus Strains Isolated from Hospitalized Patients in Tehran, Iran. Iranian J Pharm Sci. 2010;6(2):125–132.
   Google Scholar
• van Duin D, Paterson D. Multidrug resistant bacteria in the community: trends and lessons learned. Infect Dis Clin North Am. 2016;30:377–390. doi:10.1016/j.idc.2016.02.004
   PubMed Web of Science ®Google Scholar
• Prestinaci F, Pezzotti P, Pantosti A. Antimicrobial resistance: a global multifaceted phenomenon. Pathog Glob Health. 2015;109:309–318. doi:10.1179/2047773215Y.0000000030
   PubMed Web of Science ®Google Scholar
• Doron S, Davidson LE. Antimicrobial Stewardship. Mayo Clin Proc. 2011;86:1113–1123. doi:10.4065/mcp.2011.0358
   PubMed Web of Science ®Google Scholar
• Meletis G. Carbapenem Resistance: overview of the Problem and Future Perspectives. Ther Adv Infect Dis. 2016;3:15–21. doi:10.1177/2049936115621709
   PubMed Web of Science ®Google Scholar
• Tamma PD, Doi Y, Bonomo RA, et al. A Primer on AmpC β-Lactamases: necessary Knowledge for an Increasingly Multidrug-Resistant World. Clin Infect Dis. 2019;69:1446–1455. doi:10.1093/cid/ciz173
   PubMed Web of Science ®Google Scholar
• Fursova NK, Astashkin EI, Knyazeva AI, et al. The Spread of BlaOXA-48 and BlaOXA-244 Carbapenemase Genes among Klebsiella Pneumoniae, Proteus Mirabilis and Enterobacter Spp. Isolated in Moscow, Russia. Ann Clin Microbiol Antimicrob. 2015;14:46. doi:10.1186/s12941-015-0108-y
   PubMed Web of Science ®Google Scholar
• Balasa G, Levengood ES, Battistelli JM, Franklin RB. Diversity of Multidrug-Resistant Bacteria in an Urbanized River: a Case Study of the Potential Risks from Combined Sewage Overflows. Water. 2021;13:2122. doi:10.3390/w13152122
   Web of Science ®Google Scholar
• Angeli P, Bernardi M, Villanueva C, et al. EASL clinical practice guidelines for the management of patients with decompensated cirrhosis. J Hepatol. 2018;69:406–460. doi:10.1016/j.jhep.2018.03.024
   PubMed Web of Science ®Google Scholar
• Tyne DV, Park DJ, Schaffner SF, et al. Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in plasmodium falciparum. PLoS Genet. 2011;7:e1001383. doi:10.1371/journal.pgen.1001383
   PubMed Web of Science ®Google Scholar
• Ventola CL. The antibiotic resistance crisis. P T. 2015;40:277–283.
   PubMedGoogle Scholar
• Martinez JL. The role of natural environments in the evolution of resistance traits in pathogenic bacteria. Proce Royal Society B. 2009;276:2521–2530. doi:10.1098/rspb.2009.0320
   PubMed Web of Science ®Google Scholar
• Environmental Factors Influencing the Development and Spread of Antibiotic Resistance | FEMS Microbiology Reviews | oxford Academic Available from: https://academic.oup.com/femsre/article/42/1/fux053/4563583. Accessed April 6, 2022.
   Google Scholar
• Colomer-Lluch M, Jofre J, Muniesa M. Antibiotic Resistance Genes in the Bacteriophage DNA Fraction of Environmental Samples. PLoS One. 2011;6:e17549. doi:10.1371/journal.pone.0017549
   PubMed Web of Science ®Google Scholar
• Santajit S, Indrawattana N. Mechanisms of Antimicrobial Resistance in ESKAPE Pathogens. Biomed Res Int. 2016;2016:e2475067. doi:10.1155/2016/2475067
   PubMed Web of Science ®Google Scholar
• Kunhikannan S, Thomas CJ, Franks AE, et al. Environmental Hotspots for Antibiotic Resistance Genes. MicrobiologyOpen. 2021;10:e1197. doi:10.1002/mbo3.1197
   PubMed Web of Science ®Google Scholar
• Pal M, Kerorsa GB, Marami LM, Kandi V. Epidemiology, pathogenicity, animal infections, antibiotic resistance, public health significance, and economic impact of Staphylococcus aureus: a comprehensive review. Am J Public Health Res. 2020;8(1):14–21.
   Google Scholar
• Eticha T, Tamire T, Gelgelu TB. Antibiotic susceptibility pattern of coagulase positive Staphylococcus aureus isolated from patients admitted at Tikur Anbessa specialized Hospital, Addis Ababa. Health Sci J. 2022;16(2):1–5.
   Google Scholar
• Grenni P. Antimicrobial resistance in rivers: a review of the genes detected and new challenges. Environ Toxicol Chem. 2022;41:687–714. doi:10.1002/etc.5289
   PubMed Web of Science ®Google Scholar
• Gillings MR. Integrons: past, Present, and Future. Microbiol Mol Biol Rev. 2014;78:257–277. doi:10.1128/MMBR.00056-13
   PubMed Web of Science ®Google Scholar
• Palma E, Tilocca B, Roncada P. Antimicrobial resistance in veterinary medicine: an overview. Int J Mol Sci. 2020;21:1914. doi:10.3390/ijms21061914
   PubMed Web of Science ®Google Scholar
• Kot B, Wierzchowska K, Piechota M, Grużewska A. Antimicrobial resistance patterns in methicillin-resistant Staphylococcus aureus from patients hospitalized during 2015–2017 in hospitals in Poland. Med Princ Pract. 2020;29(1):61–68. doi:10.1159/000501788
   PubMed Web of Science ®Google Scholar
• Tamire T, Eticha T, Gelgelu TB. Methicillin-Resistant Staphylococcus aureus: the Magnitude and Risk Factors among Patients Admitted to Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. Int J Microbiol. 2021. doi:10.1155/2021/9933926
   PubMed Web of Science ®Google Scholar
• Krause KM, Serio AW, Kane TR, Connolly LE. Aminoglycosides: an Overview. Cold Spring Harb Perspect Med. 2016;6:a027029. doi:10.1101/cshperspect.a027029
   PubMed Web of Science ®Google Scholar
• Frost LS. Conjugation, Bacterial. In: Schaechter M, editor. Encyclopedia of Microbiology (Third Edition). Oxford: Academic Press; 2009:517–531.
   Google Scholar
• Zatyka M, Thomas CM. Control of genes for conjugative transfer of plasmids and other mobile elements. FEMS Microbiol Rev. 1998;21:291–319. doi:10.1111/j.1574-6976.1998.tb00355.x
   PubMed Web of Science ®Google Scholar
• Mindlin S, Maslova O, Beletsky A, et al. Ubiquitous conjugative mega-plasmids of Acinetobacter species and their role in horizontal transfer of multi-drug resistance. Front Microbiol. 2021;12:728644.
   PubMed Web of Science ®Google Scholar
• Shearer JES, Wireman J, Hostetler J, et al. Major families of multiresistant plasmids from geographically and epidemiologically diverse staphylococci. G3 Genes|Genomes|Genetics. 2011;1:581–591. doi:10.1534/g3.111.000760
   Web of Science ®Google Scholar
• Bennani S, Nsarellah N, Birouk A, et al. Effective Selection Criteria for Screening Drought Tolerant and High Yielding Bread Wheat Genotypes. Univ J Agr Res. 2016;4:134–142. doi:10.13189/ujar.2016.040404
   Google Scholar
• Hawkey PM. Antibiotic Resistance. In: Brenner S, Miller JH, editors. Encyclopedia of Genetics. New York: Academic Press; 2001:74–76.
   Google Scholar
• Jin F, Conrad JC, Gibiansky ML, Wong GCL. Bacteria Use Type-IV Pili to Slingshot on Surfaces. Proc Natl Acad Sci U S A. 2011;108:12617–12622. doi:10.1073/pnas.1105073108
   PubMed Web of Science ®Google Scholar
• Partridge SR, Kwong SM, Firth N, Jensen SO. Mobile Genetic Elements Associated with Antimicrobial Resistance. Clin Microbiol Rev. 2018;31:e00088–17. doi:10.1128/CMR.00088-17
   PubMed Web of Science ®Google Scholar
• Álvarez-Rodríguez I, Arana L, Ugarte-Uribe B, et al. Type IV coupling proteins as potential targets to control the dissemination of antibiotic resistance. Front Mol Biosciences. 2020;7:7. doi:10.3389/fmolb.2020.00007
   PubMed Web of Science ®Google Scholar
• Gössweiner-Mohr N, Arends K, Keller W, Grohmann E. Conjugation in gram-positive bacteria. Microbiology Spectrum. 2014;2. doi:10.13140/2.1.5056.5763
   Google Scholar
• Wolfe ND, Dunavan CP, Diamond J. Origins of major human infectious diseases. Nature. 2007;447:279–283. doi:10.1038/nature05775
   PubMed Web of Science ®Google Scholar
• Holmes RK, Jobling MG, Baron S, editors. University of Texas Medical Branch at Galveston: galveston (TX), Genetics. In: In Medical Microbiology; 1996.
   Google Scholar
• Yanagiya K, Maejima Y, Nakata H, et al. Novel self-transmissible and broad-host-range plasmids exogenously captured from anaerobic granules or cow manure. Front Microbiol. 2018;9:9.
   PubMed Web of Science ®Google Scholar
• Wright O, Delmans M, Stan G-B, Ellis T. GeneGuard: a Modular Plasmid System Designed for Biosafety. ACS Synth Biol. 2015;4:307–316. doi:10.1021/sb500234s
   PubMed Web of Science ®Google Scholar
• Bartosik AA, Glabski K, Kulinska A, et al. Convenient Broad-Host-Range Unstable Vectors for Studying Stabilization Cassettes in Diverse Bacteria. BMC Microbiol. 2016;16:59. doi:10.1186/s12866-016-0674-y
   PubMed Web of Science ®Google Scholar
• Poole K. Pseudomonas Aeruginosa: resistance to the Max. Front Microbiol. 2011;2:2. doi:10.3389/fmicb.2011.00002
   PubMed Web of Science ®Google Scholar
• Vrancianu CO, Popa LI, Bleotu C, Chifiriuc MC. Targeting plasmids to limit acquisition and transmission of antimicrobial resistance. Front Microbiol. 2020;11:761. doi:10.3389/fmicb.2020.00761
   PubMed Web of Science ®Google Scholar
• Jain A, Srivastava P. Broad host range plasmids. FEMS Microbiol Lett. 2013;348:87–96. doi:10.1111/1574-6968.12241
   PubMed Web of Science ®Google Scholar
• Chopra I, Roberts M. Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. Microbiol Mol Biol Rev. 2001;65:232–260. doi:10.1128/MMBR.65.2.232-260.2001
   PubMed Web of Science ®Google Scholar
• Selim S, Faried OA, Almuhayawi MS, et al. Incidence of vancomycin-resistant Staphylococcus aureus strains among patients with urinary tract infections. Antibiotics. 2022;11:408. doi:10.3390/antibiotics11030408
   Google Scholar