318
Views
3
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Drug Resistance Profile Among HIV-1 Infections Experiencing ART with Low-Level Viral Load in Guangdong China During 2011–2022: A Retrospective Study

, , , , , , , , , & ORCID Icon show all
Pages 4953-4964 | Received 02 May 2023, Accepted 27 Jul 2023, Published online: 31 Jul 2023

References

  • Daltro ACB, Almeida CS, Unfried AGC, de Aquino TR, Travassos AGÁ. Virological failure and adherence to antiretroviral therapy in adolescents and young adults living with human immunodeficiency virus. Trop Med Int Health. 2023;28(3):162–174. doi:10.1111/tmi.13854
  • 1.14 million people infected with HIV in China. Available from: https://www.shine.cn/news/nation/2112018939/. Accessed December 3, 2021.
  • Crespo-Bermejo C, de Arellano ER, Lara-Aguilar V, et al. Persistent low-Level viremia in persons living with HIV undertreatment: an unresolved status. Virulence. 2021;12(1):2919–2931. doi:10.1080/21505594.2021.2004743
  • Chen J, He Y, Zhong H, et al. Transcriptome analysis of CD4+ T cells from HIV-infected individuals receiving ART with LLV revealed novel transcription factors regulating HIV-1 promoter activity. Virol Sin. 2023;S1995–820X(23):22. doi:10.1016/j.virs.2023.03.001
  • McCluskey SM, Siedner MJ, Marconi VC. Management of virologic failure and HIV drug resistance. Infect Dis Clin North Am. 2019;33(3):707–742. doi:10.1016/j.idc.2019.05.004
  • Nettles RE, Kieffer TL, Kwon P, et al. Intermittent HIV-1 viremia (Blips) and drug resistance in patients receiving HAART. JAMA. 2005;293(7):817–829. doi:10.1001/jama.293.7.817
  • Santoro MM, Fabeni L, Armenia D, et al. Reliability and clinical relevance of the HIV-1 drug resistance test in patients with low viremia levels. Clin Infect Dis. 2014;58(8):1156–1164. doi:10.1093/cid/ciu020
  • World Health Organization. Consolidated Guidelines on HIV Prevention, Testing, Treatment, Service Delivery and Monitoring: Recommendations for a Public Health Approach. Geneva: World Health Organization; 2021.
  • U.S. Department of Health and Human Services. Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the Use of Antiretroviral Agents inAdults and Adolescents with HIV; 2021. Available from: https://clinicalinfo.hiv.gov/en/guidelines/adult-and-adolescent-arv/whats-new-guidelines. Accessed July 28, 2023.
  • European AIDS clinical society. European guidelines for treatment of HIV infected adults in Europe; 2019. Available from: https://eacsociety.org/files/2019_guide.lines-10.0_final.pdf. Accessed July 27, 2023.
  • Temereanca A, Ruta S. Strategies to overcome HIV drug resistance-current and future perspectives. Front Microbiol. 2023;14:1133407. doi:10.3389/fmicb.2023.1133407
  • Galli L, Parisi MR, Poli A, et al. Burden of disease in PWH harboring a multidrug-resistant virus: data from the PRESTIGIO registry. Open Forum Infect Dis. 2020;7(11):ofaa456. doi:10.1093/ofid/ofaa456
  • Li L, Li H, Lan Y, et al. Impact of low level viremia on the antiviral effect of human immunodeficiency virus/acquired immunodeficiency syndrome patients received anti-retroviral therapy. Chinese J Infect Dis. 2021;39(8):470–474. Chinese. doi:10.3760/cma.j.cn311365-20200703-00693
  • Li Q, Chen M, Zhao H, et al. Persistent low-level viremia is an independent risk factor for virologic failure: a retrospective cohort study in China. Infect Drug Resist. 2021;14:4529–4537. doi:10.2147/IDR.S332924
  • Swenson LC, Min JE, Woods CK, et al. HIV drug resistance detected during low-level viraemia is associated with subsequent virologic failure. AIDS. 2014;28(8):1125–1134. doi:10.1097/QAD.0000000000000203
  • Bareng OT, Choga WT, Maphorisa ST, et al. HIV-1C in-House RNA-based genotyping assay for detection of drug resistance mutations in samples with low-level viral loads. Infect Drug Resist. 2022;15:7565–7576. doi:10.2147/IDR.S388816
  • People’s government of Guangdong Province: the overall AIDS epidemic in Guangdong Province is at a low epidemic level. Available from:http://www.gd.gov.cn/zwgk/zdlyxxgkzl/ylws/content/post_4056940.html. Accessed December 2, 2022.
  • Li Q, Yu F, Song C, et al. A concentration method for HIV drug resistance testing in low-level viremia samples. Biomed Res Int. 2022;2022:2100254. doi:10.1155/2022/2100254
  • Li Q, Yu F, Song C, et al. HIV-1 genotypic resistance testing using sanger and next-generation sequencing in adults with low-level viremia in China. Infect Drug Resist. 2022;15:6711–6722. doi:10.2147/IDR.S387215
  • Yuan D, Zhou Y, Shi L, et al. HIV-1 drug resistance profiles of low-level viremia patients and factors associated with the treatment effect of ART-treated patients: a cross-sectional study in Jiangsu, China. Front Public Health. 2022;10:944990. doi:10.3389/fpubh.2022.944990
  • Lan Y, He X, Li L, et al. Complicated genotypes circulating among treatment naïve HIV-1 patients in Guangzhou, China. Infect Genet Evol. 2021;87:104673. doi:10.1016/j.meegid.2020.104673
  • Struck D, Lawyer G, Ternes AM, Schmit JC, Bercoff DP. COMET: adaptive context-based modeling for ultrafast HIV-1 subtype identification. Nucleic Acids Res. 2014;42(18):e144. doi:10.1093/nar/gku739
  • Pineda-Peña AC, Faria NR, Imbrechts S, et al. Automated subtyping of HIV-1 genetic sequences for clinical and surveillance purposes: performance evaluation of the new REGA version 3 and seven other tools. Infect Genet Evol. 2013;19:337–348. doi:10.1016/j.meegid.2013.04.032
  • Guindon S, Dufayard JF, Lefort V, Anisimova M, Hordijk W, Gascuel O. New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Syst Biol. 2010;59(3):307–321. doi:10.1093/sysbio/syq010
  • Liu TF, Shafer RW. Web resources for HIV type 1 genotypic-resistance test interpretation. Clin Infect Dis. 2006;42(11):1608–1618. doi:10.1086/503914
  • Assoumou L, Charpentier C, Recordon-Pinson P, et al. Prevalence of HIV-1 drug resistance in treated patients with viral load >50 copies/mL: a 2014 French nationwide study. J Antimicrob Chemother. 2017;72(6):1769–1773. doi:10.1093/jac/dkx042
  • Bangalee A, Hans L, Steegen K. Feasibility and clinical relevance of HIV-1 drug resistance testing in patients with low-level viraemia in South Africa. J Antimicrob Chemother. 2021;76(10):2659–2665. doi:10.1093/jac/dkab220
  • Lyu S, Bai R, Dai M, et al. Features analysis of HIV-1 genotype resistance in patients with low-level viremia after antiretroviral therapy. Chin J AIDS. 2022;28(10):1187–1190. Chinese. doi:10.13419/j.cnki.aids.2022.10.16
  • He X, Xing H, Ruan Y, et al. A comprehensive mapping of HIV-1 genotypes in various risk groups and regions across China based on a nationwide molecular epidemiologic survey. PLoS One. 2012;7(10):e47289. doi:10.1371/journal.pone.0047289
  • Zhou PP, Yu G, Kuang YQ, et al. Rapid and complicated HIV genotype expansion among high-risk groups in Guangdong Province, China. BMC Infect Dis. 2019;19(1):185. doi:10.1186/s12879-019-3788-7
  • Lan Y, Li L, He X, et al. Transmitted drug resistance and transmission clusters among HIV-1 treatment-naïve patients in Guangdong, China: a cross-sectional study. Virol J. 2021;18(1):181. doi:10.1186/s12985-021-01653-6
  • Tisdale M, Kemp SD, Parry NR, Larder BA. Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3’-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase. Proc Natl Acad Sci USA. 1993;90(12):5653–5656. doi:10.1073/pnas.90.12.5653
  • Melikian GL, Rhee SY, Varghese V, et al. Non-nucleoside reverse transcriptase inhibitor (NNRTI) cross-resistance: implications for preclinical evaluation of novel NNRTIs and clinical genotypic resistance testing. J Antimicrob Chemother. 2014;69(1):12–20. doi:10.1093/jac/dkt316
  • Rhee SY, Kassaye SG, Barrow G, Sundaramurthi JC, Jordan MR, Shafer RW. HIV-1 transmitted drug resistance surveillance: shifting trends in study design and prevalence estimates. J Int AIDS Soc. 2020;23(9):e25611. doi:10.1002/jia2.25611
  • Panichsillapakit T, Smith DM, Wertheim JO, Richman DD, Little SJ, Mehta SR. Prevalence of transmitted HIV drug resistance among recently infected persons in San Diego, CA 1996–2013. J Acquir Immune Defic Syndr. 2016;71(2):228–236. doi:10.1097/QAI.0000000000000831
  • Rossetti B, Di Giambenedetto S, Torti C, et al. Evolution of transmitted HIV-1 drug resistance and viral subtypes circulation in Italy from 2006 to 2016. HIV Med. 2018;19(9):619–628. doi:10.1111/hiv.12640
  • Liu Y, Zhang Y, Li H, et al. Natural presence of the V179D and K103R/V179D mutations associated with resistance to nonnucleoside reverse transcriptase inhibitors in HIV-1 CRF65_cpx strains. BMC Infect Dis. 2020;20(1):313. doi:10.1186/s12879-020-05007-5
  • Gonzalez-Serna A, Min JE, Woods C, et al. Performance of HIV-1 drug resistance testing at low-level viremia and its ability to predict future virologic outcomes and viral evolution in treatment-naive individuals. Clin Infect Dis. 2014;58(8):1165–1173. doi:10.1093/cid/ciu019
  • Gonzalez-Serna A, Swenson LC, Watson B, et al. A single untimed plasma drug concentration measurement during low-level HIV viremia predicts virologic failure. Clin Microbiol Infect. 2016;22(12):1004.e9–1004.e16. doi:10.1016/j.cmi.2016.08.012
  • Inzaule SC, Bertagnolio S, Kityo CM, et al. The relative contributions of HIV drug resistance, nonadherence and low-level viremia to viremic episodes on antiretroviral therapy in sub-Saharan Africa. AIDS. 2020;34(10):1559–1566. doi:10.1097/QAD.0000000000002588
  • Lan Y, Deng X, Li L, et al. HIV-1 drug resistance and genetic transmission networks among MSM failing antiretroviral therapy in South China 2014–2019. Infect Drug Resist. 2021;14:2977–2989. doi:10.2147/IDR.S317187
  • Cai X, Lan Y, Li J, et al. Analysis on drug resistance in HIV/AIDS patients with HAART through different infection routes in Guangdong. Chin J AIDS. 2015;21(5):369–372. Chinese. doi:10.13419/j.cnki.aids.2015.05.06
  • Yang Z, Wei S, Liu J, et al. Characterization of HIV-1 subtypes and drug resistance mutations in Henan Province, China (2017–2019). Arch Virol. 2020;165(6):1453–1461. doi:10.1007/s00705-020-04606-6
  • Chen J, Liu Y, Liu S, et al. HIV-1 drug resistance, distribution of subtypes, and drug resistance-associated mutations in virologic failure individuals in Chengdu, Southwest China, 2014–2016. Biomed Res Int. 2020;2020:5894124. doi:10.1155/2020/5894124