Genomic Analysis of Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae in a Chinese Tertiary Hospital

References

• Podschun R, Ullmann U. Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors. Clin Microbiol Rev. 1998;11(4):589–603. doi:10.1128/CMR.11.4.589
   PubMed Web of Science ®Google Scholar
• Shon AS, Bajwa RP, Russo TA. Hypervirulent (hypermucoviscous) Klebsiella pneumoniae: a new and dangerous breed. Virulence. 2013;4(2):107–118. doi:10.4161/viru.22718
   PubMed Web of Science ®Google Scholar
• Wang JH, Liu Y-C, Lee SS-J, et al. Primary liver abscess due to Klebsiella pneumoniae in Taiwan. Clin Infect Dis. 1998;26(6):1434–1438. doi:10.1086/516369
   PubMed Web of Science ®Google Scholar
• Xu M, Fu Y, Fang Y, et al. High prevalence of KPC-2-producing hypervirulent Klebsiella pneumoniae causing meningitis in Eastern China. Infect Drug Resist. 2019;12:641–653. doi:10.2147/IDR.S191892
   PubMed Web of Science ®Google Scholar
• Bialek-Davenet S, Criscuolo A, Ailloud F, et al. Genomic definition of hypervirulent and multidrug-resistant Klebsiella pneumoniae Clonal Groups. Emerg Infect Dis. 2014;20(11):1812–1820. doi:10.3201/eid2011.140206
   PubMed Web of Science ®Google Scholar
• Catalan-Najera JC, Garza-Ramos U, Barrios-Camacho H. Hypervirulence and hypermucoviscosity: two different but complementary Klebsiella spp. phenotypes? Virulence. 2017;8(7):1111–1123. doi:10.1080/21505594.2017.1317412
   PubMed Web of Science ®Google Scholar
• Gu D, Dong N, Zheng Z, et al. A fatal outbreak of ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae in a Chinese hospital: a molecular epidemiological study. Lancet Infect Dis. 2018;18(1):37–46. doi:10.1016/S1473-3099(17)30489-9
   PubMed Web of Science ®Google Scholar
• Zhang R, Lin D, Chan EW-C, et al. Emergence of carbapenem-resistant serotype K1 hypervirulent Klebsiella pneumoniae strains in China. Antimicrob Agents Chemother. 2016;60(1):709–711. doi:10.1128/AAC.02173-15
   PubMed Web of Science ®Google Scholar
• Wozniak JE, Band VI, Conley AB, et al. A nationwide screen of carbapenem-resistant Klebsiella pneumoniae reveals an isolate with enhanced virulence and clinically undetected colistin heteroresistance. Antimicrob Agents Chemother. 2019;63(5). doi:10.1128/AAC.00107-19
   Web of Science ®Google Scholar
• Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing, 26th Informational Supplement (M100-S26). Clinical and Laboratory Standards Institute; 2022.
   Google Scholar
• Liu C, Guo J. Characteristics of ventilator-associated pneumonia due to hypervirulent Klebsiella pneumoniae genotype in genetic background for the elderly in two tertiary hospitals in China. Antimicrob Resist Infect Control. 2018;7(1):95. doi:10.1186/s13756-018-0371-8
   PubMedGoogle Scholar
• Zhang Y, Zhao C, Wang Q, et al. High prevalence of hypervirulent Klebsiella pneumoniae infection in china: geographic distribution, clinical characteristics, and antimicrobial resistance. Antimicrob Agents Chemother. 2016;60(10):6115–6120. doi:10.1128/AAC.01127-16
   PubMed Web of Science ®Google Scholar
• Akturk H, Sutcu M, Somer A, et al. Carbapenem-resistant Klebsiella pneumoniae colonization in pediatric and neonatal intensive care units: risk factors for progression to infection. Braz J Infect Dis. 2016;20(2):134–140. doi:10.1016/j.bjid.2015.12.004
   PubMed Web of Science ®Google Scholar
• Borer A, Saidel-Odes L, Eskira S, et al. Risk factors for developing clinical infection with carbapenem-resistant Klebsiella pneumoniae in hospital patients initially only colonized with carbapenem-resistant K pneumoniae. Am J Infect Control. 2012;40(5):421–425. doi:10.1016/j.ajic.2011.05.022
   PubMed Web of Science ®Google Scholar
• Wang Z, Qin -R-R, Huang L, et al. Risk factors for carbapenem-resistant Klebsiella pneumoniae infection and mortality of Klebsiella pneumoniae infection. Chin Med J. 2018;131(1):56–62. doi:10.4103/0366-6999.221267
   PubMed Web of Science ®Google Scholar
• Zhang Y, Guo L-Y, Song W-Q, et al. Risk factors for carbapenem-resistant K. pneumoniae bloodstream infection and predictors of mortality in Chinese paediatric patients. BMC Infect Dis. 2018;18(1):248. doi:10.1186/s12879-018-3160-3
   PubMed Web of Science ®Google Scholar
• Yang Q, Jia X, Zhou M, et al. Emergence of ST11-K47 and ST11-K64 hypervirulent carbapenem-resistant Klebsiella pneumoniae in bacterial liver abscesses from China: a molecular, biological, and epidemiological study. Emerg Microbes Infect. 2020;9(1):320–331. doi:10.1080/22221751.2020.1721334
   PubMed Web of Science ®Google Scholar
• Wu H, Li D, Zhou H, et al. Bacteremia and other body site infection caused by hypervirulent and classic Klebsiella pneumoniae. Microb Pathog. 2017;104:254–262. doi:10.1016/j.micpath.2017.01.049
   PubMed Web of Science ®Google Scholar
• Yang X, Sun Q, Li J, et al. Molecular epidemiology of carbapenem-resistant hypervirulent Klebsiella pneumoniae in China. Emerg Microbes Infect. 2022;11(1):841–849. doi:10.1080/22221751.2022.2049458
   PubMed Web of Science ®Google Scholar
• Cienfuegos-Gallet AV, Zhou Y, Ai W, et al. Multicenter Genomic Analysis of Carbapenem-Resistant Klebsiella pneumoniae from Bacteremia in China. Microbiol Spectr. 2022;10(2):e0229021. doi:10.1128/spectrum.02290-21
   PubMed Web of Science ®Google Scholar
• Vubil D, Figueiredo R, Reis T, et al. Outbreak of KPC-3-producing ST15 and ST348 Klebsiella pneumoniae in a Portuguese hospital. Epidemiol Infect. 2017;145(3):595–599. doi:10.1017/S0950268816002442
   PubMed Web of Science ®Google Scholar
• Han YL, Wen X-H, Zhao W, et al. Epidemiological characteristics and molecular evolution mechanisms of carbapenem-resistant hypervirulent Klebsiella pneumoniae. Front Microbiol. 2022;13:1003783. doi:10.3389/fmicb.2022.1003783
   PubMed Web of Science ®Google Scholar
• Bonomo RA, Burd EM, Conly J, et al. Carbapenemase-producing organisms: a global scourge. Clin Infect Dis. 2018;66(8):1290–1297. doi:10.1093/cid/cix893
   PubMed Web of Science ®Google Scholar
• Lee C-R, Lee JH, Park KS, et al. Antimicrobial resistance of hypervirulent Klebsiella pneumoniae: epidemiology, hypervirulence-associated determinants, and resistance mechanisms. Front Cell Infect Microbiol. 2017;7:483. doi:10.3389/fcimb.2017.00483
   PubMed Web of Science ®Google Scholar
• Teo JQ, Tang CY, Tan SH, et al. Genomic surveillance of carbapenem-resistant Klebsiella pneumoniae from a Major Public Health Hospital in Singapore. Microbiol Spectr. 2022;10(5):e0095722. doi:10.1128/spectrum.00957-22
   PubMedGoogle Scholar
• Du Q, Pan F, Wang C, et al. Nosocomial dissemination of hypervirulent Klebsiella pneumoniae with high-risk clones among children in Shanghai. Front Cell Infect Microbiol. 2022;12:984180. doi:10.3389/fcimb.2022.984180
   PubMed Web of Science ®Google Scholar