321
Views
1
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Synergistic Effects of Gentamicin, Cefepime, and Ciprofloxacin on Biofilm of Pseudomonas aeruginosa

ORCID Icon, , ORCID Icon, , , , , ORCID Icon, ORCID Icon & ORCID Icon show all
Pages 5887-5898 | Received 11 Jul 2023, Accepted 19 Aug 2023, Published online: 06 Sep 2023

References

  • Barbier M, Owings JP, Martínez-Ramos I, et al. Lysine trimethylation of EF-Tu mimics platelet-activating factor to initiate Pseudomonas aeruginosa pneumonia. MBio. 2013;4(3):e00207–13. doi:10.1128/mBio.00207-13
  • Fazzeli H, Akbari R, Moghim S, Narimani T. Pseudomonas aeruginosa infections in patients, hospital means, and personnel’s specimens. Univ Med Sci. 2012;17(7):671–675.
  • Thaden JT, Park LP, Maskarinec SA, Ruffin F, Fowler VG, van Duin D. Results from a 13-year prospective cohort study show increased mortality associated with bloodstream infections caused by Pseudomonas aeruginosa compared to other bacteria. Antimicrob Agents Chemother. 2017;61(6):e02671–16. doi:10.1128/AAC.02671-16
  • Micek ST, Wunderink RG, Kollef MH, et al. An international multicenter retrospective study of Pseudomonas aeruginosa nosocomial pneumonia: impact of multidrug resistance. Critical Care. 2015;19:1–8. doi:10.1186/s13054-015-0926-5
  • Tamma P, Aitken S. Bonomo R IDSA guidance on the treatment of antimicrobial-resistant gram-negative infections: version 1.0. IDSA. 2022.
  • Kadri SS, Adjemian J, Lai YL, et al. Difficult-to-treat resistance in gram-negative bacteremia at 173 US hospitals: retrospective cohort analysis of prevalence, predictors, and outcome of resistance to all first-line agents. Clin Infect Dis. 2018;67(12):1803. doi:10.1093/cid/ciy378
  • Al Salman J, Al Dabal L, Bassetti M, et al. Management of infections caused by WHO critical priority Gram-negative pathogens in Arab countries of the Middle East: a consensus paper. Int J Antimicrob Agents. 2020;56(4):106104. doi:10.1016/j.ijantimicag.2020.106104
  • Rhodes A, Evans LE, Alhazzani W, et al. Sobrevivir Sepsis Campaign: directrices internacionales para el manejo de la sepsis y el shock séptico: 2016. Intensive Care Med. 2017;43(3):304–377. doi:10.1007/s00134-017-4683-6
  • Bassetti M, Vena A, Croxatto A, Righi E, Guery B. How to manage Pseudomonas aeruginosa infections. Drugs in Context. 2018;7:1–18. doi:10.7573/dic.212527
  • Bassetti M, Vena A, Russo A, Croxatto A, Calandra T, Guery B. Rational approach in the management of Pseudomonas aeruginosa infections. Curr Opin Infect Dis. 2018;31(6):578–586. doi:10.1097/QCO.0000000000000505
  • Zakhour J, Sharara SL, Hindy J-R, Haddad SF, Kanj SS. Antimicrobial Treatment of Pseudomonas aeruginosa Severe Sepsis. Antibiotics. 2022;11(10):1432. doi:10.3390/antibiotics11101432
  • Burgess DS, Nathisuwan S. Cefepime, piperacillin/tazobactam, gentamicin, ciprofloxacin, and levofloxacin alone and in combination against Pseudomonas aeruginosa. Diagn Microbiol Infect Dis. 2002;44(1):35–41. doi:10.1016/S0732-8893(02)00420-0
  • Macia M, Rojo-Molinero E, Oliver A. Antimicrobial susceptibility testing in biofilm-growing bacteria. Clin Microbiol Infection. 2014;20(10):981–990. doi:10.1111/1469-0691.12651
  • Noreen A, Masood H, Zaib J, et al. Investigating the Role of Antibiotics on Induction, Inhibition and Eradication of Biofilms of Poultry Associated Escherichia coli Isolated from Retail Chicken Meat. Antibiotics. 2022;11(11):1663. doi:10.3390/antibiotics11111663
  • Nucleo E, Steffanoni L, Fugazza G, et al. Growth in glucose-based medium and exposure to subinhibitory concentrations of imipenem induce biofilm formation in a multidrug-resistant clinical isolate of Acinetobacter baumannii. BMC Microbiol. 2009;9(1):1–14. doi:10.1186/1471-2180-9-270
  • Clinical and Laboratory Standard Institute (CLSI). M100 Performance Standards for Antimicrobial Susceptibility Testing 30th ed.; An Informational Supplement; CLSI: Wayne, PA, USA; 2020. Available from: https://www.nih.org.pk/wp-content/uploads/2021/02/CLSI-2020.pdf. Accessed August 27, 2023.
  • Jarlier V, Nicolas M-H, Fournier G, Philippon A. Extended broad-spectrum β-lactamases conferring transferable resistance to newer β-lactam agents in Enterobacteriaceae: hospital prevalence and susceptibility patterns. Clin Infect Dis. 1988;10(4):867–878. doi:10.1093/clinids/10.4.867
  • Anderson K, Lonsway D, Rasheed J, et al. Evaluation of Methods to Identify the Klebsiella pneumoniae in. J Clin Microbiol. 2007;45(8):2723–2725. doi:10.1128/JCM.00015-07
  • Ali I, Rafaque Z, Ahmed I, et al. Phylogeny, sequence-typing and virulence profile of uropathogenic Escherichia coli (UPEC) strains from Pakistan. BMC Infect Dis. 2019;19(1):1–9. doi:10.1186/s12879-019-4258-y
  • Rafaque Z, Abid N, Liaqat N, et al. In-vitro investigation of antibiotics efficacy against uropathogenic Escherichia coli biofilms and antibiotic induced biofilm formation at sub-minimum inhibitory concentration of ciprofloxacin. Infect Drug Resist;2020. 2801–2810. doi:10.2147/IDR.S258355
  • Drago L, De Vecchi E, Nicola L, Colombo A, Guerra A, Gismondo MR. Activity of levofloxacin and ciprofloxacin in combination with cefepime, ceftazidime, imipenem, piperacillin-tazobactam and amikacin against different Pseudomonas aeruginosa phenotypes and Acinetobacter spp. Chemotherapy. 2004;50(4):202–210. doi:10.1159/000081033
  • Thiyagarajan D, Das G, Ramesh A. Amphiphilic Cargo‐Loaded Nanocarrier Enhances Antibiotic Uptake and Perturbs Efflux: effective Synergy for Mitigation of Methicillin‐Resistant Staphylococcus aureus. ChemMedChem. 2017;12(14):1125–1132. doi:10.1002/cmdc.201700260
  • Wang L, Di Luca M, Tkhilaishvili T, Trampuz A, Gonzalez Moreno M. Synergistic activity of fosfomycin, ciprofloxacin, and gentamicin against Escherichia coli and Pseudomonas aeruginosa biofilms. Front Microbiol. 2019;10:2522. doi:10.3389/fmicb.2019.02522
  • Dosler S, Karaaslan E, Alev Gerceker A. Antibacterial and anti-biofilm activities of melittin and colistin, alone and in combination with antibiotics against Gram-negative bacteria. J Chemother. 2016;28(2):95–103. doi:10.1179/1973947815Y.0000000004
  • Almaaytah A, Abualhaijaa A, Alqudah O. The evaluation of the synergistic antimicrobial and antibiofilm activity of AamAP1-Lysine with conventional antibiotics against representative resistant strains of both Gram-positive and Gram-negative bacteria. Infect Drug Resist. 2019;1371–1380. doi:10.2147/IDR.S204626
  • Ghorbani H, Memar MY, Sefidan FY, Yekani M, Ghotaslou R. In vitro synergy of antibiotic combinations against planktonic and biofilm Pseudomonas aeruginosa. GMS Hygiene Infection Control. 2017;12. doi:10.3205/dgkh000302
  • Gupta P, Chhibber S, Harjai K. Subinhibitory concentration of ciprofloxacin targets quorum sensing system of Pseudomonas aeruginosa causing inhibition of biofilm formation & reduction of virulence. Indian J Med Res. 2016;143(5):643. doi:10.4103/0971-5916.187114
  • Ellappan K, Narasimha HB, Kumar S. Coexistence of multidrug resistance mechanisms and virulence genes in carbapenem-resistant Pseudomonas aeruginosa strains from a tertiary care hospital in South India. J Global Antimicrobial Resistance. 2018;12:37–43. doi:10.1016/j.jgar.2017.08.018
  • Ullah W, Qasim M, Rahman H, et al. Multi drug resistant Pseudomonas aeruginosa: pathogen burden and associated antibiogram in a tertiary care hospital of Pakistan. Microb Pathog. 2016;97:209–212. doi:10.1016/j.micpath.2016.06.017
  • Gimeno C, Cantón R, García A, Gobernado M. Comparative activity of doripenem, meropenem, and imipenem in recent clinical isolates obtained during the COMPACT-Spain epidemiological surveillance study. Revista Espanola de Quimioterapia. 2010;23(3):144–152.
  • Shenkutie AM, Zhang J, Yao M, Asrat D, Chow FW, Leung PH. Effects of sub-minimum inhibitory concentrations of imipenem and colistin on expression of biofilm-specific antibiotic resistance and virulence genes in Acinetobacter baumannii sequence type 1894. Int J Mol Sci. 2022;23(20):12705. doi:10.3390/ijms232012705
  • Paul M, Carrara E, Retamar P, et al. European Society of Clinical Microbiology and Infectious Diseases (ESCMID) guidelines for the treatment of infections caused by multidrug-resistant Gram-negative bacilli (endorsed by European society of intensive care medicine). Clin Microbiol Infection. 2022;28(4):521–547. doi:10.1016/j.cmi.2021.11.025
  • Anderl JN, Franklin MJ, Stewart PS. Role of antibiotic penetration limitation in Klebsiella pneumoniae biofilm resistance to ampicillin and ciprofloxacin. Antimicrob Agents Chemother. 2000;44(7):1818–1824. doi:10.1128/AAC.44.7.1818-1824.2000
  • Vrany JD, Stewart PS, Suci PA. Comparison of recalcitrance to ciprofloxacin and levofloxacin exhibited by Pseudomonas aeruginosa biofilms displaying rapid-transport characteristics. Antimicrob Agents Chemother. 1997;41(6):1352–1358. doi:10.1128/AAC.41.6.1352