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Infection and Drug Resistance Volume 16, 2023 - Issue
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ORIGINAL RESEARCH

Clinical Manifestations and Risk Factors of Tigecycline-Associated Thrombocytopenia

Yuanchao ZhuDepartment of Pharmacy, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Key Laboratory of Assessment of Clinical Drugs Risk and Individual Application (Beijing Hospital), Beijing, 100730, People’s Republic of ChinaView further author information
,
Fei ZhaoDepartment of Pharmacy, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Key Laboratory of Assessment of Clinical Drugs Risk and Individual Application (Beijing Hospital), Beijing, 100730, People’s Republic of ChinaView further author information
&
Pengfei JinDepartment of Pharmacy, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Key Laboratory of Assessment of Clinical Drugs Risk and Individual Application (Beijing Hospital), Beijing, 100730, People’s Republic of ChinaCorrespondence[email protected]
View further author information
Pages 6225-6235 | Received 16 Jun 2023, Accepted 31 Aug 2023, Published online: 15 Sep 2023

References

  • Mckeage K, Keating GM. Tigecycline. Drugs. 2008;68(18):2633–2644. doi:10.2165/0003495-200868180-00008
  • Giamarellou H, Poulakou G. Pharmacokinetic and pharmacodynamics evaluation of tigecycline. Expert Opin Drug Metab Toxicol. 2011;7(11):1459–1470. doi:10.1517/17425255.2011.623126
  • Kasbekar N. Tigecycline: a critical safety review. Expert Opin Drug Saf. 2015;14(2):335–342. doi:10.2146/ajhp050487
  • Peterson LR. A review of tigecycline--the first glycylcycline. Int J Antimicrob Agents. 2008;32(Suppl 4):S215–22. doi:10.1016/S0924-8579(09)70005-6
  • Giryes S, Azzam ZS, Reem IB, Norberto K, Gidon B. Severe Coagulation Disorder and Thrombocytopenia Associated with Tigecycline - Case Report and Review of Literature. Curr Drug Saf. 2017;12(1):7–9. doi:10.2174/1574886311666160920090714
  • Guo M, Liang J, Li D. Coagulation dysfunction events associated with tigecycline: a real-world study from FDA adverse event reporting system (FAERS) database. Thromb J. 2022;20(1):12.
  • NIH. Common Terminology Criteria for Adverse Events.CTCAE. v6.0; 2020. Available from: https://ctep.cancer.gov/protocolDevelopment/electronic_applications/ctc.htm. Accessed December 19, 2022.
  • Kam T, Alexander M. Drug-induced immune thrombocytopenia. Drug Saf. 2004;27(15):1243–1252. doi:10.2165/00002018-200427150-00007
  • Mitta A, Curtis BR, Reese JA, George JN. Drug-induced thrombocytopenia: 2019 Update of clinical and laboratory data. Am J Hematol. 2019;94(3):E76–E78. doi:10.1002/ajh.25379
  • Aster RH, Bougie DW. Drug-induced immune thrombocytopenia. N Engl J Med. 2007;357:580–587. doi:10.1177/0897190014546099
  • Loo AS, Gerzenshtein L, Ison MG. Antimicrobial drug-induced thrombocytopenia: a review of the literature. Semin Thromb Hemost. 2012;38(8):818–829. doi:10.1055/s-0032-1328882
  • FDA Label. TYGACIL; 2020. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/021821s049lbl.pdf. Accessed December 19, 2022.
  • Josefsdottir KS, Baldridge MT, Kadmon CS, King KY. Antibiotics impair murine hematopoiesis by depleting the intestinal microbiota. Blood. 2017;129(6):729–739. doi:10.1182/blood-2016-03-708594
  • Lassandro G, Palladino V, Palmieri VV, Amoruso A, Del Vecchio GC, Giordano P. Covid-19 and Children with Immune Thrombocytopenia: emerging Issues. Mediterr J Hematol Infect Dis. 2020;12(1):e2020028. doi:10.4084/MJHID.2020.028
  • Babinchak T, Ellis-Grosse E, Dartois N, Gilbert MR, Evan L; Tigecycline 301 Study Group, Tigecycline 306 Study Group. The efficacy and safety of tigecycline for the treatment of complicated intra-abdominal infections: analysis of pooled clinical trial data. Clin Infect Dis. 2005;41(Suppl 5):S354–67. doi:10.1086/431676
  • Hanai Y, Matsuo K, Ogawa M, et al. A retrospective study of the risk factors for linezolid-induced thrombocytopenia and anemia. J Infect Chemother. 2016;22(8):536–542. doi:10.1016/j.jiac.2016.05.003
  • Hu J, Xiao YH, Zheng Y, Lai YX, Fang XL, Fang Q. Clinical characteristics and risk factors of tigecycline-associated hypofibrinogenaemia in critically ill patients. Eur J Clin Pharmacol. 2020;76(7):913–922. doi:10.1007/s00228-020-02860-w
  • Hoffmann M, DeMaio W, Jordan RA, et al. Metabolism, excretion, and pharmacokinetics of [14C] tigecycline, a firstin-class glycylcycline antibiotic after intravenous infusion to healthy male subjects. Drug Metab Dispos. 2007;35:1543–1553. doi:10.1124/dmd.107.015735
  • Yaghoubi S, Zekiy AO, Krutova M, et al. Tigecycline antibacterial activity, clinical effectiveness, and mechanisms and epidemiology of resistance: narrative review. Eur J Clin Microbiol Infect Dis. 2022;41(7):1003–1022. doi:10.1007/s10096-020-04121-1
  • Beier K, Eppanapally S, Bazick HS, et al. Elevation of blood urea nitrogen is predictive of long-term mortality in critically ill patients independent of normal creatinine. Crit Care Med. 2011;39:305–313. doi:10.1097/CCM.0b013e3181ffe22a
  • Ballmer PE, McNurlan MA, Hulter HN, Anderson SE, Garlick PJ, Krapf R. Chronic metabolic acidosis decreases albumin synthesis and induces negative nitrogen balance in humans. J Clin Investigation. 1995;95:39–45. doi:10.1172/JCI117668
  • Chen WJ, Oashi E, Kasai M. Amino acid metabolism in parenteral nutrition: with special reference to the calorie: nitrogen ratio and the blood urea nitrogen level. Metabolism. 1974;23(12):1117–1123. doi:10.1016/0026-0495(74)90028-6
  • Farruggia P, Fioredda F, Puccio G, et al. Idiopathic neutropenia of infancy: data from the Italian Neutropenia Registry. Am J Hematol. 2019;94(2):216–222. doi:10.1002/ajh.25353
  • Von Drygalski A, Curtis BR, Bougie DW, et al. Vancomycin-induced immune thrombocytopenia. N Engl J Med. 2007;356:904–910. doi:10.1056/NEJMoa065066

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