Advanced search
Publication Cover
Infection and Drug Resistance Volume 17, 2024 - Issue
Submit an article Journal homepage
99
Views
0
CrossRef citations to date
0
Altmetric
SHORT REPORT

Peripheral Blood CD8+T Cell as a Prognostic Biomarker for Hospitalised COVID-19 Patients Without Antiviral Treatment

Yuming Sun1 Department of Plastic and Cosmetic Surgery, Xiangya Hospital, Central South University, Changsha, People’s Republic of China;2 National Engineering Research Centre of Personalized Diagnostic and Therapeutic Technology, Xiangya Hospital, Central South University, Changsha, People’s Republic of China;3 Furong Laboratory, Central South University, Changsha, People’s Republic of China;4 Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Centre of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, People’s Republic of China;5 National Clinical Research Centre for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, People’s Republic of China;6 Department of Dermatology, Xiangya Hospital, Central South University, Changsha, People’s Republic of ChinaView further author information
,
Peilin Liu7 Clinical Laboratory Department, Xiangya Hospital, Central South University, Changsha, People’s Republic of ChinaView further author information
,
Lifang Zhang8 Department of Plastic and Cosmetic Surgery, Changsha Mylike Cosmetic Hospital, Changsha, People’s Republic of ChinaView further author information
,
Shaorong Lei1 Department of Plastic and Cosmetic Surgery, Xiangya Hospital, Central South University, Changsha, People’s Republic of ChinaView further author information
&
Qian Gao7 Clinical Laboratory Department, Xiangya Hospital, Central South University, Changsha, People’s Republic of ChinaCorrespondence[email protected] [email protected]
View further author information
Pages 109-117 | Received 07 Sep 2023, Accepted 14 Dec 2023, Published online: 11 Jan 2024

References

  • Dong E, Ratcliff J, Goyea TDCOVID-19 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU). Johns Hopkins University; 2021.
  • Hirotsu Y, Maejima M, Shibusawa M, et al. Classification of omicron BA.1, BA.1.1, and BA.2 sublineages by TaqMan assay consistent with whole genome analysis data. Int J Infect Dis. 2022;122:486–491. doi:10.1016/j.ijid.2022.06.039
  • Cheung AT, Ho LLK, Li WHC, Chung JOK, Smith GD. Psychological distress experienced by nurses amid the fifth wave of the COVID-19 pandemic in Hong Kong: a qualitative study. Front Public Health. 2022;10:1023302. doi:10.3389/fpubh.2022.1023302
  • Mefsin YM, Chen D, Bond HS, et al. Epidemiology of infections with SARS-CoV-2 omicron BA.2 variant, Hong Kong, January-March 2022. Emerg Infect Dis. 2022;28(9):1856–1858. doi:10.3201/eid2809.220613
  • Xu B, Fan CY, Wang AL, et al. Suppressed T cell-mediated immunity in patients with COVID-19: a clinical retrospective study in Wuhan, China. J Infect. 2020;81(1):e51–e60. doi:10.1016/j.jinf.2020.04.012
  • Sette A, Crotty S. Adaptive immunity to SARS-CoV-2 and COVID-19. Cell. 2021;184(4):861–880. doi:10.1016/j.cell.2021.01.007
  • Rha MS, Shin EC. Activation or exhaustion of CD8(+) T cells in patients with COVID-19. Cell Mol Immunol. 2021;18(10):2325–2333. doi:10.1038/s41423-021-00750-4
  • Lamontagne F, Stegemann M, Agarwal A, et al. A living WHO guideline on drugs to prevent covid-19. BMJ. 2021;372:n526. doi:10.1136/bmj.n526
  • Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ. 2009;339:b2700.
  • Cantenys-Molina S, Fernandez-Cruz E, Francos P, Lopez Bernaldo D, Quiros JC, Munoz P. Lymphocyte subsets early predict mortality in a large series of hospitalized COVID-19 patients in Spain. Clin Exp Immunol. 2021;203(3):424–432. doi:10.1111/cei.13547
  • Ye H, Liu ZM, Zhou L, et al. Levels of peripheral IL-6 and CD4+ and CD8+ T cells and their prognostic significance in COVID-19. Eur Rev Med Pharmacol Sci. 2023;27(6):2686–2691. doi:10.26355/eurrev_202303_31806
  • Du RH, Liang LR, Yang CQ, et al. Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study. Eur Respir J. 2020;55(5):2000524. doi:10.1183/13993003.00524-2020
  • Wen XS, Jiang D, Gao L, et al. Clinical characteristics and predictive value of lower CD4(+)T cell level in patients with moderate and severe COVID-19: a multicenter retrospective study. BMC Infect Dis. 2021;21(1):57. doi:10.1186/s12879-020-05741-w
  • Luo M, Liu J, Jiang W, Yue S, Liu H, Wei S. IL-6 and CD8+ T cell counts combined are an early predictor of in-hospital mortality of patients with COVID-19. JCI Insight. 2020;5(13). doi:10.1172/jci.insight.139024
  • Li Z, Chen G, Cai Z, et al. Genomic and transcriptional profiling of tumor infiltrated CD8(+) CD8 +T cells revealed functional heterogeneity of antitumor immunity in hepatocellular carcinoma. Oncoimmunology. 2019;8(2):e1538436. doi:10.1080/2162402X.2018.1538436
  • An N, Wang H, Jia W, et al. The prognostic role of circulating CD8(+) T cell proliferation in patients with untreated extensive stage small cell lung cancer. J Transl Med. 2019;17(1):402. doi:10.1186/s12967-019-02160-7
  • Jiao X, Cao X, Zou J, Ji J, Ding X, Yu X. The proportion of memory cd8+ t cell predicts infection event in patients with peritoneal dialysis. Kidney Blood Press Res. 2022;47(11):674–682. doi:10.1159/000526207
  • Cui N, Wang H, Long Y, Liu D. CD8(+) T-cell counts: an early predictor of risk and mortality in critically ill immunocompromised patients with invasive pulmonary aspergillosis. Crit Care. 2013;17(4):R157. doi:10.1186/cc12836
  • Mirsharif ES, Chenary MR, Bozorgmehr M, et al. Immunophenotyping characteristics of COVID-19 patients: peripheral blood CD8+ HLA-DR+ T cells as a biomarker for mortality outcome. J Med Virol. 2023;95(1):e28192. doi:10.1002/jmv.28192
  • Tan M, Liu Y, Zhou R, et al. Immunopathological characteristics of coronavirus disease 2019 cases in Guangzhou, China. Immunology. 2020;160(3):261–268. doi:10.1111/imm.13223
  • Santos-Zas I, Lemarie J, Zlatanova I, et al. Cytotoxic CD8(+) T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling. Nat Commun. 2021;12(1):1483. doi:10.1038/s41467-021-21737-9
  • Li M, Guo W, Dong Y, et al. Elevated exhaustion levels of NK and CD8(+) T cells as indicators for progression and prognosis of COVID-19 disease. Front Immunol. 2020;11:580237. doi:10.3389/fimmu.2020.580237
  • Reina-Campos M, Scharping NE, Goldrath AW. CD8(+) T cell metabolism in infection and cancer. Nat Rev Immunol. 2021;21(11):718–738. doi:10.1038/s41577-021-00537-8

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.