Characterisation of a Novel Hybrid IncFII_pHN7A8:IncR:IncN Plasmid Co-Harboring bla_NDM-5 and bla_KPC-2 from a Clinical ST11 Carbapenem-Resistant Klebsiella pneumoniae Strain

References

• Ben-David D, Kordevani R, Keller N, et al. Outcome of carbapenem resistant Klebsiella pneumoniae bloodstream infections. Clin Microbiol Infect. 2012;18(1):54–60. doi:10.1111/j.1469-0691.2011.03478.x
   PubMed Web of Science ®Google Scholar
• Tamma PD, Goodman KE, Harris AD, et al. Comparing the outcomes of patients with carbapenemase-producing and non-carbapenemase-producing carbapenem-resistant Enterobacteriaceae bacteremia. Clin Infect Dis. 2017;64(3):257–264. doi:10.1093/cid/ciw741
   PubMed Web of Science ®Google Scholar
• Yahav D, Giske CG, Gramatniece A, Abodakpi H, Tam VH, Leibovici L. New beta-lactam-beta-lactamase inhibitor combinations. Clin Microbiol Rev. 2020;34(1). doi:10.1128/CMR.00115-20
   PubMed Web of Science ®Google Scholar
• Wang Q, Wang X, Wang J, et al. Phenotypic and genotypic characterization of carbapenem-resistant Enterobacteriaceae: data from a longitudinal large-scale CRE Study in China (2012–2016). Clin Infect Dis. 2018;67(suppl_2):S196–S205. doi:10.1093/cid/ciy660
   PubMed Web of Science ®Google Scholar
• Han R, Shi Q, Wu S, et al. Dissemination of carbapenemases (KPC, NDM, OXA-48, IMP, and VIM) among carbapenem-resistant Enterobacteriaceae isolated from adult and children patients in China. Front Cell Infect Mi. 2020;10:314. doi:10.3389/fcimb.2020.00314
   PubMed Web of Science ®Google Scholar
• Wu W, Feng Y, Tang G, Qiao F, McNally A, Zong Z. NDM metallo-beta-lactamases and their bacterial producers in health care settings. Clin Microbiol Rev. 2019;32(2). doi:10.1128/CMR.00115-18
   PubMed Web of Science ®Google Scholar
• Vasquez-Ponce F, Dantas K, Becerra J, et al. Detecting KPC-2 and NDM-1 coexpression in Klebsiella pneumoniae complex from human and animal hosts in South America. Microbiol Spectr. 2022;10(5):e115922. doi:10.1128/spectrum.01159-22
   Google Scholar
• Tekeli A, Dolapci I, Evren E, Oguzman E, Karahan ZC. Characterization of Klebsiella pneumoniae coproducing KPC and NDM-1 Carbapenemases from Turkey. Microb Drug Resist. 2020;26(2):118–125. doi:10.1089/mdr.2019.0086
   PubMed Web of Science ®Google Scholar
• Hu R, Li Q, Zhang F, Ding M, Liu J, Zhou Y. Characterisation of bla (NDM-5) and bla (KPC-2) co-occurrence in K64-ST11 carbapenem-resistant Klebsiella pneumoniae. J Glob Antimicrob Resist. 2021;27:63–66. doi:10.1016/j.jgar.2021.08.009
   PubMed Web of Science ®Google Scholar
• Tang M, Li J, Liu Z, et al. Clonal transmission of polymyxin B-resistant hypervirulent Klebsiella pneumoniae isolates coharboring bla (NDM-1) and bla (KPC-2) in a tertiary hospital in China. BMC Microbiol. 2023;23(1):64. doi:10.1186/s12866-023-02808-x
   PubMed Web of Science ®Google Scholar
• Hao J, Zhang B, Deng J, Wei Y, Xiao X, Liu J. Emergence of a hypervirulent tigecycline-resistant Klebsiella pneumoniae strain co-producing bla (NDM-1) and bla (KPC-2) with an uncommon sequence type ST464 in Southwestern China. Front Microbiol. 2022;13:868705. doi:10.3389/fmicb.2022.868705
   PubMed Web of Science ®Google Scholar
• Ahmed M, Yang Y, Yang Y, et al. Emergence of hypervirulent carbapenem-resistant Klebsiella pneumoniae coharboring a bla (NDM-1)-carrying virulent plasmid and a bla (KPC-2)-carrying plasmid in an Egyptian hospital. Msphere. 2021;6(3). doi:10.1128/mSphere.00088-21
   PubMed Web of Science ®Google Scholar
• Fu L, Wang S, Zhang Z, et al. Co-carrying of KPC-2, NDM-5, CTX-M-3 and CTX-M-65 in three plasmids with serotype O89: H10 Escherichia coli strain belonging to the ST2 clone in China. Microb Pathogenesis. 2019;128:1–6. doi:10.1016/j.micpath.2018.12.033
   PubMed Web of Science ®Google Scholar
• Li Y, Fang C, Qiu Y, Dai X, Zhang L. Genomic characterization of a carbapenem-resistant Citrobacter freundii cocarrying bla (KPC-2) and bla (NDM-1). J Glob Antimicrob Resist. 2022;29:289–292. doi:10.1016/j.jgar.2022.04.014
   PubMed Web of Science ®Google Scholar
• Bes T, Nagano D, Martins R, et al. Bloodstream infections caused by Klebsiella pneumoniae and Serratia marcescens isolates co-harboring NDM-1 and KPC-2. Ann Clin Microbiol Antimicrob. 2021;20(1):57. doi:10.1186/s12941-021-00464-5
   PubMed Web of Science ®Google Scholar
• Gao H, Liu Y, Wang R, Wang Q, Jin L, Wang H. The transferability and evolution of NDM-1 and KPC-2 co-producing Klebsiella pneumoniae from clinical settings. Ebiomedicine. 2020;51:102599. doi:10.1016/j.ebiom.2019.102599
   PubMed Web of Science ®Google Scholar
• Zhang F, Li Z, Liu X, et al. Carbapenem-resistant Citrobacter freundii harboring bla (KPC-2) and bla (NDM-1): a study on their transferability and potential dissemination via generating a transferrable hybrid plasmid mediated by IS6100. Front Microbiol. 2023;14:1239538. doi:10.3389/fmicb.2023.1239538
   PubMed Web of Science ®Google Scholar
• Luo X, Dong F, Dai P, et al. Coexistence of blaKPC-2 and blaNDM-1 in one IncHI5 plasmid confers transferable carbapenem resistance from a clinical isolate of Klebsiella michiganensis in China. J Glob Antimicrob Resist. 2023;35:104–109. doi:10.1016/j.jgar.2023.09.006
   PubMed Web of Science ®Google Scholar
• Quan J, Dai H, Liao W, et al. Etiology and prevalence of ESBLs in adult community-onset urinary tract infections in East China: a prospective multicenter study. J Infection. 2021;83(2):175–181. doi:10.1016/j.jinf.2021.06.004
   PubMed Web of Science ®Google Scholar
• Wick RR, Judd LM, Gorrie CL, Holt KE, Phillippy AM. Unicycler: resolving bacterial genome assemblies from short and long sequencing reads. PLOS Comput Biol. 2017;13(6):e1005595. doi:10.1371/journal.pcbi.1005595
   PubMed Web of Science ®Google Scholar
• Aziz RK, Bartels D, Best AA, et al. The RAST server: rapid annotations using subsystems technology. BMC Genomics. 2008;9(1):75. doi:10.1186/1471-2164-9-75
   PubMed Web of Science ®Google Scholar
• Siguier P, Perochon J, Lestrade L, Mahillon J, Chandler M. ISfinder: the reference centre for bacterial insertion sequences. Nucleic Acids Res. 2006;34(Database issue):D32–D36. doi:10.1093/nar/gkj014
   PubMed Web of Science ®Google Scholar
• Li X, Xie Y, Liu M, et al. oriTfinder: a web-based tool for the identification of origin of transfers in DNA sequences of bacterial mobile genetic elements. Nucleic Acids Res. 2018;46(W1):W229–W234. doi:10.1093/nar/gky352
   PubMed Web of Science ®Google Scholar
• Sullivan MJ, Petty NK, Beatson SA. Easyfig: a genome comparison visualizer. Bioinformatics. 2011;27(7):1009–1010. doi:10.1093/bioinformatics/btr039
   PubMed Web of Science ®Google Scholar
• Chen YT, Chang HY, Lai YC, Pan CC, Tsai SF, Peng HL. Sequencing and analysis of the large virulence plasmid pLVPK of Klebsiella pneumoniae CG43. Gene. 2004;337:189–198. doi:10.1016/j.gene.2004.05.008
   PubMed Web of Science ®Google Scholar
• Yang X, Dong N, Chan EW, Zhang R, Chen S. Carbapenem resistance-encoding and virulence-encoding conjugative plasmids in Klebsiella pneumoniae. Trends Microbiol. 2021;29(1):65–83. doi:10.1016/j.tim.2020.04.012
   PubMed Web of Science ®Google Scholar
• Xiao W, Wang X, Qu Y, et al. Identification of two novel carbapenemase-encoding hybrid plasmids harboring bla (NDM-5) and bla (KPC-2) in a clinical ST11-KL47 Klebsiella pneumoniae. Infect Drug Resist. 2023;16:4073–4081. doi:10.2147/IDR.S408824
   PubMedGoogle Scholar
• Cerdeira LT, Lam M, Wyres KL, et al. Small IncQ1 and col-like plasmids harboring bla (KPC-2) and non-Tn4401 elements (NTE (KPC)-IId) in high-risk lineages of Klebsiella pneumoniae CG258. Antimicrob Agents Chemother. 2019;63(3). doi:10.1128/AAC.02140-18
   Web of Science ®Google Scholar
• Octavia S, Kalisvar M, Venkatachalam I, et al. Klebsiella pneumoniae and Klebsiella quasipneumoniae define the population structure of blaKPC-2Klebsiella: a 5 year retrospective genomic study in Singapore. J Antimicrob Chemoth. 2019;74(11):3205–3210. doi:10.1093/jac/dkz332
   PubMed Web of Science ®Google Scholar
• Chen L, Mathema B, Chavda KD, DeLeo FR, Bonomo RA, Kreiswirth BN. Carbapenemase-producing Klebsiella pneumoniae: molecular and genetic decoding. Trends Microbiol. 2014;22(12):686–696. doi:10.1016/j.tim.2014.09.003
   PubMed Web of Science ®Google Scholar
• de la Cruz F, Frost LS, Meyer RJ, Zechner EL. Conjugative DNA metabolism in gram-negative bacteria. Fems Microbiol Rev. 2010;34(1):18–40. doi:10.1111/j.1574-6976.2009.00195.x
   PubMed Web of Science ®Google Scholar
• Fu P, Tang Y, Li G, Yu L, Wang Y, Jiang X. Pandemic spread of bla((KPC-2)) among Klebsiella pneumoniae ST11 in China is associated with horizontal transfer mediated by IncFII-like plasmids. Int J Antimicrob Ag. 2019;54(2):117–124. doi:10.1016/j.ijantimicag.2019.03.014
   PubMed Web of Science ®Google Scholar
• Hornsey M, Phee L, Wareham DW. A novel variant, NDM-5, of the New Delhi metallo-β-lactamase in a multidrug-resistant Escherichia coli ST648 isolate recovered from a patient in the United Kingdom. Antimicrob Agents Chemother. 2011;55(12):5952–5954. doi:10.1128/AAC.05108-11
   PubMed Web of Science ®Google Scholar
• He S, Hickman AB, Varani AM, et al. Insertion sequence IS26 reorganizes plasmids in clinically isolated multidrug-resistant bacteria by replicative transposition. Mbio. 2015;6(3):e762. doi:10.1128/mBio.00762-15
   PubMed Web of Science ®Google Scholar
• Zhao QY, Zhu JH, Cai RM, et al. IS26 is responsible for the evolution and transmission of bla (NDM)-harboring plasmids in Escherichia coli of Poultry Origin in China. Msystems. 2021;6(4):e64621. doi:10.1128/mSystems.00646-21
   Web of Science ®Google Scholar
• Hudson CM, Bent ZW, Meagher RJ, Williams KP, Hall R. Resistance determinants and mobile genetic elements of an NDM-1-encoding Klebsiella pneumoniae strain. PLoS One. 2014;9(6):e99209. doi:10.1371/journal.pone.0099209
   PubMed Web of Science ®Google Scholar
• Koraimann G, Wagner MA. Social behavior and decision making in bacterial conjugation. Front Cell Infect Mi. 2014;4:54. doi:10.3389/fcimb.2014.00054
   PubMed Web of Science ®Google Scholar
• Boralli C, Paganini JA, Meneses RS, et al. Characterization of bla (KPC-2) and bla (NDM-1) plasmids of a K. pneumoniae ST11 outbreak clone. Antibiotics-Basel. 2023;12(5). doi:10.3390/antibiotics12050926
   PubMed Web of Science ®Google Scholar