Plasma thrombomodulin as a candidate biomarker for the diagnosis and prognosis of HBV-related acute-on-chronic liver failure

References

• Ma S, Xie Z, Zhang L, et al. Identification of a potential miRNA-mRNA regulatory network associated with the prognosis of HBV-ACLF. Front Mol Biosci. 2021;8:657631. doi:10.3389/fmolb.2021.657631
   PubMed Web of Science ®Google Scholar
• Weiss E, Saner F, Asrani SK, et al. When is a critically ill cirrhotic patient too sick to transplant? Development of consensus criteria by a multidisciplinary panel of 35 international experts. Transplantation. 2021;105(3):561–568. doi:10.1097/TP.0000000000003364
   PubMed Web of Science ®Google Scholar
• Wu T, Li J, Shao L, et al. Development of diagnostic criteria and a prognostic score for hepatitis B virus-related acute-on-chronic liver failure. Gut. 2018;67(12):2181–2191. doi:10.1136/gutjnl-2017-314641
   PubMed Web of Science ®Google Scholar
• Luo J, Liang X, Xin J, et al. Predicting the onset of hepatitis B virus-related acute-on-chronic liver failure. Clin Gastroenterol Hepatol. 2022;2022:1 doi:10.1016/j.cgh.2022.03.016
   Google Scholar
• Ke B. Thrombomodulin, a Novel Immune Regulator in Liver Inflammatory Injury? Am J Transplant. 2017;17(1):7–8. doi:10.1111/ajt.14030
   PubMed Web of Science ®Google Scholar
• Boehme MW, Galle P, Stremmel W. Kinetics of thrombomodulin release and endothelial cell injury by neutrophil-derived proteases and oxygen radicals. Immunology. 2002;107(3):340–349. doi:10.1046/j.1365-2567.2002.01469.x
   PubMed Web of Science ®Google Scholar
• Budzyń M, Iskra M, Turkiewicz W, Krasiński Z, Gryszczyńska B, Kasprzak MP. Plasma concentration of selected biochemical markers of endothelial dysfunction in women with various severity of chronic venous insufficiency (CVI)-A pilot study. PLoS One. 2018;13(1):e0191902. doi:10.1371/journal.pone.0191902
   PubMed Web of Science ®Google Scholar
• Alemán-Valls MR, González-Reimers E, Santolaria-Fernández F, Rodríguez-Martín JM, Díaz-Romero F, Raya-Sánchez JM. Lack of relationship between plasma thrombomodulin and portal hypertension in alcoholic liver disease. Alcohol. 2000;20(2):205–206. doi:10.1016/S0741-8329(99)00072-5
   PubMed Web of Science ®Google Scholar
• Tacke F, Schöffski P, Trautwein C, Manns MP, Ganser A, von Depka M. Tissue factor and thrombomodulin levels are correlated with stage of cirrhosis in patients with liver disease. Blood Coagul Fibrinolysis. 2001;12(7):539–545. doi:10.1097/00001721-200110000-00005
   PubMed Web of Science ®Google Scholar
• Takatori M, Iwabuchi S, Ro S, et al. Increased serum levels and sinusoidal expression of thrombomodulin in acute liver damage. Thromb Res. 1999;93(3):113–120. doi:10.1016/S0049-3848(98)00167-4
   PubMed Web of Science ®Google Scholar
• Wei X, Du X, Liu Y, Wu J, Zhang J. High plasma soluble thrombomodulin levels indicated poor prognosis of decompensated liver cirrhosis: a prospective cohort study. Eur J Gastroenterol Hepatol. 2022;34(11):1140–1146. doi:10.1097/MEG.0000000000002428
   PubMed Web of Science ®Google Scholar
• Li J, Liang X, Jiang J, et al. PBMC transcriptomics identifies immune-metabolism disorder during the development of HBV-ACLF. Gut. 2022;71(1):163–175. doi:10.1136/gutjnl-2020-323395
   PubMed Web of Science ®Google Scholar
• Lok AS, McMahon BJ. Chronic hepatitis B: update 2009. Hepatology. 2009;50(3):661–662. doi:10.1002/hep.23190
   PubMed Web of Science ®Google Scholar
• Moreau R, Jalan R, Gines P, et al. Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis. Gastroenterology. 2013;144(7):1426–1437. doi:10.1053/j.gastro.2013.02.042
   PubMed Web of Science ®Google Scholar
• Hänzelmann S, Castelo R, Guinney J. GSVA: gene set variation analysis for microarray and RNA-seq data. BMC Bioinf. 2013;14:7. doi:10.1186/1471-2105-14-7
   PubMed Web of Science ®Google Scholar
• Li S, Rouphael N, Duraisingham S, et al. Molecular signatures of antibody responses derived from a systems biology study of five human vaccines. Nat Immunol. 2014;15(2):195–204. doi:10.1038/ni.2789
   PubMed Web of Science ®Google Scholar
• Farooqui N, Elhence A. A current understanding of bile acids in chronic liver disease. J Clin Exp Hepatol. 2022;12(1):155–173. doi:10.1016/j.jceh.2021.08.017
   PubMed Web of Science ®Google Scholar
• Kim WR, Biggins SW, Kremers WK, et al. Hyponatremia and mortality among patients on the liver-transplant waiting list. N Engl J Med. 2008;359(10):1018–1026. doi:10.1056/NEJMoa0801209
   PubMed Web of Science ®Google Scholar
• Li J, Liang X, You S, et al. Development and validation of a new prognostic score for hepatitis B virus-related acute-on-chronic liver failure. J Hepatol. 2021;75(5):1104–1115. doi:10.1016/j.jhep.2021.05.026
   PubMed Web of Science ®Google Scholar
• Camp RL, Dolled-Filhart M, Rimm DL. X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization. Clin Cancer Res. 2004;10(21):7252–7259. doi:10.1158/1078-0432.CCR-04-0713
   PubMed Web of Science ®Google Scholar
• Hernaez R, Solà E, Moreau R, Ginès P. Acute-on-chronic liver failure: an update. Gut. 2017;66(3):541–553. doi:10.1136/gutjnl-2016-312670
   PubMed Web of Science ®Google Scholar
• Won T, Wood MK, Hughes DM, et al. Endothelial thrombomodulin downregulation caused by hypoxia contributes to severe infiltration and coagulopathy in COVID-19 patient lungs. EBioMedicine. 2022;75:103812. doi:10.1016/j.ebiom.2022.103812
   PubMed Web of Science ®Google Scholar
• Zanetto A, Pelizzaro F, Campello E, et al. Severity of systemic inflammation is the main predictor of ACLF and bleeding in individuals with acutely decompensated cirrhosis. J Hepatol. 2022;2022:1 doi:10.1016/j.jhep.2022.09.005.
   Google Scholar
• Boehme MW, Deng Y, Raeth U, et al. Release of thrombomodulin from endothelial cells by concerted action of TNF-alpha and neutrophils: in vivo and in vitro studies. Immunology. 1996;87(1):134–140.
   PubMed Web of Science ®Google Scholar
• Monteiro ACC, Flori H, Dahmer MK, et al. Thrombomodulin is associated with increased mortality and organ failure in mechanically ventilated children with acute respiratory failure: biomarker analysis from a multicenter randomized controlled trial. Crit Care. 2021;25(1):271. doi:10.1186/s13054-021-03626-1
   PubMed Web of Science ®Google Scholar
• Orwoll BE, Spicer AC, Zinter MS, et al. Elevated soluble thrombomodulin is associated with organ failure and mortality in children with acute respiratory distress syndrome (ARDS): a prospective observational cohort study. Crit Care. 2015;19(1):435. doi:10.1186/s13054-015-1145-9
   PubMedGoogle Scholar
• Ohlin AK, Larsson K, Hansson M. Soluble thrombomodulin activity and soluble thrombomodulin antigen in plasma. J Thromb Haemost. 2005;3(5):976–982. doi:10.1111/j.1538-7836.2005.01267.x
   PubMed Web of Science ®Google Scholar
• Iba T, Aihara K, Watanabe S, et al. Recombinant thrombomodulin improves the visceral microcirculation by attenuating the leukocyte-endothelial interaction in a rat LPS model. Thromb Res. 2013;131(4):295–299. doi:10.1016/j.thromres.2012.11.025
   PubMed Web of Science ®Google Scholar
• Kudo D, Toyama M, Aoyagi T, et al. Involvement of high mobility group box 1 and the therapeutic effect of recombinant thrombomodulin in a mouse model of severe acute respiratory distress syndrome. Clin Exp Immunol. 2013;173(2):276–287. doi:10.1111/cei.12106
   PubMed Web of Science ®Google Scholar
• Saito H, Maruyama I, Shimazaki S, et al. Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: results of a Phase III, randomized, double-blind clinical trial. J Thromb Haemost. 2007;5(1):31–41. doi:10.1111/j.1538-7836.2006.02267.x
   PubMed Web of Science ®Google Scholar