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ORIGINAL RESEARCH

Investigation of Gut Microbiota Disorders in Sepsis and Sepsis Complicated with Acute Gastrointestinal Injury Based on 16S rRNA Genes Illumina Sequencing

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Pages 7389-7403 | Received 07 Oct 2023, Accepted 22 Nov 2023, Published online: 30 Nov 2023

References

  • Napolitano LM. Sepsis 2018: definitions and Guideline Changes. Surgical Infections. 2018;19(2):117–125. doi:10.1089/sur.2017.278
  • Srzić I, Nesek Adam V, Tunjić Pejak D. Sepsis Definition: what’s New 
In The Treatment Guidelines. Acta Clin Croatica. 2022;61(Suppl 1):67–72. doi:10.20471/acc.2022.61.s1.11
  • Reintam Blaser A, Preiser JC, Fruhwald S, et al. Gastrointestinal dysfunction in the critically ill: a systematic scoping review and research agenda proposed by the Section of Metabolism, Endocrinology and Nutrition of the European Society of Intensive Care Medicine. Critical Care. 2020;24(1):224. doi:10.1186/s13054-020-02889-4
  • Sun JK, Nie S, Chen YM, et al. Effects of permissive hypocaloric vs standard enteral feeding on gastrointestinal function and outcomes in sepsis. World j Gastroenterol. 2021;27(29):4900–4912. doi:10.3748/wjg.v27.i29.4900
  • Reintam Blaser A, Starkopf J, Moonen PJ, Malbrain M, Oudemans-van Straaten HM. Perioperative gastrointestinal problems in the ICU. Anaesthesiol Intensive Therapy. 2018;50(1):59–71. doi:10.5603/AIT.a2017.0064
  • Reintam Blaser A, Jakob SM, Starkopf J. Gastrointestinal failure in the ICU. Curr Opinion Critical Care. 2016;22(2):128–141. doi:10.1097/MCC.0000000000000286
  • An R, Wilms E, Masclee AAM, Smidt H, Zoetendal EG, Jonkers D. Age-dependent changes in GI physiology and microbiota: time to reconsider? Gut. 2018;67(12):2213–2222. doi:10.1136/gutjnl-2017-315542
  • Adak A, Khan MR. An insight into gut microbiota and its functionalities. Cell Mol Life Sci. 2019;76(3):473–493. doi:10.1007/s00018-018-2943-4
  • Chen Y, Zhou J, Wang L. Role and Mechanism of Gut Microbiota in Human Disease. Front Cell Infection Microbiol. 2021;11:625913. doi:10.3389/fcimb.2021.625913
  • Haak BW, Wiersinga WJ. The role of the gut microbiota in sepsis. lancet Gastroenterol Hepatol. 2017;2(2):135–143. doi:10.1016/S2468-1253(16)30119-4
  • Adelman MW, Woodworth MH, Langelier C, et al. The gut microbiome’s role in the development, maintenance, and outcomes of sepsis. Critical Care. 2020;24(1):278. doi:10.1186/s13054-020-02989-1
  • Agudelo-Ochoa GM, Valdés-Duque BE, Giraldo-Giraldo NA. Gut microbiota profiles in critically ill patients, potential biomarkers and risk variables for sepsis. Gut Microbes. 2020;12(1):1707610. doi:10.1080/19490976.2019.1707610
  • Kullberg RFJ, Wiersinga WJ, Haak BW. Gut microbiota and sepsis: from pathogenesis to novel treatments. Curr Opin Gastroenterol. 2021;37(6):578–585. doi:10.1097/MOG.0000000000000781
  • Bassetti M, Bandera A, Gori A. Therapeutic Potential of the Gut Microbiota in the Management of Sepsis. Critical Care. 2020;24(1):105. doi:10.1186/s13054-020-2780-3
  • Niu M, Chen P. Crosstalk between gut microbiota and sepsis. Burns & Trauma. 2021;9:tkab036. doi:10.1093/burnst/tkab036
  • Rapin A, Pattaroni C, Marsland BJ, Harris NL. Microbiota Analysis Using an Illumina MiSeq Platform to Sequence 16S rRNA Genes. Curr Protocols Mouse Biol. 2017;7(2):100–129. doi:10.1002/cpmo.29
  • Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):801–810. doi:10.1001/jama.2016.0287
  • Reintam Blaser A, Malbrain ML, Starkopf J, et al. Gastrointestinal function in intensive care patients: terminology, definitions and management. Recommendations of the ESICM Working Group on Abdominal Problems. Intensive Care Med. 2012;38(3):384–394. doi:10.1007/s00134-011-2459-y
  • Kanehisa M, Furumichi M, Tanabe M, Sato Y, Morishima K. KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017;45(D1):D353–d361. doi:10.1093/nar/gkw1092
  • Jensen LJ, Julien P, Kuhn M, et al. eggNOG: automated construction and annotation of orthologous groups of genes. Nucleic Acids Res. 2008;36(Database issue):56.
  • Karp PD, Riley M, Paley SM, Pellegrini-Toole A. The MetaCyc Database. Nucleic Acids Res. 2002;30(1):59–61. doi:10.1093/nar/30.1.59
  • Šimundić AM. Measures of Diagnostic Accuracy: basic Definitions. Ejifcc. 2009;19(4):203–211.
  • Haak BW, Prescott HC, Wiersinga WJ. Therapeutic Potential of the Gut Microbiota in the Prevention and Treatment of Sepsis. Front Immunol. 2018;9:2042. doi:10.3389/fimmu.2018.02042
  • Liu Y, Guo Y, Hu S, et al. Analysis of the dynamic changes in gut microbiota in patients with different severity in sepsis. BMC Infect Dis. 2023;23(1):614. doi:10.1186/s12879-023-08608-y
  • Lee SJ, Kim D, Ann HW, et al. Deciphering gut microbiota in patients with severe sepsis and septic shock. Shock Augusta Ga. 2023. doi:10.1097/SHK.0000000000002241
  • Fang H, Fang M, Wang Y, et al. Indole-3-Propionic Acid as a Potential Therapeutic Agent for Sepsis-Induced Gut Microbiota Disturbance. Microbiology Spectrum. 2022;10(3):e0012522. doi:10.1128/spectrum.00125-22
  • Tyszko M, Citrulline L-PA. Intestinal Fatty Acid-Binding Protein and the Acute Gastrointestinal Injury Score as Predictors of Gastrointestinal Failure in Patients with Sepsis and Septic Shock. Nutrients. 2023;15(9):2100.
  • Han C, Guo N, Bu Y, et al. Intestinal microbiota and antibiotic-associated acute gastrointestinal injury in sepsis mice. Aging. 2021;13(7):10099–10111. doi:10.18632/aging.202768
  • Jandhyala SM, Talukdar R, Subramanyam C, Vuyyuru H, Sasikala M, Nageshwar Reddy D. Role of the normal gut microbiota. World j Gastroenterol. 2015;21(29):8787–8803. doi:10.3748/wjg.v21.i29.8787
  • Li Y, Zhao H, Sun G, et al. Alterations in the gut microbiome and metabolome profiles of septic rats treated with aminophylline. J Translational Med. 2022;20(1):69. doi:10.1186/s12967-022-03280-3
  • Szabó BG, Kiss R, Makra N, et al. Composition and changes of blood microbiota in adult patients with community-acquired sepsis: a pilot study from bench to bedside. Front Cell Infection Microbiol. 2022;12:1067476. doi:10.3389/fcimb.2022.1067476
  • Han B, Chao K, Wang D, et al. A purified membrane protein from Akkermansia muciniphila blunted the sepsis-induced acute lung injury by modulation of gut microbiota in rats. Int Immunopharmacol. 2023;121:110432. doi:10.1016/j.intimp.2023.110432
  • Wexler HM. Bacteroides: the good, the bad, and the nitty-gritty. Clin Microbiol Rev. 2007;20(4):593–621. doi:10.1128/CMR.00008-07
  • Han S, Zheng H, Han F, et al. Lactobacillus johnsonii 6084 alleviated sepsis-induced organ injury by modulating gut microbiota. Food Science & Nutrition. 2022;10(11):3931–3941. doi:10.1002/fsn3.2989
  • Parker BJ, Wearsch PA, Veloo ACM, Rodriguez-Palacios A. The Genus Alistipes: gut Bacteria With Emerging Implications to Inflammation, Cancer, and Mental Health. Front Immunol. 2020;11:906. doi:10.3389/fimmu.2020.00906
  • Daddi L, Dorsett Y, Geng T, Bokoliya S. Baseline Gut Microbiome Signatures Correlate with Immunogenicity of SARS-CoV-2 mRNA Vaccines. Nutrients. 2023;24(14):67.
  • Tan J, Zhong Z, Tang Y, Qin W. Intestinal dysbiosis featuring abundance of Streptococcus associates with Henoch-Schönlein purpura nephritis (IgA vasculitis with nephritis) in adult. BMC Nephrol. 2022;23(1):10. doi:10.1186/s12882-021-02638-x
  • Hu X, Du J, Xie Y, et al. Fecal microbiota characteristics of Chinese patients with primary IgA nephropathy: a cross-sectional study. BMC Nephrol. 2020;21(1):97. doi:10.1186/s12882-020-01741-9
  • Zhao J, Bai M, Ning X, et al. Expansion of Escherichia-Shigella in Gut Is Associated with the Onset and Response to Immunosuppressive Therapy of IgA Nephropathy. Journal of the American Society of Nephrology: JASN. 2022;33(12):2276–2292. doi:10.1681/ASN.2022020189
  • Sun J, Ding X, Liu S, Duan X, Liang H, Sun T. Adipose-derived mesenchymal stem cells attenuate acute lung injury and improve the gut microbiota in septic rats. Stem Cell Research & Therapy. 2020;11(1):384. doi:10.1186/s13287-020-01902-5
  • Liu X, Mao B. Blautia-a new functional genus with potential probiotic properties? Jan-Dec. 2021;13(1):1–21.
  • Suchodolski JS, Markel ME, Garcia-Mazcorro JF, et al. The fecal microbiome in dogs with acute diarrhea and idiopathic inflammatory bowel disease. PLoS One. 2012;7(12):e51907. doi:10.1371/journal.pone.0051907
  • Jenq RR, Ubeda C, Taur Y, et al. Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation. J exp med. 2012;209(5):903–911. doi:10.1084/jem.20112408
  • Stein-Thoeringer CK, Nichols KB. Lactose drives Enterococcus expansion to promote graft-versus-host disease. Science (New York, N.Y.). 2019;366(6469):1143–1149. doi:10.1126/science.aax3760
  • Hu XS, Zhu JG, Jiang CY, Chen XH, Yu ZB, Han SP. A clinical analysis of sepsis in very low birth weight infants. Chine j Contemporary Pediatrics. 2021;23(7):684–689. doi:10.7499/j.issn.1008-8830.2102114
  • Presley LL, Wei B, Braun J, Borneman J. Bacteria associated with immunoregulatory cells in mice. Appl. Environ. Microbiol. 2010;76(3):936–941. doi:10.1128/AEM.01561-09
  • He Z, Liu R, Wang M, et al. Combined effect of microbially derived cecal SCFA and host genetics on feed efficiency in broiler chickens. Microbiome. 2023;11(1):198. doi:10.1186/s40168-023-01627-6
  • Lozano CP, Wilkens LR, Shvetsov YB. Associations of the Dietary Inflammatory Index with total adiposity and ectopic fat through the gut microbiota, LPS, and C-reactive protein in the Multiethnic Cohort-Adiposity Phenotype Study. The American Journal of Clinical Nutrition. 2022;115(5):1344–1356. doi:10.1093/ajcn/nqab398
  • He X, Zhang M, Li ST, et al. Alteration of gut microbiota in high-fat diet-induced obese mice using carnosic acid from rosemary. Food Science & Nutrition. 2022;10(7):2325–2332. doi:10.1002/fsn3.2841
  • Liu J, Hao W, He Z, et al. Blueberry and cranberry anthocyanin extracts reduce bodyweight and modulate gut microbiota in C57BL/6 J mice fed with a high-fat diet. European Journal of Nutrition. 2021;60(5):2735–2746. doi:10.1007/s00394-020-02446-3
  • Mukherjee A, Lordan C, Ross RP. Gut microbes from the phylogenetically diverse genus Eubacterium and their various contributions to gut health. Gut Microbes. 2020;12(1):1802866. doi:10.1080/19490976.2020.1802866
  • Spitzer JJ, Bagby GJ, Mészáros K, Lang CH. Alterations in lipid and carbohydrate metabolism in sepsis. JPEN J Parenter Enteral Nutr. 1988;12(6 Suppl):53s–58s. doi:10.1177/014860718801200604
  • Della Giustina A, Goldim MP, Danielski LG, et al. Alpha-lipoic acid attenuates acute neuroinflammation and long-term cognitive impairment after polymicrobial sepsis. Neurochemistry Int. 2017;108:436–447. doi:10.1016/j.neuint.2017.06.003
  • Zorzoli A, Grayczyk JP. Staphylococcus aureus Tissue Infection During Sepsis Is Supported by Differential Use of Bacterial or Host-Derived Lipoic Acid. PLoS Pathogens. 2016;12(10):e1005933. doi:10.1371/journal.ppat.1005933
  • Chen Q, Liang X, Wu T, et al. Integrative analysis of metabolomics and proteomics reveals amino acid metabolism disorder in sepsis. Nutrients. 2022;20(1):123.
  • Rigatti SJ. Random Forest. J Insurance Med. 2017;47(1):31–39. doi:10.17849/insm-47-01-31-39.1