Vitamin D Improves Klebsiella-Induced Severe Pneumonia in Rats by Regulating Intestinal Microbiota

References

• Marr CM, Russo TA. Hypervirulent Klebsiella pneumoniae: a new public health threat. Expert Rev Anti Infect Ther. 2019;17(2):71–73. doi:10.1080/14787210.2019.1555470
   PubMed Web of Science ®Google Scholar
• Piperaki ET, Syrogiannopoulos GA, Tzouvelekis LS, Daikos GL. Klebsiella pneumoniae: virulence, biofilm and antimicrobial resistance. Pediatr Infect Dis J. 2017;36(10):1002–1005. doi:10.1097/INF.0000000000001675
   PubMed Web of Science ®Google Scholar
• Wang G, Zhao G, Chao X, Xie L, Wang H. The characteristic of virulence, biofilm and antibiotic resistance of Klebsiella pneumoniae. Int J Environ Res Public Health. 2020;17(17). doi:10.3390/ijerph17176278
   Web of Science ®Google Scholar
• Bhardwaj S, Mehra P, Dhanjal DS, et al. Antibiotics and antibiotic resistance- flipsides of the same coin. Curr Pharm Des. 2022;28(28):2312–2329. doi:10.2174/1381612828666220608120238
   PubMed Web of Science ®Google Scholar
• Stojowska-Swedrzynska K, Lupkowska A, Kuczynska-Wisnik D, Laskowska E. Antibiotic Heteroresistance in Klebsiella pneumoniae. Int J Mol Sci. 2021;23(1). doi:10.3390/ijms23010449
   PubMed Web of Science ®Google Scholar
• Antimicrobial Resistance C. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet. 2022;399(10325):629–655. doi:10.1016/S0140-6736(21)02724-0
   PubMed Web of Science ®Google Scholar
• Hardie KR. Antimicrobial resistance: the good, the bad, and the ugly. Emerg Top Life Sci. 2020;4(2):129–136. doi:10.1042/ETLS20190194
   PubMedGoogle Scholar
• Wyres KL, Lam MMC, Holt KE. Population genomics of Klebsiella pneumoniae. Nat Rev Microbiol. 2020;18(6):344–359. doi:10.1038/s41579-019-0315-1
   PubMed Web of Science ®Google Scholar
• Cassini A, Hogberg LD, Plachouras D, et al. Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis. Lancet Infect Dis. 2019;19(1):56–66. doi:10.1016/S1473-3099(18)30605-4
   PubMed Web of Science ®Google Scholar
• Wongdee K, Chanpaisaeng K, Teerapornpuntakit J, Charoenphandhu N. Intestinal calcium absorption. Compr Physiol. 2021;11(3):2047–2073. doi:10.1002/cphy.c200014
   PubMed Web of Science ®Google Scholar
• Voutsadakis IA. Vitamin D receptor (VDR) and metabolizing enzymes CYP27B1 and CYP24A1 in breast cancer. Mol Biol Rep. 2020;47(12):9821–9830. doi:10.1007/s11033-020-05780-1
   PubMed Web of Science ®Google Scholar
• Rizvi I, Garg RK, Jain A, et al. Vitamin D status, vitamin D receptor and toll like receptor-2 polymorphisms in tuberculous meningitis: a case-control study. Infection. 2016;44(5):633–640. doi:10.1007/s15010-016-0907-x
   PubMed Web of Science ®Google Scholar
• Liao S, Huang Y, Zhang J, et al. Vitamin D promotes epithelial tissue repair and host defense responses against influenza H1N1 virus and Staphylococcus aureus infections. Respir Res. 2023;24(1):175. doi:10.1186/s12931-023-02477-4
   PubMed Web of Science ®Google Scholar
• Battistini C, Ballan R, Herkenhoff ME, Saad SMI, Sun J. Vitamin D modulates intestinal microbiota in inflammatory bowel diseases. Int J Mol Sci. 2020;22(1). doi:10.3390/ijms22010362
   PubMed Web of Science ®Google Scholar
• Li KL, Wang BZ, Li ZP, Li YL, Liang JJ. Alterations of intestinal flora and the effects of probiotics in children with recurrent respiratory tract infection. World J Pediatr. 2019;15(3):255–261. doi:10.1007/s12519-019-00248-0
   PubMed Web of Science ®Google Scholar
• Schuijt TJ, Lankelma JM, Scicluna BP, et al. The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia. Gut. 2016;65(4):575–583. doi:10.1136/gutjnl-2015-309728
   PubMed Web of Science ®Google Scholar
• Zhang Y, Zhu C, Zhao H, Sun Z, Wang X. Anti-inflammatory effect of chlorogenic acid in Klebsiella pneumoniae-induced pneumonia by inactivating the p38MAPK pathway. Int J Med Microbiol. 2023;313(2):151576. doi:10.1016/j.ijmm.2023.151576
   PubMed Web of Science ®Google Scholar
• Ohl F, van der Staay FJ. Animal welfare: at the interface between science and society. Vet J. 2012;192(1):13–19. doi:10.1016/j.tvjl.2011.05.019
   PubMed Web of Science ®Google Scholar
• Al-Hassan S, Attia H, Alomar H, Arafa M, Ali RA. The inhibitory mechanisms of losartan and vitamin D on amiodarone-induced lung inflammation in rats: role of mitogen-activated protein kinases/activator protein-1. J Biochem Mol Toxicol. 2021;35(12):e22923. doi:10.1002/jbt.22923
   PubMed Web of Science ®Google Scholar
• Zhang M, Dong M, Liu W, et al. 1alpha,25-dihydroxyvitamin D3 ameliorates seawater aspiration-induced acute lung injury via NF-kappaB and RhoA/Rho kinase pathways. PLoS One. 2014;9(8):e104507. doi:10.1371/journal.pone.0104507
   PubMed Web of Science ®Google Scholar
• Du J, Zhang P, Luo J, et al. Dietary betaine prevents obesity through gut microbiota-drived microRNA-378a family. Gut Microbes. 2021;13(1):1–19. doi:10.1080/19490976.2020.1862612
   PubMed Web of Science ®Google Scholar
• Martineau AR, Jolliffe DA, Greenberg L, et al. Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis. Health Technol Assess. 2019;23(2):1–44. doi:10.3310/hta23020
   PubMed Web of Science ®Google Scholar
• Ao T, Kikuta J, Ishii M. The effects of vitamin D on immune system and inflammatory diseases. Biomolecules. 2021;11(11). doi:10.3390/biom11111624
   PubMed Web of Science ®Google Scholar
• Jiang Q, Xu Q, Kenez A, Chen S, Yang G. Klebsiella pneumoniae infection is associated with alterations in the gut microbiome and lung metabolome. Microbiol Res. 2022;263:127139. doi:10.1016/j.micres.2022.127139
   PubMedGoogle Scholar
• Teramoto S, Yoshida K, Hizawa N. Update on the pathogenesis and management of pneumonia in the elderly-roles of aspiration pneumonia. Respir Investig. 2015;53(5):178–184. doi:10.1016/j.resinv.2015.01.003
   PubMedGoogle Scholar
• Effah CY, Sun T, Liu S, Wu Y. Klebsiella pneumoniae: an increasing threat to public health. Ann Clin Microbiol Antimicrob. 2020;19(1):1. doi:10.1186/s12941-019-0343-8
   PubMed Web of Science ®Google Scholar
• Bassetti M, Righi E, Carnelutti A, Graziano E, Russo A. Multidrug-resistant Klebsiella pneumoniae: challenges for treatment, prevention and infection control. Expert Rev Anti Infect Ther. 2018;16(10):749–761. doi:10.1080/14787210.2018.1522249
   PubMed Web of Science ®Google Scholar
• Yang C, Lu Y, Wan M, et al. Efficacy of high-dose vitamin D supplementation as an adjuvant treatment on pneumonia: systematic review and a meta-analysis of randomized controlled studies. Nutr Clin Pract. 2021;36(2):368–384. doi:10.1002/ncp.10585
   PubMed Web of Science ®Google Scholar
• Manaseki-Holland S, Qader G, Isaq Masher M, et al. Effects of vitamin D supplementation to children diagnosed with pneumonia in Kabul: a randomised controlled trial. Trop Med Int Health. 2010;15(10):1148–1155. doi:10.1111/j.1365-3156.2010.02578.x
   PubMed Web of Science ®Google Scholar
• Gupta P, Dewan P, Shah D, et al. Vitamin D supplementation for treatment and prevention of pneumonia in under-five children: a randomized double-blind placebo controlled trial. Indian Pediatr. 2016;53(11):967–976. doi:10.1007/s13312-016-0970-5
   PubMed Web of Science ®Google Scholar
• Choudhary N, Gupta P. Vitamin D supplementation for severe pneumonia--a randomized controlled trial. Indian Pediatr. 2012;49(6):449–454. doi:10.1007/s13312-012-0073-x
   PubMed Web of Science ®Google Scholar
• Das RR, Singh M, Naik SS. Vitamin D as an adjunct to antibiotics for the treatment of acute childhood pneumonia. Cochrane Database Syst Rev. 2023;1(1):CD011597. doi:10.1002/14651858.CD011597.pub3
   PubMedGoogle Scholar
• Fakhoury HMA, Kvietys PR, AlKattan W, et al. Vitamin D and intestinal homeostasis: barrier, microbiota, and immune modulation. J Steroid Biochem Mol Biol. 2020;200:105663. doi:10.1016/j.jsbmb.2020.105663
   PubMed Web of Science ®Google Scholar
• Sirbe C, Rednic S, Grama A, Pop TL. An update on the effects of vitamin D on the immune system and autoimmune diseases. Int J Mol Sci. 2022;23(17). doi:10.3390/ijms23179784
   Web of Science ®Google Scholar
• Thibeault C, Suttorp N, Opitz B. The microbiota in pneumonia: from protection to predisposition. Sci Transl Med. 2021;13(576). doi:10.1126/scitranslmed.aba0501
   PubMed Web of Science ®Google Scholar
• Ma PJ, Wang MM, Wang Y. Gut microbiota: a new insight into lung diseases. Biomed Pharmacother. 2022;155:113810. doi:10.1016/j.biopha.2022.113810
   PubMed Web of Science ®Google Scholar
• Jiang Y, Bao C, Zhao X, Chen Y, Song Y, Xiao Z. Intestinal bacteria flora changes in patients with Mycoplasma pneumoniae pneumonia with or without wheezing. Sci Rep. 2022;12(1):5683. doi:10.1038/s41598-022-09700-0
   PubMed Web of Science ®Google Scholar
• Deng L, Shi Y, Liu P, et al. GeGen QinLian decoction alleviate influenza virus infectious pneumonia through intestinal flora. Biomed Pharmacother. 2021;141:111896. doi:10.1016/j.biopha.2021.111896
   PubMed Web of Science ®Google Scholar
• Rastogi S, Mohanty S, Sharma S, Tripathi P. Possible role of gut microbes and host’s immune response in gut-lung homeostasis. Front Immunol. 2022;13:954339. doi:10.3389/fimmu.2022.954339
   PubMed Web of Science ®Google Scholar
• Pettigrew MM, Kwon J, Gent JF, et al. Comparison of the respiratory resistomes and microbiota in children receiving short versus standard course treatment for community-acquired pneumonia. mBio. 2022;13(2):e0019522. doi:10.1128/mbio.00195-22
   PubMed Web of Science ®Google Scholar
• Miyashita N. Atypical pneumonia: pathophysiology, diagnosis, and treatment. Respir Investig. 2022;60(1):56–67. doi:10.1016/j.resinv.2021.09.009
   PubMed Web of Science ®Google Scholar
• Cantorna MT, Lin YD, Arora J, et al. Vitamin D regulates the microbiota to control the numbers of RORgammat/FoxP3+ Regulatory T cells in the colon. Front Immunol. 2019;10:1772. doi:10.3389/fimmu.2019.01772
   PubMed Web of Science ®Google Scholar
• Kellermann L, Jensen KB, Bergenheim F, et al. Mucosal vitamin D signaling in inflammatory bowel disease. Autoimmun Rev. 2020;19(11):102672. doi:10.1016/j.autrev.2020.102672
   PubMed Web of Science ®Google Scholar