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ORIGINAL RESEARCH

Association Between Hemoglobin-Albumin-Lymphocyte-Platelet Index and Mortality in Hospitalized COVID-19 Omicron BA.2 Infected Patients

, ORCID Icon, ORCID Icon, & ORCID Icon
Pages 1467-1476 | Received 06 Dec 2023, Accepted 13 Mar 2024, Published online: 11 Apr 2024

References

  • Yuan HY, Liang J, Hossain MP. Impacts of social distancing, rapid antigen test and vaccination on the Omicron outbreak during large temperature variations in Hong Kong: a modelling study. J Infect Public Health. 2022;15(12):1427–1435. doi:10.1016/j.jiph.2022.10.026
  • Khan Z, Ali SA, Mohsin M, Parvin F, Shamim SK, Ahmad A. A district-level vulnerability assessment of next COVID-19 variant (Omicron BA.2) in Uttarakhand using quantitative SWOT analysis. Environ Dev Sustain. 2022;1–30. doi:10.1007/s10668-022-02727-3
  • Strasser ZH, Greifer N, Hadavand A, Murphy SN, Estiri H. Estimates of SARS-CoV-2 Omicron BA.2 Subvariant Severity in New England. JAMA Network Open. 2022;5(10):e2238354. doi:10.1001/jamanetworkopen.2022.38354
  • Liu Y, Yang Y, Zhang C, et al. Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury. Sci China Life Sci. 2020;63(3):364–374. doi:10.1007/s11427-020-1643-8
  • Lippi G, Plebani M, Henry BM. Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: a meta-analysis. Int J Clin Chem. 2020;506:145–148. doi:10.1016/j.cca.2020.03.022
  • Tahir Huyut M, Huyut Z, Ilkbahar F, Mertoğlu C. What is the impact and efficacy of routine immunological, biochemical and hematological biomarkers as predictors of COVID-19 mortality? Int Immunopharmacol. 2022;105:108542. doi:10.1016/j.intimp.2022.108542
  • Huyut MT, Huyut Z. Effect of ferritin, INR, and D-dimer immunological parameters levels as predictors of COVID-19 mortality: a strong prediction with the decision trees. Heliyon. 2023;9(3):e14015. doi:10.1016/j.heliyon.2023.e14015
  • Huyut MT, Huyut Z. Forecasting of oxidant/antioxidant levels of COVID-19 patients by using expert models with biomarkers used in the diagnosis/prognosis of COVID-19. Int Immunopharmacol. 2021;100:108127.
  • Mertoglu C, Huyut MT, Arslan Y, Ceylan Y, Coban TA. How do routine laboratory tests change in coronavirus disease 2019? Scand J Clin Lab Invest. 2021;81(1):24–33. doi:10.1080/00365513.2020.1855470
  • Velichko A, Huyut MT, Belyaev M, Izotov Y, Korzun D. Machine learning sensors for diagnosis of COVID-19 disease using routine blood values for internet of things application. Sensors. 2022;22(20):7886. doi:10.3390/s22207886
  • Huyut MT, Ilkbahar F. The effectiveness of blood routine parameters and some biomarkers as a potential diagnostic tool in the diagnosis and prognosis of Covid-19 disease. Int Immunopharmacol. 2021;98:107838. doi:10.1016/j.intimp.2021.107838
  • Bilge M, Akilli IK, Karaayvaz EB, Yesilova A, Kart Yasar K. Comparison of systemic immune-inflammation index (SII), early warning score (ANDC) and prognostic nutritional index (PNI) in hospitalized patients with malignancy, and their influence on mortality from COVID-19. Infect Agent Cancer. 2021;16(1):60. doi:10.1186/s13027-021-00400-4
  • Qiu W, Shi Q, Chen F, Wu Q, Yu X, Xiong L. The derived neutrophil to lymphocyte ratio can be the predictor of prognosis for COVID-19 Omicron BA.2 infected patients. Front Immunol. 2022;13:1065345. doi:10.3389/fimmu.2022.1065345
  • Liu Y, Du X, Chen J, et al. Neutrophil-to-lymphocyte ratio as an independent risk factor for mortality in hospitalized patients with COVID-19. J Infect. 2020;81(1):e6–e12. doi:10.1016/j.jinf.2020.04.002
  • Hung KC, Ko CC, Wang LK, et al. Association of prognostic nutritional index with severity and mortality of hospitalized patients with COVID-19: a systematic review and meta-analysis. Diagnostics. 2022;12(7):1.
  • Fernandes AL, Reis BZ, Murai IH, Pereira RMR. Prognostic nutritional index and oxygen therapy requirement associated with longer hospital length of stay in patients with moderate to severe COVID-19: multicenter prospective cohort analyses. Front Nutr. 2022;9:802562. doi:10.3389/fnut.2022.802562
  • Bodolea C, Nemes A, Avram L, et al. Nutritional risk assessment scores effectively predict mortality in critically ill patients with severe COVID-19. Nutrients. 2022;14(10):1.
  • Zhao Z, Yin XN, Wang J, Chen X, Cai ZL, Zhang B. Prognostic significance of hemoglobin, albumin, lymphocyte, platelet in gastrointestinal stromal tumors: a propensity matched retrospective cohort study. World J Gastroenterol. 2022;28(27):3476–3487. doi:10.3748/wjg.v28.i27.3476
  • Cong L, Hu L. The value of the combination of hemoglobin, albumin, lymphocyte and platelet in predicting platinum-based chemoradiotherapy response in male patients with esophageal squamous cell carcinoma. Int Immunopharmacol. 2017;46:75–79. doi:10.1016/j.intimp.2017.02.027
  • Han H, Hu S, Du J. Predictive value of the hemoglobin-albumin-lymphocyte-platelet (HALP) index for ICU mortality in patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD). Int Emerg Med. 2022;18(1):85–96. doi:10.1007/s11739-022-03132-4
  • Güç ZG, Alacacıoğlu A, Kalender ME, et al. HALP score and GNRI: simple and easily accessible indexes for predicting prognosis in advanced stage NSCLC patients. The İzmir oncology group (IZOG) study. Front Nutr. 2022;9:905292. doi:10.3389/fnut.2022.905292
  • Xu M, Chen L, Hu Y, et al. The HALP (hemoglobin, albumin, lymphocyte, and platelet) score is associated with early-onset post-stroke cognitive impairment. Neurol Sci. 2022;2022:1.
  • Hou YC, Su WL, Chao YC. COVID-19 illness severity in the elderly in relation to vegetarian and non-vegetarian diets: a single-center experience. Front Nutr. 2022;9:837458. doi:10.3389/fnut.2022.837458
  • Jiang P, Kong W, Gong C, et al. Predicting the recurrence of operable cervical cancer patients based on Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) score and classical clinicopathological parameters. J Inflamm Res. 2022;15:5265–5281. doi:10.2147/JIR.S383742
  • Lu N, Gu T, Tian X, et al. Acetylshikonin inhibits inflammatory responses and papain-like protease activity in murine model of COVID-19. Signal Transduct Target Ther. 2022;7(1):371. doi:10.1038/s41392-022-01220-7
  • Prasad AS, Malysa A, Bepler G, Fribley A, Bao B. The mechanisms of zinc action as a potent anti-viral agent: the clinical therapeutic implication in COVID-19. Antioxidants. 2022;11(10):1862. doi:10.3390/antiox11101862
  • Yalcinkaya M, Liu W, Islam MN, et al. Modulation of the NLRP3 inflammasome by Sars-CoV-2 envelope protein. Sci Rep. 2021;11(1):24432. doi:10.1038/s41598-021-04133-7
  • Zheng M, Gao Y, Wang G, et al. Functional exhaustion of antiviral lymphocytes in COVID-19 patients. Cell Mol Immunol. 2020;17(5):533–535.
  • Sun Y, Zou Y, Wang H, Cui G, Yu Z, Ren Z. Immune response induced by novel coronavirus infection. Front Cell Infect Microbiol. 2022;12:988604. doi:10.3389/fcimb.2022.988604
  • Mabrouk M, Guessous F, Naya A, Merhi Y, Zaid Y. The pathophysiological role of platelet-derived extracellular vesicles. Semin Thromb Hemost. 2022;49(3):279–283. doi:10.1055/s-0042-1756705
  • Carestia A, Godin LC, Jenne CN. Step up to the platelet: role of platelets in inflammation and infection. Thromb Res. 2023;231:182–194. doi:10.1016/j.thromres.2022.10.001
  • Can B, Senturk Durmus N, Olgun Yıldızeli S, Kocakaya D, Ilhan B, Tufan A. Nutrition risk assessed by nutritional risk screening 2002 is associated with in-hospital mortality in older patients with COVID-19. Nutr Clin Pract. 2022;37(3):605–614. doi:10.1002/ncp.10860
  • Liu H, Zhou L, Wang H, et al. Malnutrition is associated with hyperinflammation and immunosuppression in COVID-19 patients: a prospective observational study. Nutr Clin Pract. 2021;36(4):863–871. doi:10.1002/ncp.10679
  • Ozcan Cetin EH, Könte HC, Temizhan A. Blood viscosity should not be overlooked when evaluating the fibrinogen to albumin ratio. Angiology. 2019;70(5):465–466. doi:10.1177/0003319718822244
  • Baratta F, Bartimoccia S, Carnevale R, Stefanini L, Angelico F, Del Ben M. Oxidative stress mediated platelet activation in patients with congenital analbuminemia: effect of albumin infusion. J Thromb Haemost. 2021;19(12):3090–3094. doi:10.1111/jth.15545
  • Lucijanic M, Veletic I, Rahelic D, et al. Assessing serum albumin concentration, lymphocyte count and prognostic nutritional index might improve prognostication in patients with myelofibrosis. Wiener klinische Wochenschrift. 2018;130(3–4):126–133. doi:10.1007/s00508-018-1318-z
  • Fang CJ, Saadat GH, Butler BA, Bokhari F. The geriatric nutritional risk index is an independent predictor of adverse outcomes for total joint arthroplasty patients. J Arthroplasty. 2022;37(8):S836–S841. doi:10.1016/j.arth.2022.01.049
  • Jin X, Li J, Sun L, et al. Prognostic value of serum albumin level in critically ill patients: observational data from large intensive care unit databases. Front Nutr. 2022;9:770674. doi:10.3389/fnut.2022.770674
  • Fang Y, Sun X, Zhang L, Xu Y, Zhu W. Hemoglobin/red blood cell distribution width ratio in peripheral blood is positively associated with prognosis of patients with primary Hepatocellular carcinoma. Med Sci Monit. 2022;28:e937146.
  • Belcher DA, Ju JA, Baek JH, et al. The quaternary state of polymerized human hemoglobin regulates oxygenation of breast cancer solid tumors: a theoretical and experimental study. PLoS One. 2018;13(2):e0191275. doi:10.1371/journal.pone.0191275
  • Patiño-Aldana AF, Ruíz Sternberg ÁM, Pinzón Rondón ÁM, Molano-Gonzalez N, Rodriguez lima DR. Interaction effect between hemoglobin and hypoxemia on COVID-19 mortality: an observational study from Bogotá, Colombia. Int J Gene Med. 2022;15:6965–6976. doi:10.2147/IJGM.S371067
  • Solmaz S, Uzun O, Sevindik OG, et al. The effect of haemoglobin, albumin, lymphocyte and platelet score on the prognosis in patients with multiple myeloma. Int J Lab Hematol. 2023;45(1):13–19. doi:10.1111/ijlh.13958
  • Tian M, Li Y, Wang X, et al. The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) score is associated with poor outcome of acute ischemic stroke. Front Neurol. 2021;11:610318. doi:10.3389/fneur.2020.610318