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ORIGINAL RESEARCH

Epidemiology, Microbiology, and Risk Factors of Bacterial Bloodstream Infections in Patients After Allogeneic Hematopoietic Stem Cell Transplantation

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Pages 1561-1569 | Received 27 Nov 2023, Accepted 27 Mar 2024, Published online: 21 Apr 2024

References

  • Yan CH, Wang Y, Mo XD, et al. Incidence, Risk Factors, Microbiology and Outcomes of Pre-engraftment Bloodstream Infection After Haploidentical Hematopoietic Stem Cell Transplantation and Comparison With HLA-identical Sibling Transplantation. Clin Infect Dis. 2018;67(suppl_2):S162–S173. doi:10.1093/cid/ciy658
  • Dellinger RP, Carlet JM, Masur H, et al. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med. 2004;32(3):858–873. doi:10.1097/01.ccm.0000117317.18092.e4
  • Kikuchi M, Akahoshi Y, Nakano H, et al. Risk factors for pre- and post-engraftment bloodstream infections after allogeneic hematopoietic stem cell transplantation. Transpl Infect Dis. 2015;17(1):56–65. doi:10.1111/tid.12345
  • Mikulska M, Raiola AM, Galaverna F, et al. Pre-Engraftment Bloodstream Infections after Allogeneic Hematopoietic Cell Transplantation: impact of T Cell-Replete Transplantation from a Haploidentical Donor. Biol Blood Marrow Transplant. 2018;24(1):109–118. doi:10.1016/j.bbmt.2017.08.024
  • Mori Y, Yoshimoto G, Nishida R, et al. Gastrointestinal Graft-versus-Host Disease Is a Risk Factor for Postengraftment Bloodstream Infection in Allogeneic Hematopoietic Stem Cell Transplant Recipients. Biol Blood Marrow Transplant. 2018;24(11):2302–2309. doi:10.1016/j.bbmt.2018.06.002
  • Poutsiaka DD, Price LL, Ucuzian A, Chan GW, Miller KB, Snydman DR. Blood stream infection after hematopoietic stem cell transplantation is associated with increased mortality. Bone Marrow Transplant. 2007;40(1):63–70. doi:10.1038/sj.bmt.1705690
  • Mikulska M, Viscoli C, Orasch C, et al. Aetiology and resistance in bacteraemias among adult and paediatric haematology and cancer patients. J Infect. 2014;68(4):321–331. doi:10.1016/j.jinf.2013.12.006
  • Freifeld AG, Bow EJ, Sepkowitz KA, et al. Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2011;52(4):427–431. doi:10.1093/cid/ciq147
  • Magiorakos AP, Srinivasan A, Carey RB, et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol and Infect. 2012;18(3):268–281. doi:10.1111/j.1469-0691.2011.03570.x
  • Lee SJ, Klein JP, Barrett AJ, et al. Severity of chronic graft-versus-host disease: association with treatment-related mortality and relapse. Blood. 2002;100(2):406–414. doi:10.1182/blood.v100.2.406
  • Przepiorka D, Weisdorf D, Martin P, et al. 1994 Consensus Conference on Acute GVHD Grading. Bone Marrow Transplant. 1995;15(6):825–828.
  • Woods GL, Brown-Elliott BA, Conville PS, et al. Susceptibility Testing of Mycobacteria, Nocardiae, and Other Aerobic Actinomycetes. 2nd: Wayne (PA): Clinical and Laboratory Standards Institute; 2011.
  • Han TT, Huang XJ, Liu KY, et al. Blood stream infections during agranulocytosis period after hematopoietic stem cell transplantation in one single center. Zhonghua Nei Ke Za Zhi. 2011;50(8):654–658.
  • Weisser M, Theilacker C, Tschudin Sutter S, et al. Secular trends of bloodstream infections during neutropenia in 15 181 haematopoietic stem cell transplants: 13-year results from a European multicentre surveillance study (ONKO-KISS). Clin Microbiol Infect. 2017;23(11):854–859. doi:10.1016/j.cmi.2017.03.020
  • Puerta-Alcalde P, Cardozo C, Marco F, et al. Changing epidemiology of bloodstream infection in a 25-years hematopoietic stem cell transplant program: current challenges and pitfalls on empiric antibiotic treatment impacting outcomes. Bone Marrow Transplant. 2020;55(3):603–612. doi:10.1038/s41409-019-0701-3
  • Cao W, Guan L, Li X, et al. Clinical Analysis of Bloodstream Infections During Agranulocytosis After Allogeneic Hematopoietic Stem Cell Transplantation. Infect Drug Resist. 2021;14:185–192. doi:10.2147/IDR.S280869
  • Gill J, Busca A, Cinatti N, et al. Bacterial Bloodstream Infections after Allogeneic Hematopoietic Stem Cell Transplantation: etiology, Risk Factors and Outcome in a Single-Center Study. Microorganisms. 2023;11(3):742. doi:10.3390/microorganisms11030742
  • Amanati A, Sajedianfard S, Khajeh S, et al. Bloodstream infections in adult patients with malignancy, epidemiology, microbiology, and risk factors associated with mortality and multi-drug resistance. BMC Infect Dis. 2021;21(1):636. doi:10.1186/s12879-021-06243-z
  • Rodríguez-Baño J, Gutiérrez-Gutiérrez B, Machuca I, Pascual A. Treatment of Infections Caused by Extended-Spectrum-Beta-Lactamase-, AmpC-, and Carbapenemase-Producing Enterobacteriaceae. Clin Microbiol Rev. 2018;31(2):e00079–17. doi:10.1128/CMR.00079-17
  • Taur Y, Xavier JB, Lipuma L, et al. Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantation. Clin Infect Dis. 2012;55(7):905–914. doi:10.1093/cid/cis580
  • Retamar P, Portillo MM, López-Prieto MD, et al. Impact of inadequate empirical therapy on the mortality of patients with bloodstream infections: a propensity score-based analysis. Antimicrob Agents Chemother. 2012;56(1):472–478. doi:10.1128/AAC.00462-11
  • Stoma I, Karpov I, Milanovich N, Uss A, Iskrov I. Risk factors for mortality in patients with bloodstream infections during the pre-engraftment period after hematopoietic stem cell transplantation. Blood Res. 2016;51(2):102–106. doi:10.5045/br.2016.51.2.102
  • Martinez-Nadal G, Puerta-Alcalde P, Gudiol C, et al. Inappropriate Empirical Antibiotic Treatment in High-risk Neutropenic Patients With Bacteremia in the Era of Multidrug Resistance. Clin Infect Dis. 2020;70(6):1068–1074. doi:10.1093/cid/ciz319
  • Chinese Society of Hematology, Chinese Medical Association; Chinese Medical Doctor Association, Hematology Branch. Chinese guidelines for the clinical application of antibacterial drugs for agranulocytosis with fever. Zhonghua Xue Ye Xue Za Zhi. 2020;41(12):969–978.
  • Labarca JA, Leber AL, Kern VL, et al. Outbreak of Stenotrophomonas maltophilia bacteremia in allogenic bone marrow transplant patients: role of severe neutropenia and mucositis. Clin Infect Dis. 2000;30(1):195–197. doi:10.1086/313591
  • Herbers AH, de Haan AF, van der Velden WJ, Donnelly JP, Blijlevens NM. Mucositis not neutropenia determines bacteremia among hematopoietic stem cell transplant recipients. Transpl Infect Dis. 2014;16(2):279–285. doi:10.1111/tid.12195
  • Gudiol C, Garcia-Vidal C, Arnan M, et al. Etiology, clinical features and outcomes of pre-engraftment and post-engraftment bloodstream infection in hematopoietic SCT recipients. Bone Marrow Transplant. 2014;49(6):824–830. doi:10.1038/bmt.2014.37
  • Girmenia C, Bertaina A, Piciocchi A, et al. Incidence, Risk Factors and Outcome of Pre-engraftment Gram-Negative Bacteremia After Allogeneic and Autologous Hematopoietic Stem Cell Transplantation: an Italian Prospective Multicenter Survey. Clin Infect Dis. 2017;65(11):1884–1896. doi:10.1093/cid/cix690
  • Ren J, Lin Q, Chen W, et al. G-CSF-primed haplo-identical HSCT with intensive immunosuppressive and myelosuppressive treatments does not increase the risk of pre-engraftment bloodstream infection: a multicenter case–control study. Eur J Clin Microbiol Infect Dis. 2019;38(5):865–876. doi:10.1007/s10096-019-03482-6
  • Youssef A, Hafez H, Madney Y, et al. Incidence, risk factors, and outcome of blood stream infections during the first 100 days post-pediatric allogeneic and autologous hematopoietic stem cell transplantations. Pediatr Transplant. 2020;24(1):e13610. doi:10.1111/petr.13610
  • Girmenia C, Rossolini GM, Piciocchi A, et al. Infections by carbapenem-resistant Klebsiella pneumoniae in SCT recipients: a nationwide retrospective survey from Italy. Bone Marrow Transplant. 2015;50(2):282–288. doi:10.1038/bmt.2014.231
  • Tomblyn M, Chiller T, Einsele H, et al. Guidelines for preventing infectious complications among hematopoietic cell transplantation recipients: a global perspective. Biol Blood Marrow Transplant. 2009;15(10):1143–1238. doi:10.1016/j.bbmt.2009.06.019
  • Averbuch D, Orasch C, Cordonnier C, et al. European guidelines for empirical antibacterial therapy for febrile neutropenic patients in the era of growing resistance: summary of the 2011 4th European Conference on Infections in Leukemia. Haematologica. 2013;98(12):1826–1835. doi:10.3324/haematol.2013.091025
  • Girmenia C, Viscoli C, Piciocchi A, et al. Management of carbapenem resistant Klebsiella pneumoniae infections in stem cell transplant recipients: an Italian multidisciplinary consensus statement. Haematologica. 2015;100(9):e373–e376. doi:10.3324/haematol.2015.125484
  • Satlin MJ, Walsh TJ. Multidrug-resistant Enterobacteriaceae, Pseudomonas aeruginosa, and vancomycin-resistant Enterococcus: three major threats to hematopoietic stem cell transplant recipients. Transpl Infect Dis. 2017;19(6). doi:10.1111/tid.12762
  • Shono Y, van den Brink MRM. Gut microbiota injury in allogeneic haematopoietic stem cell transplantation. Nat Rev Cancer. 2018;18(5):283–295. doi:10.1038/nrc.2018.10
  • Eriguchi Y, Takashima S, Oka H, et al. Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of α-defensins. Blood. 2012;120(1):223–231. doi:10.1182/blood-2011-12-401166
  • Levinson A, Pinkney K, Jin Z, et al. Acute gastrointestinal graft-vs-host disease is associated with increased enteric bacterial bloodstream infection density in pediatric allogeneic hematopoietic cell transplant recipients. Clin Infect Dis. 2015;61(3):350–357. doi:10.1093/cid/civ285
  • Satwani P, Freedman JL, Chaudhury S, et al. A Multicenter Study of Bacterial Blood Stream Infections in Pediatric Allogeneic Hematopoietic Cell Transplantation Recipients: the Role of Acute Gastrointestinal Graft-versus-Host Disease. Biol Blood Marrow Transplant. 2017;23(4):642–647. doi:10.1016/j.bbmt.2017.01.073
  • Petersen J, Lindner C, Hakki M. Incidence and Outcomes of Bacterial Bloodstream Infections during Acute Graft-versus-Host Disease Involving the Gastrointestinal Tract after Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant. 2019;25(8):1648–1653. doi:10.1016/j.bbmt.2019.04.016
  • Modi A, Rybicki L, Majhail NS, Mossad SB. Severity of acute gastrointestinal graft-vs-host disease is associated with incidence of bloodstream infection after adult allogeneic hematopoietic stem cell transplantation. Transpl Infect Dis. 2020;22(1):e13217. doi:10.1111/tid.13217
  • Inoue Y, Okinaka K, Fuji S, et al. Severe acute graft-versus-host disease increases the incidence of blood stream infection and mortality after allogeneic hematopoietic cell transplantation: Japanese transplant registry study. Bone Marrow Transplant. 2021;56(9):2125–2136. doi:10.1038/s41409-021-01291-0
  • Poutsiaka DD, Munson D, Price LL, Chan GW, Snydman DR. Blood stream infection (BSI) and acute GVHD after hematopoietic SCT (HSCT) are associated. Bone Marrow Transplant. 2011;46(2):300–307. doi:10.1038/bmt.2010.112
  • Blennow O, Mattsson J, Remberger M. Pre-engraftment blood stream infection is a risk factor for acute GVHD grades II–IV. Bone Marrow Transplant. 2013;48(12):1583–1584. doi:10.1038/bmt.2013.103
  • Mikulska M, Averbuch D, Tissot F, et al. Fluoroquinolone prophylaxis in haematological cancer patients with neutropenia: ECIL critical appraisal of previous guidelines. J Infect. 2018;76(1):20–37. doi:10.1016/j.jinf.2017.10.009
  • Mikulska M, Del Bono V, Raiola AM, et al. Blood stream infections in allogeneic hematopoietic stem cell transplant recipients: reemergence of Gram-negative rods and increasing antibiotic resistance. Biol Blood Marrow Transplant. 2009;15(1):47–53. doi:10.1016/j.bbmt.2008.10.024