Inhibiting Peptidoglycan Hydrolase Alleviates MRSA Pneumonia Through Autolysin-Mediated MDP-NOD2 Pathway

References

• Tasneem U, Mehmood K, Majid M, et al Methicillin resistant staphylococcus aureus: a brief review of virulence and resistance. J Pak Med Assoc. 2022;72(3):509–515. doi:10.47391/JPMA.0504
   PubMed Web of Science ®Google Scholar
• Lakhundi S, Zhang K. Methicillin-resistant staphylococcus aureus: molecular characterization, evolution, and epidemiology. Clin Microbiol Revs. 2018;31(4):e00020–18. doi:10.1128/CMR.00020-18
   PubMed Web of Science ®Google Scholar
• Rehman S. A parallel and silent emerging pandemic: antimicrobial resistance (AMR) amid COVID-19 pandemic. J Infect Public Health. 2023;16(4):611–617. doi:10.1016/j.jiph.2023.02.021
   PubMed Web of Science ®Google Scholar
• Alkharsah KR, Rehman S, Alkhamis F, et al Comparative and molecular analysis of MRSA isolates from infection sites and carrier colonization sites. Ann Clin Microbiol Antimicrob. 2018;17(1):7. doi:10.1186/s12941-018-0260-2
   PubMedGoogle Scholar
• Güven Gökmen T, Kalayci Y, Yaman A, et al Molecular characterization of methicillin-resistant Staphylococcus aureus strains by spa typing and pulsed field gel electrophoresis methods. BMC Microbiol. 2018;18(1):155. doi:10.1186/s12866-018-1305-6
   PubMedGoogle Scholar
• Vollmer W, Blanot D, de Pedro MA. Peptidoglycan structure and architecture. FEMS Microbiol Rev. 2008;32(2):149–167. doi:10.1111/j.1574-6976.2007.00094.x
   PubMed Web of Science ®Google Scholar
• Sutton JAF, Carnell OT, Lafage L, et al Staphylococcus aureus cell wall structure and dynamics during host-pathogen interaction. PLoS Pathog. 2021;17(3):e1009468. doi:10.1371/journal.ppat.1009468
   PubMed Web of Science ®Google Scholar
• Apostolos AJ, Pidgeon SE, Pires MM. Remodeling of cross-bridges controls peptidoglycan cross-linking levels in bacterial cell walls. Chem Biol. 2020;15(5):1261–1267. doi:10.1021/acschembio.0c00002
   Google Scholar
• Pazos M, Peters K. Peptidoglycan. Subcell Biochem. 2019;92:127–168. doi:10.1007/978-3-030-18768-2_5
   PubMedGoogle Scholar
• Shaku M, Ealand C, Matlhabe O, et al Peptidoglycan biosynthesis and remodeling revisited. Adv Appl Microbiol. 2020;112:67–103. doi:10.1016/bs.aambs.2020.04.001
   PubMed Web of Science ®Google Scholar
• Nagarajan R. Antibacterial activities and modes of action of vancomycin and related glycopeptides. Antimicrob Agents Chemother. 1991;35(4):605–609. doi:10.1128/AAC.35.4.605
   PubMed Web of Science ®Google Scholar
• Rodríguez-Tébar A, Vázquez D. Penicillin-binding proteins and peptidoglycan peptide-interacting proteins. Microbiol Sci. 1984;1(9):211–214.
   PubMedGoogle Scholar
• Wang M, Buist G, van Dijl JM. Staphylococcus aureus cell wall maintenance - The multifaceted roles of peptidoglycan hydrolases in bacterial growth, fitness, and virulence. FEMS. Microbiol Rev. 2022;46(5):fuac025. doi:10.1093/femsre/fuac025
   Google Scholar
• Rohs PDA, Bernhardt TG. Growth and division of the peptidoglycan matrix. Rev Microbiol. 2021;75:315–336. doi:10.1146/annurev-micro-020518-120056
   Google Scholar
• Dubrac S, Boneca IG, Poupel O, Msadek T. New insights into the WalK/WalR (YycG/YycF) essential signal transduction pathway reveal a major role in controlling cell wall metabolism and biofilm formation in Staphylococcus aureus. J Bacteriol. 2007;189(22):8257–8269. doi:10.1128/JB.00645-07
   PubMed Web of Science ®Google Scholar
• Buchad H, Nair M. The small RNA sprx regulates the autolysin regulator walr in Staphylococcus aureus. Microbiol Res. 2021;250:126785. doi:10.1016/j.micres.2021.126785
   PubMedGoogle Scholar
• Kathirvel M, Buchad H, Nair M. Enhancement of the pathogenicity of Staphylococcus aureus strain Newman by a small noncoding RNA sprx1. Med Microbiol Immunol. 2016;205(6):563–574. doi:10.1007/s00430-016-0467-9
   PubMed Web of Science ®Google Scholar
• Nega M, Tribelli PM, Hipp K, et al New insights in the coordinated amidase and glucosaminidase activity of the major autolysin (Atl) in Staphylococcus aureus. Commun Biol. 2020;3(1):695. doi:10.1038/s42003-020-01405-2
   PubMed Web of Science ®Google Scholar
• Bose JL, Lehman MK, Fey PD, Bayles KW. Contribution of the Staphylococcus Aureus Atl AM and GL murein hydrolase activities in cell division, autolysis, and biofilm formation. PLoS One. 2012;7(7):e42244. doi:10.1371/journal.pone.0042244
   PubMed Web of Science ®Google Scholar
• Houston P, Rowe SE, Pozzi C, et al Essential role for the major autolysin in the fibronectin-binding protein-mediated Staphylococcus aureus biofilm phenotype. Infect Immun. 2011;79(3):1153–1165. doi:10.1128/IAI.00364-10
   PubMed Web of Science ®Google Scholar
• Xie Y, Wang L, Yang Y, et al Antibacterial and anti-biofilm activity of diarylureas against Enterococcus faecium by suppressing the gene expression of peptidoglycan hydrolases and adherence. Front Microbiol. 2022;13:1071255. doi:10.3389/fmicb.2022.1071255
   PubMed Web of Science ®Google Scholar
• Brückner R. Gene replacement in Staphylococcus carnosus and Staphylococcus xylosus. FEMS Microbiol Lett. 1997;151(1):1–8. doi:10.1111/j.1574-6968.1997.tb10387.x
   PubMed Web of Science ®Google Scholar
• Biswas R, Voggu L, Simon UK, et al Activity of the major staphylococcal autolysin Atl. FEMS Microbiol Lett. 2006;259(2):260–268. doi:10.1111/j.1574-6968.2006.00281.x
   PubMed Web of Science ®Google Scholar
• Chen Q, Zhang Q, Cao P, et al NOD2-mediated HDAC6/NF-κb signalling pathway regulates ferroptosis induced by extracellular histone H3 in acute liver failure. J Cell Mol Med. 2022;26(21):5528–5538. doi:10.1111/jcmm.17582
   PubMed Web of Science ®Google Scholar
• Zhu QY, Tai S, Tang L, et al N-acetyl cysteine ameliorates aortic fibrosis by promoting M2 macrophage polarization in aging mice. Redox Rep. 2021;26(1):170–175. doi:10.1080/13510002.2021.1976568
   PubMed Web of Science ®Google Scholar
• Gao K, Su B, Dai J, et al Anti-Biofilm and Anti-Hemolysis Activities of 10-Hydroxy-2-decenoic Acid against Staphylococcus aureus. Molecules. 2022;27(5):1485. doi:10.3390/molecules27051485
   PubMed Web of Science ®Google Scholar
• Günther G, Herlax V, Lillo MP, et al Study of rabbit erythrocytes membrane solubilization by sucrose monomyristate using laurdan and phasor analysis. Colloids Surf B Biointerfaces. 2018;161:375–385. doi:10.1016/j.colsurfb.2017.10.068
   PubMed Web of Science ®Google Scholar
• Ouyang J, Sun F, Feng W, et al Antimicrobial activity of galangin and its effects on murein hydrolases of vancomycin-intermediate Staphylococcus aureus (VISA) strain mu50. Chemotherapy. 2018;63(1):20–28. doi:10.1159/000481658
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25(4):402–408. doi:10.1006/meth.2001.1262
   PubMed Web of Science ®Google Scholar
• Wang M, van den Berg S, Mora Hernández Y, et al Differential binding of human and murine IgGs to catalytic and cell wall binding domains of Staphylococcus aureus peptidoglycan hydrolases. Sci Rep. 2021;11(1):13865. doi:10.1038/s41598-021-93359-6
   PubMed Web of Science ®Google Scholar
• Salamaga B, Kong L, Pasquina-Lemonche L, et al Demonstration of the role of cell wall homeostasis in Staphylococcus aureus growth and the action of bactericidal antibiotics. Proc Natl Acad Sci U S A. 2021;118(44):e2106022118. doi:10.1073/pnas.2106022118
   PubMed Web of Science ®Google Scholar
• Liu G, Xiang H, Tang X, et al Transcriptional and functional analysis shows sodium houttuyfonate-mediated inhibition of autolysis in Staphylococcus aureus. Molecules. 2011;16(10):8848–8865. doi:10.3390/molecules16108848
   PubMed Web of Science ®Google Scholar
• Ledala N, Wilkinson BJ, Jayaswal RK. Effects of oxacillin and tetracycline on autolysis, autolysin processing and atl transcription in Staphylococcus aureus. Int J Antimicrob Agents. 2006;27(6):518–524. doi:10.1016/j.ijantimicag.2006.03.008
   PubMed Web of Science ®Google Scholar
• Antignac A, Sieradzki K, Tomasz A. Perturbation of cell wall synthesis suppresses autolysis in Staphylococcus aureus: evidence for coregulation of cell wall synthetic and hydrolytic enzymes. J Bacteriol. 2007;189(21):7573–7580. doi:10.1128/JB.01048-07
   PubMed Web of Science ®Google Scholar
• Tomasz A, Albino A, Zanati E. Multiple antibiotic resistance in a bacterium with suppressed autolytic system. Nature. 1970;227:5254):138–140. doi:10.1038/227138a0
   Web of Science ®Google Scholar
• Chan YG, Frankel MB, Missiakas D, et al SagB glucosaminidase is a determinant of staphylococcus aureus glycan chain length, antibiotic susceptibility, and protein secretion. J Bacteriol. 2016;198(7):1123–1136. doi:10.1128/JB.00983-15
   PubMed Web of Science ®Google Scholar
• Bersch KL, DeMeester KE, Zagani R, et al Bacterial peptidoglycan fragments differentially regulate innate immune signaling. ACS Cent Sci. 2021;7(4):688–696. doi:10.1021/acscentsci.1c00200
   PubMed Web of Science ®Google Scholar
• Brahma B, Patra MC, Mishra P, et al Computational studies on receptor-ligand interactions between novel buffalo (Bubalus bubalis) nucleotide-binding oligomerization domain-containing protein 2 (NOD2) variants and muramyl dipeptide (MDP). J Mol Graph Model. 2016;65:15–26. doi:10.1016/j.jmgm.2016.02.004
   PubMed Web of Science ®Google Scholar
• Gao J, Wang L, Jiang J, et al A probiotic bi-functional peptidoglycan hydrolase sheds NOD2 ligands to regulate gut homeostasis in female mice. Nat Commun. 2023;14(1):3338. doi:10.1038/s41467-023-38950-3
   PubMed Web of Science ®Google Scholar