Advanced search
Publication Cover
Journal of Inflammation Research Volume 16, 2023 - Issue
Submit an article Journal homepage
141
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

CHINAT-CD4 Score Predicts Transplant-Free Survival in Patients with Acute-on-Chronic Liver Failure

Chenlu Huang1 Department of Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0003-1752-1614View further author information
ORCID Icon,
Weixia Li2 Department of Infectious Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaView further author information
,
Chong Chen2 Department of Infectious Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaView further author information
,
Wei Xu1 Department of Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaView further author information
,
Ling Fei1 Department of Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaView further author information
,
Shuai Tao3 Research Unit, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaView further author information
,
Qiankun Hu1 Department of Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaView further author information
,
Xudong Xie1 Department of Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaView further author information
,
Xiongyue Cao1 Department of Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaView further author information
,
Xiao-Yu Zhang1 Department of Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of China;4 Section of Education, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-2041-9955View further author information
ORCID Icon,
Liang Chen1 Department of Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaView further author information
,
Qiang Li1 Department of Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0003-3831-9001View further author information
ORCID Icon &
Yuxian Huang1 Department of Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaCorrespondence[email protected] [email protected]
View further author information
 show all
Pages 197-207 | Received 25 Sep 2022, Accepted 06 Jan 2023, Published online: 13 Jan 2023

References

  • Sarin SK, Choudhury A, Sharma MK, et al. Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update. Hepatol Int. 2019;13(4):353–390. doi:10.1007/s12072-019-09946-3
  • Mezzano G, Juanola A, Cardenas A, et al. Global burden of disease: acute-on-chronic liver failure, a systematic review and meta-analysis. Gut. 2022;71(1):148–155. doi:10.1136/gutjnl-2020-322161
  • Li J, Liang X, Jiang J, et al. PBMC transcriptomics identifies immune-metabolism disorder during the development of HBV-ACLF. Gut. 2022;71(1):163–175. doi:10.1136/gutjnl-2020-323395
  • Ramzan M, Iqbal A, Murtaza HG, Javed N, Rasheed G, Bano K. Comparison of CLIF-C ACLF score and MELD score in predicting ICU mortality in patients with acute-on-chronic liver failure. Cureus. 2020;12(2):e7087. doi:10.7759/cureus.7087
  • Li N, Huang C, Yu KK, Lu Q, Shi GF, Zheng JM. Validation of prognostic scores to predict short-term mortality in patients with HBV-related acute-on-chronic liver failure: the CLIF-C OF is superior to MELD, CLIF SOFA, and CLIF-C ACLF. Medicine. 2017;96(17):e6802. doi:10.1097/MD.0000000000006802
  • Moreau R, Jalan R, Gines P, et al. Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis. Gastroenterology. 2013;144(7):1426–1437. doi:10.1053/j.gastro.2013.02.042
  • Jalan R, Saliba F, Pavesi M, et al. Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure. J Hepatol. 2014;61(5):1038–1047. doi:10.1016/j.jhep.2014.06.012
  • Wu T, Li J, Shao L, et al. Development of diagnostic criteria and a prognostic score for hepatitis B virus-related acute-on-chronic liver failure. Gut. 2018;67(12):2181–2191. doi:10.1136/gutjnl-2017-314641
  • Choudhury A, Jindal A, Maiwall R, et al. Liver failure determines the outcome in patients of acute-on-chronic liver failure (ACLF): comparison of APASL ACLF research consortium (AARC) and CLIF-SOFA models. Hepatol Int. 2017;11(5):461–471. doi:10.1007/s12072-017-9816-z
  • Chinese Society of Organ Transplantation C, Chinese Society of Hepatology CMA. The practice guideline on prophylaxis and treatment of hepatitis B for liver transplantation in China (2016 edition). Zhonghua Gan Zang Bing Za Zhi. 2016;24(12):885–891. doi:10.3760/cma.j.issn.1007-3418.2016.12.002
  • Tibshirani R. Regression shrinkage and selection via the lasso: a retrospective. J R Stat Soc Ser B. 2011;73:273–282. doi:10.1111/j.1467-9868.2011.00771.x
  • Camp RL, Dolled-Filhart M, Rimm DL. X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization. Clin Cancer Res. 2004;10(21):7252–7259. doi:10.1158/1078-0432.CCR-04-0713
  • Wasmuth HE, Kunz D, Yagmur E, et al. Patients with acute on chronic liver failure display “sepsis-like” immune paralysis. J Hepatol. 2005;42(2):195–201. doi:10.1016/j.jhep.2004.10.019
  • Antoniades CG, Wendon J, Vergani D. Paralysed monocytes in acute on chronic liver disease. J Hepatol. 2005;42(2):163–165. doi:10.1016/j.jhep.2004.12.005
  • Xing T, Li L, Cao H, Huang J. Altered immune function of monocytes in different stages of patients with acute on chronic liver failure. Clin Exp Immunol. 2007;147(1):184–188. doi:10.1111/j.1365-2249.2006.03259.x
  • Leber B, Mayrhauser U, Rybczynski M, Stadlbauer V. Innate immune dysfunction in acute and chronic liver disease. Wien Klin Wochenschr. 2009;121(23–24):732–744. doi:10.1007/s00508-009-1288-2
  • Liu Q. Role of cytokines in the pathophysiology of acute-on-chronic liver failure. Blood Purif. 2009;28(4):331–341. doi:10.1159/000232940
  • Zhang Z, Zou ZS, Fu JL, et al. Severe dendritic cell perturbation is actively involved in the pathogenesis of acute-on-chronic hepatitis B liver failure. J Hepatol. 2008;49(3):396–406. doi:10.1016/j.jhep.2008.05.017
  • Dong X, Gong Y, Zeng H, et al. Imbalance between circulating CD4+ regulatory T and conventional T lymphocytes in patients with HBV-related acute-on-chronic liver failure. Liver Int. 2013;33(10):1517–1526. doi:10.1111/liv.12248
  • Li Y, Kong Y, Shi K, et al. CD200R combined neutrophil-lymphocyte ratio predict 90-day mortality in HBV-related acute-on-chronic liver failure. Front Med. 2021;8:762296. doi:10.3389/fmed.2021.762296
  • Tan NH, Chen B, Peng J, Du S. Treg/Th17 cell balance in patients with hepatitis B virus-related acute-on-chronic liver failure at different disease stages. Biomed Res Int. 2021;2021:9140602. doi:10.1155/2021/9140602
  • Wang F, Sun W, Xiao Q, et al. Peripheral T lymphocytes predict the severity and prognosis in patients with HBV-related acute-on-chronic liver failure. Medicine. 2021;100(5):e24075. doi:10.1097/MD.0000000000024075
  • Zhai S, Zhang L, Dang S, et al. The ratio of Th-17 to Treg cells is associated with survival of patients with acute-on-chronic hepatitis B liver failure. Viral Immunol. 2011;24(4):303–310. doi:10.1089/vim.2010.0135
  • Du B, Teng J, Yin R, et al. Increased circulating T follicular helper cells induced via IL-12/21 in patients with acute on chronic hepatitis B liver failure. Front Immunol. 2021;12:641362. doi:10.3389/fimmu.2021.641362
  • Xu C, Lu Y, Zheng X, et al. TLR2 Expression IN PERIpheral CD4+ T cells promotes Th17 response and is associated with disease aggravation of hepatitis B virus-related acute-on-chronic liver failure. Front Immunol. 2020;11:1566. doi:10.3389/fimmu.2020.01566
  • Zhang JY, Zhang Z, Lin F, et al. Interleukin-17-producing CD4(+) T cells increase with severity of liver damage in patients with chronic hepatitis B. Hepatology. 2010;51(1):81–91. doi:10.1002/hep.23273

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.