Nucleotide‐Binding Oligomerization Domain (NOD)-Like Receptor Subfamily C (NLRC) as a Prognostic Biomarker for Glioblastoma Multiforme Linked to Tumor Microenvironment: A Bioinformatics, Immunohistochemistry, and Machine Learning-Based Study

References

• Zhao HF, Wang J, Shao W, et al. Recent advances in the use of PI3K inhibitors for glioblastoma multiforme: current preclinical and clinical development. Mol Cancer. 2017;16(1):100.
   PubMedGoogle Scholar
• Batash R, Asna N, Schaffer P, Francis N, Schaffer M. Glioblastoma multiforme, diagnosis and treatment; recent literature review. Curr Med Chem. 2017;24(27):3002–3009.
   PubMed Web of Science ®Google Scholar
• Muir M, Gopakumar S, Traylor J, Lee S, Rao G. Glioblastoma multiforme: novel therapeutic targets. Expert Opin Ther Targets. 2020;24(7):605–614.
   PubMed Web of Science ®Google Scholar
• Bianconi A, Aruta G, Rizzo F, et al. Systematic review on tumor microenvironment in glial neoplasm: from understanding pathogenesis to future therapeutic perspectives. Int J Mol Sci. 2022;23(8):54.
   Web of Science ®Google Scholar
• Saaid A, Monticelli M, Ricci AA, et al. Prognostic analysis of the IDH1 G105G (rs11554137) SNP in IDH-wildtype glioblastoma. Genes. 2022;13(8):25.
   Web of Science ®Google Scholar
• Velloso FJ, Trombetta-Lima M, Anschau V, Sogayar MC, Correa RG. NOD-like receptors: major players (and targets) in the interface between innate immunity and cancer. Biosci Rep. 2019;39(4):65.
   Google Scholar
• Kong X, Yuan Z, Cheng J. The function of NOD-like receptors in central nervous system diseases. J Neurosci Res. 2017;95(8):1565–1573.
   Web of Science ®Google Scholar
• Castaño-Rodríguez N, Kaakoush NO, Mitchell HM. Pattern-recognition receptors and gastric cancer. Front Immunol. 2014;5:336.
   PubMed Web of Science ®Google Scholar
• Kay C, Wang R, Kirkby M, Man SM. Molecular mechanisms activating the NAIP-NLRC4 inflammasome: implications in infectious disease, autoinflammation, and cancer. Immunol Rev. 2020;297(1):67–82.
   PubMed Web of Science ®Google Scholar
• Liu R, Truax AD, Chen L, et al. Expression profile of innate immune receptors, NLRs and AIM2, in human colorectal cancer: correlation with cancer stages and inflammasome components. Oncotarget. 2015;6(32):33456–33469.
   PubMedGoogle Scholar
• Hu B, Elinav E, Huber S, et al. Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4. Proc Natl Acad Sci U S A. 2010;107(50):21635–21640.
   PubMed Web of Science ®Google Scholar
• Velloso FJ, Sogayar MC, Correa RG. Expression and in vitro assessment of tumorigenicity for NOD1 and NOD2 receptors in breast cancer cell lines. BMC Res Notes. 2018;11(1):222.
   Google Scholar
• Velloso FJ, Campos AR, Sogayar MC, Correa RG. Proteome profiling of triple negative breast cancer cells overexpressing NOD1 and NOD2 receptors unveils molecular signatures of malignant cell proliferation. BMC Genom. 2019;20(1):152.
   Google Scholar
• Bindea G, Mlecnik B, Tosolini M, et al. Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity. 2013;39(4):782–795.
   PubMed Web of Science ®Google Scholar
• Zhang X, Justice AC, Hu Y, et al. Epigenome-wide differential DNA methylation between HIV-infected and uninfected individuals. Epigenetics. 2016;11(10):750–760.
   PubMed Web of Science ®Google Scholar
• Lim J, Kim MJ, Park Y, et al. Upregulation of the NLRC4 inflammasome contributes to poor prognosis in glioma patients. Sci Rep. 2019;9(1):7895.
   Google Scholar
• Zong Z, Song Y, Xue Y, et al. Knockdown of LncRNA SCAMP1 suppressed malignant biological behaviours of glioma cells via modulating miR-499a-5p/LMX1A/NLRC5 pathway. J Cell Mol Med. 2019;23(8):5048–5062.
   PubMed Web of Science ®Google Scholar
• Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646–674.
   PubMed Web of Science ®Google Scholar
• Kai F, Drain AP, Weaver VM. The extracellular matrix modulates the metastatic journey. Dev Cell. 2019;49(3):332–346.
   PubMed Web of Science ®Google Scholar
• Jiang HY, Najmeh S, Martel G, et al. Activation of the pattern recognition receptor NOD1 augments colon cancer metastasis. Protein Cell. 2020;11(3):187–201.
   Web of Science ®Google Scholar
• Bidou L, Bugaud O, Belakhov V, Baasov T, Namy O. Characterization of new-generation aminoglycoside promoting premature termination codon readthrough in cancer cells. RNA Biol. 2017;14(3):378–388.
   PubMed Web of Science ®Google Scholar
• Rashidi A, Miska J, Lee-Chang C, et al. GCN2 is essential for CD8(+) T cell survival and function in murine models of malignant glioma. Cancer Immunol Immunother. 2020;69(1):81–94.
   PubMed Web of Science ®Google Scholar
• Leprivier G, Remke M, Rotblat B, et al. The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation. Cell. 2013;153(5):1064–1079.
   PubMed Web of Science ®Google Scholar
• Mäkelä K, Helén P, Haapasalo H, Paavonen T. Complement activation in astrocytomas: deposition of C4d and patient outcome. BMC Cancer. 2012;12:565.
   Web of Science ®Google Scholar
• Petterson SA, Sørensen MD, Kristensen BW. Expression profiling of primary and recurrent glioblastomas reveals a reduced level of pentraxin 3 in recurrent glioblastomas. J Neuropathol Exp Neurol. 2020;79(9):975–985.
   Web of Science ®Google Scholar
• West AJ, Tsui V, Stylli SS, et al. The role of interleukin-6-STAT3 signalling in glioblastoma. Oncol Lett. 2018;16(4):4095–4104.
   Web of Science ®Google Scholar
• Ohno Y, Kitamura H, Takahashi N, et al. IL-6 down-regulates HLA class II expression and IL-12 production of human dendritic cells to impair activation of antigen-specific CD4(+) T cells. Cancer Immunol Immunother. 2016;65(2):193–204.
   PubMed Web of Science ®Google Scholar
• Yu S, Liu C, Su K, et al. Tumor exosomes inhibit differentiation of bone marrow dendritic cells. J Immunol. 2007;178(11):6867–6875.
   PubMed Web of Science ®Google Scholar
• Lamano JB, Lamano JB, Li YD, et al. Glioblastoma-derived IL6 induces immunosuppressive peripheral myeloid cell PD-L1 and promotes tumor growth. Clin Cancer Res. 2019;25(12):3643–3657.
   Web of Science ®Google Scholar
• Yang Y, Chu L, Zeng Z, et al. Four specific biomarkers associated with the progression of glioblastoma multiforme in older adults identified using weighted gene co-expression network analysis. Bioengineered. 2021;12(1):6643–6654.
   PubMed Web of Science ®Google Scholar
• Zhang B, Wu Q, Xu R, et al. The promising novel biomarkers and candidate small molecule drugs in lower-grade glioma: evidence from bioinformatics analysis of high-throughput data. J Cell Biochem. 2019;120(9):15106–15118.
   Web of Science ®Google Scholar
• D’Urso PI, D’Urso OF, Storelli C, et al. miR-155 is up-regulated in primary and secondary glioblastoma and promotes tumour growth by inhibiting GABA receptors. Int J Oncol. 2012;41(1):228–234.
   Web of Science ®Google Scholar
• Demaria O, Vivier E. Immuno-oncology beyond tils: unleashing TILCs. Cancer Cell. 2020;37(4):428–430.
   Web of Science ®Google Scholar
• Huang S, Song Z, Zhang T, et al. Identification of immune cell infiltration and immune-related genes in the tumor microenvironment of glioblastomas. Front Immunol. 2020;11:585034.
   Web of Science ®Google Scholar
• Xiong Y, Xiong Z, Cao H, Li C, Wanggou S, Li X. Multi-dimensional omics characterization in glioblastoma identifies the purity-associated pattern and prognostic gene signatures. Cancer Cell Int. 2020;20:37.
   Web of Science ®Google Scholar
• Schulze Heuling E, Knab F, Radke J, et al. Prognostic relevance of tumor purity and interaction with MGMT methylation in glioblastoma. Mol Cancer Res. 2017;15(5):532–540.
   Web of Science ®Google Scholar
• Wang H, Wu X, Chen Y. Stromal-immune score-based gene signature: a prognosis stratification tool in gastric cancer. Front Oncol. 2019;9:1212.
   PubMed Web of Science ®Google Scholar
• Lee K, Do T, Nguyen-Trinh T-D, Nguyen N, Hung T, Thi Thu Trang N. Identification of gene expression signatures for psoriasis classification using machine learning techniques. Med Omics. 2020;1:125.
   Google Scholar
• Ho Thanh Lam L, Le NH, Van Tuan L, et al. Machine learning model for identifying antioxidant proteins using features calculated from primary sequences. Biology. 2020;9(10):542.
   Google Scholar
• Vo TH, Nguyen NTK, Kha QH, Le NQK. On the road to explainable AI in drug-drug interactions prediction: a systematic review. Comput Struct Biotechnol J. 2022;20:2112–2123.
   Web of Science ®Google Scholar