Research Progress on Autophagy Regulation by Active Ingredients of Traditional Chinese Medicine in the Treatment of Acute Lung Injury

References

• Glick D, Barth S, Macleod KF. Autophagy: cellular and molecular mechanisms. J Pathol. 2010;221(1):3–12. doi:10.1002/path.2697
   PubMed Web of Science ®Google Scholar
• Maiuri MC, Zalckvar E, Kimchi A, Kroemer G. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol. 2007;8(9):741–752.
   PubMed Web of Science ®Google Scholar
• Force AD, Ranieri VM, Rubenfeld GD. Acute Respiratory Distress Syndrome: the Berlin Definition. JAMA. 2012;307(23).
   Google Scholar
• Matthay MA, Zemans RL, Zimmerman GA, et al. Acute respiratory distress syndrome. Nat Rev Dis Primers. 2019;5(1):18.
   PubMed Web of Science ®Google Scholar
• Rubinsztein DC, Codogno P, Levine B. Autophagy modulation as a potential therapeutic target for diverse diseases. Nat Rev Drug Discov. 2012;11(9):709–730.
   PubMed Web of Science ®Google Scholar
• Choi AMK, Ryter SW, Levine B. Autophagy in human health and disease. N Engl J Med. 2013;368(7):651–662.
   PubMed Web of Science ®Google Scholar
• Galluzzi L, Bravo-San Pedro JM, Levine B, Green DR, Kroemer G. Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat Rev Drug Discov. 2017;16(7):487–511.
   PubMed Web of Science ®Google Scholar
• Law BYK, Mok SWF, Wu AG, Lam CWK, Yu MXY, Wong VKW. New Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of Autophagy. Molecules. 2016;21(3):359.
   PubMed Web of Science ®Google Scholar
• Levine B, Mizushima N, Virgin HW. Autophagy in immunity and inflammation. Nature. 2011;469(7330):323–335.
   PubMed Web of Science ®Google Scholar
• Marzella L, Ahlberg J, Glaumann H. Autophagy, heterophagy, microautophagy and crinophagy as the means for intracellular degradation. Virchows Arch B Cell Pathol Incl Mol Pathol. 1981;36(1):219–234. doi:10.1007/BF02912068
   PubMedGoogle Scholar
• Orenstein SJ, Cuervo AM. Chaperone-mediated autophagy: molecular mechanisms and physiological relevance. Semin Cell Dev Biol. 2010;21(7):719–726.
   PubMed Web of Science ®Google Scholar
• Yang Z, Klionsky DJ. An Overview of the Molecular Mechanism of Autophagy. Curr Top Microbiol Immunol. 2009;335:1–32.
   PubMed Web of Science ®Google Scholar
• Rubinsztein DC, Gestwicki JE, Murphy LO, Klionsky DJ. Potential therapeutic applications of autophagy. Nat Rev Drug Discov. 2007;6(4):304–312.
   PubMed Web of Science ®Google Scholar
• Shintani T, Klionsky DJ. Autophagy in Health and Disease: a Double-Edged Sword. Science. 2004;306(5698):990–995.
   PubMed Web of Science ®Google Scholar
• Parzych KR, Klionsky DJ. An overview of autophagy: morphology, mechanism, and regulation. Antioxid Redox Signal. 2014;20(3):460–473.
   PubMed Web of Science ®Google Scholar
• Yang Z, Klionsky DJ. Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol. 2010;22(2):124–131.
   PubMed Web of Science ®Google Scholar
• Gwinn DM, Shackelford DB, Egan DF, et al. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell. 2008;30(2):214–226.
   PubMed Web of Science ®Google Scholar
• Inoki K, Li Y, Zhu T, Wu J, Guan KL. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol. 2002;4(9):648–657.
   PubMed Web of Science ®Google Scholar
• Ma L, Chen Z, Erdjument-Bromage H, Tempst P, Pandolfi PP. Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell. 2005;121(2):179–193.
   PubMed Web of Science ®Google Scholar
• Levine B, Abrams J. p53: the Janus of autophagy? Nat Cell Biol. 2008;10(6):637–639.
   PubMed Web of Science ®Google Scholar
• Pattingre S, Tassa A, Qu X, et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell. 2005;122(6):927–939.
   PubMed Web of Science ®Google Scholar
• Wei Y, Pattingre S, Sinha S, Bassik M, Levine B. JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell. 2008;30(6):678–688.
   PubMed Web of Science ®Google Scholar
• Zhou YY, Li Y, Jiang WQ, Zhou LF. MAPK/JNK signalling: a potential autophagy regulation pathway. Biosci Rep. 2015;35(3):e00199.
   PubMedGoogle Scholar
• Mariño G, Niso-Santano M, Baehrecke EH, Kroemer G. Self-consumption: the interplay of autophagy and apoptosis. Nat Rev Mol Cell Biol. 2014;15(2):81–94.
   PubMed Web of Science ®Google Scholar
• Matsunaga K, Saitoh T, Tabata K, et al. Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat Cell Biol. 2009;11(4):385–396.
   PubMed Web of Science ®Google Scholar
• Takahashi Y, Coppola D, Matsushita N, et al. Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat Cell Biol. 2007;9(10):1142–1151.
   PubMed Web of Science ®Google Scholar
• Liu H, Zhou K, Liao L, Zhang T, Yang M, Sun C. Lipoxin A4 receptor agonist BML-111 induces autophagy in alveolar macrophages and protects from acute lung injury by activating MAPK signaling. Respir Res. 2018;19(1):243.
   PubMedGoogle Scholar
• Thompson BT, Chambers RC, Liu KD. Acute Respiratory Distress Syndrome. Drazen JM. N Engl J Med. 2017;377(6):562–572.
   PubMed Web of Science ®Google Scholar
• Huppert LA, Matthay MA, Ware LB. Pathogenesis of Acute Respiratory Distress Syndrome. Semin Respir Crit Care Med. 2019;40(1):31–39.
   PubMed Web of Science ®Google Scholar
• Ma L, Li W, Jin F. Research progress of pathogenesis of acute lung injury and acute respiratory distress syndrome. Chine J Lung Dis. 2013;6(01):65–68.
   Google Scholar
• Donnelly SC, Haslett C. Cellular mechanisms of acute lung injury: implications for future treatment in the adult respiratory distress syndrome. Thorax. 1992;47(4):260–263.
   PubMedGoogle Scholar
• Park WY, Goodman RB, Steinberg KP, et al. Cytokine balance in the lungs of patients with acute respiratory distress syndrome. Am J Respir Crit Care Med. 2001;164(10 Pt 1):1896–1903.
   PubMed Web of Science ®Google Scholar
• Cadwell K. Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis. Nat Rev Immunol. 2016;16(11):661–675.
   PubMed Web of Science ®Google Scholar
• Randow F, Youle RJ. Self and nonself: how autophagy targets mitochondria and bacteria. Cell Host Microbe. 2014;15(4):403–411.
   PubMed Web of Science ®Google Scholar
• Martinez J, Malireddi RKS, Lu Q, et al. Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins. Nat Cell Biol. 2015;17(7):893–906.
   PubMed Web of Science ®Google Scholar
• Figueiredo N, Chora A, Raquel H, et al. Anthracyclines Induce DNA Damage Response-Mediated Protection against Severe Sepsis. Immunity. 2013;39(5):874–884.
   PubMedGoogle Scholar
• Dan HC, Cooper MJ, Cogswell PC, Duncan JA, Ting JPY, Baldwin AS. Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK. Genes Dev. 2008;22(11):1490–1500.
   PubMed Web of Science ®Google Scholar
• Jia X, Cao B, An Y, Zhang X, Wang C. Rapamycin ameliorates lipopolysaccharide-induced acute lung injury by inhibiting IL-1β and IL-18 production. Int Immunopharmacol. 2019;67:211–219.
   PubMed Web of Science ®Google Scholar
• Gao Y, Wang N, Li RH, Xiao YZ. The Role of Autophagy and the Chemokine (C-X-C Motif) Ligand 16 During Acute Lung Injury in Mice. Med Sci Monit. 2018;24:2404–2412.
   PubMedGoogle Scholar
• Takahama M, Akira S, Saitoh T. Autophagy limits activation of the inflammasomes. Immunol Rev. 2018;281(1):62–73.
   PubMed Web of Science ®Google Scholar
• Saitoh T, Akira S. Regulation of inflammasomes by autophagy. J Allergy Clin Immunol. 2016;138(1):28–36.
   PubMed Web of Science ®Google Scholar
• Nakahira K, Haspel JA, Rathinam VAK, et al. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol. 2011;12(3):222–230.
   PubMed Web of Science ®Google Scholar
• Byrne BG, Dubuisson JF, Joshi AD, Persson JJ, Swanson MS. Inflammasome Components Coordinate Autophagy and Pyroptosis as Macrophage Responses to Infection. mBio. 2013;4(1):e00620–12.
   PubMed Web of Science ®Google Scholar
• Liu Q, Wu J, Zhang X, et al. Circulating mitochondrial DNA-triggered autophagy dysfunction via STING underlies sepsis-related acute lung injury. Cell Death Dis. 2021;12(7):673.
   PubMedGoogle Scholar
• Kim I, Lemasters JJ. Mitophagy Selectively Degrades Individual Damaged Mitochondria After Photoirradiation. Antioxid Redox Signal. 2011;14(10):1919–1928.
   PubMed Web of Science ®Google Scholar
• Hou W, Han J, Lu C, Goldstein LA, Rabinowich H. Autophagic degradation of active caspase-8. Autophagy. 2010;6(7):891–900.
   PubMed Web of Science ®Google Scholar
• Sandilands E, Serrels B, Wilkinson S, Frame MC. Src-dependent autophagic degradation of Ret in FAK-signalling-defective cancer cells. EMBO Rep. 2012;13(8):733–740.
   PubMedGoogle Scholar
• Young MM, Takahashi Y, Khan O, et al. Autophagosomal Membrane Serves as Platform for Intracellular Death-inducing Signaling Complex (iDISC)-mediated Caspase-8 Activation and Apoptosis. J Biol Chem. 2012;287(15):12455–12468.
   PubMed Web of Science ®Google Scholar
• Ma X, Liu H, Foyil SR, et al. Impaired Autophagosome Clearance Contributes to Cardiomyocyte Death in Ischemia-Reperfusion Injury. Circulation. 2012;125(25):3170–3181.
   PubMed Web of Science ®Google Scholar
• Luo S, Rubinsztein DC. Apoptosis blocks Beclin 1-dependent autophagosome synthesis – an effect rescued by Bcl-xL. Cell Death Differ. 2010;17(2):268–277.
   PubMed Web of Science ®Google Scholar
• Oral O, Oz-Arslan D, Itah Z, et al. Cleavage of Atg3 protein by caspase-8 regulates autophagy during receptor-activated cell death. Apoptosis. 2012;17(8):810–820.
   PubMed Web of Science ®Google Scholar
• Hu R, Chen ZF, Yan J, et al. Complement C5a exacerbates acute lung injury induced through autophagy-mediated alveolar macrophage apoptosis. Cell Death Dis. 2014;5:e110.
   Google Scholar
• Tu GW, Ren YH, Shi Y, Ma GG, Hao GW, Luo Z. Correlation between alveolar macrophage subtypes and acute lung injury. Chine J Clin Med. 2017;24(03):470–475.
   Google Scholar
• Qiu P, Liu Y, Chen K, Dong Y, Liu S, Zhang J. Hydrogen-rich saline regulates the polarization and apoptosis of alveolar macrophages and attenuates lung injury via suppression of autophagy in septic rats. Ann Transl Med. 2021;9(12):974.
   PubMedGoogle Scholar
• Ruaro B, Salton F, Braga L, et al. The history and mystery of alveolar epithelial type ii cells: focus on their physiologic and pathologic role in lung. Int J Mol Sci. 2021;22:2566.
   PubMed Web of Science ®Google Scholar
• Yu Y, Li W, Ren L, et al. Inhibition of autophagy enhanced cobalt chloride-induced apoptosis in rat alveolar type II epithelial cells. Mol Med Rep. 2018;18(2):2124–2132.
   PubMedGoogle Scholar
• Li X, Wang L, Hao J, et al. The Role of Autophagy in Lamellar Body Formation and Surfactant Production in Type 2 Alveolar Epithelial Cells. Int J Biol Sci. 2022;18(3):1107–1119.
   PubMedGoogle Scholar
• Li J, Zhou J, Zhang D, Song Y, She J, Bai C. Bone marrow-derived mesenchymal stem cells enhance autophagy via PI3K/AKT signalling to reduce the severity of ischaemia/reperfusion-induced lung injury. J Cell Mol Med. 2015;19(10):2341–2351.
   PubMed Web of Science ®Google Scholar
• Sies H, Cadenas E. Oxidative stress: damage to intact cells and organs. Philos Trans R Soc Lond B Biol Sci. 1985;311(1152):617–631.
   PubMed Web of Science ®Google Scholar
• Holmström KM, Finkel T. Cellular mechanisms and physiological consequences of redox-dependent signalling. Nat Rev Mol Cell Biol. 2014;15(6):411–421.
   PubMed Web of Science ®Google Scholar
• Kobayashi A, Kang MI, Watai Y, et al. Oxidative and Electrophilic Stresses Activate Nrf2 through Inhibition of Ubiquitination Activity of Keap1. Mol Cell Biol. 2006;26(1):221–229.
   PubMed Web of Science ®Google Scholar
• Suzuki T, Yamamoto M. Stress-sensing mechanisms and the physiological roles of the Keap1–Nrf2 system during cellular stress. J Biol Chem. 2017;292(41):16817–16824.
   PubMed Web of Science ®Google Scholar
• Jain A, Lamark T, Sjøttem E, et al. p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription. J Biol Chem. 2010;285(29):22576–22591.
   PubMed Web of Science ®Google Scholar
• Georgakopoulos ND, Frison M, Alvarez MS, Bertrand H, Wells G, Campanella M. Reversible Keap1 inhibitors are preferential pharmacological tools to modulate cellular mitophagy. Sci Rep. 2017;7:10303.
   PubMedGoogle Scholar
• Zhang S, Yang G, Guan W, Li B, Feng X, Fan H. Autophagy Plays a Protective Role in Sodium Hydrosulfide-Induced Acute Lung Injury by Attenuating Oxidative Stress and Inflammation in Rats. Chem Res Toxicol. 2021;34(3):857–864.
   PubMedGoogle Scholar
• Kolaczkowska E, Kubes P. Neutrophil recruitment and function in health and inflammation. Nat Rev Immunol. 2013;13(3):159–175.
   PubMed Web of Science ®Google Scholar
• Zemans RL, Colgan SP, Downey GP. Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury. Am J Respir Cell Mol Biol. 2009;40(5):519–535.
   PubMed Web of Science ®Google Scholar
• Matthay MA, Zemans RL. The Acute Respiratory Distress Syndrome: pathogenesis and Treatment. Annu Rev Pathol. 2011;6:147–163.
   PubMed Web of Science ®Google Scholar
• Verhoeven J, Baelen J, Agrawal M, Agostinis P. Endothelial cell autophagy in homeostasis and cancer. FEBS Lett. 2021;595(11):1497–1511.
   PubMedGoogle Scholar
• Reglero-Real N, Pérez-Gutiérrez L, Yoshimura A, et al. Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation. Immunity. 2021;54(9):1989–2004.e9.
   PubMed Web of Science ®Google Scholar
• Dong W, He B, Qian H, et al. RAB26-dependent autophagy protects adherens junctional integrity in acute lung injury. Autophagy. 2018;14(10):1677–1692.
   PubMed Web of Science ®Google Scholar
• Flemming S, Burkard N, Renschler M, et al. Soluble VE-cadherin is involved in endothelial barrier breakdown in systemic inflammation and sepsis. Cardiovasc Res. 2015;107(1):32–44.
   PubMed Web of Science ®Google Scholar
• Taddei A, Giampietro C, Conti A, et al. Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5. Nat Cell Biol. 2008;10(8):923–934.
   PubMed Web of Science ®Google Scholar
• Simons M, Gordon E, Claesson-Welsh L. Mechanisms and regulation of endothelial VEGF receptor signalling. Nat Rev Mol Cell Biol. 2016;17(10):611–625.
   PubMed Web of Science ®Google Scholar
• Slavin SA, Leonard A, Grose V, Fazal F, Rahman A. Autophagy inhibitor 3-methyladenine protects against endothelial cell barrier dysfunction in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2018;314(3):L388–L396.
   PubMedGoogle Scholar
• Wang NF, Bai CX. Bone marrow-derived mesenchymal stem cells modulate autophagy in RAW264.7 macrophages via the phosphoinositide 3-kinase/protein kinase B/heme oxygenase-1 signaling pathway under oxygen-glucose deprivation/restoration conditions. Chin Med J. 2021;134(6):699–707.
   PubMedGoogle Scholar
• Sui H, Luo M, Miao Y, et al. Cystic fibrosis transmembrane conductance regulator ameliorates lipopolysaccharide-induced acute lung injury by inhibiting autophagy through PI3K/AKT/mTOR pathway in mice. Respir Physiol Neurobiol. 2020;273:103338.
   PubMed Web of Science ®Google Scholar
• Xu X, Li H, Gong Y, Zheng H, Zhao D. Hydrogen sulfide ameliorated lipopolysaccharide-induced acute lung injury by inhibiting autophagy through PI3K/Akt/mTOR pathway in mice. Biochem Biophys Res Commun. 2018;507(1–4):514–518.
   PubMedGoogle Scholar
• Luk T, Malam Z, Marshall JC. Pre-B cell colony-enhancing factor (PBEF)/visfatin: a novel mediator of innate immunity. J Leukoc Biol. 2008;83(4):804–816.
   PubMed Web of Science ®Google Scholar
• Pittelli M, Formentini L, Faraco G, et al. Inhibition of Nicotinamide Phosphoribosyltransferase. J Biol Chem. 2010;285(44):34106–34114.
   PubMedGoogle Scholar
• Zheng Q, Wang YC, Liu QX, et al. FK866 attenuates sepsis-induced acute lung injury through c-jun-N-terminal kinase (JNK)-dependent autophagy. Life Sci. 2020;250:117551.
   PubMed Web of Science ®Google Scholar
• Li B, Zhou P, Xu K, et al. Metformin induces cell cycle arrest, apoptosis and autophagy through ROS/JNK signaling pathway in human osteosarcoma. Int J Biol Sci. 2020;16(1):74–84.
   PubMed Web of Science ®Google Scholar
• Wu Q, Wu W, Fu B, Shi L, Wang X, Kuca K. JNK signaling in cancer cell survival. Med Res Rev. 2019;39(6):2082–2104.
   PubMed Web of Science ®Google Scholar
• Xu X, Zhi T, Chao H, et al. ERK1/2/mTOR/Stat3 pathway-mediated autophagy alleviates traumatic brain injury-induced acute lung injury. Biochim Biophys Acta Mol Basis Dis. 2018;1864(5 Pt A):1663–1674.
   PubMedGoogle Scholar
• Wang Y, Zhang J, Bo J, Wang X, Zhu J. Hydrogen-rich saline ameliorated LPS-induced acute lung injury via autophagy inhibition through the ROS/AMPK/mTOR pathway in mice. Exp Biol Med (Maywood). 2019;244(9):721–727.
   PubMedGoogle Scholar
• Yoshii SR, Mizushima N. Autophagy machinery in the context of mammalian mitophagy. Biochim Biophys Acta. 2015;1853(10 Pt B):2797–2801.
   PubMed Web of Science ®Google Scholar
• Narendra D, Tanaka A, Suen DF, Youle RJ. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol. 2008;183(5):795–803.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Chen Z, Liu R, et al. Bcl-2 Proteins Regulate Mitophagy in Lipopolysaccharide-Induced Acute Lung Injury via PINK1/Parkin Signaling Pathway. Oxid Med Cell Longev. 2020;2020:6579696.
   PubMedGoogle Scholar
• Qu L, Chen C, He W, et al. Glycyrrhizic acid ameliorates LPS-induced acute lung injury by regulating autophagy through the PI3K/AKT/mTOR pathway. Am J Transl Res. 2019;11(4):2042–2055.
   PubMedGoogle Scholar
• Liu B, Zhao H, Wang Y, Zhang H, Ma Y. Astragaloside IV attenuates lipopolysaccharides-induced pulmonary epithelial cell injury through inhibiting autophagy. Pharmacology. 2020;105(1–2):90–101.
   PubMedGoogle Scholar
• Mancuso C, Santangelo R. Panax ginseng and Panax quinquefolius: from pharmacology to toxicology. Food Chem Toxicol. 2017;107:362–372.
   PubMed Web of Science ®Google Scholar
• Ji Q, Sun Z, Yang Z, et al. Protective effect of ginsenoside Rg1 on LPS-induced apoptosis of lung epithelial cells. Mol Immunol. 2021;136:168–174.
   PubMedGoogle Scholar
• Hsieh YH, Deng JS, Chang YS, Huang GJ. Ginsenoside Rh2 Ameliorates Lipopolysaccharide-Induced Acute Lung Injury by Regulating the TLR4/PI3K/Akt/mTOR, Raf-1/MEK/ERK, and Keap1/Nrf2/HO-1 Signaling Pathways in Mice. Nutrients. 2018;10(9):E1208.
   PubMed Web of Science ®Google Scholar
• Yang J, Li S, Wang L, et al. Ginsenoside Rg3 Attenuates Lipopolysaccharide-Induced Acute Lung Injury via MerTK-Dependent Activation of the PI3K/AKT/mTOR Pathway. Front Pharmacol. 2018;9:850.
   PubMedGoogle Scholar
• Wang W, Yang X, Chen Q, et al. Sinomenine attenuates septic-associated lung injury through the Nrf2-Keap1 and autophagy. J Pharm Pharmacol. 2020;72(2):259–270.
   PubMed Web of Science ®Google Scholar
• Shi Y, Xie DX, Liu W, Li L, Lin TT. Curcumin inhibiting inflammation in lung tissue via enhancing autophagy level after acute lung injury in rats. Modern Prevent Med. 2021;48(06):1089–1093.
   Google Scholar
• Dong Y, Zhang L, Jiang Y, Dai J, Tang L, Liu G. Emodin reactivated autophagy and alleviated inflammatory lung injury in mice with lethal endotoxemia. Exp Anim. 2019;68(4):559–568.
   PubMedGoogle Scholar
• Wen H, Zhang H, Wang W, Li Y. Tetrahydropalmatine protects against acute lung injury induced by limb ischemia/reperfusion through restoring PI3K/AKT/mTOR-mediated autophagy in rats. Pulm Pharmacol Ther. 2020;64:101947.
   PubMedGoogle Scholar
• Yin X, Li W, Zhang J, et al. AMPK-Mediated Metabolic Switching Is High Effective for Phytochemical Levo-Tetrahydropalmatine (l-THP) to Reduce Hepatocellular Carcinoma Tumor Growth. Metabolites. 2021;11(12):811.
   PubMedGoogle Scholar
• Haftcheshmeh SM, Abedi M, Mashayekhi K, et al. Berberine as a natural modulator of inflammatory signaling pathways in the immune system: focus on NF-κB, JAK / STAT, and MAPK signaling pathways. Phytother Res. 2022;36(3):1216–1230. doi:10.1002/ptr.7407
   PubMedGoogle Scholar
• Li C-L, Tan L-H, Wang Y-F, et al. Comparison of anti-inflammatory effects of berberine, and its natural oxidative and reduced derivatives from Rhizoma Coptidis in vitro and in vivo. Phytomedicine. 2019;52:272–283. doi:10.1016/j.phymed.2018.09.228
   PubMed Web of Science ®Google Scholar
• Zhao R, Wang B, Wang D, Wu B, Ji P, Tan D. Oxyberberine Prevented Lipopolysaccharide-Induced Acute Lung Injury through Inhibition of Mitophagy. Oxid Med Cell Longev. 2021;2021:e6675264.
   PubMedGoogle Scholar
• Lan X, Zhao J, Zhang Y, Chen Y, Liu Y, Xu F. Oxymatrine exerts organ- and tissue-protective effects by regulating inflammation, oxidative stress, apoptosis, and fibrosis: from bench to bedside. Pharmacol Res. 2020;151:104541.
   PubMed Web of Science ®Google Scholar
• Xiong Z, Xu J, Liu X. Oxymatrine exerts a protective effect in myocardial ischemia/reperfusion‑induced acute lung injury by inhibiting autophagy in diabetic rats. Mol Med Rep. 2021;23(3):183.
   PubMedGoogle Scholar
• Bertelli M, Kiani AK, Paolacci S, et al. Hydroxytyrosol: a natural compound with promising pharmacological activities. J Biotechnol. 2020;309:29–33.
   PubMed Web of Science ®Google Scholar
• Yang X, Jing T, Li Y, et al. Hydroxytyrosol Attenuates LPS-Induced Acute Lung Injury in Mice by Regulating Autophagy and Sirtuin Expression. Curr Mol Med. 2017;17(2):149–159.
   PubMedGoogle Scholar
• Breuss JM, Atanasov AG, Uhrin P. Resveratrol and Its Effects on the Vascular System. Int J Mol Sci. 2019;20(7):E1523.
   PubMed Web of Science ®Google Scholar
• Chao H, Lin C, Zuo Q, et al. Cardiolipin-Dependent Mitophagy Guides Outcome after Traumatic Brain Injury. J Neurosci. 2019;39(10):1930–1943. doi:10.1523/JNEUROSCI.3415-17.2018
   PubMed Web of Science ®Google Scholar
• Chu CT, Ji J, Dagda RK, et al. Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells. Nat Cell Biol. 2013;15(10):1197–1205.
   PubMed Web of Science ®Google Scholar
• Wang C, Yuan J, Du J. Resveratrol alleviates acute lung injury through regulating PLSCR-3-mediated mitochondrial dysfunction and mitophagy in a cecal ligation and puncture model. Eur J Pharmacol. 2021;913:174643.
   PubMedGoogle Scholar
• Wang Q, Li Y, Li KW, Zhou CZ. Sophoridine: a review of its pharmacology, pharmacokinetics and toxicity. Phytomedicine. 2022;95:153756.
   PubMedGoogle Scholar
• Liang J, Liu J, Tang Y, et al. Sophoridine inhibits endotoxin-induced acute lung injury by enhancing autophagy of macrophage and reducing inflammation. J Leukoc Biol. 2022;112(1):115–125.
   PubMedGoogle Scholar
• Yuan A, Zeng J, Zhou H, et al. Anti-type I allergic effects of Jing-Fang powder extracts via PI3K/Akt pathway in vitro and in vivo. Mol Immunol. 2021;135:408–420.
   PubMedGoogle Scholar
• Rao Z, Cao H, Shi B, Liu X, Luo J, Zeng N. Inhibitory Effect of Jing-Fang Powder n-Butanol Extract and Its Isolated Fraction D on Lipopolysaccharide-Induced Inflammation in RAW264.7 Cells. J Pharmacol Exp Ther. 2019;370(1):62–71.
   PubMedGoogle Scholar
• Rao Z, Zeng J, Li X, et al. JFNE-A isolated from Jing-Fang n-butanol extract attenuates lipopolysaccharide-induced acute lung injury by inhibiting oxidative stress and the NF-κB signaling pathway via promotion of autophagy. Phytomedicine. 2022;96:153891.
   PubMedGoogle Scholar
• Sarfraz A, Rasul A, Sarfraz I, et al. Hispolon: a natural polyphenol and emerging cancer killer by multiple cellular signaling pathways. Environ Res. 2020;190:110017.
   PubMedGoogle Scholar
• Huang CY, Deng JS, Huang WC, Jiang WP, Huang GJ. Attenuation of Lipopolysaccharide-Induced Acute Lung Injury by Hispolon in Mice, Through Regulating the TLR4/PI3K/Akt/mTOR and Keap1/Nrf2/HO-1 Pathways, and Suppressing Oxidative Stress-Mediated ER Stress-Induced Apoptosis and Autophagy. Nutrients. 2020;12(6):1742.
   PubMed Web of Science ®Google Scholar
• Li FJ, Hu JH, Ren X, Zhou CM, Liu Q, Zhang YQ. Toad venom: a comprehensive review of chemical constituents, anticancer activities, and mechanisms. Arch Pharm. 2021;354(7):e2100060.
   PubMed Web of Science ®Google Scholar
• Wang C, Mei X, Wu Y, Yang Y, Zeng Z. Cinobufagin alleviates lipopolysaccharide-induced acute lung injury by regulating autophagy through activation of the p53/mTOR pathway. Front Pharmacol. 2022;13:994625.
   PubMedGoogle Scholar
• Karami A, Fakhri S, Kooshki L, Khan H. Polydatin: pharmacological Mechanisms, Therapeutic Targets, Biological Activities, and Health Benefits. Molecules. 2022;27(19):6474.
   PubMedGoogle Scholar
• Li T, Liu Y, Xu W, et al. Polydatin mediates Parkin-dependent mitophagy and protects against mitochondria-dependent apoptosis in acute respiratory distress syndrome. Lab Invest. 2019;99(6):819–829.
   PubMed Web of Science ®Google Scholar
• Badamjav R, Zhang L, Sonom D, et al. Thalictrum minus L. ameliorates particulate matter-induced acute lung injury in mice. J Ethnopharmacol. 2021;264:113379.
   PubMedGoogle Scholar
• Badamjav R, Sonom D, Wu Y, et al. The protective effects of Thalictrum minus L. on lipopolysaccharide-induced acute lung injury. J Ethnopharmacol. 2020;248:112355.
   PubMedGoogle Scholar
• Liu C, Ju A, Zhou D, et al. Simultaneous Qualitative and Quantitative Analysis of Multiple Chemical Constituents in YiQiFuMai Injection by Ultra-Fast Liquid Chromatography Coupled with Ion Trap Time-of-Flight Mass Spectrometry. Molecules. 2016;21(5):640.
   PubMedGoogle Scholar
• Xia Y, Jiang SD, et al. YiQiFuMai lyophilized injection attenuates particulate matter-induced acute lung injury in mice via TLR4-mTOR-autophagy pathway. Biomed Pharmacother. 2018;108:906–913.
   PubMedGoogle Scholar
• Galluzzi L, Bravo-San Pedro JM, Vitale I, et al. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ. 2015;22(1):58–73.
   PubMed Web of Science ®Google Scholar
• Mizushima N, Yoshimorim T, Levine B. Methods in Mammalian Autophagy Research. Cell. 2010;140(3):313–326.
   PubMed Web of Science ®Google Scholar
• He YQ, Zhou CC, Yu LY, et al. Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms. Pharmacol Res. 2021;163:105224.
   PubMed Web of Science ®Google Scholar
• Zhang H. Autophagy functions as a double-edged sword during acute lung injury. Chine J Pathophysiol. 2020;36(04):725–734.
   Google Scholar
• Jung CH, Jun CB, Ro SH, et al. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell. 2009;20(7):1992–2003.
   PubMed Web of Science ®Google Scholar
• Hosokawa N, Hara T, Kaizuka T, et al. Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell. 2009;20(7):1981–1991.
   PubMed Web of Science ®Google Scholar
• Backer JM. The regulation and function of Class III PI3Ks: novel roles for Vps34. Biochem J. 2008;410(1):1–17.
   PubMed Web of Science ®Google Scholar
• Backer JM. The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34. Biochem J. 2016;473(15):2251–2271.
   PubMedGoogle Scholar
• Ohsumi Y. Molecular dissection of autophagy: two ubiquitin-like systems. Nat Rev Mol Cell Biol. 2001;2(3):211–216.
   PubMed Web of Science ®Google Scholar
• Geng J, Klionsky DJ. The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. “Protein modifications: beyond the usual suspects” review series. EMBO Rep. 2008;9(9):859–864.
   PubMed Web of Science ®Google Scholar
• Orsi A, Razi M, Dooley HC, et al. Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy. Mol Biol Cell. 2012;23(10):1860–1873.
   PubMed Web of Science ®Google Scholar
• Eskelinen EL. Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy. Mol Aspects Med. 2006;27(5–6):495–502.
   PubMedGoogle Scholar
• Gutierrez MG, Munafó DB, Berón W, Colombo MI. Rab7 is required for the normal progression of the autophagic pathway in mammalian cells. J Cell Sci. 2004;117(Pt 13):2687–2697.
   PubMed Web of Science ®Google Scholar
• Dingjan I, Linders PTA, Verboogen DRJ, Revelo NH, Ter Beest M. Endosomal and Phagosomal SNAREs. Physiol Rev. 2018;98(3):1465–1492.
   PubMedGoogle Scholar