Circulating Leukocyte as an Inflammatory Biomarker: Association with Fibrinogen and Neuronal Damage in Acute Ischemic Stroke

References

• Hollist M, Morgan L, Cabatbat R, Au K, Kirmani MF, Kirmani BF. Acute stroke management: overview and recent updates. Aging Dis. 2021;12(4):1000–1009. doi:10.14336/AD.2021.0311
   PubMed Web of Science ®Google Scholar
• Tu WJ, Hua Y, Yan F, et al. Prevalence of stroke in China, 2013–2019: a population-based study. Lancet Reg Health West Pac. 2022;28:100550. doi:10.1016/j.lanwpc.2022.100550
   PubMedGoogle Scholar
• Baek BH, Kim HS, Yoon W, et al. Inflammatory mediator expression within retrieved clots in acute ischemic stroke. Ann Clin Transl Neurol. 2018;5(3):273–279. doi:10.1002/acn3.529
   PubMedGoogle Scholar
• Shi K, Tian DC, Li ZG, Ducruet AF, Lawton MT, Shi FD. Global brain inflammation in stroke. Lancet Neurol. 2019;18(11):1058–1066. doi:10.1016/S1474-4422(19)30078-X
   PubMed Web of Science ®Google Scholar
• Chen J, Wang L, Xu H, Wang Y, Liang Q. The lymphatic drainage system of the CNS plays a role in lymphatic drainage, immunity, and neuroinflammation in stroke. J Leukoc Biol. 2021;110(2):283–291. doi:10.1002/JLB.5MR0321-632R
   PubMedGoogle Scholar
• Huang J, Yin G, Duan L, et al. Prognostic value of blood-based inflammatory biomarkers in secondary hemophagocytic lymphohistiocytosis. J Clin Immunol. 2020;40(5):718–728. doi:10.1007/s10875-020-00801-x
   PubMedGoogle Scholar
• Sun Y, Deng W, Yao G, et al. Citrullinated fibrinogen impairs immunomodulatory function of bone marrow mesenchymal stem cells by triggering toll-like receptor. Clin Immunol. 2018;193:38–45. doi:10.1016/j.clim.2018.01.008
   PubMed Web of Science ®Google Scholar
• Del Zoppo GJ, Levy DE, Wasiewski WW, et al. Hyperfibrinogenemia and functional outcome from acute ischemic stroke. Stroke. 2009;40(5):1687–1691. doi:10.1161/STROKEAHA.108.527804
   PubMedGoogle Scholar
• Yang X, Lu T, Qu Z, Zhang Y, Liu P, Ma Y. Plasma D-dimer level is associated with clinical outcomes in patients with atrial fibrillation related acute ischemic stroke after pneumonia. BMC Neurol. 2021;21(1):137. doi:10.1186/s12883-021-02168-x
   PubMedGoogle Scholar
• You S, Yin X, Liu H, et al. Hyperfibrinogenemia is significantly associated with an increased risk of in-hospital mortality in acute ischemic stroke patients. Curr Neurovasc Res. 2017;14(3):242–249. doi:10.2174/1567202614666170621103604
   PubMed Web of Science ®Google Scholar
• Kim JY, Park J, Chang JY, Kim SH, Lee JE. Inflammation after ischemic stroke: the role of leukocytes and glial cells. Exp Neurobiol. 2016;25(5):241–251. doi:10.5607/en.2016.25.5.241
   PubMed Web of Science ®Google Scholar
• Rayasam A, Hsu M, Kijak JA, et al. Immune responses in stroke: how the immune system contributes to damage and healing after stroke and how this knowledge could be translated to better cures? Immunology. 2018;154(3):363–376. doi:10.1111/imm.12918
   PubMed Web of Science ®Google Scholar
• Hu Y, Meng R, Zhang X, et al. Serum neuron specific enolase may be a marker to predict the severity and outcome of cerebral venous thrombosis. J Neurol. 2018;265(1):46–51. doi:10.1007/s00415-017-8659-9
   PubMed Web of Science ®Google Scholar
• Missler U, Wiesmann M, Friedrich C, Kaps M. S-100 protein and neuron-specific enolase concentrations in blood as indicators of infarction volume and prognosis in acute ischemic stroke. Stroke. 1997;28(10):1956–1960. doi:10.1161/01.STR.28.10.1956
   PubMed Web of Science ®Google Scholar
• Silva LM, Doyle AD, Greenwell-Wild T, et al. Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier. Science. 2021;374(6575):eabl5450. doi:10.1126/science.abl5450
   PubMed Web of Science ®Google Scholar
• Pierot L, Jayaraman MV, Szikora I, et al. Standards of practice in acute ischemic stroke intervention: international recommendations. AJNR Am J Neuroradiol. 2018;39(11):E112–E117. doi:10.3174/ajnr.A5853
   PubMedGoogle Scholar
• Hong RH, Zhu J, Li ZZ, et al. Red blood cell distribution width is associated with neuronal damage in acute ischemic stroke. Aging. 2020;12(10):9855–9867. doi:10.18632/aging.103250
   PubMedGoogle Scholar
• Liberale L, Bonetti NR, Puspitasari YM, et al. TNF-alpha antagonism rescues the effect of ageing on stroke: perspectives for targeting inflamm-ageing. Eur J Clin Invest. 2021;51(11):e13600. doi:10.1111/eci.13600
   PubMedGoogle Scholar
• Liberale L, Bonetti NR, Puspitasari YM, et al. Postischemic administration of IL-1alpha neutralizing antibody reduces brain damage and neurological deficit in experimental stroke. Circulation. 2020;142(2):187–189. doi:10.1161/CIRCULATIONAHA.120.046301
   PubMedGoogle Scholar
• Liberale L, Ministrini S, Carbone F, Camici GG, Montecucco F. Cytokines as therapeutic targets for cardio- and cerebrovascular diseases. Basic Res Cardiol. 2021;116(1):23. doi:10.1007/s00395-021-00863-x
   PubMed Web of Science ®Google Scholar
• Tirandi A, Sgura C, Carbone F, Montecucco F, Liberale L. Inflammatory biomarkers of ischemic stroke. Intern Emerg Med. 2023. doi:10.1007/s11739-023-03201-2
   PubMedGoogle Scholar
• Xiao Y, Jin J, Chang M, et al. Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation. Nat Med. 2013;19(5):595–602. doi:10.1038/nm.3111
   PubMedGoogle Scholar
• Wihersaari L, Tiainen M, Skrifvars MB, et al. Usefulness of neuron specific enolase in prognostication after cardiac arrest: impact of age and time to ROSC. Resuscitation. 2019;139:214–221. doi:10.1016/j.resuscitation.2019.04.021
   PubMedGoogle Scholar
• Sawada Y, Konno A, Nagaoka J, Hirai H. Inflammation-induced reversible switch of the neuron-specific enolase promoter from Purkinje neurons to Bergmann glia. Sci Rep. 2016;6:27758. doi:10.1038/srep27758
   PubMedGoogle Scholar
• Lissner Ostlund E, Levin H, Nielsen N, Frigyesi A, Lybeck A. Neuron-specific enolase and long-term neurological outcome after OHCA - A validation study. Resuscitation. 2021;168:206–213. doi:10.1016/j.resuscitation.2021.09.001
   PubMedGoogle Scholar
• Rech TH, Vieira SR, Nagel F, Brauner JS, Scalco R. Serum neuron-specific enolase as early predictor of outcome after in-hospital cardiac arrest: a cohort study. Crit Care. 2006;10(5):R133. doi:10.1186/cc5046
   PubMedGoogle Scholar
• Haque A, Polcyn R, Matzelle D, Banik NL. New insights into the role of neuron-specific enolase in neuro-inflammation, neurodegeneration, and neuroprotection. Brain Sci. 2018;8(2). doi:10.3390/brainsci8020033
   PubMedGoogle Scholar
• Wang R, Zhu Y, Liu Z, et al. Neutrophil extracellular traps promote tPA-induced brain hemorrhage via cGAS in mice with stroke. Blood. 2021;138(1):91–103. doi:10.1182/blood.2020008913
   PubMed Web of Science ®Google Scholar
• Jin R, Liu L, Zhang S, Nanda A, Li G. Role of inflammation and its mediators in acute ischemic stroke. J Cardiovasc Transl Res. 2013;6(5):834–851. doi:10.1007/s12265-013-9508-6
   PubMed Web of Science ®Google Scholar
• Arnaoutoglou E, Kouvelos G, Papa N, et al. Prospective evaluation of postimplantation syndrome evolution on patient outcomes after endovascular aneurysm repair for abdominal aortic aneurysm. J Vasc Surg. 2016;63(5):1248–1255. doi:10.1016/j.jvs.2015.11.043
   PubMedGoogle Scholar
• Whiteley W, Jackson C, Lewis S, et al. Association of circulating inflammatory markers with recurrent vascular events after stroke: a prospective cohort study. Stroke. 2011;42(1):10–16. doi:10.1161/STROKEAHA.110.588954
   PubMed Web of Science ®Google Scholar
• Derbisz J, Nowak K, Wnuk M, et al. Prognostic significance of stroke-associated infection and other readily available parameters in acute ischemic stroke treated by intravenous thrombolysis. J Stroke Cerebrovasc Dis. 2021;30(2):105525. doi:10.1016/j.jstrokecerebrovasdis.2020.105525
   PubMedGoogle Scholar
• Shi J, Shi R, Qin W, et al. Dynamic changes in fibrinogen and prognosis of acute ischemic stroke patients treated with intravenous thrombolysis. Neurotox Res. 2020;38(3):775–784. doi:10.1007/s12640-020-00241-w
   PubMedGoogle Scholar
• Wijeratne T, Sales C, Karimi L, Crewther SG. Acute ischemic stroke in COVID-19: a case-based systematic review. Front Neurol. 2020;11:1031. doi:10.3389/fneur.2020.01031
   PubMed Web of Science ®Google Scholar
• Skalny AV, Klimenko LL, Turna AA, et al. Serum trace elements are associated with hemostasis, lipid spectrum and inflammatory markers in men suffering from acute ischemic stroke. Metab Brain Dis. 2017;32(3):779–788. doi:10.1007/s11011-017-9967-6
   PubMedGoogle Scholar
• Stark K, Massberg S. Interplay between inflammation and thrombosis in cardiovascular pathology. Nat Rev Cardiol. 2021;18(9):666–682. doi:10.1038/s41569-021-00552-1
   PubMed Web of Science ®Google Scholar
• Besteman SB, Callaghan A, Hennus MP, Westerlaken GHA, Meyaard L, Bont LL. Signal inhibitory receptor on leukocytes (SIRL)-1 and leukocyte- associated immunoglobulin-like receptor (LAIR)-1 regulate neutrophil function in infants. Clin Immunol. 2020;211:108324. doi:10.1016/j.clim.2019.108324
   PubMedGoogle Scholar
• Jin R, Yang G, Li G. Inflammatory mechanisms in ischemic stroke: role of inflammatory cells. J Leukoc Biol. 2010;87(5):779–789. doi:10.1189/jlb.1109766
   PubMed Web of Science ®Google Scholar
• Mohammadhosayni M, Sadat Mohammadi F, Ezzatifar F, et al. Matrix metalloproteinases are involved in the development of neurological complications in patients with Coronavirus disease 2019. Int Immunopharmacol. 2021;100:108076. doi:10.1016/j.intimp.2021.108076
   PubMedGoogle Scholar
• Serra R, Gallelli L, Grande R, et al. Hemorrhoids and matrix metalloproteinases: a multicenter study on the predictive role of biomarkers. Surgery. 2016;159(2):487–494. doi:10.1016/j.surg.2015.07.003
   PubMed Web of Science ®Google Scholar
• Ekblom-Bak E, Halldin M, Vikstrom M, et al. Physical activity attenuates cardiovascular risk and mortality in men and women with and without the metabolic syndrome - a 20-year follow-up of a population-based cohort of 60-year-olds. Eur J Prev Cardiol. 2021;28(12):1376–1385. doi:10.1177/2047487320916596
   PubMed Web of Science ®Google Scholar
• Yuan D, Jiang P, Zhu P, et al. Prognostic value of fibrinogen in patients with coronary artery disease and prediabetes or diabetes following percutaneous coronary intervention: 5-year findings from a large cohort study. Cardiovasc Diabetol. 2021;20(1):143. doi:10.1186/s12933-021-01335-1
   PubMed Web of Science ®Google Scholar
• Luyendyk JP, Schoenecker JG, Flick MJ. The multifaceted role of fibrinogen in tissue injury and inflammation. Blood. 2019;133(6):511–520. doi:10.1182/blood-2018-07-818211
   PubMed Web of Science ®Google Scholar
• Kopec AK, Joshi N, Cline-Fedewa H, et al. Fibrin(ogen) drives repair after Acetaminophen-induced liver injury via leukocyte alphaMbeta2 integrin-dependent upregulation of Mmp12. J Hepatol. 2017;66(4):787–797. doi:10.1016/j.jhep.2016.12.004
   PubMedGoogle Scholar
• Odrljin TM, Haidaris CG, Lerner NB, Simpson-Haidaris PJ. Integrin alphavbeta3-mediated endocytosis of immobilized fibrinogen by A549 lung alveolar epithelial cells. Am J Respir Cell Mol Biol. 2001;24(1):12–21. doi:10.1165/ajrcmb.24.1.3992
   PubMedGoogle Scholar