Multi-Omics Analysis and Verification of the Oncogenic Value of CCT8 in Pan-Cancers

References

• Qin H, Lu Y, Du L, et al. Pan-cancer analysis identifies LMNB1 as a target to redress Th1/Th2 imbalance and enhance PARP inhibitor response in human cancers. Cancer Cell Int. 2022;22:101. doi:10.1186/s12935-022-02467-4
   PubMed Web of Science ®Google Scholar
• Liao Q, Ren Y, Yang Y, et al. CCT8 recovers WTp53-suppressed cell cycle evolution and EMT to promote colorectal cancer progression. Oncogenesis. 2021;10:84. doi:10.1038/s41389-021-00374-3
   PubMed Web of Science ®Google Scholar
• Yang X, Ren H, Shao Y, et al. Chaperonin-containing T‑complex protein 1 subunit 8 promotes cell migration and invasion in human esophageal squamous cell carcinoma by regulating α-actin and β-tubulin expression. Int J Oncol. 2018;52(6):2021–2030. doi:10.3892/ijo.2018.4335
   PubMed Web of Science ®Google Scholar
• Qiu X, He X, Huang Q, et al. Overexpression of CCT8 and its significance for tumor cell proliferation, migration and invasion in glioma. Pathol Res Pract. 2015;211:717–725. doi:10.1016/j.prp.2015.04.012
   PubMed Web of Science ®Google Scholar
• Huang X, Wang X, Cheng C, et al. Chaperonin containing TCP1, subunit 8 (CCT8) is upregulated in hepatocellular carcinoma and promotes HCC proliferation. APMIS. 2014;122:1070–1079. doi:10.1111/apm.12258
   PubMed Web of Science ®Google Scholar
• Cui X, Zhang X, Liu M, et al. A pan-cancer analysis of the oncogenic role of staphylococcal nuclease domain-containing protein 1 (SND1) in human tumors. Genomics. 2020;112:3958–3967. doi:10.1016/j.ygeno.2020.06.044
   PubMed Web of Science ®Google Scholar
• Fang Z, Li P, Li H, et al. New insights into PTBP3 in human cancers: immune cell infiltration, TMB, MSI, PDCD1 and m6A markers. Front Pharmacol. 2022;13:811338. doi:10.3389/fphar.2022.811338
   PubMed Web of Science ®Google Scholar
• Wei C, Wang B, Peng D, et al. Pan-cancer analysis shows that ALKBH5 is a potential prognostic and immunotherapeutic biomarker for multiple cancer types including gliomas. Front Immunol. 2022;13:849592. doi:10.3389/fimmu.2022.849592
   PubMed Web of Science ®Google Scholar
• Chen AS, Wardwell-Ozgo J, Shah NN, et al. Drak/STK17A drives neoplastic glial proliferation through modulation of MRLC signaling. Cancer Res. 2019;79:1085–1097. doi:10.1158/0008-5472.CAN-18-0482
   PubMed Web of Science ®Google Scholar
• Gao L, Zhang W, Zhang J, et al. KIF15-mediated stabilization of AR and AR-V7 contributes to enzalutamide resistance in prostate cancer. Cancer Res. 2021;81:1026–1039. doi:10.1158/0008-5472.CAN-20-1965
   PubMed Web of Science ®Google Scholar
• Tang Z, Kang B, Li C, Chen T, Zhang Z. GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis. Nucleic Acids Res. 2019;47:W556–W60. doi:10.1093/nar/gkz430
   PubMed Web of Science ®Google Scholar
• Uhlen M, Fagerberg L, Hallstrom BM, et al. Proteomics. Tissue-based map of the human proteome. Science. 2015;347:1260419. doi:10.1126/science.1260419
   PubMed Web of Science ®Google Scholar
• Barretina J, Caponigro G, Stransky N, et al. The cancer cell line encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature. 2012;483:603–607. doi:10.1038/nature11003
   PubMed Web of Science ®Google Scholar
• Kao T-J, Wu -C-C, Phan NN, et al. Prognoses and genomic analyses of proteasome 26S subunit, ATPase (PSMC) family genes in clinical breast cancer. Aging. 2021;13:17970. doi:10.18632/aging.203345
   PubMedGoogle Scholar
• Li W, Ma J-A, Sheng X, Xiao C. Screening of CXC chemokines in the microenvironment of ovarian cancer and the biological function of CXCL10. World J Surg Oncol. 2021;19:329. doi:10.1186/s12957-021-02440-x
   PubMed Web of Science ®Google Scholar
• Modhukur V, Iljasenko T, Metsalu T, Lokk K, Laisk-Podar T, Vilo J. MethSurv: a web tool to perform multivariable survival analysis using DNA methylation data. Epigenomics. 2018;10:277–288. doi:10.2217/epi-2017-0118
   PubMed Web of Science ®Google Scholar
• Anuraga G, Wang W-J, Phan NN, et al. Potential prognostic biomarkers of NIMA (Never in Mitosis, Gene A)-Related Kinase (NEK) family members in breast cancer. J Pers Med. 2021;11:1089. doi:10.3390/jpm11111089
   PubMed Web of Science ®Google Scholar
• Song Y, Ma R. Identifying the potential roles of PBX4 in human cancers based on integrative analysis. Biomolecules. 2022;12:822. doi:10.3390/biom12060822
   PubMed Web of Science ®Google Scholar
• Zhong M, Wang X, Zhu E, et al. Analysis of pyroptosis-related immune signatures and identification of pyroptosis-related LncRNA prognostic signature in clear cell renal cell carcinoma. Front Genet. 2022;13:905051. doi:10.3389/fgene.2022.905051
   PubMed Web of Science ®Google Scholar
• Subramanian A, Narayan R, Corsello SM, et al. A next generation connectivity map: L1000 Platform and the First 1,000,000 Profiles. Cell. 2017;171:1437–1452.e17. doi:10.1016/j.cell.2017.10.049
   PubMed Web of Science ®Google Scholar
• Wang C-Y, Chiao -C-C, Phan NN, et al. Gene signatures and potential therapeutic targets of amino acid metabolism in estrogen receptor-positive breast cancer. Am J Cancer Res. 2020;10:95–113.
   PubMed Web of Science ®Google Scholar
• Tu Z, Peng J, Long X, et al. Sperm autoantigenic protein 17 predicts the prognosis and the immunotherapy response of cancers: a pan-cancer analysis. Front Immunol. 2022;13:844736. doi:10.3389/fimmu.2022.844736
   PubMedGoogle Scholar
• Jones PA. Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat Rev Genet. 2012;13:484–492. doi:10.1038/nrg3230
   PubMed Web of Science ®Google Scholar
• Liu P, Kong L, Jin H, Wu Y, Tan X, Song B. Differential secretome of pancreatic cancer cells in serum-containing conditioned medium reveals CCT8 as a new biomarker of pancreatic cancer invasion and metastasis. Cancer Cell Int. 2019;19:262. doi:10.1186/s12935-019-0980-1
   PubMed Web of Science ®Google Scholar
• Li J, Xie J, Wu D, et al. A pan-cancer analysis revealed the role of the SLC16 family in cancer. Channels. 2021;15:528–540. doi:10.1080/19336950.2021.1965422
   PubMed Web of Science ®Google Scholar
• Xie J, Ruan S, Zhu Z, et al. Database mining analysis revealed the role of the putative H+/sugar transporter solute carrier family 45 in skin cutaneous melanoma. Channels. 2021;15:496–506. doi:10.1080/19336950.2021.1956226
   PubMed Web of Science ®Google Scholar
• Chen S, Li K, Cao W, et al. Codon-resolution analysis reveals a direct and context-dependent impact of individual synonymous mutations on mRNA level. Mol Biol Evol. 2017;34:2944–2958. doi:10.1093/molbev/msx229
   PubMed Web of Science ®Google Scholar
• Stranger BE, Forrest MS, Dunning M, et al. Relative impact of nucleotide and copy number variation on gene expression phenotypes. Science. 2007;315:848–853. doi:10.1126/science.1136678
   PubMed Web of Science ®Google Scholar
• Thorsson V, Gibbs DL, Brown SD, et al. The Immune Landscape of Cancer. Immunity. 2018;48:812–30 e14. doi:10.1016/j.immuni.2018.03.023
   PubMed Web of Science ®Google Scholar
• Aran D, Sirota M, Butte AJ. Systematic pan-cancer analysis of tumour purity. Nat Commun. 2015;6:8971. doi:10.1038/ncomms9971
   PubMed Web of Science ®Google Scholar
• Yoshihara K, Shahmoradgoli M, Martinez E, et al. Inferring tumour purity and stromal and immune cell admixture from expression data. Nat Commun. 2013;4:2612. doi:10.1038/ncomms3612
   PubMed Web of Science ®Google Scholar
• Oftedal BE, Maio S, Handel AE, et al. The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function. Commun Biol. 2021;4:681. doi:10.1038/s42003-021-02203-0
   PubMed Web of Science ®Google Scholar
• Basu A, Ramamoorthi G, Albert G, et al. Differentiation and Regulation of TH cells: a balancing act for cancer immunotherapy. Front Immunol. 2021;12:669474. doi:10.3389/fimmu.2021.669474
   PubMed Web of Science ®Google Scholar
• Saravia J, Chapman NM, Helper CH. T cell differentiation. Cell Mol Immunol. 2019;16:634–643. doi:10.1038/s41423-019-0220-6
   PubMed Web of Science ®Google Scholar
• Zhang S, Nguyen LH, Zhou K, et al. Knockdown of anillin actin binding protein blocks cytokinesis in hepatocytes and reduces liver tumor development in mice without affecting regeneration. Gastroenterology. 2018;154:1421–1434. doi:10.1053/j.gastro.2017.12.013
   PubMed Web of Science ®Google Scholar
• Dobrzanski MJ. Expanding roles for CD4 T cells and their subpopulations in tumor immunity and therapy. Front Oncol. 2013;3:63. doi:10.3389/fonc.2013.00063
   PubMedGoogle Scholar
• Luckheeram RV, Zhou R, Verma AD, Xia B. CD4(+)T cells: differentiation and functions. Clin Dev Immunol. 2012;2012:925135. doi:10.1155/2012/925135
   PubMedGoogle Scholar
• Takashima Y, Kawaguchi A, Kanayama T, Hayano A, Yamanaka R. Correlation between lower balance of Th2 helper T-cells and expression of PD-L1/PD-1 axis genes enables prognostic prediction in patients with glioblastoma. Oncotarget. 2018;9:19065–19078. doi:10.18632/oncotarget.24897
   PubMedGoogle Scholar
• Maier B, Leader AM, Chen ST, et al. A conserved dendritic-cell regulatory program limits antitumour immunity. Nature. 2020;580:257–262. doi:10.1038/s41586-020-2134-y
   PubMed Web of Science ®Google Scholar
• Mahata B, Zhang X, Kolodziejczyk AA, et al. Single-cell RNA sequencing reveals T helper cells synthesizing steroids de novo to contribute to immune homeostasis. Cell Rep. 2014;7:1130–1142. doi:10.1016/j.celrep.2014.04.011
   PubMed Web of Science ®Google Scholar
• DeNardo DG, Barreto JB, Andreu P, et al. CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell. 2009;16:91–102. doi:10.1016/j.ccr.2009.06.018
   PubMed Web of Science ®Google Scholar