Electroacupuncture Pretreatment at Zusanli (ST36) Ameliorates Hepatic Ischemia/Reperfusion Injury in Mice by Reducing Oxidative Stress via Activating Vagus Nerve-Dependent Nrf2 Pathway

References

• Zhang Q, Lai Y, Deng J, et al. Vagus nerve stimulation attenuates hepatic ischemia/reperfusion injury via the Nrf2/HO-1 pathway. Oxid Med Cell Longev. 2019;2019:9549506. doi:10.1155/2019/9549506
   PubMedGoogle Scholar
• Li C, Jackson RM. Reactive species mechanisms of cellular hypoxia-reoxygenation injury. Am J Physiol Cell Physiol. 2002;282(2):C227–41. doi:10.1152/ajpcell.00112.2001
   PubMed Web of Science ®Google Scholar
• Wu L, Xiong X, Wu X, et al. Targeting oxidative stress and inflammation to prevent ischemia-reperfusion injury. Front Mol Neurosci. 2020;13:28. doi:10.3389/fnmol.2020.00028
   PubMed Web of Science ®Google Scholar
• Xu D, Chen L, Chen X, et al. The triterpenoid CDDO-imidazolide ameliorates mouse liver ischemia-reperfusion injury through activating the Nrf2/HO-1 pathway enhanced autophagy. Cell Death Dis. 2017;8(8):e2983. doi:10.1038/cddis.2017.386
   PubMed Web of Science ®Google Scholar
• Xiao Y, Chen W, Zhong Z, et al. Electroacupuncture preconditioning attenuates myocardial ischemia-reperfusion injury by inhibiting mitophagy mediated by the mTORC1-ULK1-FUNDC1 pathway. Biomed Pharmacother. 2020;127:110148. doi:10.1016/j.biopha.2020.110148
   PubMed Web of Science ®Google Scholar
• Mei ZG, Huang YG, Feng ZT, et al. Electroacupuncture ameliorates cerebral ischemia/reperfusion injury by suppressing autophagy via the SIRT1-FOXO1 signaling pathway. Aging. 2020;12(13):13187–13205. doi:10.18632/aging.103420
   PubMedGoogle Scholar
• Oh JE, Kim SN. Anti-inflammatory effects of acupuncture at ST36 point: a literature review in animal studies. Front Immunol. 2021;12:813748. doi:10.3389/fimmu.2021.813748
   PubMed Web of Science ®Google Scholar
• Geng Z, Nie X, Ling L, et al. Electroacupuncture may inhibit oxidative stress of premature ovarian failure mice by regulating intestinal microbiota. Oxid Med Cell Longev. 2022;2022:4362317. doi:10.1155/2022/4362317
   PubMed Web of Science ®Google Scholar
• Cahn AM, Carayon P, Hill C, Flamant R. Acupuncture in gastroscopy. Lancet. 1978;1(8057):182–183. doi:10.1016/s0140-6736(78)90614-1
   PubMedGoogle Scholar
• Chen CY, Ke MD, Kuo CD, Huang CH, Hsueh YH, Chen JR. The influence of electro-acupuncture stimulation to female constipation patients. Am J Chin Med. 2013;41(2):301–313. doi:10.1142/s0192415x13500225
   PubMedGoogle Scholar
• Zhu YJ, Wu XY, Wang W, et al. Acupuncture for quality of life in gastric cancer patients undergoing adjuvant chemotherapy. J Pain Symptom Manage. 2022;63(2):210–220. doi:10.1016/j.jpainsymman.2021.09.009
   PubMed Web of Science ®Google Scholar
• Jang JH, Yeom MJ, Ahn S, et al. Acupuncture inhibits neuroinflammation and gut microbial dysbiosis in a mouse model of Parkinson’s disease. Brain Behav Immun. 2020;89:641–655. doi:10.1016/j.bbi.2020.08.015
   PubMed Web of Science ®Google Scholar
• Zhao H, Dong F, Li Y, et al. Inhibiting ATG5 mediated autophagy to regulate endoplasmic reticulum stress and CD4(+) T lymphocyte differentiation: mechanisms of acupuncture’s effects on asthma. Biomed Pharmacother. 2021;142:112045. doi:10.1016/j.biopha.2021.112045
   PubMed Web of Science ®Google Scholar
• Huang CL, Tsai PS, Wang TY, Yan LP, Xu HZ, Huang CJ. Acupuncture stimulation of ST36 (Zusanli) attenuates acute renal but not hepatic injury in lipopolysaccharide-stimulated rats. Anesth Analg. 2007;104(3):646–654. doi:10.1213/01.ane.0000255288.68199.eb
   PubMed Web of Science ®Google Scholar
• Ucar BI, Ucar G, Saha S, Buttari B, Profumo E, Saso L. Pharmacological protection against ischemia-reperfusion injury by regulating the Nrf2-Keap1-ARE signaling pathway. Antioxidants. 2021;10(6). doi:10.3390/antiox10060823
   Google Scholar
• Tonelli C, Chio IIC, Tuveson DA. Transcriptional regulation by Nrf2. Antioxid Redox Signal. 2018;29(17):1727–1745. doi:10.1089/ars.2017.7342
   PubMed Web of Science ®Google Scholar
• Tanaka N, Ikeda Y, Ohta Y, et al. Expression of Keap1-Nrf2 system and antioxidative proteins in mouse brain after transient middle cerebral artery occlusion. Brain Res. 2011;1370:246–253. doi:10.1016/j.brainres.2010.11.010
   PubMed Web of Science ®Google Scholar
• Thimmulappa RK, Lee H, Rangasamy T, et al. Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis. J Clin Invest. 2006;116(4):984–995. doi:10.1172/jci25790
   PubMed Web of Science ®Google Scholar
• Shih AY, Li P, Murphy TH. A small-molecule-inducible Nrf2-mediated antioxidant response provides effective prophylaxis against cerebral ischemia in vivo. J Neurosci. 2005;25(44):10321–10335. doi:10.1523/jneurosci.4014-05.2005
   PubMed Web of Science ®Google Scholar
• Liu M, Grigoryev DN, Crow MT, et al. Transcription factor Nrf2 is protective during ischemic and nephrotoxic acute kidney injury in mice. Kidney Int. 2009;76(3):277–285. doi:10.1038/ki.2009.157
   PubMed Web of Science ®Google Scholar
• Zhang Y, Sano M, Shinmura K, et al. 4-hydroxy-2-nonenal protects against cardiac ischemia-reperfusion injury via the Nrf2-dependent pathway. J Mol Cell Cardiol. 2010;49(4):576–586. doi:10.1016/j.yjmcc.2010.05.011
   PubMed Web of Science ®Google Scholar
• Fonseca RC, Bassi GS, Brito CC, et al. Vagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liver. Brain Behav Immun. 2019;81:444–454. doi:10.1016/j.bbi.2019.06.041
   PubMedGoogle Scholar
• Izumi T, Imai J, Yamamoto J, et al. Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation. Nat Commun. 2018;9(1):5300. doi:10.1038/s41467-018-07747-0
   PubMedGoogle Scholar
• Han J-S. Acupuncture: neuropeptide release produced by electrical stimulation of different frequencies. Trends Neurosci. 2003;26:17–22. doi:10.1016/s0166-2236(02)00006-1
   PubMed Web of Science ®Google Scholar
• Xu M, Hang H, Huang M, et al. DJ-1 deficiency in hepatocytes improves liver ischemia-reperfusion injury by enhancing mitophagy. Cell Mol Gastroenterol Hepatol. 2021;12(2):567–584. doi:10.1016/j.jcmgh.2021.03.007
   PubMedGoogle Scholar
• Jiao J, Jiang Y, Qian Y, et al. Expression of STING is increased in monocyte-derived macrophages and contributes to liver inflammation in hepatic ischemia-reperfusion injury. Am J Pathol. 2022. doi:10.1016/j.ajpath.2022.09.002
   PubMedGoogle Scholar
• Zhi S, Congcong Z, Zhiling G, et al. Quantitative proteomics of HFD-induced fatty liver uncovers novel transcription factors of lipid metabolism. Int J Biol Sci. 2022;18(8):3298–3312. doi:10.7150/ijbs.71431
   PubMedGoogle Scholar
• Zhang T, Yang WX, Wang YL, et al. Electroacupuncture preconditioning attenuates acute myocardial ischemia injury through inhibiting NLRP3 inflammasome activation in mice. Life Sci. 2020;248:117451. doi:10.1016/j.lfs.2020.117451
   PubMed Web of Science ®Google Scholar
• Wen J, Chen X, Yang Y, et al. Acupuncture medical therapy and its underlying mechanisms: a systematic review. Am J Chin Med. 2021;49(1):1–23. doi:10.1142/S0192415X21500014
   PubMed Web of Science ®Google Scholar
• Bardallo GR, Panisello‐Roselló A, Sanchez‐Nuno S, et al. Nrf2 and oxidative stress in liver ischemia/reperfusion injury. FEBS J. 2022;289(18):5463–5479. doi:10.1111/febs.16336
   PubMedGoogle Scholar
• Lu MJ, Yu Z, He Y, Yin Y, Xu B. Electroacupuncture at ST36 modulates gastric motility via vagovagal and sympathetic reflexes in rats. World J Gastroenterol. 2019;25(19):2315–2326. doi:10.3748/wjg.v25.i19.2315
   PubMed Web of Science ®Google Scholar
• Gusmao J, Fonseca KM, Ferreira BSP, et al. Electroacupuncture reduces inflammation but not bone loss on periodontitis in arthritic rats. Inflammation. 2021;44(1):116–128. doi:10.1007/s10753-020-01313-x
   PubMedGoogle Scholar
• Jaeschke H, Woolbright BL. Current strategies to minimize hepatic ischemia-reperfusion injury by targeting reactive oxygen species. Transplant Rev. 2012;26(2):103–114. doi:10.1016/j.trre.2011.10.006
   Google Scholar
• Enomoto A, Itoh K, Nagayoshi E, et al. High sensitivity of Nrf2 knockout mice to Acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes. Toxicol Sci. 2001;59(1):169–177. doi:10.1093/toxsci/59.1.169
   PubMed Web of Science ®Google Scholar
• Zhang YK, Yeager RL, Tanaka Y, Klaassen CD. Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet. Toxicol Appl Pharmacol. 2010;245(3):326–334. doi:10.1016/j.taap.2010.03.016
   PubMedGoogle Scholar
• Li S, Zhu Z, Xue M, et al. The protective effects of fibroblast growth factor 10 against hepatic ischemia-reperfusion injury in mice. Redox Biol. 2021;40:101859. doi:10.1016/j.redox.2021.101859
   PubMedGoogle Scholar
• Zhan Y, Xu D, Tian Y, et al. Novel role of macrophage TXNIP-mediated CYLD-NRF2-OASL1 axis in stress-induced liver inflammation and cell death. JHEP Rep. 2022;4(9):100532. doi:10.1016/j.jhepr.2022.100532
   PubMedGoogle Scholar
• Yu JB, Shi J, Gong LR, et al. Role of Nrf2/ARE pathway in protective effect of electroacupuncture against endotoxic shock-induced acute lung injury in rabbits. PLoS One. 2014;9(8):e104924. doi:10.1371/journal.pone.0104924
   PubMed Web of Science ®Google Scholar
• Borovikova LV, Ivanova S, Zhang M, et al. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature. 2000;405(6785):458–462. doi:10.1038/35013070
   PubMed Web of Science ®Google Scholar