Ciliated Cells Express a Novel Pattern of Brain-Derived Neurotrophic Factor in Allergic Rhinitis

References

• Meltzer EO. Allergic rhinitis: burden of illness, quality of life, comorbidities, and control. Immunol Allergy Clin North Am. 2016;36(2):235–248. doi:10.1016/j.iac.2015.12.002
   PubMed Web of Science ®Google Scholar
• Bousquet J, Anto JM, Bachert C, et al. Allergic rhinitis. Nat Rev Dis Primers. 2020;6(1):95. doi:10.1038/s41572-020-00227-0
   PubMed Web of Science ®Google Scholar
• Dainichi T, Kitoh A, Otsuka A, et al. The epithelial immune microenvironment (EIME) in atopic dermatitis and psoriasis. Nat Immunol. 2018;19(12):1286–1298. doi:10.1038/s41590-018-0256-2
   PubMed Web of Science ®Google Scholar
• Steelant B, Seys SF, Van Gerven L, et al. Histamine and T helper cytokine-driven epithelial barrier dysfunction in allergic rhinitis. J Allergy Clin Immunol. 2018;141(3):951–963.e958. doi:10.1016/j.jaci.2017.08.039
   PubMed Web of Science ®Google Scholar
• Van Cauwenberge PB. Nasal sensitization. Allergy. 1997;52(33):7–9. doi:10.1111/j.1398-9995.1997.tb04797.x
   PubMedGoogle Scholar
• Tomazic PV, Birner-Gruenberger R, Leitner A, Darnhofer B, Spoerk S, Lang-Loidolt D. Apolipoproteins have a potential role in nasal mucus of allergic rhinitis patients: a proteomic study. Laryngoscope. 2015;125(3):E91–96. doi:10.1002/lary.25003
   PubMed Web of Science ®Google Scholar
• Mikolajczyk M, Janukowicz K, Majewska E, Baj Z. Impact of allergic rhinitis on nasal mucociliary clearance time in children. Int Arch Allergy Immunol. 2019;179(4):297–303. doi:10.1159/000499740
   PubMed Web of Science ®Google Scholar
• Liu J, Liu Y. Nasal ultrastructure ciliates and symptoms changing in rat model of allergic rhinitis. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2010;24(8):365–368.
   PubMedGoogle Scholar
• Kirtsreesakul V, Somjareonwattana P, Ruttanaphol S. The correlation between nasal symptom and mucociliary clearance in allergic rhinitis. Laryngoscope. 2009;119(8):1458–1462. doi:10.1002/lary.20146
   PubMed Web of Science ®Google Scholar
• Peng Y, Chen Z, Guan WJ, et al. Downregulation and aberrant localization of forkhead box J1 in allergic nasal mucosa. Int Arch Allergy Immunol. 2018;176(2):115–123. doi:10.1159/000488014
   PubMed Web of Science ®Google Scholar
• Sanico AM, Koliatsos VE, Stanisz AM, Bienenstock J, Togias A. Neural hyperresponsiveness and nerve growth factor in allergic rhinitis. Int Arch Allergy Immunol. 1999;118:154–158. doi:10.1159/000024054.
   PubMed Web of Science ®Google Scholar
• Raap U, Braunstahl GJ. The role of neurotrophins in the pathophysiology of allergic rhinitis. Curr Opin Allergy Clin Immunol. 2010;10:8–13. doi:10.1097/ACI.0b013e328334f5de
   PubMed Web of Science ®Google Scholar
• Raap U, Fokkens W, Bruder M, Hoogsteden H, Kapp A, Braunstahl GJ. Modulation of neurotrophin and neurotrophin receptor expression in nasal mucosa after nasal allergen provocation in allergic rhinitis. Allergy. 2008;63(4):468–475. doi:10.1111/j.1398-9995.2008.01626.x
   PubMed Web of Science ®Google Scholar
• Song M, Martinowich K, Lee FS. BDNF at the synapse: why location matters. Mol Psychiatry. 2017;22(10):1370–1375. doi:10.1038/mp.2017.144
   PubMed Web of Science ®Google Scholar
• Jin P, Andiappan AK, Quek JM, et al. A functional brain-derived neurotrophic factor (BDNF) gene variant increases the risk of moderate-to-severe allergic rhinitis. J Allergy Clin Immunol. 2015;135(6):1486–1493.e1488. doi:10.1016/j.jaci.2014.12.1870
   PubMed Web of Science ®Google Scholar
• Caporali A, Emanueli C. Cardiovascular actions of neurotrophins. Physiol Rev. 2009;89(1):279–308. doi:10.1152/physrev.00007.2008
   PubMed Web of Science ®Google Scholar
• Hahn C, Islamian AP, Renz H, Nockher WA. Airway epithelial cells produce neurotrophins and promote the survival of eosinophils during allergic airway inflammation. J Allergy Clin Immunol. 2006;117(4):787–794. doi:10.1016/j.jaci.2005.12.1339
   PubMed Web of Science ®Google Scholar
• Salvador AFM, Kipnis J. Immune response after central nervous system injury. Semin Immunol. 2022;59:101629. doi:10.1016/j.smim.2022.101629
   PubMed Web of Science ®Google Scholar
• Guo W, Nagappan G, Lu B. Differential effects of transient and sustained activation of BDNF-TrkB signaling. Dev Neurobiol. 2018;78(7):647–659. doi:10.1002/dneu.22592
   PubMed Web of Science ®Google Scholar
• Prakash Y, Thompson MA, Meuchel L, et al. Neurotrophins in lung health and disease. Expert Rev Respir Med. 2010;4(3):395–411. doi:10.1586/ers.10.29
   PubMedGoogle Scholar
• Yang YG, Tian WM, Zhang H, Li M, Shang YX. Nerve growth factor exacerbates allergic lung inflammation and airway remodeling in a rat model of chronic asthma. Exp Ther Med. 2013;6(5):1251–1258. doi:10.3892/etm.2013.1284
   PubMed Web of Science ®Google Scholar
• Bi C, Fu Y, Zhang Z, Li B. Prostaglandin E2 confers protection against diabetic coronary atherosclerosis by stimulating M2 macrophage polarization via the activation of the CREB/BDNF/TrkB signaling pathway. FASEB j. 2020;34(6):7360–7371. doi:10.1096/fj.201902055R
   PubMed Web of Science ®Google Scholar
• Shapouri-Moghaddam A, Mohammadian S, Vazini H, et al. Macrophage plasticity, polarization, and function in health and disease. J Cell Physiol. 2018;233(9):6425–6440. doi:10.1002/jcp.26429
   PubMed Web of Science ®Google Scholar
• Castano R, Welman M, Trudeau C, Castellanos L, Maghni K, Malo JL. Specific inhalation challenge with flour induced release of brain-derived neurotrophic factor in nasal fluid. Int Forum Allergy Rhinol. 2014;4(1):49–55. doi:10.1002/alr.21223
   PubMed Web of Science ®Google Scholar
• Paris AJ, Hayer KE, Oved JH, et al. STAT3-BDNF-TrkB signalling promotes alveolar epithelial regeneration after lung injury. Nat Cell Biol. 2020;22(10):1197–1210. doi:10.1038/s41556-020-0569-x
   PubMed Web of Science ®Google Scholar
• Rao F, Wang Y, Zhang D, et al. Aligned chitosan nanofiber hydrogel grafted with peptides mimicking bioactive brain-derived neurotrophic factor and vascular endothelial growth factor repair long-distance sciatic nerve defects in rats. Theranostics. 2020;10(4):1590–1603. doi:10.7150/thno.36272
   PubMed Web of Science ®Google Scholar
• Steelant B, Farré R, Wawrzyniak P, et al. Impaired barrier function in patients with house dust mite-induced allergic rhinitis is accompanied by decreased occludin and zonula occludens-1 expression. J Allergy Clin Immunol. 2016;137(4):1043–1053.e1045. doi:10.1016/j.jaci.2015.10.050
   PubMed Web of Science ®Google Scholar
• Steelant B. Epithelial dysfunction in chronic respiratory diseases, a shared endotype? Curr Opin Pulm Med. 2020;26(1):20–26. doi:10.1097/MCP.0000000000000638
   PubMed Web of Science ®Google Scholar
• Liu S. Neurotrophic factors in enteric physiology and pathophysiology. Neurogastroenterol Motil. 2018;30(10):e13446. doi:10.1111/nmo.13446
   PubMed Web of Science ®Google Scholar
• Gomperts BN, Kim LJ, Flaherty SA, Hackett BP. IL-13 regulates cilia loss and foxj1 expression in human airway epithelium. Am J Respir Cell Mol Biol. 2007;37(3):339–346. doi:10.1165/rcmb.2006-0400OC
   PubMed Web of Science ®Google Scholar
• Jornot L, Lacroix JS, Rochat T. Neuroendocrine cells of nasal mucosa are a cellular source of brain-derived neurotrophic factor. Eur Respir J. 2008;32(3):769–774. doi:10.1183/09031936.00051608
   PubMed Web of Science ®Google Scholar