Resolvin D1 Attenuates Inflammation and Pelvic Pain Associated with EAP by Inhibiting Oxidative Stress and NLRP3 Inflammasome Activation via the Nrf2/HO-1 Pathway

References

• Collins MM, Stafford RS, O’Leary MP, Barry MJ. How common is prostatitis? A national survey of physician visits. J Urol. 1998;159(4):1224–1228. doi:10.1097/00005392-199804000-00037
   PubMed Web of Science ®Google Scholar
• Schwartz ES, Xie A, La JH, Gebhart GF. Nociceptive and inflammatory mediator upregulation in a mouse model of chronic prostatitis. Pain. 2015;156(8):1537–1544. doi:10.1097/j.pain.0000000000000201
   PubMed Web of Science ®Google Scholar
• Rees J, Abrahams M, Doble A, Cooper A; Prostatitis Expert Reference Group (PERG). Diagnosis and treatment of chronic bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome: a consensus guideline. BJU Int. 2015;116(4):509–525. doi:10.1111/bju.13101
   PubMed Web of Science ®Google Scholar
• Schaeffer AJ. Clinical practice. Chronic prostatitis and the chronic pelvic pain syndrome. N Engl J Med. 2006;355(16):1690–1698. doi:10.1056/NEJMcp060423
   PubMed Web of Science ®Google Scholar
• Magistro G, Wagenlehner FM, Grabe M, Weidner W, Stief CG, Nickel JC. Contemporary Management of Chronic Prostatitis/Chronic Pelvic Pain Syndrome. Eur Urol. 2016;69(2):286–297. doi:10.1016/j.eururo.2015.08.061
   PubMed Web of Science ®Google Scholar
• Polackwich AS, Shoskes DA. Chronic prostatitis/chronic pelvic pain syndrome: a review of evaluation and therapy. Prostate Cancer Prostatic Dis. 2016;19(2):132–138. doi:10.1038/pcan.2016.8
   PubMed Web of Science ®Google Scholar
• Serhan CN. Pro-resolving lipid mediators are leads for resolution physiology. Nature. 2014;510(7503):92–101. doi:10.1038/nature13479
   PubMed Web of Science ®Google Scholar
• Li J, Deng X, Bai T, Wang S, Jiang Q, Xu K. Resolvin D1 mitigates non-alcoholic steatohepatitis by suppressing the TLR4-MyD88-mediated NF-κB and MAPK pathways and activating the Nrf2 pathway in mice. Int Immunopharmacol. 2020;88:106961. doi:10.1016/j.intimp.2020.106961
   PubMed Web of Science ®Google Scholar
• Abshagen K, Hartmann A, Grüner L, Liebig M, Vollmar B. Limited potential of resolvin D1 in treatment of cholestatic liver fibrosis. Hepatobiliary Surg Nutr. 2020;9(5):587–596. doi:10.21037/hbsn.2019.08.07
   PubMed Web of Science ®Google Scholar
• Sun W, Ma J, Zhao H, et al. Resolvin D1 suppresses pannus formation via decreasing connective tissue growth factor caused by upregulation of miRNA-146a-5p in rheumatoid arthritis. Arthritis Res Ther. 2020;22(1):61. doi:10.1186/s13075-020-2133-2
   PubMed Web of Science ®Google Scholar
• Lee HN, Surh YJ. Resolvin D1-mediated NOX2 inactivation rescues macrophages undertaking efferocytosis from oxidative stress-induced apoptosis. Biochem Pharmacol. 2013;86(6):759–769. doi:10.1016/j.bcp.2013.07.002
   PubMed Web of Science ®Google Scholar
• Saito P, Melo CPB, Martinez RM, et al. The Lipid Mediator Resolvin D1 Reduces the Skin Inflammation and Oxidative Stress Induced by UV Irradiation in Hairless Mice. Front Pharmacol. 2018;9:1242. doi:10.3389/fphar.2018.01242
   PubMed Web of Science ®Google Scholar
• o EK J, Kim JK, Shin DM, Sasakawa C. Molecular mechanisms regulating NLRP3 inflammasome activation. Cell Mol Immunol. 2016;13(2):148–159. doi:10.1038/cmi.2015.95
   PubMed Web of Science ®Google Scholar
• Strowig T, Henao-Mejia J, Elinav E, Flavell R. Inflammasomes in health and disease. Nature. 2012;481(7381):278–286. doi:10.1038/nature10759
   PubMed Web of Science ®Google Scholar
• Zhang LG, Chen J, Meng JL, et al. Effect of alcohol on chronic pelvic pain and prostatic inflammation in a mouse model of experimental autoimmune prostatitis. Prostate. 2019;79(12):1439–1449. doi:10.1002/pros.23866
   PubMed Web of Science ®Google Scholar
• Zang L, Tian F, Yao Y, et al. Qianliexin capsule exerts anti-inflammatory activity in chronic non-bacterial prostatitis and benign prostatic hyperplasia via NF-κB and inflammasome. J Cell Mol Med. 2021;25(12):5753–5768. doi:10.1111/jcmm.16599
   PubMed Web of Science ®Google Scholar
• Chen H, Xie Y, Deng C, et al. The Anti-Inflammatory and Antioxidative Effects of Ningmitai Capsule in the Experimental Autoimmune Prostatitis Rat Model. Evid Based Complement Alternat Med. 2020;2020:5847806. doi:10.1155/2020/5847806
   PubMed Web of Science ®Google Scholar
• Hu Y, Niu X, Wang G, Huang J, Liu M, Peng B. Chronic prostatitis/chronic pelvic pain syndrome impairs erectile function through increased endothelial dysfunction, oxidative stress, apoptosis, and corporal fibrosis in a rat model. Andrology. 2016;4(6):1209–1216. doi:10.1111/andr.12273
   PubMed Web of Science ®Google Scholar
• Pasqualotto FF, Sharma RK, Potts JM, Nelson DR, Thomas AJ, Agarwal A. Seminal oxidative stress in patients with chronic prostatitis. Urology. 2000;55(6):881–885. doi:10.1016/s0090-4295(99)00613-5
   PubMed Web of Science ®Google Scholar
• Shahed AR, Shoskes DA. Oxidative stress in prostatic fluid of patients with chronic pelvic pain syndrome: correlation with gram positive bacterial growth and treatment response. J Androl. 2000;21(5):669–675. doi:10.1002/j.1939-4620.2000.tb02135
   PubMedGoogle Scholar
• Rudick CN, Schaeffer AJ, Thumbikat P. Experimental autoimmune prostatitis induces chronic pelvic pain. Am J Physiol Regul Integr Comp Physiol. 2008;294(4):R1268–1275. doi:10.1152/ajpregu.00836.2007
   PubMed Web of Science ®Google Scholar
• Liu X, Zhu Q, Zhang M, et al. Isoliquiritigenin Ameliorates Acute Pancreatitis in Mice via Inhibition of Oxidative Stress and Modulation of the Nrf2/HO-1 Pathway. Oxid Med Cell Longev. 2018;2018:7161592. doi:10.1155/2018/7161592
   PubMed Web of Science ®Google Scholar
• Breser ML, Motrich RD, Sanchez LR, Rivero VE. Chronic Pelvic Pain Development and Prostate Inflammation in Strains of Mice With Different Susceptibility to Experimental Autoimmune Prostatitis. Prostate. 2017;77(1):94–104. doi:10.1002/pros.23252
   PubMed Web of Science ®Google Scholar
• Wei LF, Zhang HM, Wang SS, et al. Changes of MDA and SOD in Brain Tissue after Secondary Brain Injury with Seawater Immersion in Rats. Turk Neurosurg. 2016;26(3):384. doi:10.5137/1019-5149.JTN.8265-13.1
   PubMed Web of Science ®Google Scholar
• Vral A, Magri V, Montanari E, et al. Topographic and quantitative relationship between prostate inflammation, proliferative inflammatory atrophy and low-grade prostate intraepithelial neoplasia: a biopsy study in chronic prostatitis patients. Int J Oncol. 2012;41(6):1950–1958. doi:10.3892/ijo.2012.1646
   PubMed Web of Science ®Google Scholar
• Kullisaar T, Türk S, Punab M, Mändar R. Oxidative stress--cause or consequence of male genital tract disorders? Prostate. 2012;72(9):977–983. doi:10.1002/pros.21502
   PubMed Web of Science ®Google Scholar
• Hyeon S, Lee H, Yang Y, Jeong W. Nrf2 deficiency induces oxidative stress and promotes RANKL-induced osteoclast differentiation. Free Radic Biol Med. 2013;65:789–799. doi:10.1016/j.freeradbiomed.2013.08.005
   PubMed Web of Science ®Google Scholar
• Condorelli RA, Russo GI, Calogero AE, Morgia G, La Vignera S. Chronic prostatitis and its detrimental impact on sperm parameters: a systematic review and meta-analysis. J Endocrinol Invest. 2017;40(11):1209–1218. doi:10.1007/s40618-017-0684-0
   PubMed Web of Science ®Google Scholar
• Theyer G, Kramer G, Assmann I, et al. Phenotypic characterization of infiltrating leukocytes in benign prostatic hyperplasia. Lab Invest. 1992;66(1):96–107.
   PubMed Web of Science ®Google Scholar
• Penna G, Amuchastegui S, Cossetti C, et al. Treatment of experimental autoimmune prostatitis in nonobese diabetic mice by the vitamin D receptor agonist elocalcitol. J Immunol. 2006;177(12):8504–8511. doi:10.4049/jimmunol.177.12.8504
   PubMed Web of Science ®Google Scholar
• John H, Barghorn A, Funke G, et al. Noninflammatory chronic pelvic pain syndrome: immunological study in blood, ejaculate and prostate tissue. Eur Urol. 2001;39(1):72–78. doi:10.1159/000052415
   PubMed Web of Science ®Google Scholar
• Motrich RD, Breser ML, Molina RI, Tissera A, Olmedo JJ, Rivero VE. Patients with chronic prostatitis/chronic pelvic pain syndrome show T helper type 1 (Th1) and Th17 self-reactive immune responses specific to prostate and seminal antigens and diminished semen quality. BJU Int. 2020;126(3):379–387. doi:10.1111/bju.15117
   PubMed Web of Science ®Google Scholar
• Nickel JC, Freedland SJ, Castro-Santamaria R, Moreira DM. Chronic Prostate Inflammation Predicts Symptom Progression in Patients with Chronic Prostatitis/Chronic Pelvic Pain. J Urol. 2017;198(1):122–128. doi:10.1016/j.juro.2017.01.035
   PubMed Web of Science ®Google Scholar
• Ozaki E, Campbell M, Doyle SL. Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives. J Inflamm Res. 2015;8:15–27. doi:10.2147/JIR.S51250
   PubMed Web of Science ®Google Scholar
• Jiang H, He H, Chen Y, et al. Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders. J Exp Med. 2017;214(11):3219–3238. doi:10.1084/jem.20171419
   PubMed Web of Science ®Google Scholar
• Li G, Chen Z, Bhat OM, et al. NLRP3 inflammasome as a novel target for docosahexaenoic acid metabolites to abrogate glomerular injury. J Lipid Res. 2017;58(6):1080–1090. doi:10.1194/jlr.M072587
   PubMed Web of Science ®Google Scholar
• Wei C, Guo S, Liu W, et al. Resolvin D1 ameliorates Inflammation-Mediated Blood-Brain Barrier Disruption After Subarachnoid Hemorrhage in rats by Modulating A20 and NLRP3 Inflammasome. Front Pharmacol. 2021;11:610734. doi:10.3389/fphar.2020.610734
   PubMed Web of Science ®Google Scholar
• Yarmohammadi F, Hayes AW, Karimi G. Possible protective effect of resolvin D1 on inflammation in atrial fibrillation: involvement of ER stress mediated the NLRP3 inflammasome pathway. Naunyn Schmiedebergs Arch Pharmacol. 2021;394(8):1613–1619. doi:10.1007/s00210-021-02115-0
   PubMed Web of Science ®Google Scholar
• Brieger K, Schiavone S, Krause KH. Reactive oxygen species: from health to disease. Swiss Med Wkly. 2012;142:w13659. doi:10.4414/smw.2012.13659
   PubMed Web of Science ®Google Scholar
• Conner EM, Grisham MB. Inflammation, free radicals, and antioxidants. Nutrition. 1996;12(4):274–277. doi:10.1016/s0899-9007(96)00000-8
   PubMed Web of Science ®Google Scholar
• Lugrin J, Rosenblatt-Velin N, Parapanov R, Liaudet L. The role of oxidative stress during inflammatory processes. Biol Chem. 2014;395(2):203–230. doi:10.1515/hsz-2013-0241
   PubMed Web of Science ®Google Scholar
• Kennett EC, Chuang CY, Degendorfer G, Whitelock JM, Davies MJ. Mechanisms and consequences of oxidative damage to extracellular matrix. Biochem Soc Trans. 2011;39(5):1279–1287. doi:10.1042/BST0391279
   PubMedGoogle Scholar
• Hamid AR, Umbas R, Mochtar CA. Recent role of inflammation in prostate diseases: chemoprevention development opportunity. Acta Med Indones. 2011;43(1):59–65.
   PubMedGoogle Scholar
• Baltaci S, Orhan D, Gögüs C, Türkölmez K, Tulunay O, Gögüs O. Inducible nitric oxide synthase expression in benign prostatic hyperplasia, low- and high-grade prostatic intraepithelial neoplasia and prostatic carcinoma. BJU Int. 2001;88(1):100–103. doi:10.1046/j.1464-410x.2001.02231.x
   PubMed Web of Science ®Google Scholar
• Kelsey NA, Wilkins HM, Linseman DA. Nutraceutical antioxidants as novel neuroprotective agents. Molecules. 2010;15(11):7792–7814. doi:10.3390/molecules15117792
   PubMed Web of Science ®Google Scholar
• Kang HJ, Hong YB, Kim HJ, Wang A, Bae I. Bioactive food components prevent carcinogenic stress via Nrf2 activation in BRCA1 deficient breast epithelial cells. Toxicol Lett. 2012;209(2):154–160. doi:10.1016/j.toxlet.2011.12.002
   PubMed Web of Science ®Google Scholar
• Bao L, Li J, Zha D, et al. Chlorogenic acid prevents diabetic nephropathy by inhibiting oxidative stress and inflammation through modulation of the Nrf2/HO-1 and NF-ĸB pathways. Int Immunopharmacol. 2018;54:245–253. doi:10.1016/j.intimp.2017.11.021
   PubMed Web of Science ®Google Scholar
• Chen H, Xie K, Han H, et al. Molecular hydrogen protects mice against polymicrobial sepsis by ameliorating endothelial dysfunction via an Nrf2/HO-1 signaling pathway. Int Immunopharmacol. 2015;28(1):643–654. doi:10.1016/j.intimp.2015.07.034
   PubMed Web of Science ®Google Scholar
• Zhao Q, Yang F, Meng L, et al. Lycopene attenuates chronic prostatitis/chronic pelvic pain syndrome by inhibiting oxidative stress and inflammation via the interaction of NF-κB, MAPKs, and Nrf2 signaling pathways in rats. Andrology. 2020;8(3):747–755. doi:10.1111/andr.12747
   PubMed Web of Science ®Google Scholar
• Lin D, Zhang M, Luo C, Wei P, Cui K, Chen Z. Targeting Ferroptosis Attenuates Inflammation, Fibrosis, and Mast Cell Activation in Chronic Prostatitis. J Immunol Res. 2022;2022:6833867. doi:10.1155/2022/6833867
   PubMed Web of Science ®Google Scholar