278
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Pan-Cancer Analysis Reveals CENPI as a Potential Biomarker and Therapeutic Target in Adrenocortical Carcinoma

, , , , , , , , & ORCID Icon show all
Pages 2907-2928 | Received 20 Mar 2023, Accepted 06 Jul 2023, Published online: 12 Jul 2023

References

  • Okada M, Cheeseman IM, Hori T, et al. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. Nat Cell Biol. 2006;8(5):446–457. doi:10.1038/ncb1396
  • Cheeseman IM, Hori T, Fukagawa T, Desai A. KNL1 and the CENP-H/I/K complex coordinately direct kinetochore assembly in vertebrates. Mol Biol Cell. 2008;19(2):587–594. doi:10.1091/mbc.e07-10-1051
  • Matson DR, Demirel PB, Stukenberg PT, Burke DJ. A conserved role for COMA/CENP-H/I/N kinetochore proteins in the spindle checkpoint. Genes Dev. 2012;26(6):542–547. doi:10.1101/gad.184184.111
  • Kim S, Yu H. Multiple assembly mechanisms anchor the KMN spindle checkpoint platform at human mitotic kinetochores. J Cell Biol. 2015;208(2):181–196. doi:10.1083/jcb.201407074
  • Hamdouch K, Rodriguez C, Perez-Venegas J, et al. Anti-CENPI autoantibodies in scleroderma patients with features of autoimmune liver diseases. Clin Chim Acta. 2011;412(23–24):2267–2271. doi:10.1016/j.cca.2011.08.024
  • Chang D, Gao F, Slavney A, et al. Accounting for eXentricities: analysis of the X chromosome in GWAS reveals X-linked genes implicated in autoimmune diseases. PLoS One. 2014;9(12):e113684. doi:10.1371/journal.pone.0113684
  • Kumar A, Purohit R. Computational investigation of pathogenic nsSNPs in CEP63 protein. Gene. 2012;503(1):75–82. doi:10.1016/j.gene.2012.04.032
  • Barra V, Fachinetti D. The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA. Nat Commun. 2018;9(1):4340. doi:10.1038/s41467-018-06545-y
  • Kumar A, Rajendran V, Sethumadhavan R, Purohit R. Identifying novel oncogenes: a machine learning approach. Interdiscip Sci. 2013;5(4):241–246. doi:10.1007/s12539-013-0151-3
  • Thangavelu PU, Lin CY, Vaidyanathan S, Nguyen THM, Dray E, Duijf PHG. Overexpression of the E2F target gene CENPI promotes chromosome instability and predicts poor prognosis in estrogen receptor-positive breast cancer. Oncotarget. 2017;8(37):62167–62182. doi:10.18632/oncotarget.19131
  • Wang LX, Chu HJ, Li N, Huang LY, Chen J, Chen J. Centromere protein I (CENP-I) is upregulated in gastric cancer, predicts poor prognosis, and promotes tumor cell proliferation and migration. Technol Cancer Res Treat. 2021;20:153303382110455. doi:10.1177/15330338211045510
  • Ding N, Li R, Shi W, He C. CENPI is overexpressed in colorectal cancer and regulates cell migration and invasion. Gene. 2018;674:80–86. doi:10.1016/j.gene.2018.06.067
  • Else T, Kim AC, Sabolch A, et al. Adrenocortical carcinoma. Endocr Rev. 2014;35(2):282–326. doi:10.1210/er.2013-1029
  • Giordano TJ, Kuick R, Else T, et al. Molecular classification and prognostication of adrenocortical tumors by transcriptome profiling. Clin Cancer Res. 2009;15(2):668–676. doi:10.1158/1078-0432.CCR-08-1067
  • de Reynies A, Assie G, Rickman DS, et al. Gene expression profiling reveals a new classification of adrenocortical tumors and identifies molecular predictors of malignancy and survival. J Clin Oncol. 2009;27(7):1108–1115. doi:10.1200/JCO.2008.18.5678
  • Lippert J, Appenzeller S, Liang R, et al. Targeted molecular analysis in adrenocortical carcinomas: a strategy toward improved personalized prognostication. J Clin Endocrinol Metab. 2018;103(12):4511–4523. doi:10.1210/jc.2018-01348
  • Li T, Fu J, Zeng Z, et al. TIMER2.0 for analysis of tumor-infiltrating immune cells. Nucleic Acids Res. 2020;48(W1):W509–W14. doi:10.1093/nar/gkaa407
  • Subramanian A, Tamayo P, Mootha VK, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005;102(43):15545–15550. doi:10.1073/pnas.0506580102
  • Yu G, Wang LG, Han Y, He QY. clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS. 2012;16(5):284–287. doi:10.1089/omi.2011.0118
  • Wang Y, Bryant SH, Cheng T, et al. PubChem BioAssay: 2017 update. Nucleic Acids Res. 2017;45(D1):D955–D63. doi:10.1093/nar/gkw1118
  • Morris GM, Huey R, Olson AJ. Using AutoDock for ligand-receptor docking. Curr Protoc Bioinformatics. 2008;24:8–14.
  • Basilico F, Maffini S, Weir JR, et al. The pseudo GTPase CENP-M drives human kinetochore assembly. Elife. 2014;3:e02978. doi:10.7554/eLife.02978
  • Lu G, Shan T, He S, et al. Overexpression of CENP-H as a novel prognostic biomarker for human hepatocellular carcinoma progression and patient survival. Oncol Rep. 2013;30(5):2238–2244. doi:10.3892/or.2013.2675
  • Wu X, Lin Y, Shi L, et al. Upregulation of centromere protein H is associated with progression of renal cell carcinoma. J Mol Histol. 2015;46(4–5):377–385. doi:10.1007/s10735-015-9635-2
  • He WL, Li YH, Yang DJ, et al. Combined evaluation of centromere protein H and Ki-67 as prognostic biomarker for patients with gastric carcinoma. Eur J Surg Oncol. 2013;39(2):141–149. doi:10.1016/j.ejso.2012.08.023
  • Liao WT, Feng Y, Li ML, et al. Overexpression of centromere protein H is significantly associated with breast cancer progression and overall patient survival. Chin J Cancer. 2011;30(9):627–637. doi:10.5732/cjc.010.10599
  • Liao WT, Wang X, Xu LH, et al. Centromere protein H is a novel prognostic marker for human nonsmall cell lung cancer progression and overall patient survival. Cancer. 2009;115(7):1507–1517. doi:10.1002/cncr.24128
  • Guo XZ, Zhang G, Wang JY, et al. Prognostic relevance of Centromere protein H expression in esophageal carcinoma. BMC Cancer. 2008;8:233. doi:10.1186/1471-2407-8-233
  • Liao WT, Song LB, Zhang HZ, et al. Centromere protein H is a novel prognostic marker for nasopharyngeal carcinoma progression and overall patient survival. Clin Cancer Res. 2007;13(2 Pt 1):508–514. doi:10.1158/1078-0432.CCR-06-1512
  • Shigeishi H, Higashikawa K, Ono S, et al. Increased expression of CENP-H gene in human oral squamous cell carcinomas harboring high-proliferative activity. Oncol Rep. 2006;16(5):1071–1075.
  • Tomonaga T, Matsushita K, Ishibashi M, et al. Centromere protein H is up-regulated in primary human colorectal cancer and its overexpression induces aneuploidy. Cancer Res. 2005;65(11):4683–4689. doi:10.1158/0008-5472.CAN-04-3613
  • Lee YC, Huang CC, Lin DY, Chang WC, Lee KH. Overexpression of centromere protein K (CENPK) in ovarian cancer is correlated with poor patient survival and associated with predictive and prognostic relevance. PeerJ. 2015;3:e1386. doi:10.7717/peerj.1386
  • Wu S, Cao L, Ke L, et al. Knockdown of CENPK inhibits cell growth and facilitates apoptosis via PTEN-PI3K-AKT signalling pathway in gastric cancer. J Cell Mol Med. 2021;25(18):8890–8903. doi:10.1111/jcmm.16850
  • Lin X, Wang F, Chen J, et al. N(6)-methyladenosine modification of CENPK mRNA by ZC3H13 promotes cervical cancer stemness and chemoresistance. Mil Med Res. 2022;9(1):19. doi:10.1186/s40779-022-00378-z
  • Xiao Y, Najeeb RM, Ma D, Yang K, Zhong Q, Liu Q. Upregulation of CENPM promotes hepatocarcinogenesis through multiple mechanisms. J Exp Clin Cancer Res. 2019;38(1):458. doi:10.1186/s13046-019-1444-0
  • Zheng C, Zhang T, Li D, et al. Upregulation of CENPM facilitates tumor metastasis via the mTOR/p70S6K signaling pathway in pancreatic cancer. Oncol Rep. 2020;44(3):1003–1012. doi:10.3892/or.2020.7673
  • Liu C, Wang Y, Dao Y, et al. Upregulation of CENPM facilitates lung adenocarcinoma progression via PI3K/AKT/mTOR signaling pathway. Acta Biochim Biophys Sin (Shanghai). 2022;54(1):99–112. doi:10.3724/abbs.2021013
  • Hinshaw DC, Shevde LA. The tumor microenvironment innately modulates cancer progression. Cancer Res. 2019;79(18):4557–4566. doi:10.1158/0008-5472.CAN-18-3962
  • Al-Lazikani B, Banerji U, Workman P. Combinatorial drug therapy for cancer in the post-genomic era. Nat Biotechnol. 2012;30(7):679–692. doi:10.1038/nbt.2284
  • Portella G, Passaro C, Chieffi P. Aurora B: a new prognostic marker and therapeutic target in cancer. Curr Med Chem. 2011;18(4):482–496. doi:10.2174/092986711794480203
  • Matson DR, Stukenberg PT. CENP-I and Aurora B act as a molecular switch that ties RZZ/Mad1 recruitment to kinetochore attachment status. J Cell Biol. 2014;205(4):541–554. doi:10.1083/jcb.201307137