The Correlation Between Aldosterone and Leukocyte-Related Inflammation: A Comparison Between Patients with Primary Aldosteronism and Essential Hypertension

References

• Unger T, Borghi C, Charchar F, et al. 2020 international society of hypertension global hypertension practice guidelines. Hypertension. 2020;75(6):1334–1357. doi:10.1161/HYPERTENSIONAHA.120.15026
   PubMed Web of Science ®Google Scholar
• Monticone S, Burrello J, Tizzani D, et al. Prevalence and clinical manifestations of primary aldosteronism encountered in primary care practice. J Am Coll Cardiol. 2017;69(14):1811–1820. doi:10.1016/j.jacc.2017.01.052
   PubMed Web of Science ®Google Scholar
• Xu Z, Yang J, Hu J, et al. Primary aldosteronism in patients in China with recently detected hypertension. J Am Coll Cardiol. 2020;75(16):1913–1922. doi:10.1016/j.jacc.2020.02.052
   PubMed Web of Science ®Google Scholar
• Calhoun DA. Is there an unrecognized epidemic of primary aldosteronism? Pro. Hypertension. 2007;50(3):447–453. doi:10.1161/HYPERTENSIONAHA.106.086116
   PubMed Web of Science ®Google Scholar
• Milliez P, Girerd X, Plouin PF, Blacher J, Safar ME, Mourad JJ. Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism. J Am Coll Cardiol. 2005;45(8):1243–1248. doi:10.1016/j.jacc.2005.01.015
   PubMed Web of Science ®Google Scholar
• Monticone S, Moretti C, Ascenzo F, et al. Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: a systematic review and meta-analysis. Lancet Diabetes Endocrinol. 2018;6(1):41–50. doi:10.1016/S2213-8587(17)30319-4
   PubMed Web of Science ®Google Scholar
• Fernández-Argüeso M, Pascual-Corrales E, Bengoa Rojano N, García Cano A, Jiménez Mendiguchía L, Araujo-Castro M. Higher risk of chronic kidney disease and progressive kidney function impairment in primary aldosteronism than in essential hypertension. Case-control study. Endocrine. 2021;73(2):439–446.
   PubMed Web of Science ®Google Scholar
• Muñoz-Durango N, Vecchiola A, Gonzalez-Gomez LM, et al. Modulation of immunity and inflammation by the mineralocorticoid receptor and aldosterone. Biomed Res Int. 2015;2015:652738. doi:10.1155/2015/652738
   PubMed Web of Science ®Google Scholar
• Rocha R, Rudolph AE, Frierdich GE, et al. Aldosterone induces a vascular inflammatory phenotype in the rat heart. Am J Physiol Heart Circ Physiol. 2002;283(5):H1802–10. doi:10.1152/ajpheart.01096.2001
   PubMed Web of Science ®Google Scholar
• Sun Y, Zhang J, Lu L, Chen SS, Quinn MT, Weber KT. Aldosterone-induced inflammation in the rat heart: role of oxidative stress. Am J Pathol. 2002;161(5):1773–1781. doi:10.1016/S0002-9440(10)64454-9
   PubMed Web of Science ®Google Scholar
• Rickard AJ, Morgan J, Tesch G, Funder JW, Fuller PJ, Young MJ. Deletion of mineralocorticoid receptors from macrophages protects against deoxycorticosterone/salt-induced cardiac fibrosis and increased blood pressure. Hypertension. 2009;54(3):537–543. doi:10.1161/HYPERTENSIONAHA.109.131110
   PubMed Web of Science ®Google Scholar
• Ferreira NS, Tostes RC, Paradis P, Schiffrin EL. Aldosterone, Inflammation, Immune System, and Hypertension. Am J Hypertens. 2021;34(1):15–27. doi:10.1093/ajh/hpaa137
   PubMed Web of Science ®Google Scholar
• Pusuroglu H, Akgul O, Erturk M, et al. A comparative analysis of leukocyte and leukocyte subtype counts among isolated systolic hypertensive, systo-diastolic hypertensive, and non-hypertensive patients. Kardiol Pol. 2014;72(8):748–754. doi:10.5603/KP.a2014.0044
   PubMed Web of Science ®Google Scholar
• Liu X, Zhang Q, Wu H, et al. Blood neutrophil to lymphocyte ratio as a predictor of hypertension. Am J Hypertens. 2015;28(11):1339–1346. doi:10.1093/ajh/hpv034
   PubMed Web of Science ®Google Scholar
• Jhuang YH, Kao TW, Peng TC, et al. Neutrophil to lymphocyte ratio as predictor for incident hypertension: a 9-year cohort study in Taiwan. Hypertens Res. 2019;42(8):1209–1214. doi:10.1038/s41440-019-0245-3
   PubMed Web of Science ®Google Scholar
• Çimen T, Sunman H, Efe TH, et al. The relationship between 24-hour ambulatory blood pressure load and neutrophil-to-lymphocyte ratio. Rev Port Cardiol. 2017;36(2):97–105. doi:10.1016/j.repc.2016.07.009
   PubMedGoogle Scholar
• Renata L, Jinbo H, Chee Min R, et al. A multicenter study of neutrophil-to-lymphocyte ratio in primary aldosteronism. J Endocr Soc. 2020;4(12). doi:10.1210/jendso/bvaa153
   Web of Science ®Google Scholar
• van der Heijden C, Smeets E, Aarntzen E, et al. Arterial wall inflammation and increased hematopoietic activity in patients with primary aldosteronism. J Clin Endocrinol Metab. 2020;105(5):e1967–80. doi:10.1210/clinem/dgz306
   PubMed Web of Science ®Google Scholar
• Funder JW, Carey RM, Mantero F, et al. The management of primary aldosteronism: case detection, diagnosis, and treatment: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2016;101(5):1889–1916. doi:10.1210/jc.2015-4061
   PubMed Web of Science ®Google Scholar
• Liu LS. Chinese guidelines for the prevention and treatment of hypertension. Chin Cardiovasc J. 2019;24(1):24–56. doi:10.3969/j.issn.1007-5410.2019.01.002
   Google Scholar
• Azab B, Zaher M, Weiserbs KF, et al. Usefulness of neutrophil to lymphocyte ratio in predicting short- and long-term mortality after non-ST-elevation myocardial infarction. Am J Cardiol. 2010;106(4):470–476. doi:10.1016/j.amjcard.2010.03.062
   PubMed Web of Science ®Google Scholar
• Bhat T, Teli S, Rijal J, et al. Neutrophil to lymphocyte ratio and cardiovascular diseases: a review. Expert Rev Cardiovasc Ther. 2013;11(1):55–59. doi:10.1586/erc.12.159
   PubMedGoogle Scholar
• Forget P, Khalifa C, Defour JP, Latinne D, Van Pel MC, De Kock M. What is the normal value of the neutrophil-to-lymphocyte ratio. BMC Res Notes. 2017;10(1):12. doi:10.1186/s13104-016-2335-5
   PubMedGoogle Scholar
• Wang J, Zhang F, Jiang F, Hu L, Chen J, Wang Y. Distribution and reference interval establishment of neutral-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) in Chinese healthy adults. J Clin Lab Anal. 2021;35(9):e23935. doi:10.1002/jcla.23935
   PubMed Web of Science ®Google Scholar
• Corriere T, Di marca S, Cataudella E, et al. Neutrophil-to-Lymphocyte Ratio is a strong predictor of atherosclerotic carotid plaques in older adults. Nutr Metab Cardiovasc Dis. 2018;28(1):23–27. doi:10.1016/j.numecd.2017.10.022
   PubMed Web of Science ®Google Scholar
• Kaya H, Ertaş F, Soydinç MS. Association between neutrophil to lymphocyte ratio and severity of coronary artery disease. Clin Appl Thromb Hemost. 2014;20(2):221. doi:10.1177/1076029613499821
   PubMed Web of Science ®Google Scholar
• Yu X, Xue Y, Bian B, et al. NLR-A simple indicator of inflammation for the diagnosis of left ventricular hypertrophy in patients with hypertension. Int Heart J. 2020;61(2):373–379. doi:10.1536/ihj.19-138
   PubMed Web of Science ®Google Scholar
• Sunbul M, Gerin F, Durmus E, et al. Neutrophil to lymphocyte and platelet to lymphocyte ratio in patients with dipper versus non-dipper hypertension. Clin Exp Hypertens. 2014;36(4):217–221. doi:10.3109/10641963.2013.804547
   PubMed Web of Science ®Google Scholar
• Belen E, Sungur A, Sungur MA, Erdoğan G. Increased neutrophil to lymphocyte ratio in patients with resistant hypertension. J Clin Hypertens. 2015;17(7):532–537. doi:10.1111/jch.12533
   Web of Science ®Google Scholar
• Auffray C, Fogg D, Garfa M, et al. Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior. Science. 2007;317(5838):666–670. doi:10.1126/science.1142883
   PubMed Web of Science ®Google Scholar
• Chapman CM, Beilby JP, McQuillan BM, Thompson PL, Hung J. Monocyte count, but not C-reactive protein or interleukin-6, is an independent risk marker for subclinical carotid atherosclerosis. Stroke. 2004;35(7):1619–1624. doi:10.1161/01.STR.0000130857.19423.ad
   PubMed Web of Science ®Google Scholar
• Berg KE, Ljungcrantz I, Andersson L, et al. Elevated CD14++CD16- monocytes predict cardiovascular events. Circ Cardiovasc Genet. 2012;5(1):122–131. doi:10.1161/CIRCGENETICS.111.960385
   PubMedGoogle Scholar
• Ducloux D, Challier B, Saas P, Tiberghien P, Chalopin JM. CD4 cell lymphopenia and atherosclerosis in renal transplant recipients. J Am Soc Nephrol. 2003;14(3):767–772. doi:10.1097/01.ASN.0000048718.43419.44
   PubMed Web of Science ®Google Scholar
• Zhang M, Wang K, Zheng H, Zhao X, Xie S, Liu C. Monocyte lymphocyte ratio predicts the new-onset of chronic kidney disease: a cohort study. Clin Chim Acta. 2020;503:181–189. doi:10.1016/j.cca.2019.11.021
   PubMed Web of Science ®Google Scholar
• Chen H, Li M, Liu L, Dang X, Zhu D, Tian G. Monocyte/lymphocyte ratio is related to the severity of coronary artery disease and clinical outcome in patients with non-ST-elevation myocardial infarction. Medicine. 2019;98(26):e16267. doi:10.1097/MD.0000000000016267
   PubMed Web of Science ®Google Scholar
• Zuo B, Zhu S, Meng X, Zhao D, Zhang J. Monocyte/lymphocyte ratio is associated with carotid stenosis in ischemic stroke: a retrospective analysis. Brain Behav. 2019;9(10):e01429. doi:10.1002/brb3.1429
   PubMed Web of Science ®Google Scholar
• Núñez J, Sastre C, D’Ascoli G, et al. Relation of low lymphocyte count to frailty and its usefulness as a prognostic biomarker in patients >65 years of age with acute coronary syndrome. Am J Cardiol. 2020;125(7):1033–1038. doi:10.1016/j.amjcard.2020.01.006
   PubMed Web of Science ®Google Scholar
• Siedlinski M, Jozefczuk E, Xu X, et al. White blood cells and blood pressure: a Mendelian randomization study. Circulation. 2020;141(16):1307–1317. doi:10.1161/CIRCULATIONAHA.119.045102
   PubMed Web of Science ®Google Scholar