Neural Stem Cell-Derived Exosomes Improve Neurological Function in Rats with Cerebral Ischemia-Reperfusion Injury by Regulating Microglia-Mediated Inflammatory Response

References

• Akinyemi RO, Owolabi MO, Ihara M, et al. Stroke, cerebrovascular diseases and vascular cognitive impairment in Africa. Brain Res Bull. 2019;145:97–108. doi:10.1016/j.brainresbull
   PubMed Web of Science ®Google Scholar
• Congqin L, Ying X, Yuqian Z, et al. Neutrophil extracellular traps exacerbate ischemic brain damage. Mol Neurobiol. 2021;59(1):643–656. doi:10.1007/s12035-021-02635-z
   PubMed Web of Science ®Google Scholar
• Jurga AM, Paleczna M, Kuter KZ. Overview of general and discriminating markers of differential microglia phenotypes. Front Cell Neurosci. 2020;14:198–215. doi:10.3389/fncel.2020.00198
   PubMed Web of Science ®Google Scholar
• Han B, Jiang W, Cui P, et al. Microglial PGC-1α protects against ischemic brain injury by suppressing neuroinflammation. Genome Med. 2021;13(1):47–65. doi:10.1186/s13073-021-00863-5
   PubMed Web of Science ®Google Scholar
• Leng F, Edison P. Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here? Nat Rev Neurol. 2020;17(3):157–172. doi:10.1038/s41582-020-00435-y
   PubMed Web of Science ®Google Scholar
• Qin C, Zhou LQ, Ma XT, et al. Dual functions of microglia in ischemic stroke. Neurosci Bull. 2019;35(5):921–933. doi:10.1007/s12264-019-00388-3
   PubMed Web of Science ®Google Scholar
• Zeng X, Geng W, Jia J, et al. Advances in stem cells transplantation for the therapy of Parkinson’s disease. Curr Stem Cell Res Ther. 2021;16(8):958–969. doi:10.2174/1574888X16666210309153949
   PubMed Web of Science ®Google Scholar
• Zhu JD, Wang JJ, Ge G, et al. Effects of Noggin-transfected neural stem cells on neural functional recovery and underlying mechanism in rats with cerebral ischemia reperfusion injury. J Stroke Cerebrovascular Dis. 2017;26(7):1547–1559. doi:10.1016/j.jstrokecerebrovasdis.2017.02.034
   PubMed Web of Science ®Google Scholar
• Hwang I, Hong S. Neural stem cells and its derivatives as a new material for melanin inhibition. Int J Mol Sci. 2017;19(1):36–53. doi:10.3390/ijms19010036
   PubMed Web of Science ®Google Scholar
• Yuluo R, Wei L, Jiaxing W, et al. Neural stem cell-derived small extracellular vesicles attenuate apoptosis and neuroinflammation after traumatic spinal cord injury by activating autophagy. Cell Death Dis. 2019;10(5):340–357. doi:10.1038/s41419-019-1571-8
   PubMedGoogle Scholar
• Zhong D, Cao Y, Li CJ, et al. Neural stem cell-derived exosomes facilitate spinal cord functional recovery after injury by promoting angiogenesis. Exp Biol Med. 2020;245(1):54–65. doi:10.1177/1535370219895491
   PubMed Web of Science ®Google Scholar
• Vogel A, Upadhya R, Shetty AK. Neural stem cell derived extracellular vesicles: attributes and prospects for treating neurodegenerative disorders. EBioMedicine. 2018;38:273–282. doi:10.1016/j.ebiom.2018.11.026
   PubMed Web of Science ®Google Scholar
• Longa E, Weinstein PR, Carlson S, et al. Reversible middle cerebral Artery occlusion without craniectomy in rats. Stroke. 1989;20(1):84–91. doi:10.1161/01.str.20.1.84
   PubMed Web of Science ®Google Scholar
• Li S, Luo L, He Y, et al. Dental pulp stem cell-derived exosomes alleviate cerebral ischaemia-reperfusion injury through suppressing inflammatory response. Cell Prolif. 2021;54(8):e13093. doi:10.1111/cpr
   PubMed Web of Science ®Google Scholar
• Vorhees CV, Williams MT. Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protoc. 2006;1(2):848–858. doi:10.1038/nprot.2006.116
   PubMed Web of Science ®Google Scholar
• Jin Y, Barnett A, Zhang Y, et al. Poststroke sonic hedgehog agonist treatment improves functional recovery by enhancing neurogenesis and angiogenesis. Stroke. 2017;48(6):1636–1645. doi:10.1161/STROKEAHA.117.016650
   PubMed Web of Science ®Google Scholar
• Liu X, Zhang M, Liu H, et al. Bone marrow mesenchymal stem cell-derived exosomes attenuate cerebral ischemia-reperfusion injury-induced neuroinflammation and pyroptosis by modulating microglia M1/M2 phenotypes. Exp Neurol. 2021;341(28):113700. doi:10.1016/j.expneurol.2021.113700
   PubMedGoogle Scholar
• Song Y, Li Z, He T, et al. M2 microglia-derived exosomes protect the mouse brain from ischemia-reperfusion injury via exosomal miR-124. Theranostics. 2019;9(10):2910–2923. doi:10.7150/thno.30879
   PubMed Web of Science ®Google Scholar
• Berchtold C, Priller J, Meisel C, Meisel A. Interaction of microglia with infiltrating immune cells in the different phases of stroke. Brain Pathol. 2020;30(6):1208–1218. doi:10.1111/bpa.12911
   PubMed Web of Science ®Google Scholar
• Jie T, Yu W, Sheng C, et al. Microglia polarization and endoplasmic reticulum stress in chronic social defeat stress induced depression mouse. Neurochem Res. 2018;43(3):985–994. doi:10.1007/s11064-018-2504-0
   PubMedGoogle Scholar
• Qin C, Fan WH, Liu Q, et al. Fingolimod protects against ischemic white matter damage by modulating microglia toward M2 polarization via STAT3 pathway. Stroke. 2017;48(12):3336–3346. doi:10.1161/STROKEAHA.117.018505
   PubMed Web of Science ®Google Scholar
• Zhou L, Zhu H, Bai X, et al. Potential mechanisms and therapeutic targets of mesenchymal stem cell transplantation for ischemic stroke. Stem Cell Res Ther. 2022;13(1):195–209. doi:10.1186/s13287-022-02876-2
   PubMed Web of Science ®Google Scholar
• Long X, Yao X, Jiang Q, Yang Y, Zhang H. Astrocyte-derived exosomes enriched with miR-873a-5p inhibit neuroinflammation via microglia phenotype modulation after traumatic brain injury. J Neuroinflammation. 2020;17(1):89–103. doi:10.1186/s12974-020-01761-0
   PubMed Web of Science ®Google Scholar
• Halurkar MS, Wang J, Chen S, Bihl JC. EPC-EXs improve astrocyte survival and oxidative stress through different uptaking pathways in diabetic hypoxia condition. Stem Cell Res Ther. 2022;13(1):91–100. doi:10.1186/s13287-022-02766-7
   PubMed Web of Science ®Google Scholar
• Webb RL, Kaiser EE, Jurgielewicz BJ, et al. Human neural stem cell extracellular vesicles improve recovery in a porcine model of ischemic stroke. Stroke. 2018;49(5):1248–1256. doi:10.1161/STROKEAHA.117.020353
   PubMed Web of Science ®Google Scholar
• Zhu Z, Jia F, Ahmed W, et al. Neural stem cell-derived exosome as a nano-sized carrier for BDNF delivery to a rat model of ischemic stroke. Neural Regen Res. 2023;18(2):404–409. doi:10.4103/1673-5374.346466
   PubMed Web of Science ®Google Scholar
• Luo L, Liu M, Fan Y, et al. Intermittent theta-burst stimulation improves motor function by inhibiting neuronal pyroptosis and regulating microglial polarization via TLR4/NFκB/NLRP3 signaling pathway in cerebral ischemic mice. J Neuroinflammation. 2022;19(1):141–167. doi:10.1186/s12974-022-02501-2
   PubMed Web of Science ®Google Scholar
• Hu X, Li P, Guo Y, et al. Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia. Stroke. 2012;43(11):3063–3070. doi:10.1161/strokeaha.112.659656
   PubMed Web of Science ®Google Scholar
• Almarghalani D, Sha X, Mrak R, Shah Z. Spatiotemporal cofilin signaling, microglial activation, neuroinflammation, and cognitive impairment following hemorrhagic brain injury. Cells. 2023;12(8):1153–1172. doi:10.3390/cells12081153
   PubMed Web of Science ®Google Scholar
• Dehghani L, Khojasteh A, Soleimani M, et al. Safety of intraparenchymal injection of allogenic placenta mesenchymal stem cells derived exosome in patients undergoing de compressive craniectomy following malignant middle cerebral artery infarct, A pilot randomized clinical trial. Int J Prev Med. 2022;13:7–14. doi:10.4103/ijpvm.ijpvm_441_21
   PubMed Web of Science ®Google Scholar