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LETTER

Preclinical Model in Sepsis: Should We Abandon the CLP? [Letter]

Pages 1757-1759 | Received 05 Apr 2023, Accepted 14 Apr 2023, Published online: 21 Apr 2023

References

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  • Hyde SR, Stith RD, McCallum RE. Mortality and bacteriology of sepsis following cecal ligation and puncture in aged mice. Infect Immun. 1990;58(3):619–624. doi:10.1128/iai.58.3.619-624.1990
  • Osuchowski MF, Ayala A, Bahrami S, et al. Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis. Shock. 2018;50(4):377–380. doi:10.1097/SHK.0000000000001212
  • Dejager L, Pinheiro I, Dejonckheere E, Libert C. Cecal ligation and puncture: the gold standard model for polymicrobial sepsis? Trends Microbiol. 2011;19(4):198–208. doi:10.1016/j.tim.2011.01.001