Serum Amyloid A 4 as a Common Marker of Persistent Inflammation in Patients with Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy

References

• Mitchell P, Liew G, Gopinath B, Wong TY. Age-related macular degeneration. Lancet. 2018;392(10153):1147–1159. doi:10.1016/S0140-6736(18)31550-2
   PubMed Web of Science ®Google Scholar
• Wong WL, Su X, Li X, et al. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Global Health. 2014;2(2):e106–e116. doi:10.1016/S2214-109X(13)70145-1
   PubMed Web of Science ®Google Scholar
• Chakravarthy U, Peto T. Current Perspective on Age-Related Macular Degeneration. JAMA. 2020;324(8):794–795. doi:10.1001/jama.2020.5576
   PubMed Web of Science ®Google Scholar
• Nashine S. Potential Therapeutic Candidates for Age-Related Macular Degeneration (AMD). Cells. 2021;10(9):2483. doi:10.3390/cells10092483
   PubMed Web of Science ®Google Scholar
• Mitchell SL, Ma C, Scott WK, et al. Plasma Metabolomics of Intermediate and Neovascular Age-Related Macular Degeneration Patients. Cells. 2021;10(11):3141. doi:10.3390/cells10113141
   PubMedGoogle Scholar
• Teo K, Gillies M, Fraser-Bell S. The Use of Vascular Endothelial Growth Factor Inhibitors and Complementary Treatment Options in Polypoidal Choroidal Vasculopathy: a Subtype of Neovascular Age-Related Macular Degeneration. Int J Mol Sci. 2018;19(9):2611. doi:10.3390/ijms19092611
   PubMed Web of Science ®Google Scholar
• Cheung C, Lai T, Ruamviboonsuk P, et al. Polypoidal Choroidal Vasculopathy: definition. Pathogenesis Diagnosis, Manage Ophthalmol. 2018;125(5):708–724. doi:10.1016/j.ophtha.2017.11.019
   Google Scholar
• Kikuchi M, Nakamura M, Ishikawa K, et al. Elevated C-reactive protein levels in patients with polypoidal choroidal vasculopathy and patients with neovascular age-related macular degeneration. Ophthalmology. 2007;114(9):1722–1727. doi:10.1016/j.ophtha.2006.12.021
   PubMedGoogle Scholar
• Agrawal R, Balne PK, Wei X, et al. Cytokine Profiling in Patients With Exudative Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy. Invest Ophthalmol Vis Sci. 2019;60(1):376–382. doi:10.1167/iovs.18-24387
   PubMed Web of Science ®Google Scholar
• Wu M, Xiong H, Xu Y, et al. Association between VEGF-A and VEGFR-2 polymorphisms and response to treatment of neovascular AMD with anti-VEGF agents: a meta-analysis. Br J Ophthalmol. 2017;101(7):976–984. doi:10.1136/bjophthalmol-2016-309418
   PubMed Web of Science ®Google Scholar
• Yerramothu P. New Therapies of Neovascular AMD-Beyond Anti-VEGFs. Vision. 2018;2(3):31. doi:10.3390/vision2030031
   Google Scholar
• Gemenetzi M, Lotery AJ, Patel PJ. Risk of geographic atrophy in age-related macular degeneration patients treated with intravitreal anti-VEGF agents. Eye. 2017;31(1):1–9. doi:10.1038/eye.2016.208
   PubMed Web of Science ®Google Scholar
• Barış ME, Menteş J, Afrashi F, Nalçaçı S, Akkın C. Subgroups and Features of Poor Responders to Anti-Vascular Endothelial Growth Factor Treatment in Eyes with Neovascular Age-Related Macular Degeneration. Turkish j Ophthalmol. 2020;50(5):275–282. doi:10.4274/tjo.galenos.2020.38488
   PubMedGoogle Scholar
• Yang S, Li T, Jia H. Targeting C3b/C4b and VEGF with a bispecific fusion protein optimized for neovascular age-related macular degeneration therapy. Sci Transl Med. 2022;14(647):eabj2177. doi:10.1126/scitranslmed.abj2177
   PubMedGoogle Scholar
• Lavalette S, Raoul W, Houssier M, et al. Interleukin-1β inhibition prevents choroidal neovascularization and does not exacerbate photoreceptor degeneration. Am J Pathol. 2011;178(5):2416–2423. doi:10.1016/j.ajpath.2011.01.013
   PubMed Web of Science ®Google Scholar
• Izumi-Nagai K, Nagai N, Ozawa Y, et al. Interleukin-6 receptor-mediated activation of signal transducer and activator of transcription-3 (STAT3) promotes choroidal neovascularization. Am J Pathol. 2007;170(6):2149–2158. doi:10.2353/ajpath.2007.061018
   PubMed Web of Science ®Google Scholar
• Huang S, Mills L, Mian B, et al. Fully humanized neutralizing antibodies to interleukin-8 (ABX-IL8) inhibit angiogenesis, tumor growth, and metastasis of human melanoma. Am J Pathol. 2002;161(1):125–134. doi:10.1016/S0002-9440(10)64164-8
   PubMed Web of Science ®Google Scholar
• Sack GH. Serum Amyloid A (SAA) Proteins. Subcell Biochem. 2020;94:421–436. doi:10.1007/978-3-030-41769-7_17
   PubMedGoogle Scholar
• Webb NR. High-Density Lipoproteins and Serum Amyloid A (SAA). Curr Atheroscler Rep. 2021;23(2):7. doi:10.1007/s11883-020-00901-4
   PubMedGoogle Scholar
• Lv M, Xia YF, Li B, et al. Serum amyloid A stimulates vascular endothelial growth factor receptor 2 expression and angiogenesis. J Physiol Biochem. 2016;72(1):71–81. doi:10.1007/s13105-015-0462-4
   PubMedGoogle Scholar
• De Buck M, Gouwy M, Wang JM, et al. The cytokine-serum amyloid A-chemokine network. Cytokine Growth Factor Rev. 2016;30:55–69. doi:10.1016/j.cytogfr.2015.12.010
   PubMed Web of Science ®Google Scholar
• Seok A, Lee HJ, Lee S, et al. Identification and Validation of SAA4 as a Rheumatoid Arthritis Prescreening Marker by Liquid Chromatography Tandem-mass Spectrometry. Molecules. 2017;22(5):805. doi:10.3390/molecules22050805
   PubMedGoogle Scholar
• Sallustio F, Stasi A, Curci C. Renal progenitor cells revert LPS-induced endothelial-to-mesenchymal transition by secreting CXCL6, SAA4, and BPIFA2 antiseptic peptides. FASEB J. 2019;33(10):10753–10766. doi:10.1096/fj.201900351R
   PubMedGoogle Scholar
• Shen C, Sun XG, Liu N, et al. Increased serum amyloid A and its association with autoantibodies, acute phase reactants and disease activity in patients with rheumatoid arthritis. Mol Med Rep. 2015;11(2):1528–1534. doi:10.3892/mmr.2014.2804
   PubMed Web of Science ®Google Scholar
• Mun S, Lee J, Park M, Shin J, Lim MK, Kang HG. Serum biomarker panel for the diagnosis of rheumatoid arthritis. Arthritis Res Ther. 2021;23(1):31. doi:10.1186/s13075-020-02405-7
   PubMed Web of Science ®Google Scholar
• Oikonomopoulou K, Ricklin D, Ward PA, Lambris JD. Interactions between coagulation and complement--their role in inflammation. Semin Immunopathol. 2012;34(1):151–165. doi:10.1007/s00281-011-0280-x
   PubMed Web of Science ®Google Scholar
• Rinsky B, Beykin G, Grunin M, et al. Analysis of the Aqueous Humor Proteome in Patients With Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2021;62(10):18. doi:10.1167/iovs.62.10.18
   PubMedGoogle Scholar
• Kim TW, Kang JW, Ahn J, et al. Proteomic analysis of the aqueous humor in age-related macular degeneration (AMD) patients. J Proteome Res. 2012;11(8):4034–4043. doi:10.1021/pr300080s
   PubMedGoogle Scholar
• Koss MJ, Hoffmann J, Nguyen N, et al. Proteomics of vitreous humor of patients with exudative age-related macular degeneration. PLoS One. 2014;9(5):e96895. doi:10.1371/journal.pone.0096895
   PubMedGoogle Scholar
• Pool FM, Kiel C, Serrano L, Luthert PJ. Repository of proposed pathways and protein-protein interaction networks in age-related macular degeneration. NPJ Aging Mechanisms Dis. 2020;6:2. doi:10.1038/s41514-019-0039-5
   PubMedGoogle Scholar
• Akter T, Annamalai B, Obert E, Simpson KN, Rohrer B. Dabigatran and Wet AMD, Results From Retinal Pigment Epithelial Cell Monolayers, the Mouse Model of Choroidal Neovascularization, and Patients From the Medicare Data Base. Front Immunol. 2022;13:896274. doi:10.3389/fimmu.2022.896274
   PubMedGoogle Scholar
• López-Contreras AK, Martínez-Ruiz MG, Olvera-Montaño C, et al. Importance of the Use of Oxidative Stress Biomarkers and Inflammatory Profile in Aqueous and Vitreous Humor in Diabetic Retinopathy. Antioxidants. 2020;9(9):891. doi:10.3390/antiox9090891
   Web of Science ®Google Scholar
• Oruc Y, Celik F, Ozgur G, et al. Altered Blood And Aqueous Humor Levels Of Asprosin, 4-Hydroxynonenal, And 8-Hydroxy-Deoxyguanosine In Patients With Diabetes Mellitus And Cataract With And Without Diabetic Retinopathy. Retina. 2020;40(12):2410–2416. doi:10.1097/IAE.0000000000002776
   PubMedGoogle Scholar
• Xue M, Ke Y, Ren X, et al. Proteomic analysis of aqueous humor in patients with pathologic myopia. J Proteomics. 2021;234:104088. doi:10.1016/j.jprot.2020.104088
   PubMedGoogle Scholar
• Armento A, Schmidt TL, Sonntag I, et al. CFH Loss in Human RPE Cells Leads to Inflammation and Complement System Dysregulation via the NF-κB Pathway. Int J Mol Sci. 2021;22(16):8727. doi:10.3390/ijms22168727
   PubMedGoogle Scholar
• Ebeling MC, Fisher CR, Kapphahn RJ, et al. Inflammasome Activation in Retinal Pigment Epithelium from Human Donors with Age-Related Macular Degeneration. Cells. 2022;11(13):2075. doi:10.3390/cells11132075
   PubMedGoogle Scholar
• Park YG, Park YS, Kim IB. Complement System and Potential Therapeutics in Age-Related Macular Degeneration. Int J Mol Sci. 2021;22(13):6851. doi:10.3390/ijms22136851
   PubMedGoogle Scholar
• de Bont CM, Boelens WC, Pruijn G. NETosis, complement, and coagulation: a triangular relationship. Cell Mol Immunol. 2019;16(1):19–27. doi:10.1038/s41423-018-0024-0
   PubMed Web of Science ®Google Scholar
• Afzali B, Noris M, Lambrecht BN, Kemper C. The state of complement in COVID-19. Nat Rev Immunol. 2022;22(2):77–84. doi:10.1038/s41577-021-00665-1
   PubMed Web of Science ®Google Scholar
• Göbel K, Eichler S, Wiendl H. The Coagulation Factors Fibrinogen, Thrombin, and Factor XII in Inflammatory Disorders-A Systematic Review. Front Immunol. 2018;9:1731. doi:10.3389/fimmu.2018.01731
   PubMed Web of Science ®Google Scholar
• Smith W, Mitchell P, Leeder SR, Wang JJ. Plasma fibrinogen levels, other cardiovascular risk factors, and age-related maculopathy: the Blue Mountains Eye Study. Arch Ophthalmol. 1998;116(5):583–587. doi:10.1001/archopht.116.5.583
   PubMedGoogle Scholar
• Low S, Vaidya T, Gadde S, et al. Decorin Concentrations in Aqueous Humor of Patients with Diabetic Retinopathy. Life. 2021;11(12):1421. doi:10.3390/life11121421
   PubMedGoogle Scholar
• Lim D, Lee H, Bokjun J. Increased level of retinol binding protein 4 in neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci. 2015;56(7):5476.
   Google Scholar
• Chen Y, Zhang T, Zeng S, et al. Transketolase in human Müller cells is critical to resist light stress through the pentose phosphate and NRF2 pathways. Redox Biol. 2022;54:102379. doi:10.1016/j.redox.2022.102379
   PubMedGoogle Scholar
• van Dijk E, Mohabati D, Veselinovic S, Chung WH, Dijkman G, Boon C. The spectrum of polypoidal choroidal vasculopathy in Caucasians: clinical characteristics and proposal of a classification. Graefe’s archive for clinical and experimental ophthalmology =. Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. 2021;259(2):351–361. doi:10.1007/s00417-020-04844-z
   Google Scholar
• Wickramasekara RN, Morrill S, Farhat Y, Smith SJ, Yilmazer-Hanke D. Glutathione and Inter-α-trypsin inhibitor heavy chain 3 (Itih3) mRNA levels in nicotine-treated Cd44 knockout mice. Toxicology Reports. 2018;5:759–764. doi:10.1016/j.toxrep.2018.06.010
   PubMedGoogle Scholar
• Bracht T, Kleefisch D, Schork K, et al. Plasma Proteomics Enable Differentiation of Lung Adenocarcinoma from Chronic Obstructive Pulmonary Disease (COPD). Int J Mol Sci. 2022;23(19):11242. doi:10.3390/ijms231911242
   PubMedGoogle Scholar
• Liu Q, Niu X, Li Y, et al. Role of the mucin-like glycoprotein FCGBP in mucosal immunity and cancer. Front Immunol. 2022;13:863317. doi:10.3389/fimmu.2022.863317
   PubMedGoogle Scholar
• Lee SH, Jung JH, Park TK, et al. Proteome alterations in the aqueous humor reflect structural and functional phenotypes in patients with advanced normal-tension glaucoma. Sci Rep. 2022;12(1):1221. doi:10.1038/s41598-022-05273-0
   PubMedGoogle Scholar
• Dabovic B, Chen Y, Colarossi C, Zambuto L, Obata H, Rifkin DB. Bone defects in latent TGF-beta binding protein (Ltbp)-3 null mice; a role for Ltbp in TGF-beta presentation. J Endocrinol. 2002;175(1):129–141. doi:10.1677/joe.0.1750129
   PubMedGoogle Scholar
• Da M, Kumar M, Khetan V. Differential diagnosis between polypoidal choroidal vasculopathy (PCV) and Age-related macular degeneration (AMD) using Deep Neural Network. Invest Ophthalmol Vis Sci. 2020;61(7):2024.
   Google Scholar
• Zhang X, Qiu B, Gong Z, Chen X, Wang Y, Nie Y. Differentially Regulated Apolipoproteins and Lipid Profiles as Novel Biomarkers for Polypoidal Choroidal Vasculopathy and Neovascular Age-Related Macular Degeneration. Front Endocrinol (Lausanne). 2022;13:946327. doi:10.3389/fendo.2022.946327
   PubMedGoogle Scholar
• Malle E, Sodin-Semrl S, Kovacevic A. Serum amyloid A: an acute-phase protein involved in tumour pathogenesis. Cellular and molecular life sciences. CMLS. 2009;66(1):9–26. doi:10.1007/s00018-008-8321-x
   PubMed Web of Science ®Google Scholar
• De Buck M, Gouwy M, Wang JM, et al. Structure and Expression of Different Serum Amyloid A (SAA) Variants and their Concentration-Dependent Functions During Host Insults. Curr Med Chem. 2016;23(17):1725–1755. doi:10.2174/0929867323666160418114600
   PubMed Web of Science ®Google Scholar
• Wong CW, Wong TY, Cheung CM. Polypoidal Choroidal Vasculopathy in Asians. J Clin Med. 2015;4(5):782–821. doi:10.3390/jcm4050782
   PubMed Web of Science ®Google Scholar
• Hrzenjak A, Artl A, Knipping G, Kostner G, Sattler W, Malle E. Silent mutations in secondary Shine-Dalgarno sequences in the cDNA of human serum amyloid A4 promotes expression of recombinant protein in Escherichia coli. Protein Eng. 2001;14(12):949–952. doi:10.1093/protein/14.12.949
   PubMedGoogle Scholar
• Schnabolk G, Rohrer B, Simpson KN. Increased Nonexudative Age-Related Macular Degeneration Diagnosis Among Medicare Beneficiaries With Rheumatoid Arthritis. Invest Ophthalmol Vis Sci. 2019;60(10):3520–3526. doi:10.1167/iovs.18-26444
   PubMedGoogle Scholar
• Siegmund SV, Schlosser M, Schildberg FA, et al. Serum Amyloid A Induces Inflammation, Proliferation and Cell Death in Activated Hepatic Stellate Cells. PLoS One. 2016;11(3):e0150893. doi:10.1371/journal.pone.0150893
   PubMedGoogle Scholar
• de Beer MC, Yuan T, Kindy MS, Asztalos BF, Roheim PS, de Beer FC. Characterization of constitutive human serum amyloid A protein (SAA4) as an apolipoprotein. J Lipid Res. 1995;36(3):526–534. doi:10.1016/S0022-2275(20)39886-2
   PubMedGoogle Scholar
• Thomas MJ, Sorci-Thomas MG. SAA: a link between cholesterol efflux capacity and inflammation? J Lipid Res. 2015;56(8):1383–1385. doi:10.1194/jlr.C061366
   PubMedGoogle Scholar
• Fernández JA, Deguchi H, Elias DJ, Griffin JH. Serum amyloid A4 is a procoagulant apolipoprotein that it is elevated in venous thrombosis patients. Res Pract Thromb Haemost. 2019;4(2):217–223. doi:10.1002/rth2.12291
   PubMedGoogle Scholar
• Cheung CMG, Lai TYY, Teo K, et al. Polypoidal Choroidal Vasculopathy: consensus Nomenclature and Non-Indocyanine Green Angiograph Diagnostic Criteria from the Asia-Pacific Ocular Imaging Society PCV Workgroup. Ophthalmology. 2021;128(3):443–452. doi:10.1016/j.ophtha.2020.08.006
   PubMedGoogle Scholar
• Mao J, Chen N, Zhang S, et al. Association between inflammatory cytokines in the aqueous humor and hyperreflective foci on optical coherence tomography in patients with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy. Front Med. 2022;9:973025. doi:10.3389/fmed.2022.973025
   Google Scholar