The Association of the Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, Lymphocyte-to-Monocyte Ratio and Systemic Inflammation Response Index with Short-Term Functional Outcome in Patients with Acute Ischemic Stroke

References

• Katan M, Luft A. Global burden of stroke. Semin Neurol. 2018;38(2):208–211. doi:10.1055/s-0038-1649503
   PubMed Web of Science ®Google Scholar
• Wang W, Jiang B, Sun H, et al. Prevalence, incidence, and mortality of stroke in China. Circulation. 2017;135(8):759–771. doi:10.1161/CIRCULATIONAHA.116.025250
   PubMed Web of Science ®Google Scholar
• Tu W, Zhao Z, P Y, et al. Estimated burden of stroke in China in 2020. JAMA Network Open. 2023;6(3):e231455. doi:10.1001/jamanetworkopen.2023.1455
   PubMed Web of Science ®Google Scholar
• Helleberg BH, Ellekjaer H, Indredavik B. Outcomes after early neurological deterioration and transitory deterioration in acute ischemic stroke patients. Cerebrovasc Dis. 2016;42(5–6):378–386. doi:10.1159/000447130
   PubMed Web of Science ®Google Scholar
• Shi K, Tian DC, Li ZG, et al. Global brain inflammation in stroke. Lancet Neurol. 2019;18(11):1058–1066. doi:10.1016/S1474-4422(19)30078-X
   PubMed Web of Science ®Google Scholar
• Macrez R, Ali C, Toutirais O, et al. Stroke and the immune system: from pathophysiology to new therapeutic strategies. Lancet Neurol. 2011;10(5):471–480. doi:10.1016/S1474-4422(11)70066-7
   PubMed Web of Science ®Google Scholar
• Tuttolomondo A, Raimondo DI, Disciacca D, et al. Inflammatory cytokines in acute ischemic stroke. Curr Pharm Des. 2008;14(33):3574–3589. doi:10.2174/138161208786848739
   PubMed Web of Science ®Google Scholar
• Anrather J, Iadecola C. Inflammation and stroke: an overview. Neurotherapeutics. 2016;13(4):661–670. doi:10.1007/s13311-016-0483-x
   PubMed Web of Science ®Google Scholar
• Huang L. Increased systemic immune-inflammation index predicts disease severity and functional outcome in acute ischemic stroke patients. Neurologist. 2023;28(1):32–38. doi:10.1097/NRL.0000000000000464
   PubMed Web of Science ®Google Scholar
• Dang H, Mao W, Wang S, et al. Systemic inflammation response index as a prognostic predictor in patients with acute ischemic stroke: a propensity score matching analysis. Front Neurol. 2022;13:1049241. doi:10.3389/fneur.2022.1049241
   PubMed Web of Science ®Google Scholar
• Chen C, Gu L, Chen L, et al. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as potential predictors of prognosis in acute ischemic stroke. Front Neurol. 2020;11:525621. doi:10.3389/fneur.2020.525621
   PubMed Web of Science ®Google Scholar
• Xue J, Huang W, Chen X, et al. Neutrophil-to-lymphocyte ratio is a prognostic marker in acute ischemic stroke. J Stroke Cerebrovasc Dis. 2017;26(3):650–657. doi:10.1016/j.jstrokecerebrovasdis.2016.11.010
   PubMed Web of Science ®Google Scholar
• Ren H, Liu X, Wang L, et al. Lymphocyte-to-monocyte ratio: a novel predictor of the prognosis of acute ischemic stroke. J Stroke Cerebrovasc Dis. 2017;26(11):2595–2602. doi:10.1016/j.jstrokecerebrovasdis.2017.06.019
   PubMed Web of Science ®Google Scholar
• Gong P, Liu Y, Gong Y, et al. The association of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and lymphocyte to monocyte ratio with post-thrombolysis early neurological outcomes in patients with acute ischemic stroke. J Neuroinflammation. 2021;18(1):51. doi:10.1186/s12974-021-02090-6
   PubMed Web of Science ®Google Scholar
• Yang K, Zeng L, Ge A, et al. A systematic review of the research progress of non-coding RNA in neuroinflammation and immune regulation in cerebral infarction/ischemia-reperfusion injury. Front Immunol. 2022;13:930171. doi:10.3389/fimmu.2022.930171
   PubMed Web of Science ®Google Scholar
• Pluta R, Januszewski S, Czuczwar SJ. Neuroinflammation in post-ischemic neurodegeneration of the brain: friend, foe, or both? Int J Mol Sci. 2021;22(9):4405. doi:10.3390/ijms22094405
   PubMed Web of Science ®Google Scholar
• Yamamoto Y, Osanai T, Nishizaki F, et al. Matrix metalloprotein-9 activation under cell-to-cell interaction between endothelial cells and monocytes: possible role of hypoxia and tumor necrosis factor-alpha. Heart Vessels. 2012;27(6):624–633. doi:10.1007/s00380-011-0214-5
   PubMed Web of Science ®Google Scholar
• Dong X, Nao J, Gao Y. Peripheral monocyte count predicts outcomes in patients with acute ischemic stroke treated with rtPA thrombolysis. Neurotox Res. 2020;37(2):469–477. doi:10.1007/s12640-019-00103-0
   PubMed Web of Science ®Google Scholar
• Liberale L, Montecucco F, Bonaventura A, et al. Monocyte count at onset predicts poststroke outcomes during a 90-day follow-up. Eur J Clin Invest. 2017;47(10):702–710. doi:10.1111/eci.12795
   PubMed Web of Science ®Google Scholar
• Franks ZG, Campbell RA, Weyrich AS, et al. Platelet-leukocyte interactions link inflammatory and thromboembolic events in ischemic stroke. Ann N Y Acad Sci. 2010;1207(1):11–17. doi:10.1111/j.1749-6632.2010.05733.x
   PubMedGoogle Scholar
• Liu YL, Wu ZQ, Qu JF, et al. High neutrophil-to-lymphocyte ratio is a predictor of poor short-term outcome in patients with mild acute ischemic stroke receiving intravenous thrombolysis. Brain Behav. 2020;10(12):e01857. doi:10.1002/brb3.1857
   PubMed Web of Science ®Google Scholar
• Kim MS, Heo MY, Joo HJ, et al. Neutrophil-to-lymphocyte ratio as a predictor of short-term functional outcomes in acute ischemic stroke patients. Int J Environ Res Public Health. 2023;20(2):898.
   PubMed Web of Science ®Google Scholar
• Zhao L, Dai Q, Chen X, et al. Neutrophil-to-lymphocyte ratio predicts length of stay and acute hospital cost in patients with acute ischemic stroke. J Stroke Cerebrovasc Dis. 2016;25(4):739–744. doi:10.1016/j.jstrokecerebrovasdis.2015.11.012
   PubMed Web of Science ®Google Scholar
• Altintas O, Altintas MO, Tasal A, et al. The relationship of platelet-to-lymphocyte ratio with clinical outcome and final infarct core in acute ischemic stroke patients who have undergone endovascular therapy. Neurol Res. 2016;38(9):759–765. doi:10.1080/01616412.2016.1215030
   PubMed Web of Science ®Google Scholar
• Ma J, Guo W, Xu J, et al. Association of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio with outcomes in stroke patients achieving successful recanalization by endovascular thrombectomy. Front Neurol. 2022;13:1039060. doi:10.3389/fneur.2022.1039060
   PubMed Web of Science ®Google Scholar
• Sun YY, Wang MQ, Wang Y, et al. Platelet-to-lymphocyte ratio at 24h after thrombolysis is a prognostic marker in acute ischemic stroke patients. Front Immunol. 2022;13:1000626. doi:10.3389/fimmu.2022.1000626
   PubMed Web of Science ®Google Scholar
• Mao X, Yu Q, Liao Y, et al. Lymphocyte-to-monocyte ratio is independently associated with progressive infarction in patients with acute ischemic stroke. Biomed Res Int. 2022;2022:2290524. doi:10.1155/2022/2290524
   PubMed Web of Science ®Google Scholar
• Li G, Hao Y, Wang C, et al. Association between neutrophil-to-lymphocyte ratio/lymphocyte-to-monocyte ratio and in-hospital clinical outcomes in ischemic stroke treated with intravenous thrombolysis. J Inflamm Res. 2022;15:5567–5578. doi:10.2147/JIR.S382876
   PubMed Web of Science ®Google Scholar
• Zhang Y, Xing Z, Zhou K, et al. The predictive role of systemic inflammation response index (SIRI) in the prognosis of stroke patients. Clin Interv Aging. 2021;16:1997–2007. doi:10.2147/CIA.S339221
   PubMed Web of Science ®Google Scholar
• Miao M, Bi Y, Hao L, et al. Triglyceride-glucose index and short-term functional outcome and in-hospital mortality in patients with ischemic stroke. Nutr Metab Cardiovasc Dis. 2023;33(2):399–407. doi:10.1016/j.numecd.2022.11.004
   PubMed Web of Science ®Google Scholar
• Yang Y, Xie D, Zhang Y. Increased platelet-to-lymphocyte ratio is an independent predictor of hemorrhagic transformation and in-hospital mortality among acute ischemic stroke with large-artery atherosclerosis patients. Int J Gen Med. 2021;14:7545–7555. doi:10.2147/IJGM.S329398
   PubMed Web of Science ®Google Scholar
• Zhang WB, Zeng YY, Wang F, et al. A high neutrophil-to-lymphocyte ratio predicts hemorrhagic transformation of large atherosclerotic infarction in patients with acute ischemic stroke. Aging. 2020;12(3):2428–2439. doi:10.18632/aging.102752
   PubMedGoogle Scholar
• Song Q, Pan R, Jin Y, et al. Lymphocyte-to-monocyte ratio and risk of hemorrhagic transformation in patients with acute ischemic stroke. Neurol Sci. 2020;41(9):2511–2520. doi:10.1007/s10072-020-04355-z
   PubMed Web of Science ®Google Scholar
• Massiot N, Lareyre F, Voury-Pons A, et al. High neutrophil to lymphocyte ratio and platelet to lymphocyte ratio are associated with symptomatic internal carotid artery stenosis. J Stroke Cerebrovasc Dis. 2019;28(1):76–83. doi:10.1016/j.jstrokecerebrovasdis.2018.09.001
   PubMed Web of Science ®Google Scholar
• Hu J, Zhou W, Zhou Z, et al. Elevated neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios predict post-stroke depression with acute ischemic stroke. Exp Ther Med. 2020;19(4):2497–2504. doi:10.3892/etm.2020.8514
   PubMed Web of Science ®Google Scholar
• Li W, He C. Association of platelet-to-lymphocyte ratio with stroke-associated pneumonia in acute ischemic stroke. J Healthc Eng. 2022;2022:1033332. doi:10.1155/2022/1033332
   PubMed Web of Science ®Google Scholar