Clinical Value of Laboratory Biomarkers for the Diagnosis and Early Identification of Culture-Positive Sepsis in Neonates

References

• Shane AL, Sanchez PJ, Stoll BJ. Neonatal sepsis. Lancet. 2017;390(10104):1770–1780. doi:10.1016/S0140-6736(17)31002-4
   PubMed Web of Science ®Google Scholar
• Glaser MA, Hughes LM, Jnah A, Newberry D. Neonatal Sepsis: a Review of Pathophysiology and Current Management Strategies. Adv Neonatal Care. 2021;21(1):49–60. doi:10.1097/ANC.0000000000000769
   PubMed Web of Science ®Google Scholar
• Kim F, Polin RA, Hooven TA. Neonatal sepsis. BMJ. 2020;371:m3672. doi:10.1136/bmj.m3672
   PubMed Web of Science ®Google Scholar
• Balayan S, Chauhan N, Chandra R, Kuchhal NK, Jain U. Recent advances in developing biosensing based platforms for neonatal sepsis. Biosens Bioelectron. 2020;169:112552. doi:10.1016/j.bios.2020.112552
   PubMed Web of Science ®Google Scholar
• Celik IH, Hanna M, Canpolat FE, Mohan P. Diagnosis of neonatal sepsis: the past, present and future. Pediatr Res. 2022;91(2):337–350.
   PubMed Web of Science ®Google Scholar
• Cantey JB, Lee JH. Biomarkers for the Diagnosis of Neonatal Sepsis. Clin Perinatol. 2021;48(2):215–227. doi:10.1016/j.clp.2021.03.012
   PubMed Web of Science ®Google Scholar
• Niederman MS, Baron RM, Bouadma L, et al. Initial antimicrobial management of sepsis. Crit Care. 2021;25(1):307. doi:10.1186/s13054-021-03736-w
   PubMed Web of Science ®Google Scholar
• Baker AH, Leland SB, Freiman E, Herigon JC, Eisenberg MA. Characteristics and Outcomes of Culture-Positive and Culture-Negative Pediatric Sepsis. J Pediatr. 2023;263:113718. doi:10.1016/j.jpeds.2023.113718
   PubMed Web of Science ®Google Scholar
• Friedman N, Yochpaz S, Zirkin S, Herzlich J, Marom R. C-reactive protein and the neonatal early-onset sepsis calculator for the diagnosis of neonatal sepsis. Eur J Clin Microbiol Infect Dis. 2021;40(6):1227–1234. doi:10.1007/s10096-021-04156-y
   PubMed Web of Science ®Google Scholar
• Newman TB, Puopolo KM, Wi S, Draper D, Escobar GJ. Interpreting complete blood counts soon after birth in newborns at risk for sepsis. Pediatrics. 2010;126(5):903–909. doi:10.1542/peds.2010-0935
   PubMed Web of Science ®Google Scholar
• Vardon-Bounes F, Ruiz S, Gratacap MP, Garcia C, Payrastre B, Minville V. Platelets Are Critical Key Players in Sepsis. Int J Mol Sci. 2019;20(14):3494. doi:10.3390/ijms20143494
   PubMed Web of Science ®Google Scholar
• Greco E, Lupia E, Bosco O, Vizio B, Montrucchio G. Platelets and Multi-Organ Failure in Sepsis. Int J Mol Sci. 2017;18(10):2200. doi:10.3390/ijms18102200
   PubMed Web of Science ®Google Scholar
• Schupp T, Weidner K, Rusnak J, et al. Diagnostic and prognostic role of platelets in patients with sepsis and septic shock. Platelets. 2023;34(1):2131753. doi:10.1080/09537104.2022.2131753
   PubMed Web of Science ®Google Scholar
• Ellahony DM, El-Mekkawy MS, Farag MM. A Study of Red Cell Distribution Width in Neonatal Sepsis. Pediatr Emerg Care. 2020;36(8):378–383. doi:10.1097/PEC.0000000000001319
   PubMed Web of Science ®Google Scholar
• Toro-Huamanchumo CJ, Cabanillas-Ramirez C, Quispe-Vicuna C, et al. Mean Platelet Volume in Neonatal Sepsis: meta-Analysis of Observational Studies. Children. 2022;9(12):548.
   PubMedGoogle Scholar
• Kim TS, Choi DH. Liver Dysfunction in Sepsis. Korean J Gastroenterol. 2020;75(4):182–187. doi:10.4166/kjg.2020.75.4.182
   PubMedGoogle Scholar
• Starr MC, Charlton JR, Guillet R. Neonatal Kidney Collaborative, Advances in Neonatal Acute Kidney Injury. Pediatrics. 2021;148(5). doi:10.1542/peds.2021-051220
   PubMed Web of Science ®Google Scholar
• Mukherjee S, Das S, Mukherjee S, Ghosh PS, Bhattacharya S. Arterial blood gas as a prognostic indicator in patients with sepsis. Indian J Med Microbiol. 2020;38(3 & 4):457–460. doi:10.4103/ijmm.IJMM_19_478
   PubMed Web of Science ®Google Scholar
• t.S.o.P.C.M.A. Subspecialty Group of Neonatology, N.S.C.M.D.A. Professional Committee of Infectious Diseases, [Expert consensus on the diagnosis and management of neonatal sepsis (version 2019)]. Zhonghua Er Ke Za Zhi. 2019;57(4):252–257. doi:10.3760/cma.j.issn.0578-1310.2019.04.005
   PubMedGoogle Scholar
• Stocker M, van Herk W, El Helou S, et al. C-Reactive Protein, Procalcitonin, and White Blood Count to Rule Out Neonatal Early-onset Sepsis Within 36 Hours: a Secondary Analysis of the Neonatal Procalcitonin Intervention Study. Clin Infect Dis. 2021;73(2):e383–e390. doi:10.1093/cid/ciaa876
   PubMed Web of Science ®Google Scholar
• Benitz WE, Achten NB. Technical assessment of the neonatal early-onset sepsis risk calculator. Lancet Infect Dis. 2021;21(5):e134–e140. doi:10.1016/S1473-3099(20)30490-4
   PubMed Web of Science ®Google Scholar
• Peerapornratana S, Manrique-Caballero CL, Gomez H, Kellum JA. Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment. Kidney Int. 2019;96(5):1083–1099. doi:10.1016/j.kint.2019.05.026
   PubMed Web of Science ®Google Scholar
• Wen Y, Parikh CR. Current concepts and advances in biomarkers of acute kidney injury. Crit Rev Clin Lab Sci. 2021;58(5):354–368. doi:10.1080/10408363.2021.1879000
   PubMed Web of Science ®Google Scholar
• Woznica EA, Inglot M, Woznica RK, Lysenko L. Liver dysfunction in sepsis. Adv Clin Exp Med. 2018;27(4):547–551. doi:10.17219/acem/68363
   PubMed Web of Science ®Google Scholar
• Scherlinger M, Richez C, Tsokos GC, Boilard E, Blanco P. The role of platelets in immune-mediated inflammatory diseases. Nat Rev Immunol. 2023;1–16.
   Web of Science ®Google Scholar
• Panda SK, Nayak MK, Thangaraj J, Das P, Pugalia R. Platelet parameters as a diagnostic marker in early diagnosis of neonatal sepsis- Seeking newer answers for older problems. J Family Med Prim Care. 2022;11(5):1748–1754. doi:10.4103/jfmpc.jfmpc_1271_21
   PubMedGoogle Scholar
• O’Reilly D, Murphy CA, Drew R, El-Khuffash A, Maguire PB, Ainle FN. Platelets in pediatric and neonatal sepsis: novel mediators of the inflammatory cascade. Pediatr Res. 2022;91(2):359–367. doi:10.1038/s41390-021-01715-z
   PubMed Web of Science ®Google Scholar
• Cai N, Chen ZQ, Tao M, Fan WT, Liao W. Mean platelet volume and red blood cell distribution width is associated with prognosis in premature neonates with sepsis. Open Medicine. 2021;16(1):1175–1181. doi:10.1515/med-2021-0323
   Web of Science ®Google Scholar
• Korniluk A, Koper-Lenkiewicz OM, Kaminska J, Kemona H, Dymicka-Piekarska V. Mean Platelet Volume (MPV): new Perspectives for an Old Marker in the Course and Prognosis of Inflammatory Conditions. Mediators Inflamm. 2019;2019:9213074. doi:10.1155/2019/9213074
   PubMed Web of Science ®Google Scholar
• Milas GP, Karageorgiou V, Bellos I. Mean platelet volume and neonatal sepsis: a systematic review and meta-analysis of diagnostic accuracy. J Matern Fetal Neonatal Med. 2022;35(25):5324–5336. doi:10.1080/14767058.2021.1879039
   PubMed Web of Science ®Google Scholar
• Giustozzi M, Ehrlinder H, Bongiovanni D, et al. Coagulopathy and sepsis: pathophysiology, clinical manifestations and treatment. Blood Rev. 2021;50:100864. doi:10.1016/j.blre.2021.100864
   PubMed Web of Science ®Google Scholar
• Martin SL, Desai S, Nanavati R, Colah RB, Ghosh K, Mukherjee MB. Red cell distribution width and its association with mortality in neonatal sepsis. J Matern Fetal Neonatal Med. 2019;32(12):1925–1930. doi:10.1080/14767058.2017.1421932
   PubMed Web of Science ®Google Scholar
• Ng WW, Lam SM, Yan WW, Shum HP, MLR, NLR, PLR and RDW to predict outcome and differentiate between viral and bacterial pneumonia in the intensive care unit. Sci Rep. 2022;12(1):15974. doi:10.1038/s41598-022-20385-3
   PubMed Web of Science ®Google Scholar
• Mao S, Zang D, Wu L, Shi W, Wang X. Diagnostic and Prognostic Value of Red Blood Cell Distribution Width in Children with Respiratory Tract Infections. Clin Lab. 2019;65(5). doi:10.7754/Clin.Lab.2018.181041
   Web of Science ®Google Scholar
• Nannan Panday RS, Lammers EMJ, Alam N, Nanayakkara PWB. An overview of positive cultures and clinical outcomes in septic patients: a sub-analysis of the Prehospital Antibiotics Against Sepsis (PHANTASi) trial. Crit Care. 2019;23(1):182. doi:10.1186/s13054-019-2431-8
   PubMedGoogle Scholar
• Velez-Paez JL, Legua P, Velez-Paez P, et al. Mean platelet volume and mean platelet volume to platelet count ratio as predictors of severity and mortality in sepsis. PLoS One. 2022;17(1):e0262356. doi:10.1371/journal.pone.0262356
   PubMed Web of Science ®Google Scholar
• Sahu P, Raj Stanly EA, Simon Lewis LE, Prabhu K, Rao M, Kunhikatta V. Prediction modelling in the early detection of neonatal sepsis. World J Pediatr. 2022;18(3):160–175. doi:10.1007/s12519-021-00505-1
   PubMed Web of Science ®Google Scholar
• Iroh Tam PY, Bendel CM. Diagnostics for neonatal sepsis: current approaches and future directions. Pediatr Res. 2017;82(4):574–583. doi:10.1038/pr.2017.134
   PubMed Web of Science ®Google Scholar