The Emerging Roles of Ferroptosis in Pathophysiology and Treatment of Acute Lung Injury

References

• Galluzzi L, Vitale I, Aaronson SA, et al. Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. Cell Death Differ. 2018;25(3):486–541. doi:10.1038/s41418-017-0012-4
   PubMed Web of Science ®Google Scholar
• Kopeina GS, Zhivotovsky B. Programmed cell death: past, present and future. Biochem Biophys Res Commun. 2022;633:55–58. doi:10.1016/j.bbrc.2022.09.022
   PubMed Web of Science ®Google Scholar
• Dixon SJ, Lemberg KM, Lamprecht MR, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149(5):1060–1072. doi:10.1016/j.cell.2012.03.042
   PubMed Web of Science ®Google Scholar
• Mokrá D. Acute lung injury - from pathophysiology to treatment. Physiol Res. 2020;69(Suppl 3):S353–s366. doi:10.33549/physiolres.934602
   PubMedGoogle Scholar
• Mowery NT, Terzian WTH, Nelson AC. Acute lung injury. Curr Probl Surg. 2020;57(5):100777. doi:10.1016/j.cpsurg.2020.100777
   PubMed Web of Science ®Google Scholar
• Li Y, Cao Y, Xiao J, et al. Inhibitor of apoptosis-stimulating protein of p53 inhibits ferroptosis and alleviates intestinal ischemia/reperfusion-induced acute lung injury. Cell Death Differ. 2020;27(9):2635–2650. doi:10.1038/s41418-020-0528-x
   PubMed Web of Science ®Google Scholar
• Zhongyin Z, Wei W, Juan X, Guohua F. Isoliquiritin apioside relieves intestinal ischemia/reperfusion-induced acute lung injury by blocking Hif-1α-mediated ferroptosis. Int Immunopharmacol. 2022;108:108852. doi:10.1016/j.intimp.2022.108852
   PubMed Web of Science ®Google Scholar
• Dong H, Xia Y, Jin S, et al. Nrf2 attenuates ferroptosis-mediated IIR-ALI by modulating TERT and SLC7A11. Cell Death Dis. 2021;12(11):1027. doi:10.1038/s41419-021-04307-1
   PubMed Web of Science ®Google Scholar
• Wang Y, Chen D, Xie H, et al. AUF1 protects against ferroptosis to alleviate sepsis-induced acute lung injury by regulating NRF2 and ATF3. Cell Mol Life Sci. 2022;79(5):228. doi:10.1007/s00018-022-04248-8
   PubMed Web of Science ®Google Scholar
• He R, Liu B, Xiong R, et al. Itaconate inhibits ferroptosis of macrophage via Nrf2 pathways against sepsis-induced acute lung injury. Cell Death Discov. 2022;8(1):43. doi:10.1038/s41420-021-00807-3
   PubMed Web of Science ®Google Scholar
• Li X, Zhuang X, Qiao T. Role of ferroptosis in the process of acute radiation-induced lung injury in mice. Biochem Biophys Res Commun. 2019;519(2):240–245. doi:10.1016/j.bbrc.2019.08.165
   PubMed Web of Science ®Google Scholar
• Qiu YB, Wan BB, Liu G, et al. Nrf2 protects against seawater drowning-induced acute lung injury via inhibiting ferroptosis. Respir Res. 2020;21(1):232. doi:10.1186/s12931-020-01500-2
   PubMed Web of Science ®Google Scholar
• Zhou H, Li F, Niu JY, et al. Ferroptosis was involved in the oleic acid-induced acute lung injury in mice. Sheng Li Xue Bao. 2019;71(5):689–697.
   PubMedGoogle Scholar
• Xu W, Deng H, Hu S, et al. Role of ferroptosis in lung diseases. J Inflamm Res. 2021;14:2079–2090. doi:10.2147/JIR.S307081
   PubMed Web of Science ®Google Scholar
• Liu J, Kang R, Tang D. Signaling pathways and defense mechanisms of ferroptosis. Febs j. 2022;289(22):7038–7050. doi:10.1111/febs.16059
   PubMed Web of Science ®Google Scholar
• Lambert AJ, Brand MD. Reactive oxygen species production by mitochondria. Methods Mol Biol. 2009;554:165–181.
   PubMedGoogle Scholar
• Checa J, Aran JM. Reactive oxygen species: drivers of physiological and pathological processes. J Inflamm Res. 2020;13:1057–1073. doi:10.2147/JIR.S275595
   PubMed Web of Science ®Google Scholar
• Niu B, Liao K, Zhou Y, et al. Application of glutathione depletion in cancer therapy: enhanced ROS-based therapy, ferroptosis, and chemotherapy. Biomaterials. 2021;277:121110. doi:10.1016/j.biomaterials.2021.121110
   PubMed Web of Science ®Google Scholar
• Liu MY, Li HM, Wang XY, et al. TIGAR drives colorectal cancer ferroptosis resistance through ROS/AMPK/SCD1 pathway. Free Radic Biol Med. 2022;182:219–231. doi:10.1016/j.freeradbiomed.2022.03.002
   PubMed Web of Science ®Google Scholar
• Doll S, Proneth B, Tyurina YY, et al. ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nat Chem Biol. 2017;13(1):91–98. doi:10.1038/nchembio.2239
   PubMed Web of Science ®Google Scholar
• Ke P, Bao X, Liu C, et al. LPCAT3 is a potential prognostic biomarker and may be correlated with immune infiltration and ferroptosis in acute myeloid leukemia: a pan-cancer analysis. Transl Cancer Res. 2022;11(10):3491–3505. doi:10.21037/tcr-22-985
   PubMedGoogle Scholar
• Kagan VE, Mao G, Qu F, et al. Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. Nat Chem Biol. 2017;13(1):81–90. doi:10.1038/nchembio.2238
   PubMed Web of Science ®Google Scholar
• Doll S, Freitas FP, Shah R, et al. FSP1 is a glutathione-independent ferroptosis suppressor. Nature. 2019;575(7784):693–698. doi:10.1038/s41586-019-1707-0
   PubMed Web of Science ®Google Scholar
• Bersuker K, Hendricks JM, Li Z, et al. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature. 2019;575(7784):688–692. doi:10.1038/s41586-019-1705-2
   PubMed Web of Science ®Google Scholar
• Sun Y, Berleth N, Wu W, et al. Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells. Cell Death Dis. 2021;12(11):1028. doi:10.1038/s41419-021-04306-2
   PubMed Web of Science ®Google Scholar
• Bai Y, Meng L, Han L, et al. Lipid storage and lipophagy regulates ferroptosis. Biochem Biophys Res Commun. 2019;508(4):997–1003. doi:10.1016/j.bbrc.2018.12.039
   PubMed Web of Science ®Google Scholar
• Liu MR, Zhu WT, Pei DS. System Xc(-): a key regulatory target of ferroptosis in cancer. Invest New Drugs. 2021;39(4):1123–1131. doi:10.1007/s10637-021-01070-0
   PubMed Web of Science ®Google Scholar
• Yang W, Wang Y, Zhang C, et al. Maresin1 protect against ferroptosis-induced liver injury through ROS Inhibition and Nrf2/HO-1/GPX4 activation. Front Pharmacol. 2022;13:865689. doi:10.3389/fphar.2022.865689
   PubMed Web of Science ®Google Scholar
• Feng Z, Qin Y, Huo F, et al. NMN recruits GSH to enhance GPX4-mediated ferroptosis defense in UV irradiation induced skin injury. Biochim Biophys Acta Mol Basis Dis. 2022;1868(1):166287. doi:10.1016/j.bbadis.2021.166287
   PubMed Web of Science ®Google Scholar
• Forcina GC, Dixon SJ. GPX4 at the crossroads of lipid homeostasis and ferroptosis. Proteomics. 2019;19(18):e1800311. doi:10.1002/pmic.201800311
   PubMed Web of Science ®Google Scholar
• Imai H, Matsuoka M, Kumagai T, Sakamoto T, Koumura T. Lipid peroxidation-dependent cell death regulated by GPx4 and ferroptosis. Curr Top Microbiol Immunol. 2017;403:143–170. doi:10.1007/82_2016_508
   PubMed Web of Science ®Google Scholar
• Dong H, Qiang Z, Chai D, et al. Nrf2 inhibits ferroptosis and protects against acute lung injury due to intestinal ischemia reperfusion via regulating SLC7A11 and HO-1. Aging. 2020;12(13):12943–12959. doi:10.18632/aging.103378
   PubMedGoogle Scholar
• Maiorino M, Conrad M, Ursini F. GPx4, lipid peroxidation, and cell death: discoveries, rediscoveries, and open issues. Antioxid Redox Signal. 2018;29(1):61–74. doi:10.1089/ars.2017.7115
   PubMed Web of Science ®Google Scholar
• Louandre C, Marcq I, Bouhlal H, et al. The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells. Cancer Lett. 2015;356(2 Pt B):971–977. doi:10.1016/j.canlet.2014.11.014
   PubMed Web of Science ®Google Scholar
• Li Y, Zeng X, Lu D, Yin M, Shan M, Gao Y. Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis. Hum Reprod. 2021;36(4):951–964. doi:10.1093/humrep/deaa363
   PubMed Web of Science ®Google Scholar
• Tang Z, Ju Y, Dai X, et al. HO-1-mediated ferroptosis as a target for protection against retinal pigment epithelium degeneration. Redox Biol. 2021;43:101971. doi:10.1016/j.redox.2021.101971
   PubMed Web of Science ®Google Scholar
• Zhang X, Yu K, Ma L, et al. Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma. Theranostics. 2021;11(12):5650–5674. doi:10.7150/thno.55482
   PubMed Web of Science ®Google Scholar
• Liu T, Jiang L, Tavana O, Gu W. The Deubiquitylase OTUB1 mediates ferroptosis via stabilization of SLC7A11. Cancer Res. 2019;79(8):1913–1924. doi:10.1158/0008-5472.CAN-18-3037
   PubMed Web of Science ®Google Scholar
• Mao C, Liu X, Zhang Y, et al. DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. Nature. 2021;593(7860):586–590. doi:10.1038/s41586-021-03539-7
   PubMed Web of Science ®Google Scholar
• Li S, He Y, Chen K, et al. RSL3 drives ferroptosis through NF-κB pathway activation and GPX4 depletion in glioblastoma. Oxid Med Cell Longev. 2021;2021:2915019. doi:10.1155/2021/2915019
   PubMed Web of Science ®Google Scholar
• Gai C, Yu M, Li Z, et al. Acetaminophen sensitizing erastin-induced ferroptosis via modulation of Nrf2/heme oxygenase-1 signaling pathway in non-small-cell lung cancer. J Cell Physiol. 2020;235(4):3329–3339. doi:10.1002/jcp.29221
   PubMed Web of Science ®Google Scholar
• Xu S, Wu B, Zhong B, et al. Naringenin alleviates myocardial ischemia/reperfusion injury by regulating the nuclear factor-erythroid factor 2-related factor 2 (Nrf2) /System xc-/ glutathione peroxidase 4 (GPX4) axis to inhibit ferroptosis. Bioengineered. 2021;12(2):10924–10934. doi:10.1080/21655979.2021.1995994
   PubMed Web of Science ®Google Scholar
• Gaschler MM, Andia AA, Liu H, et al. FINO(2) initiates ferroptosis through GPX4 inactivation and iron oxidation. Nat Chem Biol. 2018;14(5):507–515. doi:10.1038/s41589-018-0031-6
   PubMed Web of Science ®Google Scholar
• Shu X, Wu J, Zhang T, et al. Statin-induced geranylgeranyl pyrophosphate depletion promotes ferroptosis-related senescence in adipose tissue. Nutrients. 2022;14:20.
   Web of Science ®Google Scholar
• Wu W, Geng Z, Bai H, Liu T, Zhang B. Ammonium ferric citrate induced ferroptosis in non-small-cell lung carcinoma through the inhibition of GPX4-GSS/GSR-GGT axis activity. Int J Med Sci. 2021;18(8):1899–1909. doi:10.7150/ijms.54860
   PubMed Web of Science ®Google Scholar
• Eling N, Reuter L, Hazin J, Hamacher-Brady A, Brady NR. Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells. Oncoscience. 2015;2(5):517–532. doi:10.18632/oncoscience.160
   PubMedGoogle Scholar
• Cramer SL, Saha A, Liu J, et al. Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth. Nat Med. 2017;23(1):120–127. doi:10.1038/nm.4232
   PubMed Web of Science ®Google Scholar
• Zhou J, Zhang L, Wang M, et al. CPX Targeting DJ-1 Triggers ROS-induced cell death and protective autophagy in colorectal cancer. Theranostics. 2019;9(19):5577–5594. doi:10.7150/thno.34663
   PubMed Web of Science ®Google Scholar
• Zhong Y, Tian F, Ma H, et al. FTY720 induces ferroptosis and autophagy via PP2A/AMPK pathway in multiple myeloma cells. Life Sci. 2020;260:118077. doi:10.1016/j.lfs.2020.118077
   PubMed Web of Science ®Google Scholar
• Clemente LP, Rabenau M, Tang S, et al. Dynasore blocks ferroptosis through combined modulation of iron uptake and inhibition of mitochondrial respiration. Cells. 2020;9(10):2259. doi:10.3390/cells9102259
   PubMed Web of Science ®Google Scholar
• Xie Y, Song X, Sun X, et al. Identification of baicalein as a ferroptosis inhibitor by natural product library screening. Biochem Biophys Res Commun. 2016;473(4):775–780. doi:10.1016/j.bbrc.2016.03.052
   PubMed Web of Science ®Google Scholar
• Sun X, Ou Z, Xie M, et al. HSPB1 as a novel regulator of ferroptotic cancer cell death. Oncogene. 2015;34(45):5617–5625. doi:10.1038/onc.2015.32
   PubMed Web of Science ®Google Scholar
• Liu P, Feng Y, Li H, et al. Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis. Cell Mol Biol Lett. 2020;25:10. doi:10.1186/s11658-020-00205-0
   PubMed Web of Science ®Google Scholar
• Rikhvanov EG, Fedoseeva IV, Varakina NN, Rusaleva TM, Fedyaeva AV. Mechanism of Saccharomyces cerevisiae yeast cell death induced by heat shock. Effect of cycloheximide on thermotolerance. Biochemistry. 2014;79(1):16–24. doi:10.1134/S0006297914010039
   PubMed Web of Science ®Google Scholar
• Baba Y, Higa JK, Shimada BK, et al. Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2018;314(3):H659–h668. doi:10.1152/ajpheart.00452.2017
   PubMed Web of Science ®Google Scholar
• Li Y, Yu P, Fu W, et al. Ginsenoside Rd inhibited ferroptosis to alleviate CCl(4)-induced acute liver injury in mice via cGAS/STING pathway. Am J Chin Med. 2023;51(1):91–105. doi:10.1142/S0192415X23500064
   PubMedGoogle Scholar
• Meyer NJ, Gattinoni L, Calfee CS. Acute respiratory distress syndrome. Lancet. 2021;398(10300):622–637. doi:10.1016/S0140-6736(21)00439-6
   PubMed Web of Science ®Google Scholar
• Zaki A, Ali MS, Hadda V, Ali SM, Chopra A, Fatma T. Long non-coding RNA (lncRNA): a potential therapeutic target in acute lung injury. Genes Dis. 2022;9(5):1258–1268. doi:10.1016/j.gendis.2021.07.004
   PubMed Web of Science ®Google Scholar
• Bhargava M, Wendt CH. Biomarkers in acute lung injury. Transl Res. 2012;159(4):205–217. doi:10.1016/j.trsl.2012.01.007
   PubMed Web of Science ®Google Scholar
• Fujishima S. Pathophysiology and biomarkers of acute respiratory distress syndrome. J Intensive Care. 2014;2(1):32. doi:10.1186/2052-0492-2-32
   PubMedGoogle Scholar
• Hussain M, Xu C, Ahmad M, et al. Acute respiratory distress syndrome: bench-to-bedside approaches to improve drug development. Clin Pharmacol Ther. 2018;104(3):484–494. doi:10.1002/cpt.1034
   PubMed Web of Science ®Google Scholar
• Ghio AJ, Carter JD, Richards JH, Richer LD, Grissom CK, Elstad MR. Iron and iron-related proteins in the lower respiratory tract of patients with acute respiratory distress syndrome. Crit Care Med. 2003;31(2):395–400. doi:10.1097/01.CCM.0000050284.35609.97
   PubMed Web of Science ®Google Scholar
• Xu Y, Li X, Cheng Y, Yang M, Wang R. Inhibition of ACSL4 attenuates ferroptotic damage after pulmonary ischemia-reperfusion. FASEB j. 2020;34(12):16262–16275. doi:10.1096/fj.202001758R
   PubMed Web of Science ®Google Scholar
• Guo XW, Zhang H, Huang JQ, et al. PIEZO1 ion channel mediates ionizing radiation-induced pulmonary endothelial cell ferroptosis via Ca(2+)/Calpain/VE-cadherin signaling. Front Mol Biosci. 2021;8:725274. doi:10.3389/fmolb.2021.725274
   PubMed Web of Science ®Google Scholar
• Liu X, Wang L, Xing Q, et al. Sevoflurane inhibits ferroptosis: a new mechanism to explain its protective role against lipopolysaccharide-induced acute lung injury. Life Sci. 2021;275:119391. doi:10.1016/j.lfs.2021.119391
   PubMed Web of Science ®Google Scholar
• Li J, Lu K, Sun F, et al. Panaxydol attenuates ferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2/HO-1 pathway. J Transl Med. 2021;19(1):96. doi:10.1186/s12967-021-02745-1
   PubMed Web of Science ®Google Scholar
• Wang YM, Gong FC, Qi X, et al. Mucin 1 inhibits ferroptosis and sensitizes vitamin E to alleviate sepsis-induced acute lung injury through GSK3β/Keap1-Nrf2-GPX4 pathway. Oxid Med Cell Longev. 2022;2022:2405943. doi:10.1155/2022/2405943
   PubMed Web of Science ®Google Scholar
• Tang X, Liu J, Yao S, Zheng J, Gong X, Xiao B. Ferulic acid alleviates alveolar epithelial barrier dysfunction in sepsis-induced acute lung injury by activating the Nrf2/HO-1 pathway and inhibiting ferroptosis. Pharm Biol. 2022;60(1):2286–2294. doi:10.1080/13880209.2022.2147549
   PubMed Web of Science ®Google Scholar
• Li T, Tan Y, Ouyang S, He J, Liu L. Resveratrol protects against myocardial ischemia-reperfusion injury via attenuating ferroptosis. Gene. 2022;808:145968. doi:10.1016/j.gene.2021.145968
   PubMed Web of Science ®Google Scholar
• Yamada N, Karasawa T, Wakiya T, et al. Iron overload as a risk factor for hepatic ischemia-reperfusion injury in liver transplantation: potential role of ferroptosis. Am J Transplant. 2020;20(6):1606–1618. doi:10.1111/ajt.15773
   PubMed Web of Science ®Google Scholar
• Tuo QZ, Liu Y, Xiang Z, et al. Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion. Signal Transduct Target Ther. 2022;7(1):59. doi:10.1038/s41392-022-00917-z
   PubMed Web of Science ®Google Scholar
• Mura M, Andrade CF, Han B, et al. Intestinal ischemia-reperfusion-induced acute lung injury and oncotic cell death in multiple organs. Shock. 2007;28(2):227–238. doi:10.1097/01.shk.0000278497.47041.e3
   PubMed Web of Science ®Google Scholar
• Qiang Z, Dong H, Xia Y, Chai D, Hu R, Jiang H. Nrf2 and STAT3 alleviates ferroptosis-mediated IIR-ALI by Regulating SLC7A11. Oxid Med Cell Longev. 2020;2020:5146982. doi:10.1155/2020/5146982
   PubMed Web of Science ®Google Scholar
• Liu T, Yang Q, Zheng H, et al. Multifaceted roles of a bioengineered nanoreactor in repressing radiation-induced lung injury. Biomaterials. 2021;277:121103. doi:10.1016/j.biomaterials.2021.121103
   PubMed Web of Science ®Google Scholar
• Kang SK, Rabbani ZN, Folz RJ, et al. Overexpression of extracellular superoxide dismutase protects mice from radiation-induced lung injury. Int J Radiat Oncol Biol Phys. 2003;57(4):1056–1066. doi:10.1016/S0360-3016(03)01369-5
   PubMed Web of Science ®Google Scholar
• Yu JB, Shi J, Gong LR, et al. Role of Nrf2/ARE pathway in protective effect of electroacupuncture against endotoxic shock-induced acute lung injury in rabbits. PLoS One. 2014;9(8):e104924. doi:10.1371/journal.pone.0104924
   PubMed Web of Science ®Google Scholar
• Jin F, Li C. Seawater-drowning-induced acute lung injury: from molecular mechanisms to potential treatments. Exp Ther Med. 2017;13(6):2591–2598. doi:10.3892/etm.2017.4302
   PubMed Web of Science ®Google Scholar
• Topf JM, Murray PT. Hypomagnesemia and hypermagnesemia. Rev Endocr Metab Disord. 2003;4(2):195–206. doi:10.1023/A:1022950321817
   PubMed Web of Science ®Google Scholar
• Mishra P, Pandey R, Pandey N, Tripathi S, Tripathi YB. Prevention of mortality in acute lung injury induced by oleic acid: application of polyherbal decoction (bronco T). Front Cell Dev Biol. 2022;10:1003767. doi:10.3389/fcell.2022.1003767
   PubMed Web of Science ®Google Scholar
• de Oliveira Rodrigues S, Patricio de Almeida MA, Castro-Faria-Neto HC, Silva AR, Felippe gonçalves-de-albuquerque C. Mouse model of oleic acid-induced acute respiratory distress syndrome. J Vis Exp. 2022;2022:184.
   Google Scholar
• Chen H, Ding Y, Chen W, Feng Y, Shi G. Glibenclamide alleviates inflammation in oleic acid model of acute lung injury through NLRP3 inflammasome signaling pathway. Drug Des Devel Ther. 2019;13:1545–1554. doi:10.2147/DDDT.S196040
   PubMed Web of Science ®Google Scholar
• Yin X, Zhu G, Wang Q, Fu YD, Wang J, Xu B. Ferroptosis, a new insight into acute lung injury. Front Pharmacol. 2021;12:709538. doi:10.3389/fphar.2021.709538
   PubMedGoogle Scholar
• Liu X, Zhang J, Xie W. The role of ferroptosis in acute lung injury. Mol Cell Biochem. 2022;477(5):1453–1461. doi:10.1007/s11010-021-04327-7
   PubMed Web of Science ®Google Scholar