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ORIGINAL RESEARCH

Umbilical Cord Stem Cell Lysate: A New Biologic Injectate for the Putative Treatment of Acute Temporomandibular Joint Inflammation

ORCID Icon, , &
Pages 4287-4300 | Received 30 May 2023, Accepted 04 Aug 2023, Published online: 27 Sep 2023

References

  • Wang XD, Zhang JN, Gan YN, et al. Current understanding of pathogenesis and treatment of TMJ osteoarthritis. J Dent Res. 2015;94(5):666–673. doi:10.1177/0022034515574770
  • Cui D, Li H, Xu X, et al. Mesenchymal stem cells for cartilage regeneration of TMJ osteoarthritis. Stem Cells Int. 2017;2017(2017):5979741. doi:10.1155/2017/5979741
  • Arinci A, Ademoglu E, Aslan A, et al. Molecular correlates of temporomandibular joint disease. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99(6):666–670. doi:10.1016/j.tripleo.2004.08.029
  • Liapaki A, Thamm JR, Ha S, et al. Is there a difference in treatment effect of different intra-articular drugs for temporomandibular joint osteoarthritis? A systematic review of randomized controlled trials. Int J Oral Maxillofac Surg. 2021;50(9):1233–1243. PMID: 33642154. doi:10.1016/j.ijom.2021.01.019
  • Wernecke C, Braun HJ, Dragoo JL. The effect of intra-articular corticosteroids on articular cartilage: a systematic review. Orthop J Sports Med. 2015;3(5):2325967115581163. PMID: 26674652; PMCID: PMC4622344. doi:10.1177/2325967115581163
  • El-Hakim IE, Abdel-Hamid IS, Bader A. Temporomandibular joint (TMJ) response to intra-articular dexamethasone injection following mechanical arthropathy: a histological study in rats. Int J Oral Maxillofac Surg. 2005;34(3):305–310. doi:10.1016/j.ijom.2004.05.004
  • Hegab AF, Ali HE, Elmasry M, Khallaf MG. Platelet-rich plasma injection as an effective treatment for temporomandibular joint osteoarthritis. J Oral Maxillofac Surg. 2015;73(9):1706–1713. PMID: 25882438. doi:10.1016/j.joms.2015.03.045
  • Bouloux GF, Chou J, Krishnan D, et al. Is hyaluronic acid or corticosteroid superior to lactated ringer solution in the short-term reduction of temporomandibular joint pain after arthrocentesis? Part 1. J Oral Maxillofac Surg. 2017;75(1):52–62. PMID: 27632069. doi:10.1016/j.joms.2016.08.006
  • Chung PY, Lin MT, Chang HP. Effectiveness of platelet-rich plasma injection in patients with temporomandibular joint osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. Oral Surg Oral Med Oral Pathol Oral Radiol. 2019;127(2):106–116. PMID: 30449691. doi:10.1016/j.oooo.2018.09.003
  • Bousnaki M, Bakopoulou A, Koidis P. Platelet-rich plasma for the therapeutic management of temporomandibular joint disorders: a systematic review. Int J Oral Maxillofac Surg. 2018;47(2):188–198. PMID: 29066000. doi:10.1016/j.ijom.2017.09.014
  • Luk F, de Witte SF, Wm B, et al. Efficacy of immunotherapy with mesenchymal stem cells in man: a systematic review. Expert Rev Clin Immunol. 2015;11(5):617–636. doi:10.1586/1744666X.2015.1029458
  • Zhu C, Wu W, Qu X. Mesenchymal stem cells in osteoarthritis therapy: a review. Am J Transl Res. 2021;13(2):448–461.
  • Wakitani S, Okabe T, Horibe S, et al. Safety of autologous bone marrow-derived mesenchymal stem cell transplantation for cartilage repair in 41 patients with 45 joints followed for up to 11 years and 5 months. J Tissue Eng Regen Med. 2011;5(2):146–150. doi:10.1002/term.299
  • Gong S, Emperumal CP, Enciso R, Enciso R. Regeneration of temporomandibular joint using in vitro human stem cells: a review. J Tissue Eng Regen Med. 2022;16(7):591–604. doi:10.1002/term.3302
  • Saad FA, Abdellah AM. Does stem cells approach ameliorate the prospective alterations of mandibular joint histology and acetylcholinesterase expression in experimentally induced alzheimer’s disease? Egypt J Histol. 2021;44(2):349–367.
  • Köhnke R, Ahlers MO, Birkelbach MA, et al. Temporomandibular joint osteoarthritis: regenerative treatment by a stem cell containing advanced therapy medicinal product (ATMP)- An in vivo animal trial. Int J Mol Sci. 2021;22(1):443. doi:10.3390/ijms22010443
  • Patel R, Kong D, Eisig SB, et al. Improving TMJ Regeneration. JOMS. 2013;71(9):E25–26. doi:10.1016/j.joms.2013.06.046
  • Zhou Y, Xei L. An update on mesenchymal stem cell-centered therapies in temporomandibular joint arthritis. Stem Cells Int. 2021;2021:1–15. doi:10.1155/2021/6619527
  • Lee RH, Pulin AA, Sao MJ, et al. Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6. Cell Stem Cell. 2009;5(1):54–63. doi:10.1016/j.stem.2009.05.003
  • Barry F. MSC therapy for osteoarthritis: an unfinished story. J Orthop Res. 2019;37(6):1229–1235. doi:10.1002/jor.24343
  • Ankrum JA, Ong JF, Karp JM. Mesenchymal stem cells: immune evasive, not immune privileged. Nat Biotechnol. 2014;32(3):252–260. doi:10.1038/nbt.2816
  • Weiss DJ, English K, Krasnodembskaya A, isaza-Correa JM, Hawthorne IJ, Mahon BP. The necrobiology of mesenchymal stromal cells affects therapeutic efficacy. Front Immunol. 2019;10:1228. doi:10.3389/fimmu.2019.01228
  • Kim H, Yang G, Park J, Choi J, Kang E, Lee B-K. Therapeutic effect of mesenchymal stem cells derived from human umbilical cord in rabbit temporomandibular joint model of osteoarthritis. Sci Rep. 2019;9:13854. doi:10.1038/s41598-019-50435-2
  • Kou X, Xu X, Chen C, et al. The Fas/Fap-1/Cav-1 complex regulates Il-1RA secretion in mesenchymal stem cells to accelerate healing. Sci Transl Med. 2018;10(432). doi:10.1126/scitranslmed.aai8524
  • Phinney DG, Pittenger MF. Concise review: MSC-derived exosomes for cell-free therapy. Stem Cells. 2017;35(4):851–858. doi:10.1002/stem.2575
  • Song I, Seol DR, Kim EM, Lim T-H, Martin J, Shin K. Therapeutic effects of MSC-exosomes on fibroblasts and synoviocytes in TMJ. IADR/AADR/CADR General Session. Presentation ID 3335; Washington, D.C, USA; 2020.
  • Hamidian JS, Li Y, Davies JE. Effect of tumor necrosis factor alpha dose and exposure time on tumor necrosis factor-induced gene-6 activation by neonatal and adult mesenchymal stromal cells. Stem Cells Dev. 2018;27(1):44–54. doi:10.1089/scd.2017.0179
  • Forbes S, Bond AR, Thirlwell KL, et al. Human umbilical cord perivascular cells improve human pancreatic islet transplant function by increasing vascularization. Sci Transl Med. 2020;12(526). doi:10.1126/scitranslmed.aan5907
  • Davies JE, Walker JT, Keating A. Concise review: Wharton’s jelly: the rich, but enigmatic, source of mesenchymal stromal cells. Stem Cells Transl Med. 2017;6(7):1620–1630. doi:10.1002/sctm.16-0492
  • L-l L, Liu Y-J, Yang S-G, et al. Isolation and characterization of human umbilical cord mesenchymal stem cells with hematopoiesis-supportive function and other potentials. Haematologica. 2006;91(8):1017–1026.
  • Sarugaser R, Lickorish D, Baksh D, Hosseini M, Davies JE. Human umbilical cord perivascular (HUCPV) cells: a source of mesenchymal progenitors. Stem Cells. 2005;23(2):220–229. doi:10.1634/stemcells.2004-0166
  • Schugar RC, Chirieleison SM, Wescoe KE, et al. High harvest yield, high expansion, and phenotype stability of CD146 mesenchymal stromal cells from whole primitive human umbilical cord tissue. J Biomed Biotechnol. 2009;2009:789526. doi:10.1155/2009/789526
  • Di Rosa M, Willoughby DA. Screens for anti-inflammatory drugs. J Pharm Pharmacol. 1971;23(4):297–298. doi:10.1111/j.2042-7158.1971.tb08661.x
  • Henriques MG, Silva PM, Martins MA, et al. Mouse paw edema. A new model for inflammation? Braz J Med Biol Res. 1987;20(2):243–249.
  • Goulart AC, Dos Santos Correia FA, de Sousa SCOM, de Cerqueira Luz JG. Study of the inflammatory process induced by injection of carrageenan or formalin in the rat temporomandibular joint. Braz Oral Res. 2005;19(2):99–105. doi:10.1590/S1806-83242005000200005
  • Sarugaser R, Ennis J, Stanford WL, Davies JE. Isolation, propagation, and characterization of Human Umbilical Cord Perivascular Cells (HUCPVCs). Methods Mol Biol. 2009;482:269–279.
  • Fuentes R, Veuthey C, Arias A, et al. Injection in temporomandibular joint of rats. Description of technical protocol. Pol J Vet Sci. 2017;20(2):207–211. doi:10.1515/pjvs-2017-0025
  • Berke HL, Wilson G, Berke ES. Size distribution changes in peripheral lymphocytes of the rat after X-irradiation. Rad Res. 1969;37(1):181–191. doi:10.2307/3572762
  • Willoughby DA, DiRosa M. Studies on the mode of action of non-steroid anti-inflammatory drugs. Ann Rheum Dis. 1972;31(6):540. doi:10.1136/ard.31.6.540
  • Porto GG, Vasconcelos BC, Andrade ES, et al. Comparison between human and rat TMJ: anatomic and histopathologic features. Acta Cir Bras. 2010;25(3):290–293. doi:10.1590/S0102-86502010000300012
  • Winter CA, Risley EA, Nuss GW. Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. Proc Soc Exp Biol Med. 1962;111:544–547. doi:10.3181/00379727-111-27849
  • Morris CJ. Carrageenan-induced paw edema in the rat and mouse. Methods Mol Biol. 2003;225:115–121. doi:10.1385/1-59259-374-7:115
  • Radhakrishnan R, Moore SA, Sluka KA. Unilateral carrageenan injection into muscle or joint induces chronic bilateral hyperalgesia in rats. Pain. 2003;104(3):567–577. doi:10.1016/S0304-3959(03)00114-3
  • Loram LC, Fuller A, Gayle Fick L, Cartmell T, Poole S, Mitchell D. Cytokine profiles during carrageenan-induced inflammatory hyperalgesia in rat muscle and hind paw. J Pain. 2007;8(2):127–136. doi:10.1016/j.jpain.2006.06.010
  • Loram LC, Themistocleous AC, Fick LG, Kamerman PR. The time course of inflammatory cytokine secretion in a rat model of postoperative pain does not coincide with the onset of mechanical hyperalgesia. Can J Physiol Pharmacol. 2007;85(6):613–620. doi:10.1139/Y07-054
  • Grinnemo H, Månsson A, Dellgren G, et al. Xenoreactivity and engraftment of human mesenchymal stem cells transplanted into infarcted rat myocardium. J Thorac Cardiovasc Surg. 2004;127(5):1293–1300. doi:10.1016/j.jtcvs.2003.07.037
  • Kwon DR, Park G-Y, Lee SC. Regenerative effects of mesenchymal stem cells by dosage in a chronic rotator cuff tendon tear in a rabbit model. Regen Med. 2019;14(11):1001–1012. doi:10.2217/rme-2018-0125
  • Eggenhofer E, Luk F, Dahlke MH, Hoogduijn MJ. The life and fate of mesenchymal stem cells. Front Immunol. 2014;5:148. doi:10.3389/fimmu.2014.00148
  • Bernardo ME, Fibbe WE. Mesenchymal stromal cells: sensors and switchers of inflammation. Cell Stem Cell. 2013;13(4):392–402. doi:10.1016/j.stem.2013.09.006
  • Le Blanc K, Mougiakakos D. Multipotent mesenchymal stromal cells and the innate immune system. Nat Rev Immunol. 2012;12(5):383–396. doi:10.1038/nri3209
  • Lässer C, Jang SC, Lötvall J. Subpopulations of extracellular vesicles and their therapeutic potential. Mol Aspects Med. 2018;60:1–14. doi:10.1016/j.mam.2018.02.002
  • Muthu S, Bapat A, Jain R, Jeyaraman N, Jeyaraman M. Exosomal therapy-a new frontier in regenerative medicine. Stem Cell Investig. 2021;8:7. doi:10.21037/sci-2020-037
  • Raposo G, Stoorvogel W. Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol. 2013;200(4):373–383. doi:10.1083/jcb.201211138
  • Liang W, Han B, Hai Y, Sun D, Yin P. Mechanism of action of mesenchymal stem cell-derived exosomes in the intervertebral disc degeneration treatment and bone repair and regeneration. Front Cell Dev Biol. 2022;9:833840. doi:10.3389/fcell.2021.833840
  • Hu JC, Zheng CX, Sui BD, Liu WJ, Jin Y. Mesenchymal stem cell-derived exosomes: a novel and potential remedy for cutaneous wound healing and regeneration. World J Stem Cells. 2022;14(5):318–329. doi:10.4252/wjsc.v14.i5.318
  • Jafari D, Shajari S, Jafari R, et al. Designer exosomes: a new platform for biotechnology therapeutics. BioDrugs. 2020;34:567–586. doi:10.1007/s40259-020-00434-x
  • Baranov MV, Kumar M, Sacanna S, Thutupalli S, van den Bogaart G. Modulation of immune responses by particle size and shape. Front Immunol. 2021;11. doi:10.3389/fimmu.2020.607945
  • Wang J, Chen D, Ho EA. Challenges in the development and establishment of exosome-based drug delivery systems. J Control Release. 2021;329:894–906. doi:10.1016/j.jconrel.2020.10.020