Therapeutic Effects of HLA-G5 Overexpressing hAMSCs on aGVHD After Allo-HSCT: Involving in the Gut Microbiota at the Intestinal Barrier

References

• Ferrara JL, Levine JE, Reddy P, Holler E. Graft-versus-host disease. Lancet. 2009;373(9674):1550–1561. doi:10.1016/S0140-6736(09)60237-3
   PubMed Web of Science ®Google Scholar
• Staffas A, Burgos da Silva M, van den Brink MRM. The intestinal microbiota in allogeneic hematopoietic cell transplant and graft-versus-host disease. Blood. 2017;129(8):927–933. doi:10.1182/blood-2016-09-691394
   PubMed Web of Science ®Google Scholar
• Malard F, Huang X, Sim JPY. Treatment and unmet needs in steroid-refractory acute graft-versus-host disease. Leukemia. 2020;34(5):1229–1240. doi:10.1038/s41375-020-0804-2
   PubMed Web of Science ®Google Scholar
• Zeiser R, Blazar BR. Acute graft-versus-host disease – biologic process, prevention, and therapy. N Engl J Med. 2017;377(22):2167–2179. doi:10.1056/NEJMra1609337
   PubMed Web of Science ®Google Scholar
• Hill GR, Koyama M. Cytokines and costimulation in acute graft-versus-host disease. Blood. 2020;136(4):418–428. doi:10.1182/blood.2019000952
   PubMed Web of Science ®Google Scholar
• Lin D, Hu B, Li P, et al. Roles of the intestinal microbiota and microbial metabolites in acute GVHD. Exp Hematol Oncol. 2021;10(1):49. doi:10.1186/s40164-021-00240-3
   PubMed Web of Science ®Google Scholar
• Chen Y, Zhao Y, Cheng Q, Wu D, Liu H. The role of intestinal microbiota in acute graft-versus-host disease. J Immunol Res. 2015;2015:145859. doi:10.1155/2015/145859
   PubMed Web of Science ®Google Scholar
• Bulati M, Miceli V, Gallo A, et al. The immunomodulatory properties of the human amnion-derived mesenchymal stromal/stem cells are induced by INF-γ produced by activated lymphomonocytes and are mediated by cell-to-cell contact and soluble factors. Front Immunol. 2020;11:54. doi:10.3389/fimmu.2020.00054
   PubMed Web of Science ®Google Scholar
• Wang Y, Chen X, Cao W, Shi Y. Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications. Nat Immunol. 2014;15(11):1009–1016. doi:10.1038/ni.3002
   PubMed Web of Science ®Google Scholar
• Liu Q, Huang Q, Wu H, et al. Characteristics and therapeutic potential of human amnion-derived stem cells. Int J Mol Sci. 2021;22(2):970. doi:10.3390/ijms22020970
   PubMed Web of Science ®Google Scholar
• Gao Y, Li W, Bu X, et al. Human amniotic mesenchymal stem cells inhibit aGVHD by regulating balance of treg and T effector cells. J Inflamm Res. 2021;14:3985–3999. doi:10.2147/JIR.S323054
   PubMed Web of Science ®Google Scholar
• Bu X, Wang J, Yin Z, et al. Human amniotic mesenchymal stem cells alleviate aGVHD after allo-HSCT by regulating interactions between gut microbiota and intestinal immunity. Stem Cell Rev Rep. 2023. doi:10.1007/s12015-023-10522-4
   PubMed Web of Science ®Google Scholar
• Bu X, Zhong J, Li W, et al. Immunomodulating functions of human leukocyte antigen-G and its role in graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Ann Hematol. 2021;100(6):1391–1400. doi:10.1007/s00277-021-04486-z
   PubMed Web of Science ®Google Scholar
• Ferreira LMR, Meissner TB, Tilburgs T, Strominger JL. HLA-G: at the Interface of Maternal-Fetal Tolerance. Trends Immunol. 2017;38(4):272–286. doi:10.1016/j.it.2017.01.009
   PubMed Web of Science ®Google Scholar
• González A, Rebmann V, LeMaoult J, et al. The immunosuppressive molecule HLA-G and its clinical implications. Crit Rev Clin Lab Sci. 2012;49(3):63–84. doi:10.3109/10408363.2012.677947
   PubMed Web of Science ®Google Scholar
• Zaborek-łyczba M, Łyczba J, Mertowska P, et al. The HLA-G immune checkpoint plays a pivotal role in the regulation of immune response in autoimmune diseases. Int J Mol Sci. 2021;22(24). doi:10.3390/ijms222413348
   PubMed Web of Science ®Google Scholar
• Lin A, Yan W. Perspective of HLA-G Induced Immunosuppression in SARS-CoV-2 Infection. Front Immunol. 2021;12:788769. doi:10.3389/fimmu.2021.788769
   PubMed Web of Science ®Google Scholar
• Lila N, Amrein C, Guillemain R, et al. Human leukocyte antigen-G expression after heart transplantation is associated with a reduced incidence of rejection. Circulation. 2002;105(16):1949–1954. doi:10.1161/01.cir.0000015075.89984.46
   PubMed Web of Science ®Google Scholar
• Curigliano G, Criscitiello C, Gelao L, Goldhirsch A. Molecular Pathways: human Leukocyte Antigen G (HLA-G). Clin Cancer Res. 2013;19(20):5564–5571. doi:10.1158/1078-0432.CCR-12-3697
   PubMed Web of Science ®Google Scholar
• HoWangYin K, Loustau M, Wu J, et al. Multimeric structures of HLA-G isoforms function through differential binding to LILRB receptors. Cell Mol Life Sci. 2012;69(23):4041–4049. doi:10.1007/s00018-012-1069-3
   PubMed Web of Science ®Google Scholar
• Zoehler B, Fracaro L, Senegaglia AC, Bicalho MDG. Infusion of mesenchymal stem cells to treat graft versus host disease: the role of HLA-G and the impact of its polymorphisms. Stem Cell Rev Rep. 2020;16(3):459–471. doi:10.1007/s12015-020-09960-1
   PubMed Web of Science ®Google Scholar
• Shi Y, Wang Y, Li Q, et al. Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases. Nat Rev Nephrol. 2018;14(8):493–507. doi:10.1038/s41581-018-0023-5
   PubMed Web of Science ®Google Scholar
• Nasef A, Mathieu N, Chapel A, et al. Immunosuppressive effects of mesenchymal stem cells: involvement of HLA-G. Transplantation. 2007;84(2):231–237.
   PubMed Web of Science ®Google Scholar
• Deschaseaux F, Gaillard J, Langonné A, et al. Regulation and function of immunosuppressive molecule human leukocyte antigen G5 in human bone tissue. FASEB J. 2013;27(8):2977–2987. doi:10.1096/fj.13-227264
   PubMed Web of Science ®Google Scholar
• Selmani Z, Naji A, Zidi I, et al. Human leukocyte antigen-G5 secretion by human mesenchymal stem cells is required to suppress T Lymphocyte and natural killer function and to induce CD4+CD25highFOXP3+regulatory T cells. Stem Cells. 2008;26(1):212–222. doi:10.1634/stemcells.2007-0554
   PubMed Web of Science ®Google Scholar
• Soontararak S, Chow L, Johnson V, et al. Mesenchymal Stem Cells (MSC) derived from Induced Pluripotent Stem Cells (iPSC) equivalent to adipose-derived MSC in promoting intestinal healing and microbiome normalization in mouse inflammatory bowel disease model. Stem Cells Transl Med. 2018;7(6):456–467. doi:10.1002/sctm.17-0305
   PubMed Web of Science ®Google Scholar
• Cooke KR, Kobzik L, Martin TR, et al. An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin. Blood. 1996;88(8):3230–3239.
   PubMed Web of Science ®Google Scholar
• Yañez R, Lamana ML, García-Castro J, et al. Adipose tissue-derived mesenchymal stem cells have in vivo immunosuppressive properties applicable for the control of the graft-versus-host disease. Stem Cells. 2006;24(11):2582–2591.
   PubMed Web of Science ®Google Scholar
• Dominici M, Le Blanc K, Mueller I, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement. Cytotherapy. 2006;8(4):315–317.
   PubMed Web of Science ®Google Scholar
• Martín-Villa JM, Vaquero-Yuste C, Molina-Alejandre M, et al. HLA-G: too much or too little? Role in cancer and autoimmune disease. Front Immunol. 2022:13. doi:10.3389/fimmu.2022.796054
   Google Scholar
• Le Maux A, Noël G, Birebent B, et al. Soluble human leucocyte antigen-G molecules in peripheral blood haematopoietic stem cell transplantation: a specific role to prevent acute graft-versus-host disease and a link with regulatory T cells. Clin Exp Immunol. 2008;152(1):50–56. doi:10.1111/j.1365-2249.2008.03598.x
   PubMed Web of Science ®Google Scholar
• Nomura S, Ito T, Katayama Y, et al. Effects of recombinant thrombomodulin therapy and soluble human leukocyte antigen-G levels during hematopoietic stem cell transplantation. Transpl Immunol. 2019;53:28–33. doi:10.1016/j.trim.2018.12.001
   PubMed Web of Science ®Google Scholar
• Kordelas L, Da Silva Nardi F, Wagner B, et al. Elevated soluble human leukocyte antigen G levels in patients after allogeneic stem cell transplantation are associated with less severe acute and chronic graft-versus-host disease. Bone Marrow Transplant. 2018;53(9):1149–1156. doi:10.1038/s41409-018-0145-1
   PubMed Web of Science ®Google Scholar
• Liu H, Chen Y, Xuan L, et al. Soluble human leukocyte antigen G molecule expression in allogeneic hematopoietic stem cell transplantation: good predictor of acute graft-versus-host disease. Acta Haematol. 2013;130(3):160–168. doi:10.1159/000350488
   PubMed Web of Science ®Google Scholar
• Zhao K, Liu Q. The clinical application of mesenchymal stromal cells in hematopoietic stem cell transplantation. J Hematol Oncol. 2016;9(1):46. doi:10.1186/s13045-016-0276-z
   PubMedGoogle Scholar
• Tolar J, Le Blanc K, Keating A, Blazar BR. Concise review: hitting the right spot with mesenchymal stromal cells. Stem Cells. 2010;28(8):1446–1455. doi:10.1002/stem.459
   PubMed Web of Science ®Google Scholar
• Singer NG, Caplan AI. Mesenchymal stem cells: mechanisms of inflammation. Annu Rev Pathol. 2011;6:457–478. doi:10.1146/annurev-pathol-011110-130230
   PubMed Web of Science ®Google Scholar
• Liu S, Bos NA, Verschuuren EAM, van Baarle D, Westra J. Biological Characteristics of HLA-G and its role in solid organ transplantation. Front Immunol. 2022;13:902093. doi:10.3389/fimmu.2022.902093
   PubMed Web of Science ®Google Scholar
• Yang S, Wei Y, Sun R, et al. Umbilical cord blood-derived mesenchymal stromal cells promote myeloid-derived suppressor cell proliferation by secreting HLA-G to reduce acute graft-versus-host disease after hematopoietic stem cell transplantation. Cytotherapy. 2020;22(12):718–733. doi:10.1016/j.jcyt.2020.07.008
   PubMed Web of Science ®Google Scholar
• Zhang L, Chu J, Yu J, Wei W. Cellular and molecular mechanisms in graft-versus-host disease. J Leukoc Biol. 2016;99(2):279–287. doi:10.1189/jlb.4RU0615-254RR
   PubMed Web of Science ®Google Scholar
• Magenau J, Runaas L, Reddy P. Advances in understanding the pathogenesis of graft-versus-host disease. Br J Haematol. 2016;173(2):190–205. doi:10.1111/bjh.13959
   PubMed Web of Science ®Google Scholar
• Kayama H, Okumura R, Takeda K. Interaction between the microbiota, Epithelia, and immune cells in the intestine. Annu Rev Immunol. 2020;38:23–48. doi:10.1146/annurev-immunol-070119-115104
   PubMed Web of Science ®Google Scholar
• Shono Y, Docampo MD, Peled JU, et al. Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice. Sci Transl Med. 2016;8(339):339r–371r. doi:10.1126/scitranslmed.aaf2311
   Web of Science ®Google Scholar
• Yuan M, Lin L, Cao H, et al. Intestinal microbiota participates in the protective effect of HO-1/BMMSCs on liver transplantation with steatotic liver grafts in rats. Front Microbiol. 2022;13:905567. doi:10.3389/fmicb.2022.905567
   PubMedGoogle Scholar
• Ilett EE, Jørgensen M, Noguera-Julian M, et al. Associations of the gut microbiome and clinical factors with acute GVHD in allogeneic HSCT recipients. Blood Adv. 2020;4(22):5797–5809. doi:10.1182/bloodadvances.2020002677
   PubMed Web of Science ®Google Scholar
• Zhu S, Li H, Lv C, et al. Combination of mesenchymal stem cell and endothelial progenitor cell infusion accelerates injured intestinal repair by regulating gut microbiota after hematopoietic cell transplantation. Transplant Cell Ther. 2021;27(2):151–152. doi:10.1016/j.jtct.2020.10.013
   Google Scholar
• Yuan Y, Liu S, Ding X, et al. Early intestinal microbiota changes in aged and adult mice with sepsis. Front Cell Infect Microbiol. 2022;12:1061444. doi:10.3389/fcimb.2022.1061444
   PubMed Web of Science ®Google Scholar
• Lee SH, Park H, Kang CD, et al. High dose intramuscular vitamin D3 supplementation impacts the gut microbiota of patients with clostridioides difficile infection. Front Cell Infect Microbiol. 2022;12:904987. doi:10.3389/fcimb.2022.904987
   PubMed Web of Science ®Google Scholar
• Cao Y, Liu H, Teng Y, et al. Gut microbiota mediates the anti-colitis effects of polysaccharides derived from Rhopilema esculentum Kishinouye in mice. Food Funct. 2023;14(4):1989–2007. doi:10.1039/d2fo02712g
   PubMed Web of Science ®Google Scholar