89
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Serum Exosomal Long Noncoding RNA Growth Arrest-Specific 5 Predicts 3-Month Mortality in Acute-on-Chronic Hepatitis B Liver Failure

ORCID Icon, , &
Pages 4603-4616 | Received 29 May 2023, Accepted 09 Oct 2023, Published online: 17 Oct 2023

References

  • Bernal W, Jalan R, Quaglia A, et al. Acute-on-chronic liver failure. Lancet. 2015;386(10003):1576–1587. doi:10.1016/S0140-6736(15)00309-8
  • Sarin SK, Choudhury A, Sharma MK, et al. Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update. Hepatol Int. 2019;13(4):353–390. doi:10.1007/s12072-019-09946-3
  • Gustot T, Jalan R. Acute-on-chronic liver failure in patients with alcohol-related liver disease. J Hepatol. 2019;70(2):319–327. doi:10.1016/j.jhep.2018.12.008
  • Wu T, Li J, Shao L, et al. Development of diagnostic criteria and a prognostic score for hepatitis B virus-related acute-on-chronic liver failure. Gut. 2018;67(12):2181–2191. doi:10.1136/gutjnl-2017-314641
  • Fernández J, Acevedo J, Wiest R, et al. Bacterial and fungal infections in acute-on-chronic liver failure: prevalence, characteristics and impact on prognosis. Gut. 2018;67(10):1870–1880. doi:10.1136/gutjnl-2017-314240
  • Colombo M, Raposo G, Théry C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu Rev Cell Dev Biol. 2014;30(1):255–289. doi:10.1146/annurev-cellbio-101512-122326
  • Szabo G, Momen-Heravi F. Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets. Nat Rev Gastroenterol Hepatol. 2017;14(8):455–466. doi:10.1038/nrgastro.2017.71
  • Murphy AG, Selaru FM. Extracellular vesicles as novel therapeutics in hepatic failure. Hepatology. 2018;67(3):1158–1160. doi:10.1002/hep.29576
  • Jin Y, Wang J, Li H, et al. Extracellular vesicles secreted by Human Adipose-derived Stem Cells (hASCs) improve survival rate of rats with acute liver failure by releasing lncRNA H19. EBioMedicine. 2018;34:231–242. doi:10.1016/j.ebiom.2018.07.015
  • Kopp F, Mendell JT. Functional classification and experimental dissection of long noncoding RNAs. Cell. 2018;172(3):393–407. doi:10.1016/j.cell.2018.01.011
  • Wahlestedt C. Targeting long non-coding RNA to therapeutically upregulate gene expression. Nat Rev Drug Discov. 2013;12(6):433–446. doi:10.1038/nrd4018
  • Kourembanas S. Exosomes: vehicles of intercellular signaling, biomarkers, and vectors of cell therapy. Annu Rev Physiol. 2015;77(1):13–27. doi:10.1146/annurev-physiol-021014-071641
  • Pegtel DM, Gould SJ. Exosomes. Annu Rev Biochem. 2019;88(1):487–514. doi:10.1146/annurev-biochem-013118-111902
  • Gao S, Fan YC, Han LY, et al. Serum exosomal long noncoding RNA nuclear-enriched abundant transcript 1 predicts 90-day mortality in acute-on-chronic hepatitis B liver failure. Expert Rev Clin Immunol. 2021;17(7):789–797. doi:10.1080/1744666X.2021.1933442
  • Bockmann JH, Dandri M, Lüth S, et al. Combined glucocorticoid and antiviral therapy of hepatitis B virus-related liver failure. World J Gastroenterol. 2015;21(7):2214–2219. doi:10.3748/wjg.v21.i7.2214
  • Kino T, Hurt DE, Ichijo T, et al. Noncoding RNA gas5 is a growth arrest- and starvation-associated repressor of the glucocorticoid receptor. Sci Signal. 2010;3(107):ra8. doi:10.1126/scisignal.2000568
  • Avgeris M, Tsilimantou A, Levis PK, et al. Loss of GAS5 tumour suppressor lncRNA: an independent molecular cancer biomarker for short-term relapse and progression in bladder cancer patients. Br J Cancer. 2018;119(12):1477–1486. doi:10.1038/s41416-018-0320-6
  • Zhao X, Wang P, Liu J, et al. Gas5 exerts tumor-suppressive functions in human glioma cells by targeting miR-222. Molecular Therapy. 2015;23(12):1899–1911. doi:10.1038/mt.2015.170
  • Dong S, Qu X, Li W, et al. The long non-coding RNA, GAS5, enhances gefitinib-induced cell death in innate EGFR tyrosine kinase inhibitor-resistant lung adenocarcinoma cells with wide-type EGFR via downregulation of the IGF-1R expression. J Hematol Oncol. 2015;8(1):43. doi:10.1186/s13045-015-0140-6
  • Xu C, Zhang Y, Wang Q, et al. Long non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signalling. Nat Commun. 2016;7(1):13287. doi:10.1038/ncomms13287
  • Arroyo V. Acute-on-chronic liver failure in cirrhosis requires expedited decisions for liver transplantation. Gastroenterology. 2019;156(5):1248–1249. doi:10.1053/j.gastro.2019.03.004
  • Quinn JJ, Chang HY. Unique features of long non-coding RNA biogenesis and function. Nat Rev Genet. 2016;17(1):47–62. doi:10.1038/nrg.2015.10
  • Khorkova O, Hsiao J, Wahlestedt C. Basic biology and therapeutic implications of lncRNA. Adv Drug Deliv Rev. 2015;87:15–24. doi:10.1016/j.addr.2015.05.012
  • Flynn RA, Chang HY. Long noncoding RNAs in cell-fate programming and reprogramming. Cell Stem Cell. 2014;14(6):752–761. doi:10.1016/j.stem.2014.05.014
  • Batista PJ, Chang HY. Long noncoding RNAs: cellular address codes in development and disease. Cell. 2013;152(6):1298–1307. doi:10.1016/j.cell.2013.02.012
  • Sun Z, Yang S, Zhou Q, et al. Emerging role of exosome-derived long non-coding RNAs in tumor microenvironment. Mol Cancer. 2018;17(1):82. doi:10.1186/s12943-018-0831-z
  • Hong CS, Funk S, Muller L, et al. Isolation of biologically active and morphologically intact exosomes from plasma of patients with cancer. J Extracell Vesicles. 2016;5(1):29289. doi:10.3402/jev.v5.29289
  • Yu X, He L, Pentok M, et al. An aptamer-based new method for competitive fluorescence detection of exosomes. Nanoscale. 2019;11(33):15589–15595. doi:10.1039/C9NR04050A
  • Fujiwara K, Yasui S, Yonemitsu Y, et al. Efficacy of combination therapy of antiviral and immunosuppressive drugs for the treatment of severe acute exacerbation of chronic hepatitis B. J Gastroenterol. 2008;43(9):711–719. doi:10.1007/s00535-008-2222-5
  • Zhao J, Zhang JY, Yu HW, et al. Improved survival ratios correlate with myeloid dendritic cell restoration in acute-on-chronic liver failure patients receiving methylprednisolone therapy. Cell Mol Immunol. 2012;9(5):417–422. doi:10.1038/cmi.2011.51
  • Pickard MR, Williams GT. Molecular and cellular mechanisms of action of tumour suppressor GAS5 LncRNA. Genes. 2015;6(3):484–499. doi:10.3390/genes6030484
  • Hudson WH, Pickard MR, de Vera IM, et al. Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate. Nat Commun. 2014;5(1):5395. doi:10.1038/ncomms6395
  • Zhang Z, Zhu Z, Watabe K, et al. Negative regulation of lncRNA GAS5 by miR-21. Cell Death Differ. 2013;20(11):1558–1568. doi:10.1038/cdd.2013.110
  • Feng S, Ji G, Ma J, et al. Long noncoding RNA GAS5 does not regulate HBV replication. J Med Virol. 2019;91(11):1949–1959. doi:10.1002/jmv.25547
  • Guo Y, Li C, Zhang R, et al. Epigenetically-regulated serum GAS5 as a potential biomarker for patients with chronic hepatitis B virus infection. Cancer Biomarkers. 2021;32(2):137–146. doi:10.3233/CBM-203169