An Overview of the Mechanisms Involved in Neuralgia

References

• Raja SN, Carr DB, Cohen M, et al. The revised international association for the study of pain definition of pain: concepts, challenges, and compromises. Pain. 2020;161(9):1976–1982. doi:10.1097/j.pain.0000000000001939
   PubMed Web of Science ®Google Scholar
• Kuner R, Flor H. Structural plasticity and reorganisation in chronic pain. Nat Rev Neurosci. 2016;18(1):20–30. doi:10.1038/nrn.2016.162
   PubMed Web of Science ®Google Scholar
• Peirs C, Seal RP. Neural circuits for pain: recent advances and current views. Science. 2016;354(6312):578–584. doi:10.1126/science.aaf8933
   PubMed Web of Science ®Google Scholar
• Cohen SP, Vase L, Hooten WM. Chronic pain: an update on burden, best practices, and new advances. Lancet. 2021;397(10289):2082–2097. doi:10.1016/S0140-6736(21)00393-7
   PubMed Web of Science ®Google Scholar
• Scholz J, Finnerup NB, Attal N, et al. Classification committee of the neuropathic pain special interest G. The IASP classification of chronic pain for ICD-11: chronic neuropathic pain. Pain. 2019;160:53–59. doi:10.1097/j.pain.0000000000001365
   PubMed Web of Science ®Google Scholar
• Finnerup NB, Kuner R, Jensen TS. Neuropathic pain: from mechanisms to treatment. Physiol Rev. 2021;101(1):259–301. doi:10.1152/physrev.00045.2019
   PubMed Web of Science ®Google Scholar
• Xie RG, Gao YJ, Park CK, et al. Spinal CCL2 promotes central sensitization, long-term potentiation, and inflammatory pain via CCR2: further insights into molecular, synaptic, and cellular mechanisms. Neurosci Bull. 2018;34(1):13–21. doi:10.1007/s12264-017-0106-5
   PubMed Web of Science ®Google Scholar
• Atta AA, Ibrahim WW, Mohamed AF, Abdelkader NF. Microglia polarization in nociplastic pain: mechanisms and perspectives. Inflammopharmacology. 2023;31(3):1053–1067. doi:10.1007/s10787-023-01216-x
   PubMed Web of Science ®Google Scholar
• Sun JL, Dai WJ, Shen XY, Lü N, Zhang YQ. Interleukin-17 is involved in neuropathic pain and spinal synapse plasticity on mice. J Neuroimmunol. 2023;377:578068. doi:10.1016/j.jneuroim.2023.578068
   PubMed Web of Science ®Google Scholar
• Kwiatkowski K, Mika J. The importance of chemokines in neuropathic pain development and opioid analgesic potency. Pharmacol Rep. 2018;70(4):821–830. doi:10.1016/j.pharep.2018.01.006
   PubMed Web of Science ®Google Scholar
• Iyengar S, Ossipov MH, Johnson KW. The role of calcitonin gene-related peptide in peripheral and central pain mechanisms including migraine. Pain. 2017;158:543–559. doi:10.1097/j.pain.0000000000000831
   PubMed Web of Science ®Google Scholar
• Zhao Z, Zhang Z, Li J, et al. Sustained TNF-α stimulation leads to transcriptional memory that greatly enhances signal sensitivity and robustness. Elife. 2020;9:e61965. doi:10.7554/eLife.61965
   PubMed Web of Science ®Google Scholar
• Greco R, Demartini C, Francavilla M, Zanaboni AM, Tassorelli C. Antagonism of CGRP receptor: central and peripheral mechanisms and mediators in an animal model of chronic migraine. Cells. 2022;11(19):3092. doi:10.3390/cells11193092
   PubMed Web of Science ®Google Scholar
• Yang G, Tan Q, Li Z, et al. The AMPK pathway triggers autophagy during CSF1-induced microglial activation and may be implicated in inducing neuropathic pain. J Neuroimmunol. 2020;345:577261. doi:10.1016/j.jneuroim.2020.577261
   PubMed Web of Science ®Google Scholar
• Kuhn JA, Vainchtein ID, Braz J, et al. Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice. Elife. 2021;10:e69056. doi:10.7554/eLife.69056
   PubMed Web of Science ®Google Scholar
• Cao YQ, Mantyh PW, Carlson EJ, Gillespie AM, Epstein CJ, Basbaum AI. Primary afferent tachykinins are required to experience moderate to intense pain. Nature. 1998;392(6674):390–394. doi:10.1038/32897
   PubMed Web of Science ®Google Scholar
• Zieglgänsberger W. Substance P and pain chronicity. Cell Tissue Res. 2019;375(1):227–241. doi:10.1007/s00441-018-2922-y
   PubMed Web of Science ®Google Scholar
• Ebrahimi S, Erfani B, Alalikhan A, et al. The in vitro pro-inflammatory functions of the SP/NK1R System in prostate cancer: a focus on nuclear factor-kappa B (NF-κB) and its pro-inflammatory target genes. Biochem Biotechnol. 2023:1. doi:10.1007/s12010-023-04495-w
   Web of Science ®Google Scholar
• Franchini L, Carrano N, Di Luca M, Gardoni F. Synaptic GluN2A-Containing NMDA receptors: from physiology to pathological synaptic plasticity. Int J Mol Sci. 2020;21(4):1538. doi:10.3390/ijms21041538
   PubMed Web of Science ®Google Scholar
• Zhang YY, Liu F, Fang ZH, et al. Differential roles of NMDAR subunits 2A and 2B in mediating peripheral and central sensitization contributing to orofacial neuropathic pain. Brain Behav Immun. 2022;106:129–146. doi:10.1016/j.bbi.2022.08.010
   PubMed Web of Science ®Google Scholar
• Zhang YY, Liu F, Lin J, et al. Activation of the N-methyl-D-aspartate receptor contributes to orofacial neuropathic and inflammatory allodynia by facilitating calcium-calmodulin-dependent protein kinase II phosphorylation in mice. Brain Res Bull. 2022;185:174–192. doi:10.1016/j.brainresbull.2022.05.003
   PubMed Web of Science ®Google Scholar
• Zhang H, Ma S-B, Gao Y-J, et al. Spinal CCL2 promotes pain sensitization by rapid enhancement of NMDA-induced currents through the ERK-GluN2B pathway in mouse lamina II neurons. Neurosci Bull. 2020;36(11):1344–1354 doi:10.1007/s12264-020-00557-9.
   Google Scholar
• Basbaum AI, Bautista DM, Scherrer G, Julius D. Cellular and molecular mechanisms of pain. Cell. 2009;139:267–284. doi:10.1016/j.cell.2009.09.028
   PubMed Web of Science ®Google Scholar
• Gold MS, Gebhart GF. Nociceptor sensitization in pain pathogenesis. Nat Med. 2010;16:1248–1257. doi:10.1038/nm.2235
   PubMed Web of Science ®Google Scholar
• Liu JA, Yu J, Cheung CW. Immune actions on the peripheral nervous system in pain. Int J Mol Sci. 2021;22(3). doi:10.3390/ijms22031448
   Web of Science ®Google Scholar
• Zhou L, Ao L, Yan Y, et al. The therapeutic potential of chemokines in the treatment of chemotherapy- induced peripheral neuropathy. Curr Drug Targets. 2020;21(3):288–301. doi:10.2174/1389450120666190906153652
   PubMed Web of Science ®Google Scholar
• Subbarayan MS, Joly-Amado A, Bickford PC, Nash KR. CX3CL1/CX3CR1 signaling targets for the treatment of neurodegenerative diseases. Pharmacol Ther. 2022;231:107989. doi:10.1016/j.pharmthera.2021.107989
   PubMed Web of Science ®Google Scholar
• Zhang ZJ, Jiang BC, Gao YJ. Chemokines in neuron-glial cell interaction and pathogenesis of neuropathic pain. Cell Mol Life Sci. 2017;74(18):3275–3291. doi:10.1007/s00018-017-2513-1
   PubMed Web of Science ®Google Scholar
• Yang F, Jing JJ, Fu SY, et al. Spinal MCP-1 contributes to central post-stroke pain by inducing central sensitization in rats. Mol Neurobiol. 2023;60(4):2086–2098. doi:10.1007/s12035-022-03184-9
   PubMed Web of Science ®Google Scholar
• Gao YJ, Zhang L, Samad OA, et al. JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain. J Neurosci. 2009;29(13):4096–4108. doi:10.1523/JNEUROSCI.3623-08.2009
   PubMed Web of Science ®Google Scholar
• Yan Y, Liang Y, Ding T, Chu H. PI3K/Akt signaling pathway may be involved in MCP-1-induced P2X4R expression in cultured microglia and cancer-induced bone pain rats. Neurosci Lett. 2019;701:100–105. doi:10.1016/j.neulet.2019.02.024
   PubMed Web of Science ®Google Scholar
• Zhu X, Xie W, Zhang J, Strong JA, Zhang JM. Sympathectomy decreases pain behaviors and nerve regeneration by downregulating monocyte chemokine CCL2 in dorsal root ganglia in the rat tibial nerve crush model. Pain. 2022;163(1):e106–e120. doi:10.1097/j.pain.0000000000002321
   PubMed Web of Science ®Google Scholar
• Jiang S, Liang J, Li W, et al. The role of CXCL1/CXCR2 axis in neurological diseases. Int Immunopharmacol. 2023;120:110330. doi:10.1016/j.intimp.2023.110330
   PubMed Web of Science ®Google Scholar
• Zhang ZJ, Cao DL, Zhang X, Ji RR, Gao YJ. Chemokine contribution to neuropathic pain: respective induction of CXCL1 and CXCR2 in spinal cord astrocytes and neurons. Pain. 2013;154(10):2185–2197. doi:10.1016/j.pain.2013.07.002
   PubMed Web of Science ®Google Scholar
• Cao DL, Zhang ZJ, Xie RG, Jiang BC, Ji RR, Gao YJ. Chemokine CXCL1 enhances inflammatory pain and increases NMDA receptor activity and COX-2 expression in spinal cord neurons via activation of CXCR2. Exp Neurol. 2014;261:328–336. doi:10.1016/j.expneurol.2014.05.014
   PubMed Web of Science ®Google Scholar
• Knerlich-Lukoschus F, von der Ropp-Brenner B, Lucius R, Mehdorn HM, HeldFeindt J. Spatiotemporal CCR1, CCL3(MIP-1α), CXCR4, CXCL12(SDF-1α) expression patterns in a rat spinal cord injury model of posttraumatic neuropathic pain. J Neurosurg Spine. 2011;14:583–597. doi:10.3171/2010.12.SPINE10480
   PubMed Web of Science ®Google Scholar
• Song ZH, Song XJ, Yang CL, et al. Up-regulation of microglial chemokine CXCL12 in anterior cingulate cortex mediates neuropathic pain in diabetic mice. Acta Pharmacol Sin. 2023;44(7):1337–1349. doi:10.1038/s41401-022-01046-7
   PubMed Web of Science ®Google Scholar
• Liu ZY, Song ZW, Guo SW, et al. CXCL12/CXCR4 signaling contributes to neuropathic pain via central sensitization mechanisms in a rat spinal nerve ligation model. CNS Neurosci Ther. 2019;25(9):922–936. doi:10.1111/cns.13128
   PubMed Web of Science ®Google Scholar
• Li M, Ransohoff RM. Multiple roles of chemokine CXCL12 in the central nervous system: a migration from immunology to neurobiology. Prog Neurobiol. 2008;84:116–131. doi:10.1016/j.pneurobio.2007.11.003
   PubMed Web of Science ®Google Scholar
• Xing F, Kong C, Bai L, et al. CXCL12/CXCR4 signaling mediated ERK1/2 activation in spinal cord contributes to the pathogenesis of postsurgical pain in rats. Mol Pain. 2017;13:1744806917718753. doi:10.1177/1744806917718753
   Web of Science ®Google Scholar
• Mines MA, Goodwin JS, Limbird LE, Cui FF, Fan GH. Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation. J Biol Chem. 2009;284:5742–5752. doi:10.1074/jbc.M808507200
   PubMed Web of Science ®Google Scholar
• Kiguchi N, Kobayashi Y, Kishioka S. Chemokines and cytokines in neuroinflammation leading to neuropathic pain. Curr Opin Pharmacol. 2012;12(1):55–61. doi:10.1016/j.coph.2011.10.007
   PubMed Web of Science ®Google Scholar
• Rojewska E, Zychowska M, Piotrowska A, Kreiner G, Nalepa I, Mika J. Involvement of macrophage inflammatory protein-1 family members in the development of diabetic neuropathy and their contribution to effectiveness of morphine. Front Immunol. 2018;9:494. doi:10.3389/fimmu.2018.00494
   PubMed Web of Science ®Google Scholar
• Kataoka A, Tozaki-Saitoh H, Koga Y, Tsuda M, Inoue K. Activation of P2X7 receptors induces CCL3 production in microglial cells through transcription factor NFAT. J Neurochem. 2009;108:115–125. doi:10.1111/j.1471-4159.2008.05744.x
   PubMed Web of Science ®Google Scholar
• Simpson JE, Newcombe J, Cuzner ML, Woodroofe MN. Expression of monocyte chemoattractant protein-1 and other beta-chemokines by resident glia and inflammatory cells in multiple sclerosis lesions. J Neuroimmunol. 1998;84:238–249. doi:10.1016/S0165-5728(97)00208-7
   PubMed Web of Science ®Google Scholar
• Ansel KM, Ngo VN, Hyman PL, et al. A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature. 2000;406(6793):309–314. doi:10.1038/35018581
   PubMed Web of Science ®Google Scholar
• Wang J, Yin C, Pan Y, et al. CXCL13 contributes to chronic pain of a mouse model of CRPS-I via CXCR5-mediated NF-κB activation and pro-inflammatory cytokine production in spinal cord dorsal horn. J Neuroinflammation. 2023;20(1):109. doi:10.1186/s12974-023-02778-x
   PubMed Web of Science ®Google Scholar
• Wu XB, Cao DL, Zhang X, et al. CXCL13/CXCR5 enhances sodium channel Nav1.8 current density via p38 MAP kinase in primary sensory neurons following inflammatory pain. Sci Rep. 2016;6:34836. doi:10.1038/srep34836
   PubMed Web of Science ®Google Scholar
• Tsymbalyuk O, Gerzanich V, Mumtaz A, et al. SUR1, newly expressed in astrocytes, mediates neuropathic pain in a mouse model of peripheral nerve injury. Mol Pain. 2021;17:17448069211006603. doi:10.1177/17448069211006603
   Web of Science ®Google Scholar
• Jin SX, Zhuang ZY, Woolf CJ, et al. p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain. J Neurosci. 2003;23(10):4017–4022. doi:10.1523/JNEUROSCI.23-10-04017.2003
   PubMed Web of Science ®Google Scholar
• Tsuda M, Shigemoto-Mogami Y, Koizumi S, et al. P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature. 2003;424(6950):778–783. doi:10.1038/nature01786
   PubMed Web of Science ®Google Scholar
• Ginhoux F, Greter M, Leboeuf M, et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science. 2010;330(6005):841–845. doi:10.1126/science.1194637
   PubMed Web of Science ®Google Scholar
• Wang Y, Szretter KJ, Vermi W, et al. IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia. Nat Immunol. 2012;13(8):753–760. doi:10.1038/ni.2360
   PubMed Web of Science ®Google Scholar
• Butovsky O, Jedrychowski MP, Moore CS, et al. Identification of a unique TGF-β-dependent molecular and functional signature in microglia. Nat Neurosci. 2014;17(1):131–143. doi:10.1038/nn.3599
   PubMed Web of Science ®Google Scholar
• Chen X, Yao J, Lai J, et al. ADAM17 aggravates the inflammatory response by modulating microglia polarization through the TGF-β1/smad pathway following experimental traumatic brain injury. J Neurotrauma. 2023;40(13–14):1495–1509. doi:10.1089/neu.2022.0373
   PubMed Web of Science ®Google Scholar
• Xie Y, Chen X, Li Y, et al. Transforming growth factor-β1 protects against LPC-induced cognitive deficit by attenuating pyroptosis of microglia via NF-κB/ERK1/2 pathways. J Neuroinflammation. 2022;19(1):194. doi:10.1186/s12974-022-02557-0
   PubMed Web of Science ®Google Scholar
• Priyanto B, Islam AA, Hatta M, Bukhari A, Rosyidi RM. Effect of MLC901 on MIR30C-5P expression, TGF-Β expression, VEGF receptor expression, degree of axon demyelination and changes in neuropathic pain behaviour in experimental animals experiencing neuropathic pain with circumferential spinal stenosis method. Ann Med Surg. 2022;81:104489. doi:10.1016/j.amsu.2022.104489
   PubMed Web of Science ®Google Scholar
• Rodríguez-Gómez JA, Kavanagh E, Engskog-Vlachos P, et al. Microglia: agents of the CNS pro-inflammatory response. Cells. 2020;9(7):1717. doi:10.3390/cells9071717
   PubMed Web of Science ®Google Scholar
• Masuda T, Tsuda M, Yoshinaga R, et al. IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype. Cell Rep. 2012;1(4):334–340. doi:10.1016/j.celrep.2012.02.014
   PubMed Web of Science ®Google Scholar
• Matsushita T, Otani K, Oto Y, et al. Sustained microglial activation in the area postrema of collagen-induced arthritis mice. Arthritis Res Ther. 2021;23(1):273. doi:10.1186/s13075-021-02657-x
   PubMed Web of Science ®Google Scholar
• Li HN, Yang QQ, Wang WT, et al. Red nucleus IL-33 facilitates the early development of mononeuropathic pain in male rats by inducing TNF-α through activating ERK, p38 MAPK, and JAK2/STAT3. J Neuroinflammation. 2021;18(1):150. doi:10.1186/s12974-021-02198-9
   PubMed Web of Science ®Google Scholar
• Liu Y, Zhou LJ, Wang J, et al. TNF-α differentially regulates synaptic plasticity in the hippocampus and spinal cord by microglia-dependent mechanisms after peripheral nerve injury. J Neurosci. 2017;37(4):871–881. doi:10.1523/JNEUROSCI.2235-16.2016
   PubMed Web of Science ®Google Scholar
• Miyamoto K, Kume K, Ohsawa M. Role of microglia in mechanical allodynia in the anterior cingulate cortex. J Pharmacol Sci. 2017;134(3):158–165. doi:10.1016/j.jphs.2017.05.010
   PubMed Web of Science ®Google Scholar
• Ni HD, Yao M, Huang B, et al. Glial activation in the periaqueductal gray promotes descending facilitation of neuropathic pain through the p38 MAPK signaling pathway. J Neurosci Res. 2016;94(1):50–61. doi:10.1002/jnr.23672
   PubMed Web of Science ®Google Scholar
• Taylor AM, Mehrabani S, Liu S, et al. Topography of microglial activation in sensory- and affect-related brain regions in chronic pain. J Neurosci Res. 2017;95(6):1330–1335. doi:10.1002/jnr.23883
   PubMed Web of Science ®Google Scholar
• Goins AE, Gomez K, Ran D, et al. Neuronal allodynic mechanisms of Slc7a5 (LAT1) in the spared nerve injury rodent model of neuropathic pain. Pflugers Arch. 2022;474(4):397–403. doi:10.1007/s00424-021-02653-9
   PubMed Web of Science ®Google Scholar
• Tilley DM, Cedeño DL, Vetri F, et al. Differential target multiplexed spinal cord stimulation programming modulates proteins involved in ion regulation in an animal model of neuropathic pain. Mol Pain. 2022;18:17448069211060181. doi:10.1177/17448069211060181
   Web of Science ®Google Scholar
• Zhang J, Rong L, Shao J, et al. Epigenetic restoration of voltage-gated potassium channel Kv1.2 alleviates nerve injury-induced neuropathic pain. J Neurochem. 2021;156(3):367–378. doi:10.1111/jnc.15117
   PubMed Web of Science ®Google Scholar
• Zhang Z, Zheng B, Du S, et al. Eukaryotic initiation factor 4 gamma 2 contributes to neuropathic pain through down-regulation of Kv1.2 and the mu opioid receptor in mouse primary sensory neurones. Br J Anaesth. 2021;126(3):706–719. doi:10.1016/j.bja.2020.10.032
   PubMed Web of Science ®Google Scholar
• Kim SS, Park J, Kim E, Hwang EM, Park JY. β-COP suppresses the surface expression of the TREK2. Cells. 2023;12(11):1500. doi:10.3390/cells12111500
   PubMed Web of Science ®Google Scholar
• Mao Q, Wu S, Gu X, et al. DNMT3a-triggered downregulation of K 2p 1.1 gene in primary sensory neurons contributes to paclitaxel-induced neuropathic pain. Int J Cancer. 2019;145:2122–2134. doi:10.1002/ijc.32155
   PubMed Web of Science ®Google Scholar
• Jia S, Wei G, Bono J, et al. TET1 overexpression attenuates paclitaxel-induced neuropathic pain through rescuing K(2p)1.1 expression in primary sensory neurons of male rats. Life Sci. 2022;297:120486. doi:10.1016/j.lfs.2022.120486
   PubMed Web of Science ®Google Scholar
• Zhang D, Zhao W, Liu J, et al. Sodium leak channel contributes to neuronal sensitization in neuropathic pain. Prog Neurobiol. 2021;202:102041. doi:10.1016/j.pneurobio.2021.102041
   PubMed Web of Science ®Google Scholar
• Bennett DL, Clark AJ, Huang J, et al. The role of voltage-gated sodium channels in pain signaling. Physiol Rev. 2019;99(2):1079–1151. doi:10.1152/physrev.00052.2017
   PubMed Web of Science ®Google Scholar
• Lu W, Cheng X, Chen J, et al. A buthus martensii Karsch scorpion sting targets Nav1.7 in mice and mimics a phenotype of human chronic pain. Pain. 2022;163(2):e202–e214. doi:10.1097/j.pain.0000000000002397
   PubMed Web of Science ®Google Scholar
• Zhang Y, Wang L, Peng D, et al. Engineering of highly potent and selective HNTX-III mutant against hNa(v)1.7 sodium channel for treatment of pain. J Biol Chem. 2021;296:100326. doi:10.1016/j.jbc.2021.100326
   PubMed Web of Science ®Google Scholar
• Zeisel A, Hochgerner H, Lönnerberg P, et al. Molecular architecture of the mouse nervous system. Cell. 2018;174(4):999–1014.e1022. doi:10.1016/j.cell.2018.06.021
   PubMed Web of Science ®Google Scholar
• Hidaka K, Maruta T, Koshida T, et al. Extracellular signal-regulated kinase phosphorylation enhancement and Na(V)1.7 sodium channel upregulation in rat dorsal root ganglia neurons contribute to resiniferatoxin-induced neuropathic pain: the efficacy and mechanism of pulsed radiofrequency therapy. Mol Pain. 2022;18:17448069221089784. doi:10.1177/17448069221089784
   Web of Science ®Google Scholar
• Li J, Stratton HJ, Lorca SA, et al. Small molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in chronic constriction injury (CCI) rats. Channels. 2022;16(1):1–8. doi:10.1080/19336950.2021.2023383
   PubMed Web of Science ®Google Scholar
• Schmidtko A, Lötsch J, Freynhagen R, et al. Ziconotide for treatment of severe chronic pain. Lancet. 2010;375(9725):1569–1577. doi:10.1016/S0140-6736(10)60354-6
   PubMed Web of Science ®Google Scholar
• George DS, Hackelberg S, Jayaraj ND, et al. Mitochondrial calcium uniporter deletion prevents painful diabetic neuropathy by restoring mitochondrial morphology and dynamics. Pain. 2022;163(3):560–578. doi:10.1097/j.pain.0000000000002391
   PubMed Web of Science ®Google Scholar
• Rios L, Pokhrel S, Li SJ, Heo G, Haileselassie B, Mochly-Rosen D. Targeting an allosteric site in dynamin-related protein 1 to inhibit Fis1-mediated mitochondrial dysfunction. Nat Commun. 2023;14(1):4356. doi:10.1038/s41467-023-40043-0
   PubMed Web of Science ®Google Scholar
• Liu X, Rothe K, Yen R, et al. A novel AHI-1-BCR-ABL-DNM2 complex regulates leukemic properties of primitive CML cells through enhanced cellular endocytosis and ROS-mediated autophagy. Leukemia. 2017;31(11):2376–2387. doi:10.1038/leu.2017.108
   PubMed Web of Science ®Google Scholar
• Gu C, Yao J, Sun P. Dynamin 3 suppresses growth and induces apoptosis of hepatocellular carcinoma cells by activating inducible nitric oxide synthase production. Oncol Lett. 2017;13(6):4776–4784. doi:10.3892/ol.2017.6057
   PubMed Web of Science ®Google Scholar
• Cai Z, Quan L, Chang X, et al. High-voltage long-duration pulsed radiofrequency attenuates neuropathic pain in CCI rats by inhibiting Cav2.2 in spinal dorsal horn and dorsal root ganglion. Brain Res. 2022;1785:147892. doi:10.1016/j.brainres.2022.147892
   PubMed Web of Science ®Google Scholar
• Zhang Y, Qian Z, Jiang D, et al. Neuromedin B receptor stimulation of Cav3.2 T-type Ca(2+) channels in primary sensory neurons mediates peripheral pain hypersensitivity. Theranostics. 2021;11(19):9342–9357. doi:10.7150/thno.62255
   PubMed Web of Science ®Google Scholar
• Qi R, Cao J, Sun Y, et al. Histone methylation-mediated microRNA-32-5p down-regulation in sensory neurons regulates pain behaviors via targeting Cav3.2 channels. Proc Natl Acad Sci USA. 2022;119(14):e2117209119. doi:10.1073/pnas.2117209119
   PubMed Web of Science ®Google Scholar
• Wang Y, Hu X, Huang H, et al. Optimization of 4-arylthiophene-3-carboxylic acid derivatives as inhibitors of ANO1: lead optimization studies toward their analgesic efficacy for inflammatory pain. Eur J Med Chem. 2022;237:114413. doi:10.1016/j.ejmech.2022.114413
   PubMed Web of Science ®Google Scholar
• Yao L, Zhang TY, Diao XT, et al. Functional expression of glycine receptors in DRG neurons of mice. Eur J Pharmacol. 2021;899:174034. doi:10.1016/j.ejphar.2021.174034
   PubMed Web of Science ®Google Scholar
• Liao YH, Wang B, Chen MX, et al. LIFU alleviates neuropathic pain by improving the KCC(2) expression and inhibiting the CaMKIV-KCC(2) pathway in the L4-L5 section of the spinal cord. Neural Plast. 2021;2021:6659668. doi:10.1155/2021/6659668
   PubMed Web of Science ®Google Scholar
• Lorenzo LE, Godin AG, Ferrini F, et al. Enhancing neuronal chloride extrusion rescues α2/α3 GABA(A)-mediated analgesia in neuropathic pain. Nat Commun. 2020;11(1):869. doi:10.1038/s41467-019-14154-6
   PubMed Web of Science ®Google Scholar
• Li J, Price TJ, Baccei ML. D1/D5 dopamine receptors and mGluR5 jointly enable non-hebbian long-term potentiation at sensory synapses onto lamina I spinoparabrachial neurons. J Neurosci. 2022;42(3):350–361. doi:10.1523/JNEUROSCI.1793-21.2021
   PubMed Web of Science ®Google Scholar
• Liu Q, Ko CY, Zheng C, et al. Decreased glutamatergic synaptic strength in the periaqueductal gray contributes to maintenance of visceral pain in male rats with experimental pancreatitis. Neuroscience. 2020;428:60–69. doi:10.1016/j.neuroscience.2019.12.004
   PubMed Web of Science ®Google Scholar
• Dong L, Zhang Y, Chen J. 新型镇痛靶点α2δ-1-NMDAR稳定表达细胞株构建及镇痛药物筛选的应用 [A novel cell tool for α2δ-1-NMDAR target-based analgesic drug discovery]. Shengwu Gongcheng Xuebao. 2022;38(3):1149–1158. Chinese. doi:10.13345/j.cjb.210162
   Google Scholar
• Xie RG, Chu WG, Liu DL, et al. Presynaptic NMDARs on spinal nociceptor terminals state-dependently modulate synaptic transmission and pain. Nat Commun. 2022;13(1):728. doi:10.1038/s41467-022-28429-y
   PubMed Web of Science ®Google Scholar
• Wu Q, Yue J, Lin L, et al. Electroacupuncture may alleviate neuropathic pain via suppressing P2X7R expression. Mol Pain. 2021;17:1744806921997654. doi:10.1177/1744806921997654
   Web of Science ®Google Scholar
• Li J, Wu Y, Chen P, et al. CXCL12 promotes spinal nerve regeneration and functional recovery after spinal cord injury. Neuroreport. 2021;32(6):450–457. doi:10.1097/WNR.0000000000001613
   PubMed Web of Science ®Google Scholar
• Luo L, Song S, Ezenwukwa CC, et al. Ion channels and transporters in microglial function in physiology and brain diseases. Neurochem Int. 2021;142:104925. doi:10.1016/j.neuint.2020.104925
   PubMed Web of Science ®Google Scholar
• Sun L, Tong CK, Morgenstern TJ, et al. Targeted ubiquitination of sensory neuron calcium channels reduces the development of neuropathic pain. Proc Natl Acad Sci USA. 2022;119(20):e2118129119. doi:10.1073/pnas.2118129119
   PubMed Web of Science ®Google Scholar
• Boinon L, Yu J, Madura CL, et al. Conditional knockout of CRMP2 in neurons, but not astrocytes, disrupts spinal nociceptive neurotransmission to control the initiation and maintenance of chronic neuropathic pain. Pain. 2022;163(2):e368–e381. doi:10.1097/j.pain.0000000000002344
   PubMed Web of Science ®Google Scholar
• Edwards RR, Dworkin RH, Sullivan MD, et al. The role of psychosocial processes in the development and maintenance of chronic pain. J Pain. 2016;17(9 Suppl):T70–92. doi:10.1016/j.jpain.2016.01.001
   PubMed Web of Science ®Google Scholar
• Ahn H, Weaver M, Lyon D, et al. Depression and pain in asian and white Americans with knee osteoarthritis. J Pain. 2017;18(10):1229–1236. doi:10.1016/j.jpain.2017.05.007
   PubMed Web of Science ®Google Scholar
• Gerrits M, van Oppen P, van Marwijk HWJ, et al. Pain and the onset of depressive and anxiety disorders. Pain. 2014;155(1):53–59. doi:10.1016/j.pain.2013.09.005
   PubMed Web of Science ®Google Scholar
• Becker S, Navratilova E, Nees F, et al. Shared mechanisms of chronic pain and emotional-motivational problems: from basic science to the clinics. Pain Res Manag. 2018;2018:9305026. doi:10.1155/2018/9305026
   PubMed Web of Science ®Google Scholar
• Wu XB, Zhu Q, Gao YJ. CCL2/CCR2 contributes to the altered excitatory-inhibitory synaptic balance in the nucleus accumbens shell following peripheral nerve injury-induced neuropathic pain. Neurosci Bull. 2021;37(7):921–933. doi:10.1007/s12264-021-00697-6
   PubMed Web of Science ®Google Scholar
• Haack M, Simpson N, Sethna N, et al. Sleep deficiency and chronic pain: potential underlying mechanisms and clinical implications. Neuropsychopharmacology. 2020;45(1):205–216. doi:10.1038/s41386-019-0439-z
   PubMed Web of Science ®Google Scholar
• Li MT, Robinson CL, Ruan QZ, et al. The influence of sleep disturbance on chronic pain. Curr Pain Headache Rep. 2022;26(10):795–804. doi:10.1007/s11916-022-01074-2
   PubMed Web of Science ®Google Scholar
• Lory P, Nicole S, Monteil A. Neuronal Cav3 channelopathies: recent progress and perspectives. Pflugers Arch. 2020;472(7):831–844. doi:10.1007/s00424-020-02429-7
   PubMed Web of Science ®Google Scholar
• Blum ID, Keleş MF, Baz ES, et al. Astroglial calcium signaling encodes sleep need in drosophila. Curr Biol. 2021;31(1):150–162.e157. doi:10.1016/j.cub.2020.10.012
   PubMed Web of Science ®Google Scholar
• Brüning F, Noya SB, Bange T, et al. Sleep-wake cycles drive daily dynamics of synaptic phosphorylation. Science. 2019;366(6462). doi:10.1126/science.aav3617
   Web of Science ®Google Scholar
• Huang S, Sigrist SJ. Presynaptic and postsynaptic long-term plasticity in sleep homeostasis. Curr Opin Neurobiol. 2021;69:1–10. doi:10.1016/j.conb.2020.11.010
   PubMed Web of Science ®Google Scholar
• Jin GJ, Peng X, Chen ZG, et al. Celastrol attenuates chronic constrictive injury-induced neuropathic pain and inhibits the TLR4/NF-κB signaling pathway in the spinal cord. J Nat Med. 2022;76(1):268–275. doi:10.1007/s11418-021-01564-4
   PubMed Web of Science ®Google Scholar
• Cheng LZ, Zhou JM, Ma JL, et al. 延胡索乙素通过抑制p38 MAPK信号通路介导的小胶质细胞活化改善糖尿病大鼠神经病理性疼痛[Tetrahydropalmatine alleviated diabetic neuropathic pain by inhibiting activation of microglia via p38 MAPK signaling pathway]. Zhongguo Zhong yao za zhi. 2022;47(9):2533–2540. Chinese. doi:10.19540/j.cnki.cjcmm.20220119.702
   PubMedGoogle Scholar
• Romeo-Guitart D, Casas C. NeuroHeal treatment alleviates neuropathic pain and enhances sensory axon regeneration. Cells. 2020;9(4):808. doi:10.3390/cells9040808
   PubMed Web of Science ®Google Scholar
• Liu Q, Li R, Yang W, et al. Role of neuroglia in neuropathic pain and depression. Pharmacol Res. 2021;174:105957. doi:10.1016/j.phrs.2021.105957
   PubMed Web of Science ®Google Scholar
• Petroianu GA, Aloum L, Adem A. Neuropathic pain: mechanisms and therapeutic strategies. Front Cell Dev Biol. 2023;11:1072629. doi:10.3389/fcell.2023.1072629
   PubMed Web of Science ®Google Scholar