The Role of Caspase-11 and Pyroptosis in the Regulation of Inflammation in Peri-Implantitis

References

• Song X, Li L, Gou H, Xu Y. Impact of implant location on the prevalence of peri-implantitis: a systematic review and meta-analysis. J Dent. 2020;103:103490. doi:10.1016/j.jdent.2020.103490
   PubMed Web of Science ®Google Scholar
• Jamalpoor Z, Asgari A, Lashkari MH, et al. Modulation of macrophage polarization for bone tissue engineering applications. Iran J Allergy Asthma Immunol. 2018;17(5):398–408. doi:10.18502/ijaai.v17i5.298
   PubMed Web of Science ®Google Scholar
• Lafaurie GI, Sabogal MA, Castillo DM, et al. Microbiome and microbial biofilm profiles of peri-implantitis: a systematic review. J Periodontol. 2017;88(10):1066–1089. doi:10.1902/jop.2017.170123
   PubMed Web of Science ®Google Scholar
• Liu LR, Liu JC, Bao JS, et al. Interaction of microglia and astrocytes in the neurovascular unit. Front Immunol. 2020;11:1024. doi:10.3389/fimmu.2020.01024
   PubMed Web of Science ®Google Scholar
• Zhu L, Liu X, Nemeth DP, et al. Interleukin-1 causes CNS inflammatory cytokine expression via endothelia-microglia bi-cellular signaling. Brain Behav Immun. 2019;81:292–304. doi:10.1016/j.bbi.2019.06.026
   PubMed Web of Science ®Google Scholar
• Van Opdenbosch N, Lamkanfi M. Caspases in cell death, inflammation, and disease. Immunity. 2019;50(6):1352–1364. doi:10.1016/j.immuni.2019.05.020
   PubMed Web of Science ®Google Scholar
• Bergsbaken T, Fink SL, Cookson BT. Pyroptosis: host cell death and inflammation. Nat Rev Microbiol. 2009;7(2):99–109. doi:10.1038/nrmicro2070
   PubMed Web of Science ®Google Scholar
• Huang C, Zhang C, Yang P, et al. Eldecalcitol Inhibits LPS-Induced NLRP3 inflammasome-dependent pyroptosis in human gingival fibroblasts by activating the Nrf2/HO-1 signaling pathway. Drug Des Devel Ther. 2020;14:4901–4913. doi:10.2147/DDDT.S269223
   PubMed Web of Science ®Google Scholar
• Anthoney N, Foldi I, Hidalgo A. Toll and Toll-like receptor signalling in development. Development. 2018;145(9):dev156018. doi:10.1242/dev.156018
   PubMed Web of Science ®Google Scholar
• Deng S, Hu Y, Zhou J, et al. TLR4 mediates alveolar bone resorption in experimental peri-implantitis through regulation of CD45(+) cell infiltration, RANKL/OPG ratio, and inflammatory cytokine production. J Periodontol. 2020;91(5):671–682. doi:10.1002/JPER.18-0748
   PubMed Web of Science ®Google Scholar
• AlQranei MS, Senbanjo LT, Aljohani H, et al. Lipopolysaccharide- TLR-4 Axis regulates Osteoclastogenesis independent of RANKL/RANK signaling. BMC Immunol. 2021;22(1):23. doi:10.1186/s12865-021-00409-9
   PubMed Web of Science ®Google Scholar
• Liu Y, Dai Y, Li Q, et al. Beta-amyloid activates NLRP3 inflammasome via TLR4 in mouse microglia. Neurosci Lett. 2020;736:135279. doi:10.1016/j.neulet.2020.135279
   PubMed Web of Science ®Google Scholar
• Li X, Tang L, Ye Myat T, Chen D. Titanium ions play a synergistic role in the activation of NLRP3 inflammasome in Jurkat T cells. Inflammation. 2020;43(4):1269–1278. doi:10.1007/s10753-020-01206-z
   PubMed Web of Science ®Google Scholar
• Chen D, Wu X, Liu Q, et al. Memory B Cell as an indicator of peri-implantitis status: a pilot study. Int J Oral Maxillofac Implants. 2021;36(1):86–93. doi:10.11607/jomi.8641
   PubMed Web of Science ®Google Scholar
• Kayagaki N, Wong MT, Stowe IB, et al. Noncanonical inflammasome activation by intracellular LPS independent of TLR4. Science. 2013;341(6151):1246–1249. doi:10.1126/science.1240248
   PubMed Web of Science ®Google Scholar
• Ye J, Zeng B, Zhong M, et al. Scutellarin inhibits Caspase-11 activation and pyroptosis in macrophages via regulating PKA signaling. Acta Pharm Sin B. 2021;11(1):112–126. doi:10.1016/j.apsb.2020.07.014
   PubMed Web of Science ®Google Scholar
• Hagar JA, Powell DA, Aachoui Y, et al. Cytoplasmic LPS activates Caspase-11: implications in TLR4-independent endotoxic shock. Science. 2013;341(6151):1250–1253. doi:10.1126/science.1240988
   PubMed Web of Science ®Google Scholar
• Rathinam VAK, Zhao Y, Shao F. Innate immunity to intracellular LPS. Nat Immunol. 2019;20(5):527–533. doi:10.1038/s41590-019-0368-3
   PubMed Web of Science ®Google Scholar
• Li W, Deng M, Loughran PA, et al. LPS induces active HMGB1 release from hepatocytes into exosomes through the coordinated activities of TLR4 and Caspase-11/GSDMD Signaling. Front Immunol. 2020;11:229. doi:10.3389/fimmu.2020.00229
   PubMed Web of Science ®Google Scholar
• Zheng Z, Ao X, Xie P, et al. The biological width around implant. J Prosthodont Res. 2021;65(1):11–18. doi:10.2186/jpr.JPOR_2019_356
   PubMed Web of Science ®Google Scholar
• Salvi GE, Cosgarea R, Sculean A. Prevalence and Mechanisms of Peri-implant Diseases. J Dent Res. 2017;96(1):31–37. doi:10.1177/0022034516667484
   PubMed Web of Science ®Google Scholar
• Zhao P, Yue Z, Nie L, et al. Hyperglycaemia-associated macrophage pyroptosis accelerates periodontal inflamm-aging. J Clin Periodontol. 2021;48(10):1379–1392. doi:10.1111/jcpe.13517
   PubMed Web of Science ®Google Scholar
• Yi YS. Caspase-11 non-canonical inflammasome: a critical sensor of intracellular lipopolysaccharide in macrophage-mediated inflammatory responses. Immunology. 2017;152(2):207–217. doi:10.1111/imm.12787
   PubMed Web of Science ®Google Scholar
• Cheng Q, Pan J, Zhou ZL, et al. Caspase-11/4 and gasdermin D-mediated pyroptosis contributes to podocyte injury in mouse diabetic nephropathy. Acta Pharmacol Sin. 2021;42(6):954–963. doi:10.1038/s41401-020-00525-z
   PubMed Web of Science ®Google Scholar
• Romero-Castro NS, Vazquez-Villamar M, Munoz-Valle JF, et al. Relationship between TNF-alpha, MMP-8, and MMP-9 levels in gingival crevicular fluid and the subgingival microbiota in periodontal disease. Odontology. 2020;108(1):25–33. doi:10.1007/s10266-019-00435-5
   PubMed Web of Science ®Google Scholar
• Zu Y, Mu Y, Li Q, et al. Icariin alleviates osteoarthritis by inhibiting NLRP3-mediated pyroptosis. J Orthop Surg Res. 2019;14(1):307. doi. doi:10.1186/s13018-019-1307-6
   PubMed Web of Science ®Google Scholar
• Li Y, Li B, Liu Y, et al. Porphyromonas gingivalis lipopolysaccharide affects oral epithelial connections via pyroptosis. J Dent Sci. 2021;16(4):1255–1263. doi:10.1016/j.jds.2021.01.003
   PubMed Web of Science ®Google Scholar
• Marquez-Flores YK, Villegas I, Cardeno A, et al. Apigenin supplementation protects the development of dextran sulfate sodium-induced murine experimental colitis by inhibiting canonical and non-canonical inflammasome signaling pathways. J Nutr Biochem. 2016;30:143–152. doi:10.1016/j.jnutbio.2015.12.002
   PubMed Web of Science ®Google Scholar
• Oka S, Li X, Sato F, et al. A deficiency of Dec2 triggers periodontal inflammation and pyroptosis. J Periodontal Res. 2021;56(3):492–500. doi:10.1111/jre.12849
   PubMed Web of Science ®Google Scholar
• He D, Li X, Zhang F, et al. Dec2 inhibits macrophage pyroptosis to promote periodontal homeostasis. J Periodontal Implant Sci. 2022;52(1):28–38. doi:10.5051/jpis.2101380069
   PubMed Web of Science ®Google Scholar
• Insua A, Monje A, Wang HL, et al. Basis of bone metabolism around dental implants during osseointegration and peri-implant bone loss. J Biomed Mater Res A. 2017;105(7):2075–2089. doi:10.1002/jbm.a.36060
   PubMed Web of Science ®Google Scholar
• Gruber R. Osteoimmunology: inflammatory osteolysis and regeneration of the alveolar bone. J Clin Periodontol. 2019;46(21):52–69. doi:10.1111/jcpe.13056
   PubMedGoogle Scholar
• Huja SS, Fernandez SA, Hill KJ, Li Y. Remodeling dynamics in the alveolar process in skeletally mature dogs. Anat Rec a Discov Mol Cell Evol Biol. 2006;288(12):1243–1249. doi:10.1002/ar.a.20396
   PubMedGoogle Scholar
• Sallman DA, List A. The central role of inflammatory signaling in the pathogenesis of myelodysplastic syndromes. Blood. 2019;133(10):1039–1048. doi:10.1182/blood-2018-10-844654
   PubMed Web of Science ®Google Scholar
• Zhu X, Zhang K, Lu K, et al. Inhibition of pyroptosis attenuates Staphylococcus aureus-induced bone injury in traumatic osteomyelitis. Ann Transl Med. 2019;7(8):170. doi:10.21037/atm.2019.03.40
   PubMed Web of Science ®Google Scholar
• Rocha FRG, Delitto AE, de Souza JAC, et al. Relevance of caspase-1 and Nlrp3 inflammasome on inflammatory bone resorption in A murine model of periodontitis. Sci Rep. 2020;10(1):7823. doi:10.1038/s41598-020-64685-y
   PubMed Web of Science ®Google Scholar
• Chadha S, Behl T, Bungau S, et al. Mechanistic insights into the role of pyroptosis in rheumatoid arthritis. Curr Res Transl Med. 2020;68(4):151–158. doi:10.1016/j.retram.2020.07.003
   PubMed Web of Science ®Google Scholar
• Zang Y, Song JH, Oh SH, et al. Targeting NLRP3 inflammasome reduces age-related experimental alveolar bone loss. J Dent Res. 2020;99(11):1287–1295. doi:10.1177/0022034520933533
   PubMed Web of Science ®Google Scholar
• Yamaguchi Y, Kurita-Ochiai T, Kobayashi R, et al. Regulation of the NLRP3 inflammasome in Porphyromonas gingivalis-accelerated periodontal disease. Inflamm Res. 2017;66(1):59–65. doi:10.1007/s00011-016-0992-4
   PubMed Web of Science ®Google Scholar
• Skirecki T, Cavaillon JM. Inner sensors of endotoxin - implications for sepsis research and therapy. FEMS Microbiol Rev. 2019;43(3):239–256. doi:10.1093/femsre/fuz004
   PubMed Web of Science ®Google Scholar
• Kaparakis-Liaskos M, Ferrero RL. Immune modulation by bacterial outer membrane vesicles. Nat Rev Immunol. 2015;15(6):375–387. doi:10.1038/nri3837
   PubMed Web of Science ®Google Scholar
• Santos JC, Dick MS, Lagrange B, et al. LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation. EMBO J. 2018;37(6):e98089. doi:10.15252/embj.201798089
   PubMed Web of Science ®Google Scholar
• Giordano NP, Cian MB, Dalebroux ZD. Outer membrane lipid secretion and the innate immune response to gram-negative bacteria. Infect Immun. 2020;88(7):e00920–19. doi:10.1128/IAI.00920-19
   PubMed Web of Science ®Google Scholar
• Vanaja SK, Russo AJ, Behl B, et al. Bacterial outer membrane vesicles mediate cytosolic localization of LPS and caspase-11 activation. Cell. 2016;165(5):1106–1119. doi:10.1016/j.cell.2016.04.015
   PubMed Web of Science ®Google Scholar
• Wang J, Li R, Peng Z, et al. HMGB1 participates in LPS‑induced acute lung injury by activating the AIM2 inflammasome in macrophages and inducing polarization of M1 macrophages via TLR2, TLR4, and RAGE/NF‑kappaB signaling pathways. Int J Mol Med. 2020;45(1):61–80. doi:10.3892/ijmm.2019.4402
   PubMed Web of Science ®Google Scholar
• Deng M, Tang Y, Li W, et al. The endotoxin delivery protein HMGB1 mediates caspase-11-dependent lethality in sepsis. Immunity. 2018;49(4):740–753.e7. doi:10.1016/j.immuni.2018.08.016
   PubMed Web of Science ®Google Scholar
• Takeuchi H, Amano A. Invasion of gingival epithelial cells by porphyromonas gingivalis. Methods Mol Biol. 2021;2210:215–224. doi:10.1007/978-1-0716-0939-2_21
   PubMedGoogle Scholar
• Shi J, Zhao Y, Wang Y, et al. Inflammatory caspases are innate immune receptors for intracellular LPS. Nature. 2014;514(7521):187–192. doi:10.1038/nature13683
   PubMed Web of Science ®Google Scholar
• Ross C, Chan AH, Von Pein J, et al. Dimerization and auto-processing induce Caspase-11 protease activation within the non-canonical inflammasome. Life Sci Alliance. 2018;1(6):e201800237. doi:10.26508/lsa.201800237
   PubMed Web of Science ®Google Scholar
• Wacker MA, Teghanemt A, Weiss JP, et al. High-affinity caspase-4 binding to LPS presented as high molecular mass aggregates or in outer membrane vesicles. Innate Immun. 2017;23(4):336–344. doi:10.1177/1753425917695446
   PubMed Web of Science ®Google Scholar
• Shi J, Gao W, Shao F. Pyroptosis: gasdermin-mediated programmed necrotic cell death. Trends Biochem Sci. 2017;42(4):245–254. doi:10.1016/j.tibs.2016.10.004
   PubMed Web of Science ®Google Scholar
• Downs KP, Nguyen H, Dorfleutner A, Stehlik C. An overview of the non-canonical inflammasome. Mol Aspects Med. 2020;76:100924. doi:10.1016/j.mam.2020.100924
   PubMed Web of Science ®Google Scholar
• Campbell L, Raheem I, Malemud CJ, et al. The relationship between NALP3 and autoinflammatory syndromes. Int J Mol Sci. 2016;17(5):725. doi:10.3390/ijms17050725
   PubMed Web of Science ®Google Scholar
• Magupalli VG, Negro R, Tian Y, et al. HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation. Science. 2020;369(6510):eaas8995. doi:10.1126/science.aas8995
   PubMed Web of Science ®Google Scholar
• Isola G, Polizzi A, Santonocito S, et al. Periodontitis activates the NLRP3 inflammasome in serum and saliva. J Periodontol. 2022;93(1):135–145. doi:10.1002/JPER.21-0049
   PubMed Web of Science ®Google Scholar
• Sakamaki K, Satou Y. Caspases: evolutionary aspects of their functions in vertebrates. J Fish Biol. 2009;74(4):727–753. doi:10.1111/j.1095-8649.2009.02184.x
   PubMed Web of Science ®Google Scholar
• Vigano E, Diamond CE, Spreafico R, et al. Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes. Nat Commun. 2015;6:8761. doi:10.1038/ncomms9761
   PubMed Web of Science ®Google Scholar
• Lagrange B, Benaoudia S, Wallet P, et al. Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine Caspase-11. Nat Commun. 2018;9(1):242. doi:10.1038/s41467-017-02682-y
   PubMed Web of Science ®Google Scholar
• Zhang XH, Chen Y, Yu SX, et al. Inhibition of C3a/C3aR axis in diverse stages of ulcerative colitis affected the prognosis of UC by modulating the pyroptosis and expression of caspase-11. Inflammation. 2020;43(6):2128–2136. doi:10.1007/s10753-020-01280-3
   PubMed Web of Science ®Google Scholar
• Kayagaki N, Stowe IB, Lee BL, et al. Caspase-11 cleaves gasdermin D for non-canonical inflammasomesignalling. Nature. 2015;526(7575):666–671. doi:10.1038/nature15541
   PubMed Web of Science ®Google Scholar
• Li Z, Cai Q, Li B, et al. Caspase-11/4 is involved in bacteria-mediated periodontitis by promoting the release of interleukin-1 β and tumor necrosis factor-α. Arch Oral Biol. 2022;142:105517. doi:10.1016/j.archoralbio.2022.105517
   PubMed Web of Science ®Google Scholar
• Isola G, Tartaglia GM, Santonocito S, Polizzi A, Williams RC, Iorio-Siciliano V. Impact of N-terminal pro-B-type natriuretic peptide and related inflammatory biomarkers on periodontal treatment outcomes in patients with periodontitis: an explorative human randomized-controlled clinical trial. J Periodontol. 2023. doi:10.1002/JPER.23-0063
   PubMed Web of Science ®Google Scholar