Programmed Cell Death in Liver Fibrosis

References

• Tarantino G, Crocetto F, Di Vito C, et al. Association of NAFLD and insulin resistance with non metastatic bladder cancer patients: a cross-sectional retrospective study. J Clin Med. 2021;10(2):346. doi:10.3390/jcm10020346
   PubMed Web of Science ®Google Scholar
• Tarantino G, Balsano C, Santini SJ, et al. It is high time physicians thought of natural products for alleviating NAFLD. Is there sufficient evidence to use them? Int J Mol Sci. 2021;22(24):13424. doi:10.3390/ijms222413424
   PubMed Web of Science ®Google Scholar
• Rauf A, Abu-Izneid T, Khalil AA, et al. Berberine as a potential anticancer agent: a comprehensive review. Molecules. 2021;26(23):7368. doi:10.3390/molecules26237368
   PubMed Web of Science ®Google Scholar
• Pol S. Similar 5-year HCC occurrence in Tenofovir- and Entecavir-treated HBV chronic infection in the French AFEF/ANRS CO22 Hepather cohort. Aliment Pharmacol Ther. 2021;53(5):616–629. doi:10.1111/apt.16197
   PubMed Web of Science ®Google Scholar
• Sanyal AJ, Anstee QM, Trauner M, et al. Cirrhosis regression is associated with improved clinical outcomes in patients with nonalcoholic steatohepatitis. Hepatology. 2022;75(5):1235–1246. doi:10.1002/hep.32204
   PubMed Web of Science ®Google Scholar
• Kisseleva T, Brenner D. Molecular and cellular mechanisms of liver fibrosis and its regression. Nat Rev Gastroenterol Hepatol. 2021;18(3):151–166. doi:10.1038/s41575-020-00372-7
   PubMed Web of Science ®Google Scholar
• Muro M, Moya-Quiles MR, Mrowiec A. Humoral response in liver allograft transplantation: a review of the role of anti-Human Leukocyte Antigen (HLA) antibodies. Curr Protein Pept Sci. 2016;17(8):776–784. doi:10.2174/1389203717666160226145101
   PubMed Web of Science ®Google Scholar
• Gaul S, Leszczynska A, Alegre F, et al. Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis. J Hepatol. 2021;74(1):156–167. doi:10.1016/j.jhep.2020.07.041
   PubMed Web of Science ®Google Scholar
• Guo R, Jia X, Ding Z, et al. Loss of MLKL ameliorates liver fibrosis by inhibiting hepatocyte necroptosis and hepatic stellate cell activation. Theranostics. 2022;12(11):5220–5236. doi:10.7150/thno.71400
   PubMed Web of Science ®Google Scholar
• Wu A, Feng B, Yu J, et al. Fibroblast growth factor 21 attenuates iron overload-induced liver injury and fibrosis by inhibiting ferroptosis. Redox Biol. 2021;46:102131. doi:10.1016/j.redox.2021.102131
   PubMed Web of Science ®Google Scholar
• An P, Wei -L-L, Zhao S, et al. Hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis. Nat Commun. 2020;11(1):2362. doi:10.1038/s41467-020-16092-0
   PubMed Web of Science ®Google Scholar
• Bai L, Kong M, Duan Z, Liu S, Zheng S, Chen Y. M2-like macrophages exert hepatoprotection in acute-on-chronic liver failure through inhibiting necroptosis-S100A9-necroinflammation axis. Cell Death Dis. 2021;12(1):93. doi:10.1038/s41419-020-03378-w
   PubMed Web of Science ®Google Scholar
• Zille M, Karuppagounder SS, Chen Y, et al. Neuronal death after hemorrhagic stroke in vitro and in vivo shares features of ferroptosis and necroptosis. Stroke. 2017;48(4):1033–1043. doi:10.1161/STROKEAHA.116.015609
   PubMed Web of Science ®Google Scholar
• Lin S-Y, Hsieh S-Y, Fan Y-T, et al. Necroptosis promotes autophagy-dependent upregulation of DAMP and results in immunosurveillance. Autophagy. 2018;14(5):778–795. doi:10.1080/15548627.2017.1386359
   PubMed Web of Science ®Google Scholar
• Qian LL, Ji JJ, Jiang Y, et al. Serpina3c deficiency induced necroptosis promotes non-alcoholic fatty liver disease through β-catenin/Foxo1/TLR4 signaling. FASEB J. 2022;36(5):e22316. doi:10.1096/fj.202101345RRR
   PubMed Web of Science ®Google Scholar
• Shi H, Wang X, Li F, et al. CD47-SIRPα axis blockade in NASH promotes necroptotic hepatocyte clearance by liver macrophages and decreases hepatic fibrosis. Sci Transl Med. 2022;14(672):eabp8309. doi:10.1126/scitranslmed.abp8309
   PubMed Web of Science ®Google Scholar
• Chen H, McKeen T, Chao X, et al. The role of MLKL in hepatic ischemia-reperfusion injury of alcoholic steatotic livers. Int J Biol Sci. 2022;18(3):1096–1106. doi:10.7150/ijbs.67533
   PubMed Web of Science ®Google Scholar
• Chen L, Cao Z, Yan L, et al. Circulating receptor-interacting protein kinase 3 are increased in HBV patients with acute-on-chronic liver failure and are associated with clinical outcome. Front Physiol. 2020;11:526. doi:10.3389/fphys.2020.00526
   PubMed Web of Science ®Google Scholar
• Afonso MB, Rodrigues PM, Simão AL, et al. miRNA-21 ablation protects against liver injury and necroptosis in cholestasis. Cell Death Differ. 2018;25(5):857–872. doi:10.1038/s41418-017-0019-x
   PubMed Web of Science ®Google Scholar
• Seehawer M, Heinzmann F, D’Artista L, et al. Necroptosis microenvironment directs lineage commitment in liver cancer. Nature. 2018;562(7725):69–75. doi:10.1038/s41586-018-0519-y
   PubMed Web of Science ®Google Scholar
• Mohammed S, Thadathil N, Selvarani R, et al. Necroptosis contributes to chronic inflammation and fibrosis in aging liver. Aging Cell. 2021;20(12):e13512. doi:10.1111/acel.13512
   PubMed Web of Science ®Google Scholar
• Yan L, Zhang T, Wang K, et al. SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation. Nat Commun. 2022;13(1):7153. doi:10.1038/s41467-022-34993-0
   PubMed Web of Science ®Google Scholar
• Afonso MB, Rodrigues PM, Mateus-Pinheiro M, et al. RIPK3 acts as a lipid metabolism regulator contributing to inflammation and carcinogenesis in non-alcoholic fatty liver disease. Gut. 2021;70(12):2359–2372. doi:10.1136/gutjnl-2020-321767
   PubMed Web of Science ®Google Scholar
• Koschel J, Nishanth G, Just S, et al. OTUB1 prevents lethal hepatocyte necroptosis through stabilization of c-IAP1 during murine liver inflammation. Cell Death Differ. 2021;28(7):2257–2275. doi:10.1038/s41418-021-00752-9
   PubMed Web of Science ®Google Scholar
• Wu R, Zhang Y, Xiang Y, et al. Association between serum S100A9 levels and liver necroinflammation in chronic hepatitis B. J Transl Med. 2018;16(1):83. doi:10.1186/s12967-018-1462-2
   PubMedGoogle Scholar
• Liu Q, Lei X, Cao Z, et al. TRPM8 deficiency attenuates liver fibrosis through S100A9-HNF4α signaling. Cell Biosci. 2022;12(1):58. doi:10.1186/s13578-022-00789-4
   PubMed Web of Science ®Google Scholar
• Jia Y, Wang F, Guo Q, et al. Curcumol induces RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling in hepatic stellate cells. Redox Biol. 2018;19:375–387. doi:10.1016/j.redox.2018.09.007
   PubMed Web of Science ®Google Scholar
• Hu M, Wang Y, Liu Z, et al. Hepatic macrophages act as a central hub for relaxin-mediated alleviation of liver fibrosis. Nat Nanotechnol. 2021;16(4):466–477. doi:10.1038/s41565-020-00836-6
   PubMed Web of Science ®Google Scholar
• Blériot C, Dupuis T, Jouvion G, Eberl G, Disson O, Lecuit M. Liver-resident macrophage necroptosis orchestrates type 1 microbicidal inflammation and type-2-mediated tissue repair during bacterial infection. Immunity. 2015;42(1):145–158. doi:10.1016/j.immuni.2014.12.020
   PubMed Web of Science ®Google Scholar
• Wu X, Fan X, McMullen MR, et al. Macrophage-derived MLKL in alcohol-associated liver disease: regulation of phagocytosis. Hepatology. 2023;77(3):902–919. doi:10.1002/hep.32612
   PubMed Web of Science ®Google Scholar
• Wei S, Zhou H, Wang Q, et al. RIP3 deficiency alleviates liver fibrosis by inhibiting ROCK1-TLR4-NF-κB pathway in macrophages. FASEB J. 2019;33(10):11180–11193. doi:10.1096/fj.201900752R
   PubMed Web of Science ®Google Scholar
• Yuan R, Zhao W, Wang -Q-Q, et al. Cucurbitacin B inhibits non-small cell lung cancer in vivo and in vitro by triggering TLR4/NLRP3/GSDMD-dependent pyroptosis. Pharmacol Res. 2021;170:105748. doi:10.1016/j.phrs.2021.105748
   PubMed Web of Science ®Google Scholar
• Kayagaki N, Kornfeld OS, Lee BL, et al. NINJ1 mediates plasma membrane rupture during lytic cell death. Nature. 2021;591(7848):131–136. doi:10.1038/s41586-021-03218-7
   PubMed Web of Science ®Google Scholar
• Wree A, Eguchi A, McGeough MD, et al. NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice. Hepatology. 2014;59(3):898–910. doi:10.1002/hep.26592
   PubMed Web of Science ®Google Scholar
• Xiao L, Magupalli VG, Wu H. Cryo-EM structures of the active NLRP3 inflammasome disc. Nature. 2023;613(7944):595–600. doi:10.1038/s41586-022-05570-8
   PubMed Web of Science ®Google Scholar
• Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell. 2002;10(2):417–426. doi:10.1016/S1097-2765(02)00599-3
   PubMed Web of Science ®Google Scholar
• Shi J, Zhao Y, Wang K, et al. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature. 2015;526(7575):660–665. doi:10.1038/nature15514
   PubMed Web of Science ®Google Scholar
• von Moltke J, Trinidad NJ, Moayeri M, et al. Rapid induction of inflammatory lipid mediators by the inflammasome in vivo. Nature. 2012;490(7418):107–111. doi:10.1038/nature11351
   PubMed Web of Science ®Google Scholar
• Mridha AR, Wree A, Robertson AAB, et al. NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice. J Hepatol. 2017;66(5):1037–1046. doi:10.1016/j.jhep.2017.01.022
   PubMed Web of Science ®Google Scholar
• Wree A, McGeough MD, Inzaugarat ME, et al. NLRP3 inflammasome driven liver injury and fibrosis: roles of IL-17 and TNF in mice. Hepatology. 2018;67(2):736–749. doi:10.1002/hep.29523
   PubMed Web of Science ®Google Scholar
• Wang Y, Zhang H, Chen Q, et al. TNF-α/HMGB1 inflammation signalling pathway regulates pyroptosis during liver failure and acute kidney injury. Cell Prolif. 2020;53(6):e12829. doi:10.1111/cpr.12829
   PubMed Web of Science ®Google Scholar
• Hernandez C, Huebener P, Pradere J-P, Antoine DJ, Friedman RA, Schwabe RF. HMGB1 links chronic liver injury to progenitor responses and hepatocarcinogenesis. J Clin Invest. 2018;128(6):2436–2451. doi:10.1172/JCI91786
   PubMed Web of Science ®Google Scholar
• Wu J, Zhang M, Xia S, et al. Hepatic HRC induces hepatocyte pyroptosis and HSCs activation via NLRP3/caspase-1 pathway. J Mol Med. 2022;100(12):1787–1799. doi:10.1007/s00109-022-02270-8
   PubMed Web of Science ®Google Scholar
• Zhang Y, Zhangdi H, Nie X, et al. Exosomes derived from BMMSCs mitigate the hepatic fibrosis via anti-pyroptosis pathway in a cirrhosis model. Cells. 2022;11(24):4004. doi:10.3390/cells11244004
   PubMed Web of Science ®Google Scholar
• Chen P, Zhou Y-K, Han C-S, et al. Stem cells from human exfoliated deciduous teeth alleviate liver cirrhosis via inhibition of gasdermin D-executed hepatocyte pyroptosis. Front Immunol. 2022;13:860225. doi:10.3389/fimmu.2022.860225
   PubMed Web of Science ®Google Scholar
• Shu B, Zhou Y-X, Li H, Zhang R-Z, He C, Yang X. The METTL3/MALAT1/PTBP1/USP8/TAK1 axis promotes pyroptosis and M1 polarization of macrophages and contributes to liver fibrosis. Cell Death Discov. 2021;7(1):368. doi:10.1038/s41420-021-00756-x
   PubMed Web of Science ®Google Scholar
• Liu Y, Kong X, You Y, et al. S100A8-mediated NLRP3 inflammasome-dependent pyroptosis in macrophages facilitates liver fibrosis progression. Cells. 2022;11(22):3579. doi:10.3390/cells11223579
   PubMed Web of Science ®Google Scholar
• Wan Y, Zhang W, Huang C, et al. Ursolic acid alleviates Kupffer cells pyroptosis in liver fibrosis by the NOX2/NLRP3 inflammasome signaling pathway. Int Immunopharmacol. 2022;113(Pt A):109321. doi:10.1016/j.intimp.2022.109321
   PubMedGoogle Scholar
• Kong D-L, Kong F-Y, Liu X-Y, et al. Soluble egg antigen of Schistosoma japonicum induces pyroptosis in hepatic stellate cells by modulating ROS production. Parasit Vectors. 2019;12(1):475. doi:10.1186/s13071-019-3729-8
   PubMed Web of Science ®Google Scholar
• Xie Z-Y, Xu Y-X, Yao L. Angiotensin II can trigger HSC-LX2 pyroptosis through both classical and non-classical pathways. Life Sci. 2022;307:120878. doi:10.1016/j.lfs.2022.120878
   PubMed Web of Science ®Google Scholar
• Liu W, Liu J, Wang W, Wang Y, Ouyang X. NLRP6 induces pyroptosis by activation of caspase-1 in gingival fibroblasts. J Dent Res. 2018;97(12):1391–1398. doi:10.1177/0022034518775036
   PubMed Web of Science ®Google Scholar
• Zhu Y, Ni T, Deng W, et al. Effects of NLRP6 on the proliferation and activation of human hepatic stellate cells. Exp Cell Res. 2018;370(2):383–388. doi:10.1016/j.yexcr.2018.06.040
   PubMed Web of Science ®Google Scholar
• Jin Y, Liu Y, Xu L, et al. Novel role for caspase 1 inhibitor VX765 in suppressing NLRP3 inflammasome assembly and atherosclerosis via promoting mitophagy and efferocytosis. Cell Death Dis. 2022;13(5):512. doi:10.1038/s41419-022-04966-8
   PubMed Web of Science ®Google Scholar
• Lan P, Fan Y, Zhao Y, et al. TNF superfamily receptor OX40 triggers invariant NKT cell pyroptosis and liver injury. J Clin Invest. 2017;127(6):2222–2234. doi:10.1172/JCI91075
   PubMed Web of Science ®Google Scholar
• Galluzzi L, Vitale I, Aaronson SA, et al. Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. Cell Death Differ. 2018;25(3):486–541. doi:10.1038/s41418-017-0012-4
   PubMed Web of Science ®Google Scholar
• Ma X, Lu C, Chen Y, et al. CCT2 is an aggrephagy receptor for clearance of solid protein aggregates. Cell. 2022;185(8):1325–1345.e22. doi:10.1016/j.cell.2022.03.005
   PubMed Web of Science ®Google Scholar
• Liu T, Wang L, Liang P, et al. USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy. Cell Mol Immunol. 2021;18(10):2431–2442. doi:10.1038/s41423-020-00567-7
   PubMed Web of Science ®Google Scholar
• Gao J, Wei B, De Assuncao TM, et al. Hepatic stellate cell autophagy inhibits extracellular vesicle release to attenuate liver fibrosis. J Hepatol. 2020;73(5):1144–1154. doi:10.1016/j.jhep.2020.04.044
   PubMed Web of Science ®Google Scholar
• Cao Y, Mai W, Li R, et al. Macrophages evoke autophagy of hepatic stellate cells to promote liver fibrosis in NAFLD mice via the PGE2/EP4 pathway. Cell Mol Life Sci. 2022;79(6):303. doi:10.1007/s00018-022-04319-w
   PubMed Web of Science ®Google Scholar
• Wu H, Chen G, Wang J, Deng M, Yuan F, Gong J. TIM-4 interference in Kupffer cells against CCL4-induced liver fibrosis by mediating Akt1/Mitophagy signalling pathway. Cell Prolif. 2020;53(1):e12731. doi:10.1111/cpr.12731
   PubMed Web of Science ®Google Scholar
• Liu K, Zhao E, Ilyas G, et al. Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization. Autophagy. 2015;11(2):271–284. doi:10.1080/15548627.2015.1009787
   PubMed Web of Science ®Google Scholar
• Lodder J, Denaës T, Chobert M-N, et al. Macrophage autophagy protects against liver fibrosis in mice. Autophagy. 2015;11(8):1280–1292. doi:10.1080/15548627.2015.1058473
   PubMed Web of Science ®Google Scholar
• Hammoutene A, Biquard L, Lasselin J, et al. A defect in endothelial autophagy occurs in patients with non-alcoholic steatohepatitis and promotes inflammation and fibrosis. J Hepatol. 2020;72(3):528–538. doi:10.1016/j.jhep.2019.10.028
   PubMed Web of Science ®Google Scholar
• Gao M, Monian P, Pan Q, Zhang W, Xiang J, Jiang X. Ferroptosis is an autophagic cell death process. Cell Res. 2016;26(9):1021–1032. doi:10.1038/cr.2016.95
   PubMed Web of Science ®Google Scholar
• Park E, Chung SW. ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation. Cell Death Dis. 2019;10(11):822. doi:10.1038/s41419-019-2064-5
   PubMed Web of Science ®Google Scholar
• Chen P, Wu Q, Feng J, et al. Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis. Signal Transduct Target Ther. 2020;5(1):51. doi:10.1038/s41392-020-0149-3
   PubMed Web of Science ®Google Scholar
• Xu Y, Li Y, Li J, Chen W. Ethyl carbamate triggers ferroptosis in liver through inhibiting GSH synthesis and suppressing Nrf2 activation. Redox Biol. 2022;53:102349. doi:10.1016/j.redox.2022.102349
   PubMed Web of Science ®Google Scholar
• Wang L, Liu Y, Du T, et al. ATF3 promotes erastin-induced ferroptosis by suppressing system Xc. Cell Death Differ. 2020;27(2):662–675. doi:10.1038/s41418-019-0380-z
   PubMed Web of Science ®Google Scholar
• Yang WS, SriRamaratnam R, Welsch ME, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014;156(1–2):317–331. doi:10.1016/j.cell.2013.12.010
   PubMed Web of Science ®Google Scholar
• Qin X, Zhang J, Wang B, et al. Ferritinophagy is involved in the zinc oxide nanoparticles-induced ferroptosis of vascular endothelial cells. Autophagy. 2021;17(12):4266–4285. doi:10.1080/15548627.2021.1911016
   PubMed Web of Science ®Google Scholar
• Gao M, Monian P, Quadri N, Ramasamy R, Jiang X. Glutaminolysis and transferrin regulate ferroptosis. Mol Cell. 2015;59(2):298–308. doi:10.1016/j.molcel.2015.06.011
   PubMed Web of Science ®Google Scholar
• Yu Y, Jiang L, Wang H, et al. Hepatic transferrin plays a role in systemic iron homeostasis and liver ferroptosis. Blood. 2020;136(6):726–739. doi:10.1182/blood.2019002907
   PubMed Web of Science ®Google Scholar
• Luo P, Liu D, Zhang Q, et al. Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1. Acta Pharm Sin B. 2022;12(5):2300–2314. doi:10.1016/j.apsb.2021.12.007
   PubMed Web of Science ®Google Scholar
• Li L, Wang K, Jia R, et al. Ferroportin-dependent ferroptosis induced by ellagic acid retards liver fibrosis by impairing the SNARE complexes formation. Redox Biol. 2022;56:102435. doi:10.1016/j.redox.2022.102435
   PubMed Web of Science ®Google Scholar
• Tsurusaki S, Tsuchiya Y, Koumura T, et al. Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis. Cell Death Dis. 2019;10(6):449. doi:10.1038/s41419-019-1678-y
   PubMed Web of Science ®Google Scholar
• Ye F, Chai W, Xie M, et al. HMGB1 regulates erastin-induced ferroptosis via RAS-JNK/p38 signaling in HL-60/NRASQ61L cells. Am J Cancer Res. 2019;9(4):730–739.
   PubMed Web of Science ®Google Scholar
• Bi Y, Liu S, Qin X, et al. FUNDC1 interacts with GPx4 to govern hepatic ferroptosis and fibrotic injury through a mitophagy-dependent manner. J Adv Res. 2023. doi:10.1016/j.jare.2023.02.012
   Web of Science ®Google Scholar
• Wu C, Shen Z, Lu Y, Sun F, Shi H. p53 promotes ferroptosis in macrophages treated with Fe3O4 nanoparticles. ACS Appl Mater Interfaces. 2022;14(38):42791–42803. doi:10.1021/acsami.2c00707
   PubMed Web of Science ®Google Scholar
• Gu Z, Liu T, Liu C, et al. Ferroptosis-strengthened metabolic and inflammatory regulation of tumor-associated macrophages provokes potent tumoricidal activities. Nano Lett. 2021;21(15):6471–6479. doi:10.1021/acs.nanolett.1c01401
   PubMed Web of Science ®Google Scholar
• Batoon L, Koh AJ, Kannan R, McCauley LK, Roca H. Caspase-9 driven murine model of selective cell apoptosis and efferocytosis. Cell Death Dis. 2023;14(1):58. doi:10.1038/s41419-023-05594-6
   PubMed Web of Science ®Google Scholar
• Jiang S, Song MJ, Shin EC, Lee MO, Kim SJ, Park JH. Apoptosis in human hepatoma cell lines by chemotherapeutic drugs via Fas-dependent and Fas-independent pathways. Hepatology. 1999;29(1):101–110. doi:10.1002/hep.510290102
   PubMed Web of Science ®Google Scholar
• Inoue S, Browne G, Melino G, Cohen GM. Ordering of caspases in cells undergoing apoptosis by the intrinsic pathway. Cell Death Differ. 2009;16(7):1053–1061. doi:10.1038/cdd.2009.29
   PubMed Web of Science ®Google Scholar
• Koda Y, Teratani T, Chu P-S, et al. CD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells. Nat Commun. 2021;12(1):4474. doi:10.1038/s41467-021-24734-0
   PubMed Web of Science ®Google Scholar
• Martí-Rodrigo A, Alegre F, Moragrega ÁB, et al. Rilpivirine attenuates liver fibrosis through selective STAT1-mediated apoptosis in hepatic stellate cells. Gut. 2020;69(5):920–932. doi:10.1136/gutjnl-2019-318372
   PubMed Web of Science ®Google Scholar
• Ding K, Li X, Ren X, et al. GBP5 promotes liver injury and inflammation by inducing hepatocyte apoptosis. FASEB J. 2022;36(1):e22119. doi:10.1096/fj.202101448R
   PubMed Web of Science ®Google Scholar
• Mohs A, Otto T, Schneider KM, et al. Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis. J Hepatol. 2021;74(3):638–648. doi:10.1016/j.jhep.2020.09.037
   PubMed Web of Science ®Google Scholar
• Wan J, Benkdane M, Teixeira-Clerc F, et al. M2 Kupffer cells promote M1 Kupffer cell apoptosis: a protective mechanism against alcoholic and nonalcoholic fatty liver disease. Hepatology. 2014;59(1):130–142. doi:10.1002/hep.26607
   PubMed Web of Science ®Google Scholar
• Malhi H, Kropp EM, Clavo VF, et al. C/EBP homologous protein-induced macrophage apoptosis protects mice from steatohepatitis. J Biol Chem. 2013;288(26):18624–18642. doi:10.1074/jbc.M112.442954
   PubMed Web of Science ®Google Scholar
• Zheng C, Sui B, Zhang X, et al. Apoptotic vesicles restore liver macrophage homeostasis to counteract type 2 diabetes. J Extracell Vesicles. 2021;10(7):e12109. doi:10.1002/jev2.12109
   PubMed Web of Science ®Google Scholar
• Li L, Shen S, Shao T, et al. Mesenchymal stem cells attenuate liver fibrosis by targeting Ly6Chi/lo macrophages through activating the cytokine-paracrine and apoptotic pathways. Cell Death Discov. 2021;7(1):239. doi:10.1038/s41420-021-00584-z
   PubMed Web of Science ®Google Scholar
• Ganesan M, Poluektova LY, Enweluzo C, Kharbanda KK, Osna NA. Hepatitis C virus-infected apoptotic hepatocytes program macrophages and hepatic stellate cells for liver inflammation and fibrosis development: role of ethanol as a second hit. Biomolecules. 2018;8(4):113. doi:10.3390/biom8040113
   PubMed Web of Science ®Google Scholar
• Ma P-F, Gao -C-C, Yi J, et al. Cytotherapy with M1-polarized macrophages ameliorates liver fibrosis by modulating immune microenvironment in mice. J Hepatol. 2017;67(4):770–779. doi:10.1016/j.jhep.2017.05.022
   PubMed Web of Science ®Google Scholar
• Radaeva S, Sun R, Jaruga B, Nguyen VT, Tian Z, Gao B. Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners. Gastroenterology. 2006;130(2):435–452. doi:10.1053/j.gastro.2005.10.055
   PubMed Web of Science ®Google Scholar
• Tsuchida T, Friedman SL. Mechanisms of hepatic stellate cell activation. Nat Rev Gastroenterol Hepatol. 2017;14(7):397–411. doi:10.1038/nrgastro.2017.38
   PubMed Web of Science ®Google Scholar
• Inaba Y, Hashiuchi E, Watanabe H, et al. The transcription factor ATF3 switches cell death from apoptosis to necroptosis in hepatic steatosis in male mice. Nat Commun. 2023;14(1):167. doi:10.1038/s41467-023-35804-w
   PubMed Web of Science ®Google Scholar
• Lu K, Shen S-Y, Luo O-Y, et al. Manipulating PP2Acα-ASK-JNK signaling to favor apoptotic over necroptotic hepatocyte fate reduces the extent of necrosis and fibrosis upon acute liver injury. Cell Death Dis. 2022;13(11):985. doi:10.1038/s41419-022-05353-z
   PubMed Web of Science ®Google Scholar
• Dillon CP, Weinlich R, Rodriguez DA, et al. RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3. Cell. 2014;157(5):1189–1202. doi:10.1016/j.cell.2014.04.018
   PubMed Web of Science ®Google Scholar
• Newton K, Wickliffe KE, Dugger DL, et al. Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis. Nature. 2019;574(7778):428–431. doi:10.1038/s41586-019-1548-x
   PubMed Web of Science ®Google Scholar
• Chen X, He W-T, Hu L, et al. Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis. Cell Res. 2016;26(9):1007–1020. doi:10.1038/cr.2016.100
   PubMed Web of Science ®Google Scholar
• Cho M, Dho SH, Shin S, et al. Caspase-10 affects the pathogenesis of primary biliary cholangitis by regulating inflammatory cell death. J Autoimmun. 2022;133:102940. doi:10.1016/j.jaut.2022.102940
   PubMed Web of Science ®Google Scholar
• Conos SA, Chen KW, De Nardo D, et al. Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner. Proc Natl Acad Sci USA. 2017;114(6):E961–E969. doi:10.1073/pnas.1613305114
   PubMed Web of Science ®Google Scholar
• Wu Q, He X, L-M W, et al. MLKL aggravates Ox-LDL-induced cell pyroptosis via activation of NLRP3 inflammasome in human umbilical vein endothelial cells. Inflammation. 2020;43(6):2222–2231. doi:10.1007/s10753-020-01289-8
   PubMed Web of Science ®Google Scholar
• Zheng M, Karki R, Vogel P, Kanneganti T-D. Caspase-6 is a key regulator of innate immunity, inflammasome activation, and host defense. Cell. 2020;181(3):674–687.e13. doi:10.1016/j.cell.2020.03.040
   PubMed Web of Science ®Google Scholar
• Zheng M, Williams EP, Malireddi RKS, et al. Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection. J Biol Chem. 2020;295(41):14040–14052. doi:10.1074/jbc.RA120.015036
   PubMed Web of Science ®Google Scholar
• Tao L, Yi Y, Chen Y, et al. RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages. Cell Death Differ. 2021;28(4):1418–1433. doi:10.1038/s41418-020-00668-w
   PubMed Web of Science ®Google Scholar
• Tong J, Lan X-T, Zhang Z, et al. Ferroptosis inhibitor liproxstatin-1 alleviates metabolic dysfunction-associated fatty liver disease in mice: potential involvement of PANoptosis. Acta Pharmacol Sin. 2023;44(5):1014–1028. doi:10.1038/s41401-022-01010-5
   PubMed Web of Science ®Google Scholar
• Liu H, Lai W, Liu X, et al. Exposure to copper oxide nanoparticles triggers oxidative stress and endoplasmic reticulum (ER)-stress induced toxicology and apoptosis in male rat liver and BRL-3A cell. J Hazard Mater. 2021;401:123349. doi:10.1016/j.jhazmat.2020.123349
   PubMed Web of Science ®Google Scholar
• Weindel CG, Martinez EL, Zhao X, et al. Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis. Cell. 2022;185(17):3214–3231.e23. doi:10.1016/j.cell.2022.06.038
   PubMed Web of Science ®Google Scholar
• Evavold CL, Hafner-Bratkovič I, Devant P, et al. Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway. Cell. 2021;184(17):4495–4511.e19. doi:10.1016/j.cell.2021.06.028
   PubMed Web of Science ®Google Scholar
• Ding Y, Chen X, Liu C, et al. Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells. J Hematol Oncol. 2021;14(1):19. doi:10.1186/s13045-020-01016-8
   PubMed Web of Science ®Google Scholar
• Zhao W, Lei M, Li J, et al. Yes-associated protein inhibition ameliorates liver fibrosis and acute and chronic liver failure by decreasing ferroptosis and necroptosis. Heliyon. 2023;9(4):e15075. doi:10.1016/j.heliyon.2023.e15075
   PubMed Web of Science ®Google Scholar
• Tan Y, Huang Y, Mei R, et al. HucMSC-derived exosomes delivered BECN1 induces ferroptosis of hepatic stellate cells via regulating the xCT/GPX4 axis. Cell Death Dis. 2022;13(4):319. doi:10.1038/s41419-022-04764-2
   PubMed Web of Science ®Google Scholar
• Tan S, Liu X, Chen L, et al. Fas/FasL mediates NF-κBp65/PUMA-modulated hepatocytes apoptosis via autophagy to drive liver fibrosis. Cell Death Dis. 2021;12(5):474. doi:10.1038/s41419-021-03749-x
   PubMed Web of Science ®Google Scholar
• Ding Q, Xie X-L, Wang -M-M, et al. The role of the apoptosis-related protein BCL-B in the regulation of mitophagy in hepatic stellate cells during the regression of liver fibrosis. Exp Mol Med. 2019;51(1):1–13. doi:10.1038/s12276-018-0199-6
   Google Scholar
• Meng D, Li Z, Wang G, Ling L, Wu Y, Zhang C. Carvedilol attenuates liver fibrosis by suppressing autophagy and promoting apoptosis in hepatic stellate cells. Biomed Pharmacother. 2018;108:1617–1627. doi:10.1016/j.biopha.2018.10.005
   PubMed Web of Science ®Google Scholar
• Sun S, Li Z, Huan S, et al. Modification of lysine deacetylation regulates curcumol-induced necroptosis through autophagy in hepatic stellate cells. Phytother Res. 2022;36(6):2660–2676. doi:10.1002/ptr.7483
   PubMed Web of Science ®Google Scholar
• Qiu T, Pei P, Yao X, et al. Taurine attenuates arsenic-induced pyroptosis and nonalcoholic steatohepatitis by inhibiting the autophagic-inflammasomal pathway. Cell Death Dis. 2018;9(10):946. doi:10.1038/s41419-018-1004-0
   PubMedGoogle Scholar
• Gao X, Ruan Y, Zhu X, et al. Deoxycholic acid promotes pyroptosis in free fatty acid-induced steatotic hepatocytes by inhibiting PINK1-mediated mitophagy. Inflammation. 2022;45(2):639–650. doi:10.1007/s10753-021-01573-1
   PubMed Web of Science ®Google Scholar