Xijiao Dihuang Decoction Protects Against Murine Sepsis-Induced Cardiac Inflammation and Apoptosis via Suppressing TLR4/NF-κB and Activating PI3K/AKT Pathway

References

• Wen R, Liu YP, Tong XX, et al. Molecular mechanisms and functions of pyroptosis in sepsis and sepsis-associated organ dysfunction. Front Cell Infect Microbiol. 2022;12:962139. doi:10.3389/fcimb.2022.962139
   PubMed Web of Science ®Google Scholar
• Zhang N, Liu YJ, Yang C, et al. Review of research progress on the role of the effective components of traditional Chinese medicine in sepsis with multiple organ dysfunction. Heliyon. 2023;9(11):e21713. doi:10.1016/j.heliyon.2023.e21713
   PubMed Web of Science ®Google Scholar
• Skei NV, Nilsen TIL, Mohus RM, et al. Trends in mortality after a sepsis hospitalization: a nationwide prospective registry study from 2008 to 2021. Infection. 2023;51(6):1773–1786. doi:10.1007/s15010-023-02082-z
   PubMedGoogle Scholar
• Sun M, Zhao H, Jin Z, et al. Silibinin protects against sepsis and septic myocardial injury in an NR1H3-dependent pathway. Free Radic Biol Med. 2022;187:141–157. doi:10.1016/j.freeradbiomed.2022.05.018
   PubMed Web of Science ®Google Scholar
• Merx MW, Weber C. Sepsis and the heart. Circulation. 2007;116(7):793–802. doi:10.1161/CIRCULATIONAHA.106.678359
   PubMed Web of Science ®Google Scholar
• Jeong HS, Lee TH, Bang CH, et al. Risk factors and outcomes of sepsis-induced myocardial dysfunction and stress-induced cardiomyopathy in sepsis or septic shock: a comparative retrospective study. Medicine. 2018;97(13):e0263. doi:10.1097/MD.0000000000010263
   PubMed Web of Science ®Google Scholar
• Xiong X, Lu L, Wang Z, et al. Irisin attenuates sepsis-induced cardiac dysfunction by attenuating inflammation-induced pyroptosis through a mitochondrial ubiquitin ligase-dependent mechanism. Biomed Pharmacother. 2022;152:113199. doi:10.1016/j.biopha.2022.113199
   PubMed Web of Science ®Google Scholar
• Wei A, Liu J, Li D, et al. Syringaresinol attenuates sepsis-induced cardiac dysfunction by inhibiting inflammation and pyroptosis in mice. Eur J Pharmacol. 2021;913:174644. doi:10.1016/j.ejphar.2021.174644
   PubMed Web of Science ®Google Scholar
• Zhao X, Zhang S, Shao H. Dexpanthenol attenuates inflammatory damage and apoptosis in kidney and liver tissues of septic mice. Bioengineere. 2022;13(5):11625–11635. doi:10.1080/21655979.2022.2070585
   PubMed Web of Science ®Google Scholar
• Zhao L, Jin L, Luo Y, et al. Shenfu injection attenuates cardiac dysfunction and inhibits apoptosis in septic mice. Ann Transl Med. 2022;10(10):597. doi:10.21037/atm-22-836
   PubMed Web of Science ®Google Scholar
• Chen XS, Wang SH, Liu CY, et al. Losartan attenuates sepsis-induced cardiomyopathy by regulating macrophage polarization via TLR4-mediated NF-κB and MAPK signaling. Pharmacol Res. 2022;185:106473. doi:10.1016/j.phrs.2022.106473
   PubMed Web of Science ®Google Scholar
• Wu M, Huang Z, Huang W, et al. microRNA-124-3p attenuates myocardial injury in sepsis via modulating SP1/HDAC4/HIF-1α axis. Cell Death Discov. 2022;8(1):40. doi:10.1038/s41420-021-00763-y
   PubMed Web of Science ®Google Scholar
• Jiang T, Peng D, Shi W, et al. IL-6/STAT3 Signaling Promotes Cardiac Dysfunction by Upregulating FUNDC1-Dependent Mitochondria-Associated Endoplasmic Reticulum Membranes Formation in Sepsis Mice. Front Cardiovasc Med. 2022;8:790612. doi:10.3389/fcvm.2021.790612
   PubMed Web of Science ®Google Scholar
• Qi Z, Wang R, Liao R, et al. Corrigendum: neferine Ameliorates Sepsis-Induced Myocardial Dysfunction Through Anti-Apoptotic and Antioxidative Effects by Regulating the PI3K/AKT/mTOR Signaling Pathway. Front Pharmacol. 2022;13:913778. doi:10.3389/fphar.2022.913778
   PubMed Web of Science ®Google Scholar
• Liu L, Yan M, Yang R, et al. Adiponectin Attenuates Lipopolysaccharide-induced Apoptosis by Regulating the Cx43/PI3K/AKT Pathway. Front Pharmacol. 2021;12:644225. doi:10.3389/fphar.2021.644225
   PubMed Web of Science ®Google Scholar
• Qi Z, Wang R, Liao R, et al. Neferine Ameliorates Sepsis-Induced Myocardial Dysfunction Through Anti-Apoptotic and Antioxidative Effects by Regulating the PI3K/AKT/mTOR Signaling Pathway. Front Pharmacol. 2021;12:706251. doi:10.3389/fphar.2021.706251
   PubMed Web of Science ®Google Scholar
• Lu J, Zhang L, Cheng L, et al. Xijiao Dihuang decoction improves prognosis of sepsis via inhibition of aerobic glycolysis. Biomed Pharmacother. 2020;129:110501. doi:10.1016/j.biopha.2020.110501
   PubMed Web of Science ®Google Scholar
• Lu J, Yan J, Yan J, et al. Network pharmacology based research into the effect and mechanism of Xijiao Dihuang decoction against sepsis. Biomed Pharmacother. 2020;122:109777. doi:10.1016/j.biopha.2019.109777
   PubMed Web of Science ®Google Scholar
• Xu Q, Xiong H, Zhu W, et al. Small molecule inhibition of cyclic GMP-AMP synthase ameliorates sepsis-induced cardiac dysfunction in mice. Life Sci. 2020;260:118315. doi:10.1016/j.lfs.2020.118315
   PubMed Web of Science ®Google Scholar
• Wang Y, Jasper H, Toan S, et al. Mitophagy coordinates the mitochondrial unfolded protein response to attenuate inflammation-mediated myocardial injury. Redox Biol. 2021;45:102049. doi:10.1016/j.redox.2021.102049
   PubMed Web of Science ®Google Scholar
• Yang H, Zhang Z. Sepsis-induced myocardial dysfunction: the role of mitochondrial dysfunction. Inflamm Res. 2021;70(4):379–387. doi:10.1007/s00011-021-01447-0
   PubMed Web of Science ®Google Scholar
• Chauin A. The Main Causes and Mechanisms of Increase in Cardiac Troponin Concentrations Other Than Acute Myocardial Infarction (Part 1): physical Exertion, Inflammatory Heart Disease, Pulmonary Embolism, Renal Failure, Sepsis. Vasc Health Risk Manag. 2021;17:601–617. doi:10.2147/VHRM.S327661
   PubMed Web of Science ®Google Scholar
• Zeng N, Jian Z, Zhu W, et al. KLF13 overexpression protects sepsis-induced myocardial injury and LPS-induced inflammation and apoptosis. Int J Exp Pathol. 2023;104(1):23–32. doi:10.1111/iep.12459
   PubMed Web of Science ®Google Scholar
• Antonucci E, Fiaccadori E, Donadello K, et al. Myocardial depression in sepsis: from pathogenesis to clinical manifestations and treatment. J Crit Care. 2014;29(4):500–511. doi:10.1016/j.jcrc.2014.03.028
   PubMed Web of Science ®Google Scholar
• Cuello F, Shankar-Hari M, Mayr U, et al. Redox state of pentraxin 3 as a novel biomarker for resolution of inflammation and survival in sepsis. Mol Cell Proteomics. 2014;13(10):2545–2557. doi:10.1074/mcp.M114.039446
   PubMed Web of Science ®Google Scholar
• Honda T, He Q, Wang F, et al. Acute and chronic remote ischemic conditioning attenuate septic cardiomyopathy, improve cardiac output, protect systemic organs, and improve mortality in a lipopolysaccharide-induced sepsis model. Basic Res Cardiol. 2019;114(3):15. doi:10.1007/s00395-019-0724-3
   PubMed Web of Science ®Google Scholar
• de Pádua Lúcio K, Rabelo ACS, Araújo CM, et al. Morus nigraAnti-Inflammatory and Antioxidant Properties of Black Mulberry (Morus nigra L.) in a Model of LPS-Induced Sepsis. Oxid Med Cell Longev. 2018;2018:5048031. doi:10.1155/2018/5048031
   PubMed Web of Science ®Google Scholar
• Kawaguchi S, Okada M, Ijiri E, et al. β3-Adrenergic receptor blockade reduces mortality in endotoxin-induced heart failure by suppressing induced nitric oxide synthase and saving cardiac metabolism. Am J Physiol Heart Circ Physiol. 2020;318(2):H283–H294. doi:10.1152/ajpheart.00108.2019
   PubMed Web of Science ®Google Scholar
• Kumari A, Dash D, Singh R. Curcumin inhibits lipopolysaccharide (LPS)-induced endotoxemia and airway inflammation through modulation of sequential release of inflammatory mediators (TNF-α and TGF-β1) in murine model. Inflammopharmacology. 2017;25(3):329–341. doi:10.1007/s10787-017-0334-3
   PubMed Web of Science ®Google Scholar
• Wu B, Ni H, Li J, et al. The Impact of Circulating Mitochondrial DNA on Cardiomyocyte Apoptosis and Myocardial Injury After TLR4 Activation in Experimental Autoimmune Myocarditis. Cell Physiol Biochem. 2017;42(2):713–728. doi:10.1159/000477889
   PubMedGoogle Scholar
• Xu J, Lin C, Wang T, et al. Ergosterol Attenuates LPS-Induced Myocardial Injury by Modulating Oxidative Stress and Apoptosis in Rats. Cell Physiol Biochem. 2018;48(2):583–592. doi:10.1159/000491887
   PubMedGoogle Scholar
• Zhang T, Liu CF, Zhang TN, et al. Overexpression of Peroxisome Proliferator-Activated Receptor γ Coactivator 1-α Protects Cardiomyocytes from Lipopolysaccharide-Induced Mitochondrial Damage and Apoptosis. Inflammation. 2020;43(5):1806–1820. doi:10.1007/s10753-020-01255-4
   PubMed Web of Science ®Google Scholar
• Liu R, Wang M, Duan JA. Antipyretic and antioxidant activities of the aqueous extract of Cornu bubali (water Buffalo horn). Am J Chin Med. 2010;38(2):293–306. doi:10.1142/S0192415X10007853
   PubMed Web of Science ®Google Scholar
• Liu J, Pei T, Mu J, et al. Systems Pharmacology Uncovers the Multiple Mechanisms of Xijiao Dihuang Decoction for the Treatment of Viral Hemorrhagic Fever. Evid Based Complement Alternat Med. 2016;2016:9025036. doi:10.1155/2016/9025036
   PubMed Web of Science ®Google Scholar
• Hu N, Wang C, Dai X, et al. Phillygenin inhibits LPS-induced activation and inflammation of LX2 cells by TLR4/MyD88/NF-κB signaling pathway. J Ethnopharmacol. 2020;248:112361. doi:10.1016/j.jep.2019.112361
   PubMed Web of Science ®Google Scholar
• Siti HN, Kamisah Y, Kamsiah J. The role of oxidative stress, antioxidants and vascular inflammation in cardiovascular disease (a review). Vascul Pharmacol. 2015;71:40–56. doi:10.1016/j.vph.2015.03.005
   PubMed Web of Science ®Google Scholar
• Romero-Bermejo FJ, Ruiz-Bailen M, Gil-Cebrian J, et al. Sepsis-induced cardiomyopathy. Curr Cardiol Rev. 2011;7(3):163–183. doi:10.2174/157340311798220494
   PubMedGoogle Scholar
• Jude B, Vetel S, Giroux-Metges MA, et al. Rapid negative inotropic effect induced by TNF-α in rat heart perfused related to PKC activation. Cytokine. 2018;107:65–69. doi:10.1016/j.cyto.2017.11.015
   PubMed Web of Science ®Google Scholar
• Zhang H, Wang HY, Bassel-Duby R, et al. Role of interleukin-6 in cardiac inflammation and dysfunction after burn complicated by sepsis. Am J Physiol Heart Circ Physiol. 2007;292(5):H2408–16. doi:10.1152/ajpheart.01150.2006
   PubMed Web of Science ®Google Scholar
• Vanhaesebroeck B, Stephens L, Hawkins P. PI3K signalling: the path to discovery and understanding. Nat Rev Mol Cell Biol. 2012;13(3):195–203. doi:10.1038/nrm3290
   PubMed Web of Science ®Google Scholar
• Chen L, Liu P, Feng X, et al. Salidroside suppressing LPS-induced myocardial injury by inhibiting ROS-mediated PI3K/Akt/mTOR pathway in vitro and in vivo. J Cell Mol Med. 2017;21(12):3178–3189. doi:10.1111/jcmm.12871
   PubMed Web of Science ®Google Scholar
• Shang X, Lin K, Yu R, et al. Resveratrol Protects the Myocardium in Sepsis by Activating the Phosphatidylinositol 3-Kinases (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Pathway and Inhibiting the Nuclear Factor-κB (NF-κB) Signaling Pathway. Med Sci Monit. 2019;25:9290–9298. doi:10.12659/MSM.918369
   PubMed Web of Science ®Google Scholar
• Liao W, Rao Z, Wu L, et al. Cariporide Attenuates Doxorubicin-Induced Cardiotoxicity in Rats by Inhibiting Oxidative Stress, Inflammation and Apoptosis Partly Through Regulation of Akt/GSK-3βand Sirt1 Signaling Pathway. Front Pharmacol. 2022;13:850053. doi:10.3389/fphar.2022.850053
   PubMed Web of Science ®Google Scholar
• Yi C, Song M, Sun L, et al. Asiatic Acid Alleviates Myocardial Ischemia-Reperfusion Injury by Inhibiting the ROS-Mediated Mitochondria-Dependent Apoptosis Pathway. Oxid Med Cell Longev. 2022;2022:3267450. doi:10.1155/2022/3267450
   PubMed Web of Science ®Google Scholar
• Chen S, Peng J, Sherchan P, et al. TREM2 activation attenuates neuroinflammation and neuronal apoptosis via PI3K/Akt pathway after intracerebral hemorrhage in mice. J Neuroinflammation. 2020;17(1):168. doi:10.1186/s12974-020-01853-x
   PubMed Web of Science ®Google Scholar