Extracellular Vesicle Content Changes Induced by Melatonin Promote Functional Recovery of Pancreatic Beta Cells in Acute Pancreatitis

References

• Norberg KJ, Nania S, Li X, et al.. RCAN1 is a marker of oxidative stress, induced in acute pancreatitis. Pancreatology. 2018;18(7):734–741. doi:10.1016/j.pan.2018.08.005
   PubMed Web of Science ®Google Scholar
• Pendharkar SA, Mathew J, Petrov MS. Age- and sex-specific prevalence of diabetes associated with diseases of the exocrine pancreas: a population-based study. Dig Liver Dis. 2017;49(5):540–544. doi:10.1016/j.dld.2016.12.010
   PubMedGoogle Scholar
• Tu J, Zhang J, Ke L, et al.. Endocrine and exocrine pancreatic insufficiency after acute pancreatitis: long-term follow-up study. BMC Gastroenterol. 2017;17(1):114. doi:10.1186/s12876-017-0663-0
   PubMedGoogle Scholar
• Wu J, Zhang L, Shi J, et al.. Macrophage phenotypic switch orchestrates the inflammation and repair/regeneration following acute pancreatitis injury. EBioMedicine. 2020;58:102920. doi:10.1016/j.ebiom.2020.102920
   PubMed Web of Science ®Google Scholar
• Van Gassen N, Staels W, Van Overmeire E, et al.. Concise Review: macrophages: versatile Gatekeepers During Pancreatic beta-Cell Development, Injury, and Regeneration. Stem Cells Transl Med. 2015;4(6):555–563. doi:10.5966/sctm.2014-0272
   PubMed Web of Science ®Google Scholar
• Guay C, Kruit JK, Rome S, et al.. Lymphocyte-Derived Exosomal MicroRNAs Promote Pancreatic beta Cell Death and May Contribute to Type 1 Diabetes Development. Cell Metab. 2019;29(2):348–61 e6. doi:10.1016/j.cmet.2018.09.011
   PubMed Web of Science ®Google Scholar
• Bai C, Li X, Gao Y, et al.. Melatonin improves reprogramming efficiency and proliferation of bovine-induced pluripotent stem cells. J Pineal Res. 2016;61(2):154–167. doi:10.1111/jpi.12334
   PubMed Web of Science ®Google Scholar
• Cordeiro Caillot AR, de Lacerda Bezerra I, Palhares L, Santana-Filho AP, Chavante SF, Sassaki GL. Structural characterization of blackberry wine polysaccharides and immunomodulatory effects on LPS-activated RAW 264.7 macrophages. Food Chem. 2018;257:143–149. doi:10.1016/j.foodchem.2018.02.122
   PubMed Web of Science ®Google Scholar
• Gao Y, Chen X, Fang L, et al.. Rhein exerts pro- and anti-inflammatory actions by targeting IKKbeta inhibition in LPS-activated macrophages. Free Radic Biol Med. 2014;72:104–112. doi:10.1016/j.freeradbiomed.2014.04.001
   PubMed Web of Science ®Google Scholar
• Ding S, Lin N, Sheng X, et al.. Melatonin stabilizes rupture-prone vulnerable plaques via regulating macrophage polarization in a nuclear circadian receptor RORalpha-dependent manner. J Pineal Res. 2019;67(2):e12581. doi:10.1111/jpi.12581
   PubMed Web of Science ®Google Scholar
• Sakaguchi Y, Inaba M, Kusafuka K, Okazaki K, Ikehara S. Establishment of animal models for three types of pancreatitis and analyses of regeneration mechanisms. Pancreas. 2006;33(4):371–381. doi:10.1097/01.mpa.0000236734.39241.99
   PubMed Web of Science ®Google Scholar
• Alonso-Herranz L, Porcuna J, Ricote M. Isolation and Purification of Tissue Resident Macrophages for the Analysis of Nuclear Receptor Activity. Methods Mol Biol. 2019;1951:59–73. doi:10.1007/978-1-4939-9130-3_5
   PubMedGoogle Scholar
• Pagliuca FW, Millman JR, Gurtler M, et al. Generation of functional human pancreatic beta cells in vitro. Cell. 2014;159(2):428–439. doi:10.1016/j.cell.2014.09.040
   PubMed Web of Science ®Google Scholar
• Crescitelli R, Lasser C, Lotvall J. Isolation and characterization of extracellular vesicle subpopulations from tissues. Nat Protoc. 2021;16(3):1548–1580. doi:10.1038/s41596-020-00466-1
   PubMed Web of Science ®Google Scholar
• Li J, Liu K, Liu Y, et al. Exosomes mediate the cell-to-cell transmission of IFN-alpha-induced antiviral activity. Nat Immunol. 2013;14(8):793–803. doi:10.1038/ni.2647
   PubMed Web of Science ®Google Scholar
• Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA. 2001;98(9):5116–5121. doi:10.1073/pnas.091062498
   PubMed Web of Science ®Google Scholar
• Varghese F, Bukhari AB, Malhotra R, De A. IHC Profiler: an open source plugin for the quantitative evaluation and automated scoring of immunohistochemistry images of human tissue samples. PloS one. 2014;9(5):e96801. doi:10.1371/journal.pone.0096801
   PubMed Web of Science ®Google Scholar
• Li ZL, Hu J, Li YL, et al. The effect of hyperoside on the functional recovery of the ischemic/reperfused isolated rat heart: potential involvement of the extracellular signal-regulated kinase 1/2 signaling pathway. Free Radic Biol Med. 2013;57:132–140. doi:10.1016/j.freeradbiomed.2012.12.023
   PubMed Web of Science ®Google Scholar
• Kluiver J, Slezak-Prochazka I, Smigielska-Czepiel K, Halsema N, Kroesen BJ, van den Berg A. Generation of miRNA sponge constructs. Methods. 2012;58(2):113–117. doi:10.1016/j.ymeth.2012.07.019
   PubMed Web of Science ®Google Scholar
• Taganov KD, Boldin MP, Chang KJ, Baltimore D. NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci USA. 2006;103(33):12481–12486. doi:10.1073/pnas.0605298103
   PubMed Web of Science ®Google Scholar
• Manna I, Iaccino E, Dattilo V, et al. Exosome-associated miRNA profile as a prognostic tool for therapy response monitoring in multiple sclerosis patients. FASEB J. 2018;32(8):4241–4246. doi:10.1096/fj.201701533R
   PubMed Web of Science ®Google Scholar
• Sun Z, Shi K, Yang S, et al. Effect of exosomal miRNA on cancer biology and clinical applications. Mol Cancer. 2018;17(1):147. doi:10.1186/s12943-018-0897-7
   PubMed Web of Science ®Google Scholar
• Roggli E, Britan A, Gattesco S, et al. Involvement of microRNAs in the cytotoxic effects exerted by proinflammatory cytokines on pancreatic beta-cells. Diabetes. 2010;59(4):978–986. doi:10.2337/db09-0881
   PubMed Web of Science ®Google Scholar
• Roggli E, Gattesco S, Caille D, et al. Changes in microRNA expression contribute to pancreatic beta-cell dysfunction in prediabetic NOD mice. Diabetes. 2012;61(7):1742–1751. doi:10.2337/db11-1086
   PubMed Web of Science ®Google Scholar
• Bravo-Egana V, Rosero S, Klein D, et al. Inflammation-Mediated Regulation of MicroRNA Expression in Transplanted Pancreatic Islets. J Transplant. 2012;2012:723614. doi:10.1155/2012/723614
   PubMedGoogle Scholar
• Samandari N, Mirza AH, Nielsen LB, et al. Circulating microRNA levels predict residual beta cell function and glycaemic control in children with type 1 diabetes mellitus. Diabetologia. 2017;60(2):354–363. doi:10.1007/s00125-016-4156-4
   PubMed Web of Science ®Google Scholar
• Melkman-Zehavi T, Oren R, Kredo-Russo S, et al. miRNAs control insulin content in pancreatic beta-cells via downregulation of transcriptional repressors. EMBO J. 2011;30(5):835–845. doi:10.1038/emboj.2010.361
   PubMed Web of Science ®Google Scholar
• Pan L, Huang BJ, Ma XE, et al. MiR-25 protects cardiomyocytes against oxidative damage by targeting the mitochondrial calcium uniporter. Int J Mol Sci. 2015;16(3):5420–5433. doi:10.3390/ijms16035420
   PubMed Web of Science ®Google Scholar
• Deconinck JF, Potvliege PR, Gepts W. The ultrasturcture of the human pancreatic islets. I. The islets of adults. Diabetologia. 1971;7(4):266–282. doi:10.1007/BF01211879
   PubMed Web of Science ®Google Scholar
• Like AA, Orci L. Embryogenesis of the human pancreatic islets: a light and electron microscopic study. Diabetes. 1972;21(2 Suppl):511–534. doi:10.2337/diab.21.2.s511
   PubMedGoogle Scholar
• Pahl HL. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene. 1999;18(49):6853–6866. doi:10.1038/sj.onc.1203239
   PubMed Web of Science ®Google Scholar
• Lawrence T. The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol. 2009;1(6):a001651. doi:10.1101/cshperspect.a001651
   PubMed Web of Science ®Google Scholar
• Yaron A, Hatzubai A, Davis M, et al. Identification of the receptor component of the IkappaBalpha-ubiquitin ligase. Nature. 1998;396(6711):590–594. doi:10.1038/25159
   PubMed Web of Science ®Google Scholar
• Vriend J, Reiter RJ. Melatonin as a proteasome inhibitor. Is there any clinical evidence?. Life Sci. 2014;115(1–2):8–14. doi:10.1016/j.lfs.2014.08.024
   PubMed Web of Science ®Google Scholar
• Min KJ, Jang JH, Kwon TK. Inhibitory effects of melatonin on the lipopolysaccharide-induced CC chemokine expression in BV2 murine microglial cells are mediated by suppression of Akt-induced NF-kappaB and STAT/GAS activity. J Pineal Res. 2012;52(3):296–304. doi:10.1111/j.1600-079X.2011.00943.x
   PubMed Web of Science ®Google Scholar
• Farre D, Roset R, Huerta M, et al. Identification of patterns in biological sequences at the ALGGEN server: PROMO and MALGEN. Nucleic Acids Res. 2003;31(13):3651–3653. doi:10.1093/nar/gkg605
   PubMed Web of Science ®Google Scholar
• Khan A, Fornes O, Stigliani A, et al. JASPAR 2018: update of the open-access database of transcription factor binding profiles and its web framework. Nucleic Acids Res. 2017. doi:10.1093/nar/gkx1126
   Web of Science ®Google Scholar
• Khan A, Fornes O, Stigliani A, et al. JASPAR 2018: update of the open-access database of transcription factor binding profiles and its web framework. Nucleic Acids Res. 2018;46(D1):D1284. doi:10.1093/nar/gkx1188
   PubMed Web of Science ®Google Scholar
• Xue Y, Sheng Y, Dai H, Cao H, Liu Z, Li Z. Risk of development of acute pancreatitis with pre-existing diabetes: a meta-analysis. Eur J Gastroenterol Hepatol. 2012;24(9):1092–1098. doi:10.1097/MEG.0b013e328355a487
   PubMed Web of Science ®Google Scholar
• Yang L, He Z, Tang X, Liu J. Type 2 diabetes mellitus and the risk of acute pancreatitis: a meta-analysis. Eur J Gastroenterol Hepatol. 2013;25(2):225–231. doi:10.1097/MEG.0b013e32835af154
   PubMed Web of Science ®Google Scholar
• Yuan D, Zhao Y, Banks WA, et al. Macrophage exosomes as natural nanocarriers for protein delivery to inflamed brain. Biomaterials. 2017;142:1–12. doi:10.1016/j.biomaterials.2017.07.011
   PubMed Web of Science ®Google Scholar
• Liu Q, Rojas-Canales DM, Divito SJ, et al. Donor dendritic cell-derived exosomes promote allograft-targeting immune response. J Clin Invest. 2016;126(8):2805–2820. doi:10.1172/JCI84577
   PubMed Web of Science ®Google Scholar
• Xiao H, Lasser C, Shelke GV, et al. Mast cell exosomes promote lung adenocarcinoma cell proliferation - role of KIT-stem cell factor signaling. Cell Commun Signaling. 2014;12:64. doi:10.1186/s12964-014-0064-8
   PubMed Web of Science ®Google Scholar
• Goetzl EJ, Goetzl L, Karliner JS, Tang N, Pulliam L. Human plasma platelet-derived exosomes: effects of aspirin. FASEB J. 2016;30(5):2058–2063. doi:10.1096/fj.201500150R
   PubMed Web of Science ®Google Scholar
• Wahlgren J, Karlson Tde L, Glader P, Telemo E, Valadi H. Activated human T cells secrete exosomes that participate in IL-2 mediated immune response signaling. PloS one. 2012;7(11):e49723.
   PubMed Web of Science ®Google Scholar
• Galli SJ, Borregaard N, Wynn TA. Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils. Nat Immunol. 2011;12(11):1035–1044. doi:10.1038/ni.2109
   PubMed Web of Science ®Google Scholar
• Calvo JR, Gonzalez-Yanes C, Maldonado MD. The role of melatonin in the cells of the innate immunity: a review. J Pineal Res. 2013;55(2):103–120. doi:10.1111/jpi.12075
   PubMed Web of Science ®Google Scholar
• Choi EY, Jin JY, Lee JY, Choi JI, Choi IS, Kim SJ. Melatonin inhibits Prevotella intermedia lipopolysaccharide-induced production of nitric oxide and interleukin-6 in murine macrophages by suppressing NF-kappaB and STAT1 activity. J Pineal Res. 2011;50(2):197–206. doi:10.1111/j.1600-079X.2010.00829.x
   PubMed Web of Science ®Google Scholar
• Zhang S, Li W, Gao Q, Wei T. Effect of melatonin on the generation of nitric oxide in murine macrophages. Eur J Pharmacol. 2004;501(1–3):25–30. doi:10.1016/j.ejphar.2004.08.015
   PubMed Web of Science ®Google Scholar